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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 30 Jun 2026 | Viewed by 311 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Thyroid Disease: From Molecular Mechanisms to Diagnosis and Therapeutic Advances

edited by

Mariana Lorena Tellechea

and Juan Nicola

submission deadline 30 Jun 2026 | Viewed by 307 | Submission Open

Keywords: thyroid disease; hypothyroidism; hyperthyroidism; autoimmune thyroid disease; thyroid nodules; thyroid cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Metabolic Mechanisms Regulating Reproduction and Development in Animals

edited by Borhan Shokrollahi and Kimberly M. Davenport

submission deadline 30 Jun 2026 | Viewed by 302 | Submission Open

Keywords: molecular nutrition; metabolic signaling; reproductive physiology; epigenetic programming; placental biology; transcriptomics and metabolomics; mitochondrial function; oxidative stress pathways; developmental programming; ruminant health

(This special issue belongs to the Section Molecular Biology)

Thyroid Hormone Signaling: Mechanisms and Pathophysiological Implications

edited by

María Laura Barreiro Arcos

and Horacio Eduardo Romeo

submission deadline 30 Jun 2026 | 1 articles | Viewed by 300 | Submission Open

Keywords: thyroid hormones; mitochondrial function; oxidative stress; redox signaling; metabolic disorders; immune modulation; cardiovascular pathology; neurodevelopment and aging; cancer progression

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Phenotype-Targeted Nanomedicine: Navigating Multiscale Biological Barriers in the 2026 Clinical Era

edited by

Athina Angelopoulou

submission deadline 30 Jun 2026 | Viewed by 300 | Submission Open

Keywords: nanomedicine; nanotherapeutic; nanobiomaterials; TME

(This special issue belongs to the Section Molecular Nanoscience)

Computational Strategies in Toxicology

edited by

Rajesh Kumar Pathak

and

Vikas Kumar

submission deadline 30 Jun 2026 | Viewed by 283 | Submission Open

Keywords: emerging pollutants; environment; molecular docking; molecular dynamics simulations; QSAR; Omics; PBPK model; predictive toxicology; risk assessment

(This special issue belongs to the Section Molecular Informatics)

Vitamin D Metabolism and Molecular Signaling in Human Diseases

edited by

Anna Cieslinska

submission deadline 30 Jun 2026 | Viewed by 282 | Submission Open

Keywords: vitamin D; vitamin D metabolism; molecular signaling; genomic and non-genomic pathways; epigenetics; immune regulation; inflammation; metabolic disorders; autoimmune diseases; cancer biology; gut microbiota; genetic polymorphisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

Preparation and Applications of Colloidal Emulsions

edited by

Bakht Ramin Shah

submission deadline 30 Jun 2026 | Viewed by 282 | Submission Open

Keywords: emulsions; fabrication; characterization; applications; encapsulation; delivery systems

(This special issue belongs to the Section Molecular Biology)

Molecular and Biochemical Advances in Kidney Diseases and Genetics

edited by

Silvio R. De Luka

submission deadline 30 Jun 2026 | Viewed by 280 | Submission Open

Keywords: pathophysiology; molecular mechanisms; biomarkers; in silico data analysis; image analysis; animal models

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies

edited by

Stefan Simović

submission deadline 30 Jun 2026 | Viewed by 278 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; oxidative stress; molecular mechanisms; translational research; antiarrhythmic therapy; cardiac remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Jun 2026 | Viewed by 277 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 30 Jun 2026 | Viewed by 270 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Affective Disorders: From Pathogenesis to Drug Therapy

edited by Lawrence Shih-Hsin Wu

submission deadline 30 Jun 2026 | Viewed by 267 | Submission Open

Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene– environment interactions; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Phenolic Compounds as Adjunct Therapy in Cardiometabolic Disorders

edited by

Dalia Marija Kopustinskiene

submission deadline 30 Jun 2026 | Viewed by 263 | Submission Open

Keywords: phenolic compounds; cardiovascular diseases; metabolism; diabetes; obesity; hypertension; mitochondria; oxidative stress; gut microbiota; inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Omega-3 Polyunsaturated Fatty Acids: From Molecular Signaling to Therapeutic Applications

edited by

Feng-Yao Tang

submission deadline 30 Jun 2026 | Viewed by 258 | Submission Open

Keywords: N-3 polyunsaturated fatty acids; bioactive signaling molecules; stem cell; cancer; gut microbiota; precision nutrition

