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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Thyroid Dysfunctions: Molecular Mechanisms Underlying Clinical Consequences

edited by

Jacopo Manso

submission deadline 20 Jun 2025 | 3 articles | Viewed by 6611 | Submission Open

Keywords: thyroid; thyroid dysfunctions; thyroid hormones; thyroid disorders; molecular mechanisms

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms

edited by

Gaia Favero

and

Luca Vanella

submission deadline 20 Jun 2025 | 2 articles | Viewed by 6558 | Submission Open

Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Research on Alzheimer’s Disease: 2nd Edition

edited by

Stella Gagliardi

and

Carlo Morasso

submission deadline 20 Jun 2025 | 3 articles | Viewed by 6533 | Submission Open

Keywords: therapy; prevention; new molecules; Alzheimer’ s disease; genetics; nanoformulation; targets; dementia; biomarker discovery

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Dry Eye Syndrome

edited by Maria Jesus Giráldez-Fernández and

Anxo Fernández Ferreiro

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6519 | Submission Open

Keywords: dry eye disease; tear film osmolarity; tear film; artificial tear substitutes; biological tear substitutes; tear fluid biomarkers; tear film lipid layer; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; ocular surface inflammation; cytokines; histological analysis; pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Skin Diseases: From Molecular Pathology to Novel Therapeutic Approaches

edited by

Alicja Forma

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6469 | Submission Open

Keywords: skin physiology and pathology; skin cancer; autoimmune skin diseases; microbial infections of skin; sexually transmitted diseases; molecular pathology; therapeutic advancements

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Immune Cells and Cytokines (2nd Edition)

edited by

Athanasia Mouzaki

submission deadline 20 Jun 2025 | 5 articles | Viewed by 6463 | Submission Open

Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis

edited by

Masato Sato

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6335 | Submission Open

Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine

(This special issue belongs to the Section Molecular Pharmacology)

Hepatocellular Carcinoma: Latest Research in Pathogenesis, Detection and Treatment, 2nd Edition

edited by

Cristian Turato

and

Stefania Cannito

submission deadline 20 Jun 2025 | 2 articles | Viewed by 6226 | Submission Open

Keywords: human hepatocellular carcinoma (HCC); tumour microenvironment; biomarkers; immunotherapy; epigenetic modulators; precise medicine; combination strategies

(This special issue belongs to the Section Molecular Oncology)

Developing Methods and Molecular Basis in Plant Biotechnology

edited by

Wojciech Makowski

and

Mateusz Labudda

submission deadline 20 Jun 2025 | 5 articles | Viewed by 6131 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Pediatric Diseases

edited by Elvira Pota and Alessandra Di Paola

submission deadline 20 Jun 2025 | 4 articles | Viewed by 6031 | Submission Open

Keywords: pediatric patients; pediatric diseases; molecular mechanisms; molecular therapies; molecular target; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Bioactives from Natural Products

edited by

Carmen Lizette Del-Toro-Sánchez

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5911 | Submission Open

Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits

(This special issue belongs to the Section Molecular Biology)

Recombinant Proteins, Protein Folding and Drug Discovery

edited by

Mohamed Raafat El-Gewely

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5891 | Submission Open

Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics

(This special issue belongs to the Section Biochemistry)

Gynecological Cancer: Targeted Therapeutics and Future Perspectives

edited by

Angela Santoro

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5883 | Submission Open

Keywords: molecular background; precision medicine; histomolecular diagnosis; targeted therapies; clinical trials; overall survival; disease-free survival; gynecological cancer; whole genomic assay; molecular biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Helicobacter pylori Infections and Treatments

edited by

Dmitry Bordin

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5876 | Submission Open

Keywords: H. pylori; gastritis; carcinogenesis; mechanisms of pathogenicity; molecular pathology; molecular genetics; microbiome modulation; antibiotic resistance; eradication

(This special issue belongs to the Section Molecular Microbiology)

Molecular Structure, Electronic and Vibrational Spectra: Experiment and Theoretical Calculations in Fundamental Science and Materials Science

edited by

Georgiy V. Girichev

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5865 | Submission Open

Keywords: molecular structure; nature of chemical bonding; IR spectra; EA spectra; NMR; XRD; DFT; ab initio

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Molecular and Cellular Mechanisms of Neurodegenerative Diseases, 2nd Edition

edited by

Hongjun (Harry) Fu

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5825 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease (AD); Parkinson’ s disease (PD); frontotemporal lobar degeneration (FTLD); amyotrophic lateral sclerosis (ALS); Huntington’ s disease (HD); prion diseases; cellular and molecular mechanisms; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5812 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

New Advances in Protein Structure, Function and Design

edited by

Angelo Facchiano

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5779 | Submission Open

Keywords: AI applications in molecular structure; molecular simulations; new bioinformatics tools; protein structure; protein function; protein– protein interaction; online resources

(This special issue belongs to the Section Molecular Informatics)

Advances in Antimicrobial Nanomaterials 2.0

edited by

Irena Maliszewska

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5700 | Submission Open

Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Infective Mycobacteria

edited by

Giovanni Stelitano

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5667 | Submission Open

Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry

(This special issue belongs to the Section Molecular Microbiology)

