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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Insights into Colorectal Cancer Treatment
edited by Fee Klupp
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3532 | Submission Open
(This special issue belongs to the Section Molecular Oncology)
Advances in Molecular Mechanisms of Neurodegenerative Diseases
edited by Aslihan Ugun-Klusek
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3504 | Submission Open
Keywords: neurodegeneration; Parkinson’ s disease; Alzheimer’ s disease; molecular signalling; neuronal death
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Zoonotic Diseases submission deadline 20 Jul 2025 | 3 articles | Viewed by 3434 | Submission Open
Keywords: mycobacterial diseases; bubonic and pneumonic plague; Q fever; cat scratch disease; Mediterranean fever; HIV; malaria; ADIS; SARS-CoV-2; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses
(This special issue belongs to the Section Molecular Microbiology)
New Therapies for Acute Myeloid Leukemia
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3394 | Submission Open
Keywords: acute myeloid leukemia; BCL2 inhibitors; leukemic cells; new therapies for AML; prognostic implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Post-transcriptional and Epigenetic Mechanisms Controlling Stem Cells Differentiation
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3390 | Submission Open
Keywords: stem cell differentiation; adipogenesis; neurogenesis; epigenetics; post-transcriptional modification; ncRNAs
(This special issue belongs to the Section Molecular Biology)
Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets submission deadline 20 Jul 2025 | 2 articles | Viewed by 3364 | Submission Open
Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases
(This special issue belongs to the Section Molecular Immunology)
Optimizing Mechanistic Rationale for Parkinson’s Disease Treatment
edited by Michael Salvatore and Jason Richardson
submission deadline 20 Jul 2025 | 1 articles | Viewed by 3320 | Submission Open
Keywords: substantia nigra; tyrosine hydroxylase; growth factors; neuroprotection; repurposed drugs; lifestyle interventions; dopamine; models of Parkinson’ s disease  
(This special issue belongs to the Section Molecular Neurobiology)
Role of Diet and Nutrition in Metabolic Diseases submission deadline 20 Jul 2025 | 1 articles | Viewed by 3302 | Submission Open
Keywords: nutrients; biomarkers; molecular targets; pahodiagnosis; treatment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Lipidomics and Lipid Metabolism in Health and Disease
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 3302 | Submission Open
Keywords: lipidomics; lipid metabolism; lipid signaling; lipid homeostasis; metabolic disease; lipid biomarkers; fatty acids; phospholipids; sphingolipids; cholesterol
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research in Fruit Crop: Second Edition
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 3297 | Submission Open
Keywords: fruit crop; biotechnology; hormonal; environmental signals
(This special issue belongs to the Section Molecular Plant Sciences)
Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine submission deadline 20 Jul 2025 | 2 articles | Viewed by 3288 | Submission Open
Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling
(This special issue belongs to the Section Molecular Biology)
The Role of Phytochemicals in Neurological Disorders submission deadline 20 Jul 2025 | 1 articles | Viewed by 3274 | Submission Open
Keywords: phytochemicals; neurodegeneration; antioxidant activity; anti-inflammatory activity; nutrition; bioactive; inhibitor; functional foods; nutraceuticals; molecular mechanism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Antibacterial Activity against Drug-Resistant Strains, 2nd Edition
edited by and
submission deadline 20 Jul 2025 | 3 articles | Viewed by 3223 | Submission Open
Keywords: antibacterial activity; novel antimicrobial agents; drug-resistant strains; molecular mechanisms; emerging drug-resistant pathogens; genetic determinants; impact of MDR pathogens on human health; molecular methods for the diagnosis of antibiotic resistance
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insight into Oxidative Stress in Plants submission deadline 20 Jul 2025 | 2 articles | Viewed by 3168 | Submission Open
Keywords: ROS detoxification pathways; enzymatic and non-enzymatic antioxidants; SOS markers at the molecular level; cross-talk of ROS with phytohormones; restoration of plant cell homeostasis; mechanisms of oxidative damages and antioxidant protection; multiple signaling cascades in SOS prevention; transcriptomic analysis in gene regulatory networks; metabolomic and proteomic analyses
(This special issue belongs to the Section Molecular Plant Sciences)
From Molecules to Medicines: Exploring Neurodegenerative Pathways for Targeted Neuropharmacology
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3106 | Submission Open
