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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Modern Plant Cell Biotechnology: From Genes to Structure, 2nd Edition submission deadline 20 Aug 2025 | 4 articles | Viewed by 5474 | Submission Open
Keywords: genetic engineering techniques; gene modification; gene editing; regulation of gene expression; plant cell biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Mitochondria: Transport of Metabolites Across Biological Membranes submission deadline 20 Aug 2025 | 2 articles | Viewed by 5452 | Submission Open
Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis
(This special issue belongs to the Section Molecular Biology)
Machine Learning and Bioinformatics in Human Health and Disease: 2nd Edition
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 5419 | Submission Open
Keywords: machine learning; bioinformatics; deep learning; multi-omics approaches; genetic risk factors; drug interactions; precision medicine; neurodegenerative diseases; disease diagnosis; epidemic prediction
(This special issue belongs to the Section Molecular Informatics)
Advances in Molecular Research on Cancer Treatments: Apoptosis, Autophagy, and Drug Selection
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 5330 | Submission Open
Keywords: autophagy; apoptosis; bioactive natural products; nanoparticles and drug delivery; cancer immunotherapy; in silico and network pharmacology; bioinformatics
(This special issue belongs to the Section Molecular Oncology)
New Horizons in Silicon Chemistry
edited by Mitsuo Kira
submission deadline 20 Aug 2025 | 3 articles | Viewed by 5216 | Submission Open
Keywords: synthesis; bonding and structures; reaction mechanism; physical properties; application; germanium; tin
(This special issue belongs to the Section Macromolecules)
Bone Tissue Engineering: Opportunities and Challenges submission deadline 20 Aug 2025 | 4 articles | Viewed by 5212 | Submission Open
Keywords: material; biocompatibility; scaffold; regeneration; bone; osteoinductivity; tissue; stem cells; microenvironment processes  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Respiration and Energy Metabolism in Cancer Cells
edited by
submission deadline 20 Aug 2025 | 4 articles | Viewed by 5209 | Submission Open
Keywords: mitochondria; respiration; cancer; ATP synthesis; mtDNA; oxidative stress; glycolysis; cell death
(This special issue belongs to the Section Molecular Oncology)
Role of MicroRNAs in Cancer Development and Treatment, 2nd Edition
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 5197 | Submission Open
Keywords: microRNAs (miRNAs); transcriptomics; functional studies; cancer pathobiology; solid tumors; hematological malignancies; molecular biomarkers; therapeutic targets; apoptosis; anticancer drugs radiotherapy; chemotharapy failure
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Photosynthesis: Mechanisms of Protein Complex Functioning, Protein Structural Modifications and Protein-Protein Interactions
edited by Ilya B. Kovalenko
submission deadline 20 Aug 2025 | 2 articles | Viewed by 5128 | Submission Open
Keywords: photosynthesis; electron transport; molecular dynamics; proteins; protein-protein interaction; conformational changes; reaction center; mobile electron carrier
(This special issue belongs to the Section Biochemistry)
Targeting Oxidative Stress for Disease: 2nd Edition submission deadline 20 Aug 2025 | 6 articles | Viewed by 5124 | Submission Open
Keywords: oxidants and free radical production; physiological activities of free radicals; detrimental effects of free radicals on human health; ROS and ROS-mediated cellular signaling; pathophysiology of oxidative stress; biomarkers of oxidative stress; chronic degenerative diseases; therapeutic approaches targeting oxidative stress; biochemical/molecular targets of chronic diseases; exogenous antioxidants and human health; flavonoids and redox biology in the pathophysiology of diseases; pro-oxidative role of antioxidants: double-sided sword; prooxidant agents in therapy
(This special issue belongs to the Section Molecular Biology)
Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 5103 | Submission Open
Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Trends in Biologically Active Compounds in Age-Related Diseases
edited by Celia Andrés Juan
submission deadline 20 Aug 2025 | 2 articles | Viewed by 5023 | Submission Open
Keywords: age-related diseases; oxidative stress and inflammation; energy failure; mitochondrial dysfunction; deregulated autophagy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Therapeutic Strategies in Allergic Diseases
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 4965 | Submission Open
Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Molecular Aspects of Colorectal Cancer
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4907 | Submission Open
Keywords: colorectal adenocarcinoma; cancer pathobiology; molecular biomarkers; diagnosis and prognosis; prediction of therapy selection; therapeutic targets; RNA molecules; microRNA; long non-coding RNA; circular RNA
(This special issue belongs to the Section Molecular Oncology)
Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4903 | Submission Open
Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Tea Tree Metabolism and Genetics
edited by Xiaoling Sun
submission deadline 20 Aug 2025 | 4 articles | Viewed by 4903 | Submission Open
Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Animal Gut Microbial Metagenome
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4800 | Submission Open
(This special issue belongs to the Section Molecular Microbiology)
