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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights in the Mechanism of Obstetrical Complications: Prevention, Diagnosis, Monitoring, Treatment

edited by

Lucia Maria Procopciuc

and

Roxana Liana Lucaciu

submission deadline 20 Jul 2026 | 6 articles | Viewed by 9302 | Submission Open

Keywords: high blood pressure; gestational diabetes; infections; preeclampsia; eclampsia; preterm labor; depresion; anxiety; pregnancy loss/miscarriage; stillbirth; premature membrane rupture; vaginal bleeding; placenta previa; anemia; intrauterine growth restriction; maternal risk factors; fetal risk factors; endothelial dysfunction; angiogenesis; oxidative stress; hormonal modifications; dyslipidemia; biochemical; genetic; epigenetic determinations; computational analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Hepatocellular Carcinoma: From Carcinogenesis to Liver Transplantation

edited by

Kevin Tak-Pan Ng

submission deadline 20 Jul 2026 | 5 articles | Viewed by 9294 | Submission Open

Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology

(This special issue belongs to the Section Molecular Oncology)

Heavy Metal Exposure on Health

edited by

Rosanna Mallamaci

submission deadline 20 Jul 2026 | 4 articles | Viewed by 9041 | Submission Open

Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments

(This special issue belongs to the Section Molecular Toxicology)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 20 Jul 2026 | 5 articles | Viewed by 8831 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Supplements and Drug-Based Strategies in Neonatal and Paediatric Health

edited by

Giulia Malaguarnera

submission deadline 20 Jul 2026 | 3 articles | Viewed by 8769 | Submission Open

Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions

(This special issue belongs to the Section Bioactives and Nutraceuticals)

HIV Infection, Pathogenesis and Treatment

edited by

Mudit Tyagi

submission deadline 20 Jul 2026 | 3 articles | Viewed by 8524 | Submission Open

Keywords: HIV Infection; HIV; host immune responses; pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

Advances and Emerging Trends in Marine Natural Products

edited by Rafael Alexandre Faria da Costa Félix and

Carina Félix

submission deadline 20 Jul 2026 | 5 articles | Viewed by 8155 | Submission Open

Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies

(This special issue belongs to the Section Molecular Pharmacology)

Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 20 Jul 2026 | 4 articles | Viewed by 8023 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Computational Approaches in Drug Discovery and Design: From Molecular Modeling to Translational Applications

edited by

Przemysław Czeleń

submission deadline 20 Jul 2026 | 5 articles | Viewed by 7211 | Submission Open

Keywords: computational drug discovery; molecular modeling; AI-driven drug design; molecular dynamics simulations; quantum chemistry; structure-based drug design; machine learning in pharmacology; virtual screening and docking; ADMET prediction; personalized medicine modeling

(This special issue belongs to the Section Molecular Informatics)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 20 Jul 2026 | 6 articles | Viewed by 7072 | Submission Open

Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

Molecular Diagnosis and Treatment of Colorectal Cancer

edited by Steven T. Brower and Robert Pergolizzi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 6985 | Submission Open

Keywords: colorectal cancer; biomarkers; epigenetics; targeted therapy; chemoresistance; personalized cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Associations Between Adipose Tissue and Diseases

edited by

Roberto Cannataro

Erika Cione

and

Maria Cristina Caroleo

submission deadline 20 Jul 2026 | 3 articles | Viewed by 6874 | Submission Open

Keywords: lipedema; adipose tissue; adipocyte; adipose organ; body fat; miRNA; ketogenic diet

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers

edited by

Antonella Virgilio

Veronica Esposito

and

Aldo Galeone

submission deadline 20 Jul 2026 | 5 articles | Viewed by 6808 | Submission Open

Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes

(This special issue belongs to the Section Molecular Biology)

Wound Repair: From Basic Biology to Tissue Engineering

edited by

Magdalena Paczkowska-Walendowska

submission deadline 20 Jul 2026 | 3 articles | Viewed by 6785 | Submission Open

Keywords: wound healing; tissue engineering; biomaterials; regenerative medicine; chronic wounds

(This special issue belongs to the Section Molecular Biology)

Latest Molecular Advances in Autophagy

edited by

Gloria Riitano

submission deadline 20 Jul 2026 | 3 articles | Viewed by 6692 | Submission Open

Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK

(This special issue belongs to the Section Molecular Biology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 20 Jul 2026 | 5 articles | Viewed by 6608 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 20 Jul 2026 | 1 articles | Viewed by 6390 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 20 Jul 2026 | 4 articles | Viewed by 6218 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Delivery Systems in Veterinary Medicine: Innovations and Applications

edited by

Hualin Fu

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5754 | Submission Open

Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Chronic Pain: Mechanisms and Therapeutic Innovations

edited by

Roberto Tedeschi

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5666 | Submission Open

Keywords: chronic pain; pain mechanisms; pain management; therapeutic innovation; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Power Up Plant Genetic Research with Genomic Data: 3rd Edition

edited by

Hon-Ming Lam

Sachiko Isobe

and

Man-Wah Li

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5566 | Submission Open

Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Biological Hallmarks and Therapeutic Strategies in Cancer

edited by Ramesh Kumar

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5423 | Submission Open

Keywords: hallmarks of cancer; cancer progression; chemotherapy; tumorigenesis; oncogenic signaling

(This special issue belongs to the Section Molecular Oncology)

Role of HLA (Human Leucocyte Antigen) in Human Diseases

edited by

Jeane Eliete Laguila Visentainer

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5389 | Submission Open

Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Design of Artificial Receptors Using Virtual Approaches

edited by Houjin Zhang

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5343 | Submission Open

Keywords: artificial receptors; protein design; computational biology; drug targeting; biosensors; tissue engineering; synthetic biology

