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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Extracellular Vesicles in Drug Delivery

edited by

Sara Biagiotti

and

Michele Guescini

submission deadline 31 May 2025 | Viewed by 124 | Submission Open

Keywords: red blood cells; red blood cell-extracellular vesicles; drug delivery systems; RNA therapies; EV engineering

(This special issue belongs to the Section Molecular Biology)

Latest Molecular Research on Polymer Coatings

edited by

Joanna Karasiewicz

submission deadline 31 May 2025 | Viewed by 124 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.

(This special issue belongs to the Section Materials Science)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 31 May 2025 | Viewed by 122 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Advanced Cell Based Biomaterials for Musculoskeletal Tissue Engineering

edited by Isabel Calejo

submission deadline 31 May 2025 | Viewed by 117 | Submission Open

Keywords: cell-based materials; bioprinting; microfluidics; hydrogels; vascularization; innervation; hierarchical; fiber technologies; microtissues

(This special issue belongs to the Section Materials Science)

Latest Progress of Photocatalysts

edited by María J. Cabrera‐Afonso

submission deadline 31 May 2025 | Viewed by 115 | Submission Open

Keywords: metallaphotoredox; visible-light; photoredox; radicals; cross-coupling; bifunctional catalyst

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications

edited by

Mu-Rong Chao

Marcus S. Cooke

and

Chiung Wen Hu

submission deadline 31 May 2025 | Viewed by 114 | Submission Open

Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis

(This special issue belongs to the Section Molecular Toxicology)

Photosynthesis and Stress Signaling

edited by

Liangsheng Wang

submission deadline 31 May 2025 | Viewed by 113 | Submission Open

Keywords: photosynthesis; chloroplasts; stress; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Psoriasis and Associated Complications: Pathogenic Mechanisms, Gene Biomarkers and Treatments

edited by

Anna Michalak-Stoma

submission deadline 31 May 2025 | Viewed by 110 | Submission Open

Keywords: psoriasis; autoimmune disease; autoinflammatory disease; psoriatic arthritis; diabetes; hypertension; lipid disorders; obesity; cardiovascular diseases (CVDs); immunological biomarkers; genetic biomarkers; epigenetic biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Phylogenomics and Genetic Diversity (3rd Edition)

edited by

Wenpan Dong

submission deadline 31 May 2025 | Viewed by 110 | Submission Open

Keywords: plant phylogenomics; genome gene; evolution species; diversity speciation; ecogenomics

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Advances and Applications in Medical and Molecular Virology

edited by

Vincent T. K. Chow

and

Julian Tang

submission deadline 31 May 2025 | Viewed by 107 | Submission Open

Keywords: medical virology; molecular virology; molecular diagnostics; genomics; metagenomics; interactomics; integrative omics

(This special issue belongs to the Section Molecular Microbiology)

Pulmonary Immune Research: Mechanisms, Disorders, and Solutions

edited by

Tsukasa Okiyoneda

and

Tsuyoshi Shuto

submission deadline 31 May 2025 | Viewed by 106 | Submission Open

Keywords: genetic lung disorders; chronic obstructive pulmonary disease (COPD); pulmonary fibrosis; asthma; inflammation; molecular mechanism; pathogen/pollutant; immune dysfunction; ciliary transport; therapeutic strategies

(This special issue belongs to the Section Molecular Immunology)

Strategies and Molecular Mechanisms to Enhance Outcomes in Orthobiologics

edited by Leonardo Oliveira

submission deadline 31 May 2025 | Viewed by 99 | Submission Open

Keywords: platelet-rich plasma; adipose-derived stem cells; microfragmented fat; nutrition; exercise; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 31 May 2025 | Viewed by 98 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 31 May 2025 | Viewed by 97 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

Autophagy and Viral Infections: The Era of New Therapeutical Strategies

edited by

Marisa Granato

submission deadline 31 May 2025 | Viewed by 96 | Submission Open

Keywords: autophagy; macroautophagy system; virus; viral infection; influenzae virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

High-Performance Composites: Molecular Design and Applications in Extreme Environments

edited by Fan Yang

submission deadline 31 May 2025 | Viewed by 92 | Submission Open

Keywords: thermal protection materials; mechanical and physical properties; extreme environments; molecular dynamics analysis; composite molecular design; preparation; simulation; and characterization

(This special issue belongs to the Section Materials Science)

Antibacterial Activity of Novel Antimicrobial Agents

edited by Paweł Kowalczyk

submission deadline 31 May 2025 | Viewed by 84 | Submission Open

Keywords: novel antimicrobial agents; antibiotic resistance; chemical entities; phage therapy; bacterial pathogens; antimicrobial peptides; resistance mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Tumor Hypoxia

edited by Klaudia K. Brodaczewska

submission deadline 31 May 2025 | Viewed by 75 | Submission Open

Keywords: tumor microenvironment; hypoxia; low oxygen; cancer therapy; cancer drug resistance; tumor immunosuppression; hypoxia biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Innovative Materials for Environmental and Climate Resilience

edited by

Sung Won Hwang

submission deadline 31 May 2025 | Viewed by 75 | Submission Open

Keywords: machine Learning; climatic condition; microplastic detection

(This special issue belongs to the Section Materials Science)