Molecular Scale Design, Synthesis, and Application of Macroporous, Mesoporous, and Microporous Materials submission deadline 20 Aug 2025 | 4 articles | Viewed by 4799 | Submission Open
Keywords: macro-; meso- and microporous; porous materials; molecular design; adsorption; porous organic frameworks
(This special issue belongs to the Section Materials Science)
Characteristics of Microorganisms Colonizing Animals and Alternative Methods of Infection Control in the Light of the “One Health” Concept
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4757 | Submission Open
Keywords: zoonotic pathogens; virulence traits; antimicrobial resistance; molecular environment of resistance genes; whole-genome sequencing; microbiome; probiotics; alternative methods of combating pathogens in animals
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Liposome-Based Drug Delivery Systems
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4717 | Submission Open
Keywords: liposomes; targeted delivery; controlled release; nanotechnology; drug delivery; diagnostics; therapeutics; multifunctional liposomes; phospholipids
(This special issue belongs to the Section Molecular Pharmacology)
Protein–RNA Interactions: Function, Mechanism, and Identification
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4712 | Submission Open
Keywords: RNA-binding protein (RBP); protein– RNA interaction; RNA structure; RNA processing; RNA stability; RNA modification; translation; gene regulatory network
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and Therapeutic Targets in Acute Settings: Ischemic and Traumatic Brain Injuries
edited by Hylde Zirpoli
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4693 | Submission Open
Keywords: ischemic brain injury; traumatic brain insult; cell-type specific molecular mechanisms; therapy; target discovery; repurposing; efficacy studies; new drug formulations; high-throughput technologies; proteomics; metabolomics; microarray; next-generation sequencing; BBB disruption; gliosis; neuronal loss; neurobehavior; age-related molecular mechanisms in brain injury
(This special issue belongs to the Section Molecular Biology)
Advances in Bioactive Molecules submission deadline 20 Aug 2025 | 3 articles | Viewed by 4630 | Submission Open
Keywords: antimicrobial profile; drug discovery; tissue regeneration; analytical techniques; chemical synthesis; high-throughput screening; therapeutic development; surface functionalization; biomaterial integration; bio-based
(This special issue belongs to the Section Molecular Biology)
The Role of Extracellular Vesicles in Inflammatory Diseases
edited by Kaushik Das
submission deadline 20 Aug 2025 | 5 articles | Viewed by 4574 | Submission Open
Keywords: extracellular vesicles; inflammation; inflammatory diseases; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Pathophysiology and Treatment of Diabetic Retinopathy
edited by Federico Gonzalez-Fernandez and
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4527 | Submission Open
Keywords: diabetic retinopathy; age-related macular degenerations; retinal; vascular endothelial growth factor; visual system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine submission deadline 20 Aug 2025 | 1 articles | Viewed by 4504 | Submission Open
Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine
(This special issue belongs to the Section Molecular Biology)
Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4381 | Submission Open
Keywords: natural products; nutraceuticals; oxidative stress; antioxidants; ROS; redox signaling; oxidative stress; pathological diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Ion Channels in Eye Development, Health, and Disease
edited by Thirumalini Vaithianathan and
submission deadline 20 Aug 2025 | 1 articles | Viewed by 4375 | Submission Open
Keywords: eye development; eye health and disease; ion channels; channelopathies; physiology; computational technology; molecular modeling; molecular biology tools; pharmacology; systems genetics
(This special issue belongs to the Section Molecular Biology)
Molecular Engineering in Dental Restorative and Regenerative Materials
edited by
submission deadline 20 Aug 2025 | 5 articles | Viewed by 4357 | Submission Open
Keywords: dental composites; ceramics; additive manufacturing; dental adhesives; bioactive; 3D printing; photopolymerization; curing devices; microstructure; degree of conversion; bulk-fill composites; lasers in dentistry; infrared spectroscopy; biocompatibility; bone regeneration; osseointegration; soft tissue regeneration
(This special issue belongs to the Section Materials Science)
Recent Research of Phytochemicals in Health and Disease
edited by Sachiko Koyama, and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4281 | Submission Open
Keywords: phytochemicals with bioactive properties; health; brain function; regeneration; wound healing; treatment; and prevention of diseases; delivery routes and delivery methods; formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability; drugs; supplements to drugs; and supplements for health maintenance; nourishment and phytochemicals; drug side effects; COVID-19
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Functional Analysis and Therapeutic Targets of Long Non-Coding RNAs
edited by Hidenori Tani
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4230 | Submission Open
Keywords: lncRNAs; gene expression; cellular processes; disease dysregulation; therapeutic targets; functional analysis; lncRNA therapeutics; lncRNA modulation; stability; localization
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles
edited by Tong Ming Liu and Xiaoman Luo
submission deadline 20 Aug 2025 | 1 articles | Viewed by 4195 | Submission Open
