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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Probiotics, Prebiotics and Postbiotics: The Secrets of Promoting Microbial Balance in the Gut

edited by

Fu-Chen Huang

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3106 | Submission Open

Keywords: probiotics; prebiotics; postbiotics; gut microbiota; gut epithelial integrity

(This special issue belongs to the Section Molecular Microbiology)

Nanofibrous Biomaterials for Biomedicine and Medical Applications

edited by Jong-Young Kwak

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3093 | Submission Open

Keywords: nanofibers; biomaterials; 3D scaffold; 3D cell culture; tissue engineering; drug release

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Pathophysiology of Cystic Fibrosis

edited by

Stefanie Krick

and George M. Solomon

submission deadline 20 Sep 2025 | 1 articles | Viewed by 3054 | Submission Open

Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds: Protecting Plants and Promoting Human Health, 2nd Edition

edited by

Gina Rosalinda De Nicola

submission deadline 20 Sep 2025 | 2 articles | Viewed by 3040 | Submission Open

Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Quadruplex DNA and Its Ligands for Disease Treatment

edited by

Ding Li

submission deadline 20 Sep 2025 | 3 articles | Viewed by 3030 | Submission Open

Keywords: quadruplex; i-motif; transcriptional regulation; apoptosis; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells and Regenerative Medicine: In Vitro and In Vivo Studies—2nd Edition

edited by

Alessia Peserico

submission deadline 20 Sep 2025 | 1 articles | Viewed by 3016 | Submission Open

Keywords: stem cells; stem cell homing; stem cell tracking; regeneration; tissue injury; immunomodulation; biomaterials; tissue-on-a-chip; organoids; differentiation

(This special issue belongs to the Section Molecular Biology)

Compounds with Added Value from Marine Algae for Biomedical Applications

edited by

Ticuta Negreanu-Pirjol

Bogdan-Stefan Negreanu-Pirjol

and

Oana Crăciunescu

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2982 | Submission Open

Keywords: algae bioactive compounds; algal biotechnology for biomedical purposes; algal-derived biomedical materials; algal-based drug delivery systems; alginate; carrageenan; fucoidan; marine polysaccharides; marine peptides; marine polyphenols; marine antioxidants; marine bioactive compounds; marine glycosaminoglycans; marine biopolymers and biomaterials; marine lipids; marine-derived pharmaceuticals; marine-derived cosmeceuticals; marine-derived nutraceuticals; marine algae added-value products; marine drugs discovery; marine natural products; marine-derived anti-inflammatory agents; marine antimicrobial compounds; marine-derived anticancer agents; marine neuroprotective compounds; marine-derived anti-aging compounds; marine-based regenerative medicine; phycobiliproteins; seaweed-based tissue engineering materials; seaweed-derived bioactive molecules; seaweed extracts; seaweed-based wound healing materials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

C. elegans as a Disease Model: Molecular Perspectives: 2nd Edition

edited by

Krisztina Takács-Vellai

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2976 | Submission Open

Keywords: Caenorhabditis elegans; model organism; disease model; neurodegenerative diseases; cancer model; ageing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Targets and Immunotherapy for Autoimmune Diseases

edited by

Neetu Srivastava

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2971 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; signaling pathway; molecular targets; antibody; T cells; B cells

(This special issue belongs to the Section Molecular Immunology)

Anti-Inflammatory and Metabolic Effects of G Protein-Coupled Receptor Signaling

edited by

Dariusz Szukiewicz

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2970 | Submission Open

Keywords: G protein-coupled receptors (GPCRs); seven transmembrane domain (7TM) receptors; metabotropic receptors; membrane receptors; GPCRs signaling; GPCRs signaling pathways; anti-inflammatory effects; inflammatory diseases; metabolic diseases; metabolic effects; anti-inflammatory treatment

(This special issue belongs to the Section Molecular Immunology)

High Fat Diet Metabolism and Diseases

edited by

Miguel Walter Fornés

and

Luís Fernando Barbisan

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2881 | Submission Open

Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Physiological Functions and Pathological Effects of Microglia

edited by Hiroshi Nakanishi

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2873 | Submission Open

Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning

(This special issue belongs to the Section Molecular Neurobiology)

Drug Discovery and Development Focusing on Natural Products

edited by

Chung-Hsin Wu

and

Szu-Chuan Shen

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2871 | Submission Open

Keywords: natural products; drug R& D; herbal medicine; gut microbiota; mechanism of action; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