Keywords: disease modeling; drug studies; therapeutic interventions; neuropharmacology; innovative pharmacological interventions
(This special issue belongs to the Section Molecular Neurobiology)
Unraveling Sugar Signaling: Insights into Plant Stress Responses
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3103 | Submission Open
Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Mechanism Based Toxicity and Hazard Assessment of NGTxC Chemicals 2.0 submission deadline 20 Jul 2025 | 1 articles | Viewed by 3054 | Submission Open
Keywords: non genotoxic carcinogens; carcinogenicity; inflammation; hazard assessment; molecular targets
(This special issue belongs to the Section Molecular Toxicology)
Molecular Insight into Alzheimer’s Disease
edited by Thierry Oster and Catherine Malaplate
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3022 | Submission Open
Keywords: Alzheimer’ s disease; cellular and molecular mechanisms; neuronal membranes; endocytosis; and vesicular trafficking; molecular crosstalk between neurons and glial cells; protein interaction with lipids or other proteins; biomarkers and diagnosis; epidemiology; risk factors; and prevention; therapeutic visions
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Investigations in Neurodevelopmental Disorders
edited by Giorgio Medici
submission deadline 20 Jul 2025 | 2 articles | Viewed by 3020 | Submission Open
Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies
(This special issue belongs to the Section Molecular Neurobiology)
Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2944 | Submission Open
Keywords: diabetic bone disease; molecular mechanisms; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cancer: Molecular Research and Novel Inflammatory Targets submission deadline 20 Jul 2025 | 3 articles | Viewed by 2818 | Submission Open
Keywords: cancer; tumor microenvironment; molecular biology; biomarkers; novel and alternative therapies; inflammation; pharmacological inhibitors
(This special issue belongs to the Section Molecular Oncology)
Antimicrobial Resistance—New Insights, 3rd Edition
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2795 | Submission Open
Keywords: antimicrobial resistance; mechanisms of antimicrobial resistance; rapid antimicrobial susceptible assays; antimicrobial dosing; molecular assays
(This special issue belongs to the Section Molecular Microbiology)
Immunophenotyping in Autoimmune Diseases and Cancer, 4th Edition submission deadline 20 Jul 2025 | 1 articles | Viewed by 2789 | Submission Open
Keywords: immunophenotyping; immune regulation; multiparameter cytometry; immuno-oncology; anti-tumor immunity; autoimmunity; cancer immunology; protein– protein interactions; structure/function relationships; sulfur amino acids
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2784 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Treatment Strategies of Myocardial Infarction
edited by Abdul-Majeed Salmasi
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2699 | Submission Open
Keywords: myocardial infarction; genetics; molecular biology; chromosomes; genes; atherosclerosis; coronary artery disease; risk factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Nutraceuticals in Gastrointestinal Diseases and the Applications in Microbiota submission deadline 20 Jul 2025 | 1 articles | Viewed by 2693 | Submission Open
Keywords: microbiota; nutraceuticals; probiotics; prebiotics; postbiotics; IBS; IBD; GERD
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Signalling Pathway and Regulation of Oxidative Stress in Lung Diseases submission deadline 20 Jul 2025 | 1 articles | Viewed by 2666 | Submission Open
Keywords: oxidative stress; lung disease; airway epithelium; steroid resistance; antioxidant treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: QSAR and Computational Approaches to Drug Discovery submission deadline 20 Jul 2025 | 2 articles | Viewed by 2662 | Submission Open
Keywords: molecular modelling; molecular simulation; drug design; drug development; molecular mechanism; mathematical chemistry; structure-activity relationship; molecular descriptor; pharmacokinetics; toxicity
(This special issue belongs to the Section Molecular Informatics)
Programmed Cell Death and Oxidative Stress: 3rd Edition
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 2661 | Submission Open
Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress
(This special issue belongs to the Section Biochemistry)
Molecular Dynamics Simulations and Structural Analysis of Protein Domains (2nd Edition) submission deadline 20 Jul 2025 | 4 articles | Viewed by 2561 | Submission Open
Keywords: protein structures; molecular dynamics; advanced molecular dynamics; variants; pathologies; drug design; allostery; protein domains; secondary structures; methodological development; protein design; ligands; normal mode analysis; machine learning
(This special issue belongs to the Section Molecular Informatics)
cGMP Signaling: From Bench to Bedside
edited by Iraida Sharina
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2554 | Submission Open
