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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Genetics and Molecular Therapy for Gastric Cancers

edited by

Binnari Kim

submission deadline 30 Jun 2026 | 2 articles | Viewed by 737 | Submission Open

Keywords: gastric cancer; molecular genetics; targeted therapy; tumor microenvironment; immunotherapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Updates on Synthetic and Natural Antioxidants (2nd Edition)

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 30 Jun 2026 | 1 articles | Viewed by 705 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Biochemistry and Biophysics Tools for Peptide and Protein Research

edited by

Wenqi Li

submission deadline 30 Jun 2026 | 1 articles | Viewed by 697 | Submission Open

Keywords: protein– protein interactions; peptide therapeutics development; biosensor and labeling technologies; high-throughput screening; mass spectrometry proteomics; protein dynamics and folding; single-molecule biophysics; analytical ultra-centrifugation; computational protein design; structural biology techniques

(This special issue belongs to the Section Biochemistry)

Characterization and Biological Function of Marine Biopolymers

edited by

Zahira Belattmania

submission deadline 30 Jun 2026 | 1 articles | Viewed by 671 | Submission Open

Keywords: marine-based biopolymers; sustainable extractions; polymer characterization; biological functions; marine resources

(This special issue belongs to the Section Materials Science)

Rare Diseases Associated with Short Stature: Genetics, Pathogenesis and Therapy, 2nd Edition

edited by

Michal Ordak

submission deadline 30 Jun 2026 | 1 articles | Viewed by 574 | Submission Open

Keywords: skeletal disorders; dwarfism; skeletal dysplasias; short stature; biomarkers; mutations; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pathophysiology and Treatment of Atherosclerosis

edited by Graziano Riccioni

submission deadline 30 Jun 2026 | Viewed by 536 | Submission Open

Keywords: atherosclerosis; pathogenetic pathway; targeted therapies; cardiovascular disease; plaque development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 30 Jun 2026 | Viewed by 527 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

Telomere Dynamics in Aging and Disease: Biology, Regulation, and Pathogenesis

edited by Jidong Shan

submission deadline 30 Jun 2026 | 1 articles | Viewed by 527 | Submission Open

Keywords: telomeres; telomere length; telomerase; aging; diseases; disorders; cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Biomarkers and Therapeutic Targets for Acute Liver and Kidney Injury

edited by

Gang Ye

submission deadline 30 Jun 2026 | 1 articles | Viewed by 444 | Submission Open

Keywords: acute liver injury; acute kidney injury; multi omics technology; network pharmacology; molecular biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Bioactive Properties of Natural Products from Medicinal Plants: Antioxidant, Antibacterial, and Anticancer Activities

edited by Fhatuwani N. Mudau

submission deadline 30 Jun 2026 | Viewed by 436 | Submission Open

Keywords: antiproliferative properties; antimicrobial activity; medicinal plants; phytochemicals; metabolomics; natural products; cancer; therapeutic properties

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genetic Regulation of Plant Growth and Protection (2nd Edition)

edited by

Yuxuan Hou

and

Zhiyong Li

submission deadline 30 Jun 2026 | Viewed by 427 | Submission Open

Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Ovarian Insufficiency: From Molecular Pathology to Novel Therapeutic Approach

edited by Aleksandar Ljubić

submission deadline 30 Jun 2026 | Viewed by 357 | Submission Open

Keywords: ovarian insufficiency; premature ovarian insufficiency; molecular pathology; regenerative medicine; stem cell therapy; platelet-rich plasma; epigenetics; intraovarian treatment; ovarian stem cells; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine

edited by Manoochehr Rasekh

submission deadline 30 Jun 2026 | Viewed by 351 | Submission Open

Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics

(This special issue belongs to the Section Materials Science)

Recent Advances in Natural Products for Antiviral Drug Discovery

edited by

Thao Quyen Cao

submission deadline 30 Jun 2026 | Viewed by 341 | Submission Open

Keywords: bioactive natural compound; secondary metabolites; antiviral activity; molecular mechanisms; metabolomic-guided discovery; natural antivirals; food-derived bioactivity; AI-assisted prediction of antiviral natural products; microbe-derived antiviral metabolites; marine-derived antiviral metabolites

