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Molecular Research on Embryo Developmental Potential: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 415

Special Issue Editor

Special Issue Information

Dear Colleagues,

Embryo developmental potential is an important factor for establishing normal pregnancy in both natural spontaneous reproduction and assisted reproduction treatment (ART) attempts. Since most existing methods of embryo quality evaluation are either too invasive (decreasing the developmental potential even in normal embryos) or not reliable enough, the need for non-invasive methods using molecular biomarkers is evident. This Special Issue is aimed at collecting relevant information on non-invasive molecular biomarkers relevant to embryo developmental potential, both in humans and other mammalian species.

Contributions relating the results of this non-invasive molecular analysis with pregnancy outcomes would be preferred, but any other data on the relationship of molecular biomarkers with embryo health and developmental potential are also welcome. In particular, data explaining the interplay between oocyte and sperm quality are of particular interest.

Finally, new ideas about possible diagnostic and treatment options adapted to particular cases of sperm and oocyte deficiencies in the context of existing ART methods are urgently needed to enable the selection of the best embryos from the available cohort to be transferred into the uterus.

Dr. Jan Tesarik
Guest Editor

Manuscript Submission Information

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Keywords

  • embryo developmental potential
  • oocyte quality
  • sperm quality
  • non-invasive techniques
  • molecular biomarkers

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Published Papers (1 paper)

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Review

12 pages, 719 KB  
Review
Clinical Strategies for Counteracting Human Ovarian Aging: Molecular Background, Update, and Outlook
by Jan Tesarik and Raquel Mendoza Tesarik
Int. J. Mol. Sci. 2025, 26(24), 11973; https://doi.org/10.3390/ijms262411973 - 12 Dec 2025
Viewed by 246
Abstract
Ovarian aging (OA) results from the senescence of different cell types present in the ovary, decreasing female fertility and quality of life and augmenting the risk of a variety of fertility-unrelated pathological conditions. The changes observed in the ovarian cells are accompanied by [...] Read more.
Ovarian aging (OA) results from the senescence of different cell types present in the ovary, decreasing female fertility and quality of life and augmenting the risk of a variety of fertility-unrelated pathological conditions. The changes observed in the ovarian cells are accompanied by changes occurring in various elements of the hypothalamic–pituitary–ovarian (HPO) axis, the complex endocrine system that regulates the female reproductive cycle. Issues pertaining to the HPO axis have been addressed in animal models via hormonal treatments with preparations inhibiting ovarian follicular recruitment at the level of the receptors of gonadotropin-releasing hormone (GnRH)-secreting neurons, mainly acting on glutamate- and gamma-aminobutyric acid (GABA)-driven signaling. GnRH agonists and antagonists have also been used in women exposed to chemotherapeutics. HPO-independent OA can be delayed through the administration of different antioxidants and mitochondria-protecting agents, among which melatonin has been shown to be particularly useful. Other therapeutic approaches used with success in women include hormonal and growth factor (GF) modulators, such as growth hormone (GH), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factors (VEGF), and dehydroepiandrosterone (DHEA), and the development of patient-tailored combination-based therapies (IGF-1 + VEGF + DHEA) has also been suggested. Intraovarian injection of autologous platelet-rich plasma (PRP), mitochondrial donation through pronuclear transfer, and ovarian tissue cryopreservation and autotransplantation have also yielded promising results in women, and their use can preserve not only fertility but also the ovarian endocrine function. Personalized mixtures of specific agents (desatinib, quercetin, rapamycin, metformin, resveratrol, melatonin, and coenzyme Q10) targeting different cell types in the ovary are currently under investigation. Overall, this review aims to present a global view of the subject, uniting the physiological and molecular background of this pathology with the history and development of potential treatment strategies and new perspectives in this domain. As such, this study may be helpful both to clinicians facing problems resulting from OA and to researchers pursuing further developments in this field. Full article
(This article belongs to the Special Issue Molecular Research on Embryo Developmental Potential: 2nd Edition)
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