Keywords: mesenchymal stem cells; extracellular vesicles; MSCs; MSC-EVs; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
From Diagnosis to Treatment of Haematological Neoplasms submission deadline 20 Aug 2025 | 2 articles | Viewed by 4190 | Submission Open
Keywords: haematological neoplasms; biomarkers; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Diabetes and Obesity
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4152 | Submission Open
Keywords: obesity; diabetes; hypothalamus; insulin resistance; glucose homeostasis; lipid metabolism; adipose tissue; cardiovascular tissue
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Myocardial Disease: Molecular Pathology and Treatments
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4064 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; amyloidosis; myocarditis; sarcoidosis; genetic abnormalities; immune mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stem Cells in Human Health and Diseases
edited by Dana Yehudai-Ofir
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4028 | Submission Open
Keywords: stem cells; stem cell biology; stem-cell-based therapy; stem cell regulation; cancer stem cell; tumor-initiating cell  
(This special issue belongs to the Section Molecular Immunology)
Bioactive Polymer-Based Materials Dedicated to Wound Healing submission deadline 20 Aug 2025 | 2 articles | Viewed by 3997 | Submission Open
Keywords: wound healing; polymer; bioactive materials; tissue engineering; biomaterials; thin films; scaffolds; hydrogels
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Therapies of Brain Tumors
edited by Oana Alexandru
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3932 | Submission Open
Keywords: brain tumors; molecular mechanisms; signal transduction; cell proliferation; apoptosis; targeted therapies; chemotherapy; radiotherapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Tea Tree Genetics and Breeding: 2nd Edition
edited by and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3903 | Submission Open
Keywords: tea plant (Camellia sinensis); molecular mechanism; secondary metabolites; stress response; quality-related component; genes identification; QTL mapping; molecular functional markers
(This special issue belongs to the Section Molecular Plant Sciences)
Bacteriophage: Molecular Ecology and Pharmacology, 2nd Edition
edited by , and Richard Allen White III
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3886 | Submission Open
Keywords: bacteriophage ecology; bacteriophage pharmacology; intercell communication of bacteria; phage-host interactions; phage-host recognition; phage receptors; phage therapy
(This special issue belongs to the Section Molecular Microbiology)
The Role of the IGF Axis in Disease, 4th Edition
edited by Claire M. Perks
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3835 | Submission Open
Keywords: IGF axis; cancer; obesity; hallmarks of cancer
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research Progress of Cereal Crop Disease Resistance
edited by and Zhenqi Su
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3800 | Submission Open
Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
Signaling Transduction in Health and Disease
edited by and
submission deadline 20 Aug 2025 | 1 articles | Viewed by 3797 | Submission Open
Keywords: signaling pathways; inflammation; human disease; oxidative stress; neurodegeneration; heart disease; antioxidants
(This special issue belongs to the Section Biochemistry)
Male Genitourinary Tumors: Molecular and Cellular Mechanism
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3769 | Submission Open
Keywords: penile carcinoma; tumor biology; immune modulator; HPV   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Big Data in Multi-Omics submission deadline 20 Aug 2025 | 2 articles | Viewed by 3755 | Submission Open
Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Shona   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Informatics)
Cellular and Molecular Mechanisms of Acute Lung Injury submission deadline 20 Aug 2025 | 3 articles | Viewed by 3721 | Submission Open
Keywords: acute lung injury; lung infection; acute respiratory distress syndrom; neutrophil-mediated immune response; alveolar epithelial injury; pulmonary oedema
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pharmacological Activities of Secondary Metabolites and Derivates of Medicinal Plants Around the World, 2nd Edition
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3716 | Submission Open
Keywords: natural products; secondary metabolites; medicinal chemistry; worldwide traditional medicine; isolation and identification of secondary metabolites; experimental studies; photochemistry; pharmacognosy; medicinal plants
(This special issue belongs to the Section Molecular Pharmacology)
Cyclodextrin-Based Polymer Systems for Biomedical Applications submission deadline 20 Aug 2025 | 1 articles | Viewed by 3635 | Submission Open
Keywords: cyclodextrins; polymers; grafting; drug delivery; hydrophobic drugs; wound healing; tissue engineering; antimicrobial systems; supramolecular systems
(This special issue belongs to the Section Macromolecules)
New Insights into the Immunopathology of Autoimmune and Drug Induced Liver Injury
edited by Eleni Geladari
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3596 | Submission Open
Keywords: liver disease; liver injury; immune system; immune dysregulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanism of Acute Myeloid Leukemia
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3569 | Submission Open
Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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