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Pathophysiology of Peripheral Neuropathies and Neuromuscular Disorders

edited by

Eleonora Galosi

submission deadline 30 Jun 2026 | Viewed by 339 | Submission Open

Keywords: peripheral neuropathies; neuromuscular disorders; small fiber neuropathy; neuropathic pain; nerve regeneration; molecular pathways; next-generation sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Biomaterials for Tissue Regeneration

edited by

Liviu Duta

submission deadline 30 Jun 2026 | 1 articles | Viewed by 318 | Submission Open

Keywords: biomaterials; tissue regeneration; molecular mechanisms; cell-instructive scaffolds; injectable hydrogels; ECM-mimetic materials; bioactive ceramics; bioactive surface coatings; mechanotransduction/mechanobiology; immunomodulation; angiogenesis and vascularization; biofabrication (3D/4D printing)

(This special issue belongs to the Section Materials Science)

Cellular Immunotherapy in Cancer: Current Trends and Future Directions

edited by

Vahid Vahedian

submission deadline 30 Jun 2026 | Viewed by 311 | Submission Open

Keywords: cellular immunotherapy; CAR-T cells; CAR-NK cells; CAR-macrophages; tumor-infiltrating lymphocytes (TILs); immune receptor signaling; tumor microenvironment; CRISPR/Cas9 genome editing; precision cancer immunotherapy; translational immuno-oncology

(This special issue belongs to the Section Molecular Immunology)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 30 Jun 2026 | Viewed by 310 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Molecular and Metabolic Mechanisms Regulating Reproduction and Development in Animals

edited by Borhan Shokrollahi and Kimberly M. Davenport

submission deadline 30 Jun 2026 | Viewed by 302 | Submission Open

Keywords: molecular nutrition; metabolic signaling; reproductive physiology; epigenetic programming; placental biology; transcriptomics and metabolomics; mitochondrial function; oxidative stress pathways; developmental programming; ruminant health

(This special issue belongs to the Section Molecular Biology)

Thyroid Disease: From Molecular Mechanisms to Diagnosis and Therapeutic Advances

edited by

Mariana Lorena Tellechea

and Juan Nicola

submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open

Keywords: thyroid disease; hypothyroidism; hyperthyroidism; autoimmune thyroid disease; thyroid nodules; thyroid cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Phenotype-Targeted Nanomedicine: Navigating Multiscale Biological Barriers in the 2026 Clinical Era

edited by

Athina Angelopoulou

submission deadline 30 Jun 2026 | Viewed by 299 | Submission Open

Keywords: nanomedicine; nanotherapeutic; nanobiomaterials; TME

(This special issue belongs to the Section Molecular Nanoscience)

Preparation and Applications of Colloidal Emulsions

edited by

Bakht Ramin Shah

submission deadline 30 Jun 2026 | Viewed by 279 | Submission Open

Keywords: emulsions; fabrication; characterization; applications; encapsulation; delivery systems

(This special issue belongs to the Section Molecular Biology)

Vitamin D Metabolism and Molecular Signaling in Human Diseases

edited by

Anna Cieslinska

submission deadline 30 Jun 2026 | Viewed by 278 | Submission Open

Keywords: vitamin D; vitamin D metabolism; molecular signaling; genomic and non-genomic pathways; epigenetics; immune regulation; inflammation; metabolic disorders; autoimmune diseases; cancer biology; gut microbiota; genetic polymorphisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

Computational Strategies in Toxicology

edited by

Rajesh Kumar Pathak

and

Vikas Kumar

submission deadline 30 Jun 2026 | Viewed by 278 | Submission Open

Keywords: emerging pollutants; environment; molecular docking; molecular dynamics simulations; QSAR; Omics; PBPK model; predictive toxicology; risk assessment

(This special issue belongs to the Section Molecular Informatics)

Molecular and Biochemical Advances in Kidney Diseases and Genetics

edited by

Silvio R. De Luka

submission deadline 30 Jun 2026 | Viewed by 277 | Submission Open

Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies

edited by

Stefan Simović

submission deadline 30 Jun 2026 | Viewed by 273 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; oxidative stress; molecular mechanisms; translational research; antiarrhythmic therapy; cardiac remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Jun 2026 | Viewed by 271 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Unraveling Affective Disorders: From Pathogenesis to Drug Therapy

edited by Lawrence Shih-Hsin Wu

submission deadline 30 Jun 2026 | Viewed by 266 | Submission Open

Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene– environment interactions; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 30 Jun 2026 | Viewed by 265 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders

edited by

Dalia Marija Kopustinskiene

submission deadline 30 Jun 2026 | Viewed by 263 | Submission Open

Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Omega-3 Polyunsaturated Fatty Acids: From Molecular Signaling to Therapeutic Applications

edited by

Feng-Yao Tang

submission deadline 30 Jun 2026 | Viewed by 253 | Submission Open

Keywords: N-3 polyunsaturated fatty acids; bioactive signaling molecules; stem cell; cancer; gut microbiota; precision nutrition