Biofunctionalization of Metals for Medical Application: Molecular Aspects

edited by

Luca Scotti

submission deadline 31 May 2025 | Viewed by 69 | Submission Open

Keywords: biofunctionalization; medical applications; nanomaterials; nanofunctionalized materials; molecular mechanisms; bacterial membranes; membrane polarity; bacterial resistance

(This special issue belongs to the Section Molecular Nanoscience)

Growth Factor Signaling in Cancer Progression

edited by

Hyeong-Reh Choi Kim

and Abdo J. Najy

submission deadline 1 Jun 2025 | Viewed by 174 | Submission Open

Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Targeting Glioblastoma Metabolism

edited by

José M. Matés

and

José Ángel Campos Sandoval

submission deadline 10 Jun 2025 | 2 articles | Viewed by 3837 | Submission Open

Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation

(This special issue belongs to the Section Molecular Oncology)

The Role of Platelets in Development and Disease: Thrombosis across the Lifespan

edited by

Jawaad Sheriff

submission deadline 10 Jun 2025 | 1 articles | Viewed by 3753 | Submission Open

Keywords: mechanobiology; biomechanics; signaling pathways; computational modeling; thrombosis; antithrombotic therapy; aging; systems biology; cardiovascular disease; diabetes; inflammation; cancer; platelet activation; platelet adhesion; platelet aggregation

(This special issue belongs to the Section Molecular Biology)

Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition

edited by

Eva E. Rufino Palomares

Amalia Pérez-Jiménez

and

José Antonio Lupiáñez

submission deadline 10 Jun 2025 | 1 articles | Viewed by 958 | Submission Open

Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders

edited by Massimiliano M. Corsi Romanelli and

Pietro Formisano

submission deadline 10 Jun 2025 | Viewed by 480 | Submission Open

Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Exosomes and Non-Coding RNA Research in Health and Disease

edited by

Stergios Boussios

submission deadline 11 Jun 2025 | 16 articles | Viewed by 51137 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Aggressive Behavior

edited by

Flavia Venetucci Gouveia

submission deadline 13 Jun 2025 | 1 articles | Viewed by 1704 | Submission Open

Keywords: aggressive behaviour; molecular mechanisms; agitation; mental disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Exosomes in Inflammatory Neurological and/or Peripheral Diseases

edited by

Eirini (Irene) Tsilioni

submission deadline 15 Jun 2025 | Viewed by 307 | Submission Open

Keywords: extracellular vesicles; neuroinflammation; peripheral inflammation; microglia; mast cells; immune response; biomarkers; blood– brain barrier; therapeutic applications; microRNAs; molecular mechanisms

(This special issue belongs to the Section Molecular Immunology)

Novel Antivirals against Respiratory Viruses

edited by

Fabiana Superti

Magda Marchetti

and

Lucia Nencioni

submission deadline 20 Jun 2025 | 10 articles | Viewed by 26023 | Submission Open

Keywords: respiratory virus; antivirals and mechanism of action; antiviral drugs; antiviral drug resistance; antiviral targets; in vitro models; antiviral combination therapy

(This special issue belongs to the Section Molecular Microbiology)

Role of Immune Cells in Non-infectious Inflammatory Diseases and Cancers

edited by

Evgeny E. Bezsonov

submission deadline 20 Jun 2025 | 10 articles | Viewed by 23398 | Submission Open

Keywords: cytokines; immunity cells; atherosclerosis; inflammation; immunity

(This special issue belongs to the Section Molecular Immunology)

Melanoma: From Molecular Pathology to Therapeutic Approaches

edited by

Michael Eccles

submission deadline 20 Jun 2025 | 8 articles | Viewed by 22739 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Molecular, Cellular, and Physiological Basis of Hearing Disorders

edited by Jing Zheng

submission deadline 20 Jun 2025 | 9 articles | Viewed by 21243 | Submission Open

Keywords: outer hair cells; biomarker; cochlear stress; hearing loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Kynurenic Acid: Emerging Research Advances and Therapeutic Implications

edited by

Piotr Paluszkiewicz

and Monika Turska-Kozłowska

submission deadline 20 Jun 2025 | 7 articles | Viewed by 20869 | Submission Open

Keywords: kynurenic acid; kynurenine pathway; kynurenine; therapeutic use; supply and distribution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Advances in Antimicrobial Biomaterials

edited by

Hah Young Yoo

and

Jin Cheol Yoo

submission deadline 20 Jun 2025 | 7 articles | Viewed by 20674 | Submission Open

Keywords: biomaterials; biopolymers production; antimicrobial agents; antimicrobial activity; natural antibiotics; antioxidants; bioelastomers; food packaging

