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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Plant Adaptation to Stress

edited by Yuanchun Ma

submission deadline 31 Jul 2025 | Viewed by 110 | Submission Open

Keywords: plant; environmental stresses; signaling pathways; stress-responsive genes; transcription factors; phytohormones; crop resilience; breeding; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience

edited by Matteo Di Segni and Rossella Ventura

submission deadline 31 Jul 2025 | Viewed by 109 | Submission Open

Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness

(This special issue belongs to the Section Molecular Neurobiology)

Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis

edited by Alberto Gajofatto

submission deadline 31 Jul 2025 | Viewed by 107 | Submission Open

Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis, Biosynthesis and Implications of Chalcones

edited by

Pal Perjesi

submission deadline 31 Jul 2025 | Viewed by 105 | Submission Open

Keywords: chalcones; biosynthesis; biochemistry

(This special issue belongs to the Section Biochemistry)

Emerging Therapeutic Potential of Organic Compound in Diseases

edited by

Katarzyna Kotwica-Mojzych

submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open

Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior

edited by

Frank Schmitz

submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open

Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels

(This special issue belongs to the Section Molecular Neurobiology)

Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges

edited by

David Rodríguez-Lucena

and

Belén Begines

submission deadline 31 Jul 2025 | Viewed by 104 | Submission Open

Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy

(This special issue belongs to the Section Materials Science)

The Interaction Between Tumor Microenvironment and Cancer Stem Cell

edited by

Na Luo

submission deadline 31 Jul 2025 | Viewed by 103 | Submission Open

Keywords: tumor microenvironment; cancer stem cells; innate and adaptive immunity; mesenchymal stromal cells

(This special issue belongs to the Section Molecular Oncology)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 31 Jul 2025 | Viewed by 102 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles as Biomarkers in Personalized Medicine

edited by Thi Thuy Nguyen Dao

submission deadline 31 Jul 2025 | Viewed by 97 | Submission Open

Keywords: extracellular vesicles; biomarkers; cancer; cardiovascular diseases; neurodegenerative diseases; personalized medicineg

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Musculoskeletal Injuries and Conditions: From Pathophysiology to Novel Therapeutic Approaches

edited by

Jai-Hong Cheng

submission deadline 31 Jul 2025 | Viewed by 97 | Submission Open

Keywords: musculoskeletal disorder; pathophysiology; diagnosis; biomarkers; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advanced of Layered Double Hydroxides (LDH) for Corrosion Protection

edited by

Henryk Kania

submission deadline 31 Jul 2025 | Viewed by 96 | Submission Open

Keywords: layered double hydroxide (LDHs); corrosion resistance; coatings; corrosion products

(This special issue belongs to the Section Materials Science)

Age-Dependence of Neuroimmune Reactions

edited by

Babak Baban

submission deadline 31 Jul 2025 | Viewed by 94 | Submission Open

Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Molecular Genetics, Genomics and Breeding in Field Crops

edited by

Xianzhong Feng

submission deadline 31 Jul 2025 | Viewed by 92 | Submission Open

Keywords: field crop; genomics; molecular genetics; breeding technologies; germplasm utilization

(This special issue belongs to the Section Molecular Plant Sciences)

DNA Methylation and Histone Modifications in Cellular Homeostasis

edited by

Xiao Chen

submission deadline 31 Jul 2025 | Viewed by 90 | Submission Open

Keywords: chromatin modification; DNA methylation; histone post-translational modifications; transcriptional regulation; epigenetic landscapes; cellular homeostasis; epigenome analysis; eukaryotic evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Extracellular Vesicles: Unraveling Molecular Pathways for Targeted Therapy

edited by

Ssang-Goo Cho

submission deadline 31 Jul 2025 | Viewed by 90 | Submission Open

Keywords: stem cells; cellular reprogramming; extracellular vesicles; exosomes; targeted therapy; regenerative medicine; rejuvenation; anti-inflammation therapy; pain syndrome

(This special issue belongs to the Section Molecular Biology)

NURR1 Biology in Neurological Disorders and Other Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 31 Jul 2025 | Viewed by 89 | Submission Open

Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases

(This special issue belongs to the Section Molecular Biology)