(This special issue belongs to the Section Molecular Biology)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 30 Jun 2026 | Viewed by 249 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Applications and Advances of Organic Synthesis in the Design of Antiparasitic, Antiviral, and Anticancer Drugs

edited by

Sergio Hernán Szajnman

and Juan B. Rodriguez

submission deadline 30 Jun 2026 | Viewed by 248 | Submission Open

Keywords: antiparasitic agents; antiviral agents; chagas disease; toxoplasmosis; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity

edited by

Hiroshi Sakaue

submission deadline 30 Jun 2026 | Viewed by 247 | Submission Open

Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant and Lichen Metabolites: Characterization and Applications

edited by

Agnieszka Hanaka

submission deadline 30 Jun 2026 | Viewed by 244 | Submission Open

Keywords: phytochemicals; secondary metabolites; bioactive compounds; bioactivity evaluation; synthesis optimization; metabolite application; metabolite extraction; elicitors; stress physiology; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by

Xuming Mao

submission deadline 30 Jun 2026 | Viewed by 243 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Cancer and Cell Metabolism—3rd Edition

edited by

Maria Mesuraca

Maria Concetta Faniello

and

Barbara Quaresima

submission deadline 30 Jun 2026 | Viewed by 240 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Oncology)

Reproductive Endocrinology Research: 2nd Edition

edited by

Tsung-Hsien Lee

submission deadline 30 Jun 2026 | Viewed by 238 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Polymeric Nanomaterials in Medicine

edited by Prabhanjan Giram

submission deadline 30 Jun 2026 | Viewed by 238 | Submission Open

Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies

(This special issue belongs to the Section Molecular Nanoscience)

Latest Insight into Spin and Isomerism of Organic Molecules

edited by

Chenwei Jiang

and

Le Yu

submission deadline 30 Jun 2026 | Viewed by 236 | Submission Open

Keywords: organic molecules; photoisomerization; spin states; isomerism; spin crossover; conformational dynamics; quantum chemistry; radical chemistry; singlet fission

(This special issue belongs to the Section Molecular Biophysics)

Anesthetics and Neurovascular Health: Molecular Pathways

edited by Gabriele Melegari

submission deadline 30 Jun 2026 | Viewed by 235 | Submission Open

Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Molecular Mechanisms Involved in Head and Neck Cancer

edited by Jae Won Chang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 234 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Plant Secondary Metabolites and Their Regulatory Mechanisms

edited by

Daniela Trono

submission deadline 30 Jun 2026 | Viewed by 234 | Submission Open

Keywords: secondary metabolites; plant growth and development; response to biotic and abiotic stresses; biosynthesis and degradation; gene and enzyme regulation; metabolic engineering; omics approaches

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Determinants of Therapeutic Response and Resistance in Urological Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 30 Jun 2026 | Viewed by 232 | Submission Open

Keywords: urological cancers; therapeutic resistance; treatment response; molecular determinants; precision oncology; biomarkers; tumor heterogeneity; genomics; epigenetics; tumor microenvironment; immune evasion; targeted therapy; immunotherapy; DNA damage repair; translational research

(This special issue belongs to the Section Molecular Oncology)

Advancing Molecular Psychiatry: Biomarkers, Mechanisms, and Precision Therapeutics

edited by Masaru Tanaka

submission deadline 30 Jun 2026 | Viewed by 223 | Submission Open

Keywords: brain organoids; induced pluripotent stem cells (iPSC); neural stem cells; CRISPER-CAS systems (CRISPR); neuropsychiatric disorders; neurodevelopmental disorders; synaptic transmission; neuroinflammation; drug discovery; animal disease models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapeutic Strategies in Diabetic Retinopathy

edited by

Rosa Fernandes

submission deadline 30 Jun 2026 | Viewed by 223 | Submission Open

Keywords: diabetic retinopathy; neurovascular unit; molecular pathways; neuroinflammation; metabolic dysregulation; blood-retinal barrier; molecular biomarkers; multi-omics; molecular therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Inflammasome Signaling

edited by

Soren Hayrabedyan

submission deadline 30 Jun 2026 | Viewed by 220 | Submission Open

Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome

(This special issue belongs to the Section Biochemistry)

Extracellular Vesicles: Biomarkers and Therapeutic Carriers in Human Health and Disease

edited by

José Eduardo Vargas

submission deadline 30 Jun 2026 | Viewed by 219 | Submission Open

Keywords: extracellular vesicles; cellular senescence; autophagy; biomarkers; drug delivery; translational medicine; human disease; cell fate

(This special issue belongs to the Section Molecular Biology)

Microfluidic-Assisted Synthesis of Nanomaterials: Precise Control of Size, Surface Chemistry and Molecular Interactions

edited by

Adelina-Gabriela Niculescu

and

Ariana Hudita

submission deadline 30 Jun 2026 | Viewed by 219 | Submission Open

Keywords: microfluidics; nanomaterials; nanocomposites; microreactors; controlled synthesis; surface chemistry; molecular interactions; flow simulation; physicochemical characterization; advanced applications