Advances in Diagnostics: Applications of Nucleic Acids and Their Analogs

edited by

Annalisa Masi

Barbara Pascucci

and

Maria Moccia

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5611 | Submission Open

Keywords: nucleic acids; PNAs; ASOs; aptamers; CRISPR; biomarkers

(This special issue belongs to the Section Molecular Genetics and Genomics)

Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment

edited by Dominika Marta Stygar and

Barbara Bażanów

submission deadline 20 Jun 2025 | 5 articles | Viewed by 5599 | Submission Open

Keywords: viral infections; virus mutations; molecular diagnostic methods; antiviral drugs/preparations; viral diseases physiological mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Hematopoietic System under Physiological Conditions and Following Hematopoietic Reconstitution or Stress: 2nd Edition

edited by

Alexander V. Belyavsky

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5569 | Submission Open

Keywords: hematopoietic stem/progenitor cells; hematopoietic differentiation; hematopoietic niches; niche-HSC/progenitor cell interactions; steady-state hematopoiesis; reconstituted hematopoiesis; hematopoietic stress response; cell fate tracing

(This special issue belongs to the Section Molecular Biology)

Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition)

edited by

Rosaria Meccariello

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5525 | Submission Open

Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Gene Transfer in Brain Disorders

edited by

Tam Thanh Quach

, Lluís Samaranch and Anne-Marie Duchemin

submission deadline 20 Jun 2025 | 1 articles | Viewed by 5495 | Submission Open

Keywords: intellectual disability; neurodegenerative disorders; psychiatric diseases; gene transfer; AAV

(This special issue belongs to the Section Molecular Neurobiology)

Growth Hormone Deficiency: Molecular Pathologies and Therapeutic Strategies

edited by

Renata Stawerska

submission deadline 20 Jun 2025 | 4 articles | Viewed by 5423 | Submission Open

Keywords: growth hormone (GH); growth hormone deficiency (GHD); growth hormone therapy; long-acting growth hormone (LAGH); insulin-like growth factor-1 (IGF-1); growth hormone secretagogues; signaling pathways of the GH-IGF-1 axis; transition phase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances of Novel Pharmaceutical Designs for Anti-Cancer Therapies, 3rd Edition

edited by

Bernhard Biersack

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5352 | Submission Open

Keywords: cancer; anticancer drugs; drug design; targeted therapy; immunotherapy; molecular target; molecular mechanism; drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Mechanisms of Pancreatic Cancer

edited by

Sanith Cheriyamundath

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5346 | Submission Open

Keywords: PDAC; metastasis; tumor microenvironment; cancer-associated fibroblasts; KRAS; immune cells; inhibitors; resistance; signaling pathways; EMT

(This special issue belongs to the Section Molecular Oncology)

Advances in Structure, Function and Molecular Targeting of DNA Topoisomerases: 2nd Edition

edited by Joseph E. Deweese and Neil Osheroff

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5295 | Submission Open

Keywords: topoisomerase; DNA supercoiling; DNA topology; anticancer; antimicrobial; DNA damage

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Lung Cancer: Translational Perspectives

edited by

Mariaenrica Tinè

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5273 | Submission Open

Keywords: lung cancer; oncogene; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Editorial Board Members’ Collection Series: "Enzyme Inhibition"

edited by

Claudiu T. Supuran

and

Piotr Paneth

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5183 | Submission Open

Keywords: enzyme inhibition; enzyme activators; magnesium/calcium-containing enzymes; zinc/iron enzymes; PROTACs; cancer; drug resistance; antiinfectives

(This special issue belongs to the Section Biochemistry)

Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition

edited by

Lorant Janosi

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5178 | Submission Open

Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking

(This special issue belongs to the Section Macromolecules)

Bioactive Compounds in the Prevention of Chronic Diseases

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5157 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Dysfunction and Oxidative Stress in Parkinson’s Disease

edited by

Iain P. Hargreaves

submission deadline 20 Jun 2025 | 2 articles | Viewed by 5077 | Submission Open

Keywords: Parkinson’ s disease (PD); reactive oxygen species (ROS); oxidative stress (OS); mitochondrial respiratory chain (MRC); mitochondrial dysfunction; glutathione; pentose phosphate pathway

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Breeding, Genetics, and Genomics of Fruit Crops

edited by Elisa Vendramin and Micali Sabrina

submission deadline 20 Jun 2025 | 4 articles | Viewed by 4914 | Submission Open

Keywords: genetics; genomics; transcriptomics; plant genetic resources; SNP; SSR; GWAS; QTLs; genomic selections; candidate genes

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Molecular Trends and Prospects in Kidney Diseases

edited by

Federico Greco

and

Carlo A. Mallio

submission deadline 20 Jun 2025 | 3 articles | Viewed by 4828 | Submission Open

Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Cancer—Implications for Diagnosis and Treatment: 3rd Edition

edited by Saak Victor Ovsepian,

Stergios Boussios

and

Matin Sheriff

submission deadline 20 Jun 2025 | 7 articles | Viewed by 4796 | Submission Open

Keywords: genomics; epigenetics; translational research; oncology precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Avian Genetics

edited by

Michael N. Romanov

submission deadline 20 Jun 2025 | 3 articles | Viewed by 4767 | Submission Open

Keywords: avian genetics; cytogenetics and genomics in wild and domesticated birds; bioinformatic analysis; molecular markers; molecular studies in birds; molecular mechanisms underlying physiology and ecology of birds; molecular insights into evolution; conservation; reproduction; illness and commercial utilization; host– pathogen interaction