(This special issue belongs to the Section Molecular Biology)

Applications and Advances of Organic Synthesis in the Design of Antiparasitic, Antiviral, and Anticancer Drugs

edited by

Sergio Hernán Szajnman

and Juan B. Rodriguez

submission deadline 30 Jun 2026 | Viewed by 246 | Submission Open

Keywords: antiparasitic agents; antiviral agents; chagas disease; toxoplasmosis; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 30 Jun 2026 | Viewed by 245 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity

edited by

Hiroshi Sakaue

submission deadline 30 Jun 2026 | Viewed by 242 | Submission Open

Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant and Lichen Metabolites: Characterization and Applications

edited by

Agnieszka Hanaka

submission deadline 30 Jun 2026 | Viewed by 239 | Submission Open

Keywords: phytochemicals; secondary metabolites; bioactive compounds; bioactivity evaluation; synthesis optimization; metabolite application; metabolite extraction; elicitors; stress physiology; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by

Xuming Mao

submission deadline 30 Jun 2026 | Viewed by 238 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Reproductive Endocrinology Research: 2nd Edition

edited by

Tsung-Hsien Lee

submission deadline 30 Jun 2026 | Viewed by 236 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Anesthetics and Neurovascular Health: Molecular Pathways

edited by Gabriele Melegari

submission deadline 30 Jun 2026 | Viewed by 231 | Submission Open

Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health

(This special issue belongs to the Section Molecular Neurobiology)

Latest Insight into Spin and Isomerism of Organic Molecules

edited by

Chenwei Jiang

and

Le Yu

submission deadline 30 Jun 2026 | Viewed by 228 | Submission Open

Keywords: organic molecules; photoisomerization; spin states; isomerism; spin crossover; conformational dynamics; quantum chemistry; radical chemistry; singlet fission

(This special issue belongs to the Section Molecular Biophysics)

Advances in Polymeric Nanomaterials in Medicine

edited by Prabhanjan Giram

submission deadline 30 Jun 2026 | Viewed by 228 | Submission Open

Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Cancer and Cell Metabolism—3rd Edition

edited by

Maria Mesuraca

Maria Concetta Faniello

and

Barbara Quaresima

submission deadline 30 Jun 2026 | Viewed by 227 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Oncology)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 30 Jun 2026 | Viewed by 226 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Determinants of Therapeutic Response and Resistance in Urological Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 30 Jun 2026 | Viewed by 224 | Submission Open

Keywords: urological cancers; therapeutic resistance; treatment response; molecular determinants; precision oncology; biomarkers; tumor heterogeneity; genomics; epigenetics; tumor microenvironment; immune evasion; targeted therapy; immunotherapy; DNA damage repair; translational research

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapeutic Strategies in Diabetic Retinopathy

edited by

Rosa Fernandes

submission deadline 30 Jun 2026 | Viewed by 222 | Submission Open

Keywords: diabetic retinopathy; neurovascular unit; molecular pathways; neuroinflammation; metabolic dysregulation; blood-retinal barrier; molecular biomarkers; multi-omics; molecular therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Molecular Psychiatry: Biomarkers, Mechanisms, and Precision Therapeutics

edited by Masaru Tanaka

submission deadline 30 Jun 2026 | Viewed by 221 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models

(This special issue belongs to the Section Molecular Neurobiology)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by

Adelina-Gabriela Niculescu

and

Ariana Hudita

submission deadline 30 Jun 2026 | Viewed by 218 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

Thyroid Hormone Signaling: Mechanisms and Pathophysiological Implications

edited by

María Laura Barreiro Arcos

and Horacio Eduardo Romeo

submission deadline 30 Jun 2026 | Viewed by 217 | Submission Open

Keywords: thyroid hormones; mitochondrial function; oxidative stress; redox signaling; metabolic disorders; immune modulation; cardiovascular pathology; neurodevelopment and aging; cancer progression

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Extracellular Vesicles: Biomarkers and Therapeutic Carriers in Human Health and Disease

edited by

José Eduardo Vargas

submission deadline 30 Jun 2026 | Viewed by 217 | Submission Open

Keywords: extracellular vesicles; cellular senescence; autophagy; biomarkers; drug delivery; translational medicine; human disease; cell fate

(This special issue belongs to the Section Molecular Biology)

Advances in Amyloids: From Structure to Tailored Function

edited by