Advancing Forensic Genetics Through Massive Parallel Sequencing

edited by Daniel Kling

submission deadline 31 Jul 2025 | Viewed by 86 | Submission Open

Keywords: forensic genetics; molecular biology; genetics and aging; biochemistry; population genetics; fo-rensic statistics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Progress in Spectroscopic Studies of Biomolecules

edited by

Mahmoud Ghomi

submission deadline 31 Jul 2025 | Viewed by 78 | Submission Open

Keywords: spectroscopic; nuclear magnetic resonance; X-ray; neutron scattering; biomolecular structure

(This special issue belongs to the Section Molecular Biophysics)

Advances in Molecular Research on Axon Demyelination and Remyelination

edited by Rachelle Frazen

submission deadline 31 Jul 2025 | Viewed by 78 | Submission Open

Keywords: myelin; Schwann; OPC/oligodendrocytes; axon— glia crosstalk; peripheral neuropathies; multiple sclerosis; remyelination; myelin maintenance; molecular targets; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Impact of Vitamins on Cardiovascular Disease

edited by León Ferder

submission deadline 31 Jul 2025 | Viewed by 75 | Submission Open

Keywords: vitamins; cardiovascular disease; atherosclerosis; hypertension; heart failure; endothelial dysfunction; mitochondrial metabolism; oxidative stress; longevity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Light-On Molecular Probes for Biomedical Analysis

edited by Aleksey A. Vasilev

submission deadline 31 Jul 2025 | Viewed by 72 | Submission Open

Keywords: fluorogenic dyes; nucleic acid binders; nucleic acid labels; molecular probes; fluorogenic polymers and nanomaterials

(This special issue belongs to the Section Materials Science)

Galectins (Gals), 2nd Edition

edited by

Luciano Pirone

submission deadline 10 Aug 2025 | 4 articles | Viewed by 1810 | Submission Open

Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers

(This special issue belongs to the Section Molecular Biology)

Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

edited by

Ming-Ju Hsieh

submission deadline 15 Aug 2025 | 2 articles | Viewed by 1330 | Submission Open

Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Characterization and Applications of Nanomaterials in Nanomedicine and Cancer Therapy

edited by

Costica Caizer

submission deadline 15 Aug 2025 | 1 articles | Viewed by 950 | Submission Open

Keywords: nanomaterials (preparation methods; characterization techniques; properties); theoretical studies of nanomaterials and computational simulations; biocompatibility and biofunctionalization; applications in nanomedicine; applications in cancer therapy; drug delivery; nanoparticle imaging; magnetic resonance imaging (MRI); contrast agents; nanotheranostics

(This special issue belongs to the Section Molecular Nanoscience)

Molecular and Cellular Therapies Barriers and Opportunities

edited by

O’neil W. Guthrie

submission deadline 15 Aug 2025 | Viewed by 119 | Submission Open

Keywords: gene therapy; gene editing; RNA therapy; RNA editing; protein therapy; stem cells; cell therapy; genomics; proteomics; molecular pathology

(This special issue belongs to the Section Molecular Biology)

The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights

edited by Ioannis Alexandros Charitos

submission deadline 15 Aug 2025 | Viewed by 96 | Submission Open

Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut– oral-microbiota– brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Strategies for Gynecological Cancer

edited by

Masayuki Sekine

submission deadline 15 Aug 2025 | Viewed by 72 | Submission Open

Keywords: gynecological cancer; therapeutic strategies; genomic medicine; multimodality treatment; biomarker; molecular targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathologies and Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

edited by

Elisa Oltra

submission deadline 20 Aug 2025 | 4 articles | Viewed by 33535 | Submission Open

Keywords: myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); diagnosis; post-exertional malaise (PEM); comorbidity; biomarker; therapy; immunity; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Targeted Therapies of Breast Cancer

edited by

Piotr Dzięgiel

, Karolina Jabłońska and

Katarzyna Nowińska

submission deadline 20 Aug 2025 | 8 articles | Viewed by 27923 | Submission Open

Keywords: breast cancer; cancer progression; cancer metastasis; tumor microenvironment; molecular mechanisms; molecular markers; epigenetics; genomics; transcriptomics; EMT; targeted therapies; signaling pathways; exosomes; EMT; hormonal regulation; drugs; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Retinal Degenerative Diseases: 2nd Edition

edited by

Diego García-Ayuso

and

Johnny Di Pierdomenico

submission deadline 20 Aug 2025 | 6 articles | Viewed by 21437 | Submission Open

Keywords: retina; photoreceptor degenerative diseases; inherited retinal degenerations; glaucoma; retinal pigment epithelial cells; retinal ganglion cells (RGCs); neuronal degeneration; glial activation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bioactive Nutrients Promoting Human Health

edited by

Baojun Xu

submission deadline 20 Aug 2025 | 10 articles | Viewed by 19537 | Submission Open