New Cardiovascular Risk Factors: 2nd Edition

edited by

Antonio Barbato

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2861 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Biology)

Cellular Metabolism and Retinal Diseases: Unraveling Molecular Pathways and Therapeutic Targets

edited by

Alessandra Puddu

and

Davide Maggi

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2849 | Submission Open

Keywords: retina; metabolic dysfunction in retinal diseases; metabolism and retinal cell function; metabolism and oxidative stress; therapeutic targets; intracellular signaling; epigenetic modification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adapter CAR T Cells: From the Idea to the Clinic

edited by

Michael P. Bachmann

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2835 | Submission Open

Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rheumatoid Arthritis: Molecular Mechanisms and Immunotherapy

edited by Irena Manolova

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2822 | Submission Open

Keywords: rheumatoid arthritis; pathogenesis; innate immunity; adaptive immunity; inflammation; cytokines; autoantibodies; immunotherapy; clinical outcome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases

edited by

Caterina Gagliano

Marco Zeppieri

and

Mario Damiano Toro

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2804 | Submission Open

Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Strategies to Overcome Antibiotic Resistance in Carbapenem-Producing Bacteria

edited by

Daniela Calina

and

Ovidiu Zlatian

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2776 | Submission Open

Keywords: antibiotic resistance; antimicrobial agents; bacterial pathogens; carbapenemases; genomics; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Heart Failure Risk Factors and Therapies on a Molecular Basis

edited by

Tomasz Urbanowicz

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2729 | Submission Open

Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Smooth Muscle Cells in Vascular Disease

edited by

Ida Daniela Perrotta

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2707 | Submission Open

Keywords: smooth muscle cells (SMCs); atherosclerosis; hypertension; aortic aneurysm; vascular ageing; extracellular matrix; endothelial cells (ECs); SMC senescence; interleukin; platelet-derived growth factor; phenotype switching; SMC plasticity; SMC-derived cells; molecular subtypes; intimal thickening; plaque stability; transcription factors; microRNAs; clonality

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Host-Directed Antiviral Therapies

edited by

Raquel Bello-Morales

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2662 | Submission Open

Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends in MOF (Metal–Organic Framework) and Metal X-ides Development, 2nd Edition

edited by Siwei Li

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2641 | Submission Open

Keywords: MOF; metal carbide; metal sulfide; metal phosphide; catalysis; biomedicine; electromagnetic absorption; energy conversion and storage

(This special issue belongs to the Section Materials Science)

Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases

edited by

Hirayuki Enomoto

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2636 | Submission Open

Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research

edited by

Zakaria Prodhan

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2594 | Submission Open

Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research

(This special issue belongs to the Section Molecular Plant Sciences)

Bilirubin: Health Challenges and Opportunities

edited by

Silvia Gazzin

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2593 | Submission Open

Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection

(This special issue belongs to the Section Molecular Biology)

Utilizing Induced Pluripotent Stem Cells and Cardiomyocytes: From Basic Research to Disease Modeling

edited by

Ofer Binah

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2575 | Submission Open

Keywords: induced pluripotent stem cells; cardiomyocytes; disease modeling; basic research; translational applications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

edited by

Ji Hyun Lee

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2549 | Submission Open

Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies

edited by Francesco Agostini

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2538 | Submission Open

Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Parvovirus

edited by Zahra Kadri

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2524 | Submission Open

Keywords: parvovirus structure; parvovirus replication; parvovirus proteome; cell signaling pathways; transcription; translation and post-translational modification; host restriction factor; host/parvovirus interaction; recombinant virus and VLP; immune evasion and/or activation; host tropism (cell type and species); new experimental models and approaches

(This special issue belongs to the Section Molecular Microbiology)

Application of Artificial Intelligence in Molecular Sciences

edited by

Jorge Mateo

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2434 | Submission Open

Keywords: artificial intelligence; deep learning; algorithms; molecular modeling and simulation; materials discovery; analysis of biological sequence data; computational chemistry; bioinformatics; genomics; protein structure prediction; molecular dynamics simulation

(This special issue belongs to the Section Molecular Informatics)

The Impact of Mitochondria on Human Disease and Health

edited by

Martina Semenzato

submission deadline 20 Sep 2025 | 3 articles | Viewed by 2428 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer

(This special issue belongs to the Section Biochemistry)

Emerging Heterocycles

edited by

David StC Black

and

Naresh Kumar

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2427 | Submission Open

Keywords: synthesis; reactions; applications; biological activity; medicinal chemistry; natural products; alkaloids; new methodology

(This special issue belongs to the Section Biochemistry)