(This special issue belongs to the Section Molecular Biophysics)

Genomic Research in Carcinogenesis, Cancer Progression and Recurrence

edited by

Magdalena Krystkiewicz-Orzechowska

submission deadline 20 Jul 2026 | 3 articles | Viewed by 5313 | Submission Open

Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers

(This special issue belongs to the Section Molecular Oncology)

New Advances in Germ Cell Research

edited by

Sheng-Hsiang Li

submission deadline 20 Jul 2026 | 3 articles | Viewed by 5288 | Submission Open

Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility

(This special issue belongs to the Section Molecular Biology)

Innovative Research on Nutrition and Epigenetics in Cancer

edited by

Marisabel Mecca

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5282 | Submission Open

Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathology and Treatment of Heart Failure

edited by

Giuseppe Armentaro

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5267 | Submission Open

Keywords: heart failure; oxidative stress; platelet activation; inflammation; biomarkers; pathophysiology; comorbidities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Ozone Therapy

edited by

Francisco Rodríguez-Esparragón

Bernadino Clavo

and

Jacob Lorenzo-Morales

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5135 | Submission Open

Keywords: antioxidant response; cellular stress responses; inflammatory signaling; mitochondrial function; molecular pathways; Nrf2; oxidative stress; ozone therapy; redox regulation; antimicrobial resistance; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Heart Failure Risk Factors and Therapies on a Molecular Basis

edited by

Tomasz Urbanowicz

submission deadline 20 Jul 2026 | 2 articles | Viewed by 5061 | Submission Open

Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy

edited by

Xinyi Yang

submission deadline 20 Jul 2026 | 4 articles | Viewed by 5018 | Submission Open

Keywords: bacterial resistance; antibiotics; antimicrobials; “ superbugs” ; clinical strains; laboratory induced-bacteria; antimicrobial peptides; antimicrobial combinations; hybrid antibiotics; repurposing drugs; anti-virulence agents; immune modulators; toxin neutralizers

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Compounds in Neurodegenerative Diseases

edited by

Silvia Lima Costa

submission deadline 20 Jul 2026 | 3 articles | Viewed by 5015 | Submission Open

Keywords: bioactive compounds; neurodegenerative diseases; neuroinflammation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Precision Medicine in Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4963 | Submission Open

Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Gastrointestinal Cancer, 3rd Edition

edited by

Aneta Koronowicz

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4861 | Submission Open

Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis

(This special issue belongs to the Section Molecular Oncology)

Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition

edited by

Joanna Kluczka

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4721 | Submission Open

Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering

(This special issue belongs to the Section Macromolecules)

Research on Intracellular Signal Transduction Systems

edited by

Takaya Satoh

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4705 | Submission Open

Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease

(This special issue belongs to the Section Molecular Biology)

Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections

edited by Fabiana Bigi and Federico Carlos Blanco

submission deadline 20 Jul 2026 | 5 articles | Viewed by 4645 | Submission Open

Keywords: Mycobacterium tuberculosis; virulence; pathogens

(This special issue belongs to the Section Molecular Microbiology)

Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition

edited by

Marko Tarle

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4505 | Submission Open

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4444 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells Research: Advancing Science and Medicine

edited by Susana Rosa

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4311 | Submission Open

Keywords: stem cell; stem cell biology; stem cell-based therapies; regenerative medicine; disease modeling

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Addiction

edited by

Aleksandra Suchanecka

and

Jolanta Chmielowiec

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4186 | Submission Open

Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Sjögren's Syndrome, 4th Edition

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4140 | Submission Open

Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

TRP Channels: Mechanisms, Functions, and Therapeutic Implications

edited by

Stefan Mergler

submission deadline 20 Jul 2026 | 4 articles | Viewed by 4120 | Submission Open

Keywords: transient receptor potential (TRP) channels; calcium signaling; ion channels; tissue homeostasis; receptor activation

(This special issue belongs to the Section Biochemistry)

Genetics and Breeding for Sugar Crops

edited by Muqing Zhang

submission deadline 20 Jul 2026 | 2 articles | Viewed by 4067 | Submission Open

Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling the Enigma of Colorectal Cancer: From Mechanisms to Therapeutic Advances

edited by Valentina Belli and

Vincenza Ciaramella

submission deadline 20 Jul 2026 | 4 articles | Viewed by 4051 | Submission Open

Keywords: Colorectal cancer; tumour microenvironment; epigenetics; diagnostic molecules; immune evasion; biomarkers; drug resistance; precision medicine; targeted

(This special issue belongs to the Section Molecular Oncology)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 20 Jul 2026 | 2 articles | Viewed by 3765 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

edited by

Nuno Taveira

and Inês Bártolo

submission deadline 20 Jul 2026 | 1 articles | Viewed by 3736 | Submission Open

Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies

(This special issue belongs to the Section Molecular Biology)

Coagulation Factors and Natural Anticoagulants in Health and Disease

edited by

Zsuzsanna Bereczky

submission deadline 20 Jul 2026 | 4 articles | Viewed by 3620 | Submission Open

Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer

edited by Rebecca Chin

submission deadline 20 Jul 2026 | 3 articles | Viewed by 3594 | Submission Open

Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids

(This special issue belongs to the Section Molecular Oncology)

Dysregulation of Bone Health–a Matter of Several Culprits

edited by Ana Gomes

submission deadline 20 Jul 2026 | 1 articles | Viewed by 3566 | Submission Open

Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 601-650 on page 13 of 65.

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