(This special issue belongs to the Section Materials Science)

Advanced Oxidation Processes and Biodegradation for Emerging Contaminants Treatment

edited by

Guilong Peng

and

Chengdu Qi

submission deadline 20 Jun 2025 | 7 articles | Viewed by 19231 | Submission Open

Keywords: advanced oxidation processes; persistent organic compounds; water pollution control; biodegradation; emerging contaminants; water treatment; wastewater treatment; toxicity assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Peptides as Biochemical Tools and Modulators of Biological Activity

edited by

Annamaria Aloisio

submission deadline 20 Jun 2025 | 4 articles | Viewed by 19127 | Submission Open

Keywords: peptides; phage display; stem cells; mesenchymal stromal cells; cancer; leukemia; tumor targeting; drug delivery

(This special issue belongs to the Section Molecular Biology)

New Challenges of Parkinson’s Disease

edited by

Cristina Agliardi

and

Franca Rosa Guerini

submission deadline 20 Jun 2025 | 8 articles | Viewed by 18822 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Jun 2025 | 6 articles | Viewed by 18297 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Skin Diseases: From Molecular Mechanisms to Pathology

edited by

Alessandro Terrinoni

submission deadline 20 Jun 2025 | 8 articles | Viewed by 17498 | Submission Open

Keywords: skin diseases; immunology; genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease

edited by

Dariusz Szukiewicz

submission deadline 20 Jun 2025 | 8 articles | Viewed by 17242 | Submission Open

Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Targets of Solid Cancer

edited by

Valentina De Falco

submission deadline 20 Jun 2025 | 6 articles | Viewed by 17185 | Submission Open

Keywords: cancer; signal transduction; kinase inhibitors; targeted therapy; precision medicine; drug resistance; survival; cell cycle; cell reprogramming; stem cells; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Mechanism of Redox Signal Transduction in Plants

edited by

Yi Han

and

Kangdi Hu

submission deadline 20 Jun 2025 | 3 articles | Viewed by 16238 | Submission Open

Keywords: reactive oxygen species; reactive nitrogen species; hydrogen sulfide; persulfidation; nitrosation; sulfenylation; redox modification; redox signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Invasion and Metastasis in Brain Cancer

edited by

Aleksandra Glogowska

and

Saeid Ghavami

submission deadline 20 Jun 2025 | 5 articles | Viewed by 16217 | Submission Open

Keywords: metastatic tumor; advanced cancer; blood– brain barrier; brain microenvironment; extracellular matrix; invadopodia; proteins posttranslational modifications

(This special issue belongs to the Section Molecular Oncology)

Stress-Related Disorders and Depression: From Molecular Basis to Therapy (2nd Edition)

edited by

Irena Nalepa

and

Agnieszka Zelek-Molik

submission deadline 20 Jun 2025 | 6 articles | Viewed by 14746 | Submission Open

Keywords: psychobiology of stress; depression; posttraumatic stress disorder; anxiety disorders; animal models; biogenic monoamines; glucocorticoids; inflammation; antidepressant and anxiolytic drugs

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Somatic Cell Cloning and Other Assisted Reproductive Technologies in Mammals

edited by

Marcin Samiec

and

Maria Skrzyszowska

submission deadline 20 Jun 2025 | 8 articles | Viewed by 14649 | Submission Open

Keywords: somatic cell nuclear transfer (SCNT); SCNT-based cloning; assisted reproductive technology (ART); in vitro embryo production (IVP); in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI); in vivo embryo production

(This special issue belongs to the Section Molecular Biology)

Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment: 2nd Edition

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Jun 2025 | 4 articles | Viewed by 14505 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid– gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Machine Learning in Disease Diagnosis and Treatment

edited by

Makrina Karaglani

submission deadline 20 Jun 2025 | 13 articles | Viewed by 14006 | Submission Open

Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Microorganisms and Their Metabolites in Agriculture, Food and the Environment: 2nd Edition

edited by

Barbara Sokolowska

submission deadline 20 Jun 2025 | 8 articles | Viewed by 13904 | Submission Open

Keywords: fermentation; biopreservation; biocontrol; biodegradation; bioremediation; bioaugmentation; omic-technologies

(This special issue belongs to the Section Molecular Microbiology)

Oral and Dental Infectious Diseases: Molecular Pathology, Diagnosis and Therapy

edited by

Hiromichi Yumoto

and

Keiji Murakami

submission deadline 20 Jun 2025 | 8 articles | Viewed by 13816 | Submission Open

Keywords: oral; dental; periodontitis; tooth decay; periodontal diseases; gingivitis; oral microorganism; oral infections; dental infections; dental caries; microbial pathogenicity; Porphyromonas gingivalis; antimicrobials; oral biofilm

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometriosis: Focusing on Molecular and Cellular Research

edited by

Alfonso Baldi

submission deadline 20 Jun 2025 | 7 articles | Viewed by 13492 | Submission Open

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

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