False-Positive and False-Negative Laboratory Biomarkers

edited by Michela Salvatici and Lorenzo Drago

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2425 | Submission Open

Keywords: biomarkers; false positives/negatives; protein biomarkers; nucleic acid markers; multi-omics; single-cell sequencing; liquid biopsy

(This special issue belongs to the Section Biochemistry)

Microbiota’s Role in Respiratory Disorders and Diseases

edited by

Ioannis Alexandros Charitos

and Mauro Carone

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2425 | Submission Open

Keywords: microbiota; microbiome; metabolome; transcriptome; microbiota gut/lung axis; microbiota gut/oral axis; respiratory disorders; respiratory diseases; respiratory rehabilitation

(This special issue belongs to the Section Molecular Microbiology)

Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias: 2nd Edition

edited by

Amal Kaddoumi

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2408 | Submission Open

Keywords: Alzheimer’ s disease; neuroinflammation; drug development; microglia; astrocytes; cytokines; TREM2; risk factors; biomarkers

(This special issue belongs to the Section Molecular Immunology)

The Gut-Brain Axis: Genomic and Metagenomic Involvement

edited by

Maria Gazouli

and Elias Odusseas Tzavellas

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2363 | Submission Open

Keywords: gut– brain axis; central nervous system; gastrointestinal tract; genomic; metagenomic

(This special issue belongs to the Section Molecular Neurobiology)

Novel Technologies in the Study of the Pathogenesis of Cardiac Diseases

edited by

Raffaella Lombardi

and

Suet Nee Chen

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2323 | Submission Open

Keywords: artificial Intelligence; multi-omics; organoids; engineered heart tissue; advanced imaging; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antiphospholipid Syndrome: From Pathophysiology to Therapy

edited by

Cristina Belizna

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2304 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: Cancer Metabolism

edited by

Giuseppe Lucarelli

Daniel W. Nixon

and

Gianfranco Peluso

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2283 | Submission Open

Keywords: cancer metabolism; metabolic pathway; glucose consumption and energy production; amino acid requirement

(This special issue belongs to the Section Molecular Oncology)

Molecular Dimensional Design, Synthesis Modification and Application of Sustainable Polymer Materials

edited by

Angelika Kmita

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2247 | Submission Open

Keywords: sustainable polymeric materials; 3D printing; sustainability; environmental impact; molecular modifications

(This special issue belongs to the Section Materials Science)

Research of Hydroxyapatite-Based Materials and Their Applications

edited by

Daniela Predoi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2203 | Submission Open

Keywords: hydroxyapatite; nanobiocomposite; biomedical applications; coatings; environment remediation; biological properties; drug delivery; pollutant adsorption efficiency; morphology and structural features

(This special issue belongs to the Section Materials Science)

New Insights into Osteoclasts

edited by

David Gyori

submission deadline 20 Sep 2025 | 2 articles | Viewed by 2198 | Submission Open

Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor

(This special issue belongs to the Section Molecular Biology)

Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy

edited by

Tetiana Zaǐchuk

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2174 | Submission Open

Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution

(This special issue belongs to the Section Molecular Oncology)

Fungal Pathogen-Host Interactions

edited by Patricia Albuquerque

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2141 | Submission Open

Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils

(This special issue belongs to the Section Molecular Microbiology)

Blueprints of Enzymatic Function and Structure in Biocatalysis

edited by

Francesco Malatesta

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2111 | Submission Open

Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design

(This special issue belongs to the Section Biochemistry)

Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment

edited by

Premila Leiphrakpam

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2089 | Submission Open

Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Olive and Its Derivatives

edited by

Fabrizio Carbone

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2049 | Submission Open

Keywords: olive; structural and functional genomics; genomic variation; breeding; biotechnologies; next-generation sequencing

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Developments in Metabolism of Algal Toxins in Animals

edited by

Alexandre Campos

and

Pedro Reis Costa

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2030 | Submission Open

Keywords: marine toxins; bioacumulation; chemical conversion; detoxification mechanisms; toxin gene clusters

(This special issue belongs to the Section Molecular Toxicology)

Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases

edited by

Gregory F. Oxenkrug

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2010 | Submission Open

Keywords: anthranilic acid; Alzheimer’ s disease; autism; schizophrenia; bipolar disorder; major depressive disorder; post-partum depression; COVID-19; interferons; attention deficit disorder; cognitive impairment; G-protein-coupled receptor 109A; microbiome; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Displaying special issue 1151-1200 on page 24 of 69.

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