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Signaling Meet the Space Environment (3rd Edition)

edited by

Khaled Kamal

and

John Lawler

submission deadline 20 Jun 2025 | 4 articles | Viewed by 4760 | Submission Open

Keywords: space exploration; microgravity; space radiation; cellular mechanism; astronaut health

(This special issue belongs to the Section Molecular Biology)

Interactions between the Nervous System and Gastrointestinal Motility

edited by Takahiko Shiina

submission deadline 20 Jun 2025 | 4 articles | Viewed by 4736 | Submission Open

Keywords: gastrointestinal tracts; central nervous system; enteric nervous system; motor regulation; peristalsis; vomiting; gastrointestinal disorder; smooth muscle; striated muscle; sphincter; esophagus; stomach; duodenum; jejunum; ileum; cecum; colon; rectum; rumen

(This special issue belongs to the Section Molecular Neurobiology)

Stem Cell Applications and Innovations in Developmental and Degenerative Disorders

edited by

Jerran Santos

and

Bruce Milthorpe

submission deadline 20 Jun 2025 | 1 articles | Viewed by 4626 | Submission Open

Keywords: stem cell; degenerative disorders; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research on N-chlorotaurine and Other Active Halogen Taurine Derivatives

edited by

Markus Nagl

and

Anthony M. Kyriakopoulos

submission deadline 20 Jun 2025 | 3 articles | Viewed by 4497 | Submission Open

Keywords: N-chlorotaurine; N-bromotaurine; halogenated taurine derivatives; anti-infective; antiseptic; antimicrobial; immunity; inflammation; cancer

(This special issue belongs to the Section Molecular Pharmacology)

Chronic Liver Disease: Latest Research in Pathogenesis, Detection and Treatment, 2nd Edition

edited by

Cristian Turato

and

Stefania Cannito

submission deadline 20 Jun 2025 | 2 articles | Viewed by 4497 | Submission Open

Keywords: NASH/NAFLD: pathogenesis; detection; and treatment; hepatocellular carcinoma: pathogenesis; detection; and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver— from homeostasis to disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breast Cancer: From Pathophysiology to Novel Therapies

edited by Jennifer Sims-Mourtada

submission deadline 20 Jun 2025 | 6 articles | Viewed by 4497 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

Focus on Hippocampus Biology: From Neurophysiology to Dysfunctions (2nd Edition)

edited by

Manuela Dicarlo

submission deadline 20 Jun 2025 | 2 articles | Viewed by 4473 | Submission Open

Keywords: hippocampus; dentate gyrus; cornu ammonis (CA); spatial memory; episodic memory; learning; spatial navigation; synaptic plasticity; neuroplasticity; neurogenesis; ischemia; neuroinflammation; chronic stress; aging; neurodegenerative diseases; Alzheimer’ s disease; epilepsy; depression; anxiety

(This special issue belongs to the Section Molecular Neurobiology)

Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality

edited by

María Serrano

and

Daniel Valero

submission deadline 20 Jun 2025 | 1 articles | Viewed by 4461 | Submission Open

Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage

(This special issue belongs to the Section Molecular Plant Sciences)

Biological Liquid-Liquid Phase Separation, Biomolecular Condensates, and Membraneless Organelles (2nd Edition)

edited by

Vladimir N. Uversky

submission deadline 20 Jun 2025 | 2 articles | Viewed by 4454 | Submission Open

(This special issue belongs to the Section Molecular Biophysics)

Sphingolipid Metabolism and Signaling: Role in Health and Diseases—2nd Edition

edited by

Paola Giussani

submission deadline 20 Jun 2025 | 4 articles | Viewed by 4439 | Submission Open

Keywords: sphingolipids; sphingosine-1-phosphate; ceramide; glycosphingolipids; sphingolipid-mediated signaling; cancer; neurodegenerative diseases; inflammatory diseases; diabetes

(This special issue belongs to the Section Biochemistry)

Immunoregulation Within the Tumor Microenvironment: Special Emphasis on Macrophages and NK Cells

edited by

Walter Fiedler

submission deadline 20 Jun 2025 | 2 articles | Viewed by 4398 | Submission Open

Keywords: microenvironment; macrophages; dendritic cells; NK cells; immune cells; MSCs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetic Dysregulation in Cancers: From Mechanism to Therapy

edited by Saverio Candido

submission deadline 20 Jun 2025 | 2 articles | Viewed by 4357 | Submission Open

Keywords: epigenetics; non-coding RNAs; microRNAs; histone modifications; chromatin remodeling; DNA methylation; 5-methyl-cytosine; biomarkers; cancer; promoter and body methylation

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 601-650 on page 13 of 68.

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