Keywords: nitric oxide; cellular signaling; cardiovascular biology; cerebrovascular regulation; aging
(This special issue belongs to the Section Molecular Biology)
Neurological Diseases: From Molecular Basis to Therapy
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2501 | Submission Open
Keywords: neurological diseases; pathogenesis; therapy; personalized medicine; early diagnosis; genetics; neurology; pharmacology
(This special issue belongs to the Section Molecular Neurobiology)
Bio-Nanopesticides
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2451 | Submission Open
Keywords: bio-nanopesticides; sustainable agriculture; pest control; plant protection; nanotechnology; eco-friendly solutions; environmental impact; toxicity
(This special issue belongs to the Section Molecular Nanoscience)
MAPK Signaling Cascades in Human Health and Diseases, 2nd Edition
edited by Galia Maik-Rachline
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2429 | Submission Open
Keywords: ERK1/2; p38; JNK; ERK5; MEK; MEKK; raf; stimulated nuclear translocation; targeted therapy; resistance mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hematologic Diseases: Molecular Insights and Novel Methods
edited by and Samantha Bruno
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2418 | Submission Open
Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Forensic Toxicology
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2404 | Submission Open
Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro; in vivo; and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)
(This special issue belongs to the Section Molecular Toxicology)
Future Perspectives and Challenges: Interleukins in Immune Diseases
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2396 | Submission Open
Keywords: immune disease; interleukin; cytokine
(This special issue belongs to the Section Molecular Immunology)
Advances in Metalloproteinase
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 2395 | Submission Open
Keywords: matrix metalloproteinases (MMPs); substrate specificity; pathological condition; metalloproteinases inhibitors
(This special issue belongs to the Section Macromolecules)
Molecular Research in Parkinson's Disease
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2394 | Submission Open
Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Drug Discovery and Synthesis: 2nd Edition submission deadline 20 Jul 2025 | 2 articles | Viewed by 2363 | Submission Open
Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Protein Folding, Misfolding, and Related Diseases submission deadline 20 Jul 2025 | 1 articles | Viewed by 2342 | Submission Open
Keywords: protein folding; misfolding; amyloid; neurodegenerative diseases; chaperons; mechanisms; regulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds in Human Health and Disease
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2334 | Submission Open
Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Stem Cell-Based Regenerative Medicine for Renal Disorders
edited by In-Yong Kim
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2311 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; stem cells; regenerative medicine; stem cell therapy; cellular reprogramming; cell transplantation
(This special issue belongs to the Section Molecular Biology)
Novel Therapeutic Approaches for Migraine Headaches
edited by Giorgio Pietramaggiori and Saja Scherer
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2282 | Submission Open
Keywords: migraines; chronic headaches; cluster headaches; occipital neuralgia; neuralgia; occipital nerve dysfunction; nerve damage; botulinum toxin
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biophysical Perspectives on Bone Physiology and Pathology
edited by Atsuhiko Ichimura and Yohei Ueda
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2196 | Submission Open
Keywords: bone formation; bone disorders; physiology; pathology; stem cells; osteoblasts; osteoclasts
(This special issue belongs to the Section Molecular Biophysics)
Molecular Biology of Senescence and Anti-Aging Strategies submission deadline 20 Jul 2025 | 1 articles | Viewed by 2152 | Submission Open
Keywords: cellular senescence; aging; delaying senescence; aging-associated diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2140 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments
edited by and Juliana Bordignon-Draibe
submission deadline 20 Jul 2025 | 1 articles | Viewed by 2130 | Submission Open
Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)
(This special issue belongs to the Section Molecular Immunology)
Fish Genomics and Developmental Biology, 2nd Edition submission deadline 20 Jul 2025 | 2 articles | Viewed by 2113 | Submission Open
Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology
edited by
submission deadline 20 Jul 2025 | 2 articles | Viewed by 2090 | Submission Open
Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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