Keywords: bioactive nutrients; antioxidants; anti-inflammatory; disease prevention; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Aug 2025 | 12 articles | Viewed by 18317 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Trace Elements in Nutrition and Health

edited by Jie Feng

submission deadline 20 Aug 2025 | 8 articles | Viewed by 17932 | Submission Open

Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research of Skin Inflammation and Related Diseases

edited by

Filomena Napolitano

and

Valentina Giudice

submission deadline 20 Aug 2025 | 9 articles | Viewed by 17511 | Submission Open

Keywords: skin; inflammation; molecular target; inflammatory skin diseases; psoriasis; urticaria; atopic dermatitis; systemic sclerosis; skin fibrosis; immune system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Skin Cancer Pathology: From Pathogenesis to Precision Therapies

edited by

Ovidiu Simion Cotoi

submission deadline 20 Aug 2025 | 4 articles | Viewed by 16179 | Submission Open

Keywords: skin cancer; melanoma; non-melanoma; immunotherapy; cutaneous malignancies; targeted therapy; early detection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neurodegenerative Diseases Research and Therapy—Third Edition

edited by

Sumonto Mitra

submission deadline 20 Aug 2025 | 8 articles | Viewed by 15748 | Submission Open

Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery

(This special issue belongs to the Section Molecular Neurobiology)

Cytokines in Inflammatory Signaling: 2nd Edition

edited by

Waipo Chong

Daniela Novick

and

Rosalinda Sorrentino

submission deadline 20 Aug 2025 | 8 articles | Viewed by 15354 | Submission Open

Keywords: cytokines; inflammation; autoimmune diseases; immune homeostasis; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Links between Sensory Nerves, Inflammation, and Pain 3.0

edited by

Zsuzsanna Helyes

and

Szőke Éva

submission deadline 20 Aug 2025 | 5 articles | Viewed by 14534 | Submission Open

Keywords: sensory neuropeptides; inflammation; neurogenic inflammation; pain; arthritis; colitis; neuropathy; migraine; novel drug targets; TRP channels; neuroinflammation

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnostics and Genomics of Tumors

edited by

Petra Korać

submission deadline 20 Aug 2025 | 10 articles | Viewed by 14119 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Photodynamic Therapy and Photodetection, 2nd Edition

edited by

Petras Juzenas

submission deadline 20 Aug 2025 | 11 articles | Viewed by 13446 | Submission Open

Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; photochemical internalization (PCI); quantum dots; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Targeted Therapies and Drugs in Cancer

edited by

Maria Teresa Vietri

submission deadline 20 Aug 2025 | 6 articles | Viewed by 13353 | Submission Open

Keywords: targeted therapies; genetic mutation; PARP inhibitors; immunotherapy; drug development; cancer molecular analysis; drug response; molecular-targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exercise and Health: Cellular and Molecular Perspectives

edited by

Annamaria Mancini

submission deadline 20 Aug 2025 | 4 articles | Viewed by 13232 | Submission Open

Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise

(This special issue belongs to the Section Molecular Biology)

Molecular Pathophysiology of Lung Diseases

edited by

Theodoros Karampitsakos

and Brenda M. Juan-Guardela

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12949 | Submission Open

Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19 interstitial lung disease; pathogenesis; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Approach to Fern Development

edited by

Helena Fernández

submission deadline 20 Aug 2025 | 5 articles | Viewed by 12270 | Submission Open

Keywords: apomixis; apogamy; asexual reproduction; fern; proteomics; genomics; plant development; evo-devo; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Biomedical Applications of Mesenchymal Stem Cells

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 20 Aug 2025 | 6 articles | Viewed by 12075 | Submission Open

Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage

(This special issue belongs to the Section Molecular Pharmacology)

Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition

edited by

Claudia Ricci

submission deadline 20 Aug 2025 | 7 articles | Viewed by 12054 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Plant Responses to Abiotic and Biotic Stresses

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Aug 2025 | 15 articles | Viewed by 12045 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways

edited by Ralf Herwig

submission deadline 20 Aug 2025 | 8 articles | Viewed by 11705 | Submission Open

Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry

(This special issue belongs to the Section Molecular Biology)

Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease

edited by