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Peptides: From Discovery and Characterization to Production, Therapeutic Applications, and Mechanistic Elucidation

edited by

José Thalles Lacerda

Taliana Bezerra

and

Luiz Juliano

submission deadline 30 Jun 2026 | Viewed by 218 | Submission Open

Keywords: bioactive peptides; mass spectrometry; machine learning; molecular dynamics simulation; synthetic biology; enzymology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Amyloids: From Structure to Tailored Function

edited by

Laurent Marichal

submission deadline 30 Jun 2026 | Viewed by 217 | Submission Open

Keywords: amyloid; aggregation; self-assembly; seeding; protein structure

(This special issue belongs to the Section Macromolecules)

Organoid Models: Advancing the Study of Disease Mechanisms and Nutritional Regulations

edited by

Xi Lin

and Pinghuang Liu

submission deadline 30 Jun 2026 | Viewed by 214 | Submission Open

Keywords: organoids; disease mechanisms; nutritional regulation; disease modeling; stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Single Cell Transcriptomics in Human Disease

edited by

Md. Mahmudul Hasan

submission deadline 30 Jun 2026 | Viewed by 211 | Submission Open

Keywords: single-cell RNA sequencing; brain aging; neurodegeneration; cellular heterogeneity; transcriptomics; neuronal aging; glial cells; senescence; cognitive decline; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Molecular and Omics Approaches in Toxicology and Precision Pharmacology

edited by

Mirjana M. Djukić

submission deadline 30 Jun 2026 | Viewed by 208 | Submission Open

Keywords: toxicology; precision pharmacology; omics technologies; proteomics; mode of action (MoA); mechanism of activity; biomarkers; prediction and modeling

(This special issue belongs to the Section Molecular Toxicology)

New Molecular Perspectives on Diabetic Retinopathy

edited by Martina Tomić and

Tomislav Bulum

submission deadline 30 Jun 2026 | Viewed by 205 | Submission Open

Keywords: diabetic retinopathy; diabetes; complications; vascular endothelial growth factor; retina; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liposome-Related Nanotechnology and Lipid-Based Nanocarriers

edited by

Carla Matos

submission deadline 30 Jun 2026 | Viewed by 199 | Submission Open

Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release

(This special issue belongs to the Section Molecular Nanoscience)

Emerging Insights into Endothelial Biology and Metabolism

edited by

Hemant Giri

submission deadline 30 Jun 2026 | Viewed by 195 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; vascular biology; endothelial migration; angiogenesis; vascular permeability; shear stress; microvascular and macrovascular remodeling; leukocyte trafficking; mitochondrial function

(This special issue belongs to the Section Molecular Biology)

Host–Microbiome Crosstalk: Mitochondria, Extracellular Vesicles, and Redox Regulation in Aging

edited by

Efthalia Moustakli

submission deadline 30 Jun 2026 | Viewed by 195 | Submission Open

Keywords: gut microbiome; redox homeostasis; mitochondria

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mediators at the Crossroads of Microbes, the Microbiome, and Cancer

edited by

Syed Azmal Ali

submission deadline 30 Jun 2026 | Viewed by 194 | Submission Open

Keywords: molecular mediators; microbiome-cancer interface; proteomics; multi-omics; functional characterization

(This special issue belongs to the Section Molecular Microbiology)

New Perspectives and Challenges in the Mechanisms, Diagnosis and Management of Skin Diseases

edited by

Emanuela Bastonini

, Daniela Kovacs and

Giorgia Cardinali

submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open

Keywords: skin diseases; precision medicine; molecular pathogenesis; regenerative medicine; lipidomics; targeted biologics; inflammatory skin diseases; skin cancers; skin aging; gut– skin axis; skin regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy in Physiology and Pathophysiology: Recent Advances

edited by

María Isabel Colombo

and Claudio Marcelo Fader

submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open

Keywords: macroautophagy; microautophagy; chaperone-mediated autophagy (CMA); autophagy-related genes (ATG); xenophagy; mitophagy; pexophagy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

KCTD Proteins in Cellular Processes Regulation: Advances and Challenges

edited by

Giovanni Pecoraro

submission deadline 30 Jun 2026 | Viewed by 190 | Submission Open

Keywords: KCTD proteins; cancer biology; cell signaling pathway; ubiquitination; genetic disorder; protein– protein interaction; developmental biology; protein stability; gene expression; new therapeutic target

(This special issue belongs to the Section Molecular Biology)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Recent Trends in Metal–Organic and Covalent Organic Frameworks

edited by

Muhammad Asad

submission deadline 30 Jun 2026 | Viewed by 180 | Submission Open

Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors

(This special issue belongs to the Section Materials Science)

Emerging Molecular Research on Photocatalytic Functional Materials

edited by Yifan Chen

submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open

Keywords: photocatalytic materials; molecular level; functional optimization; mechanism; synergistic effects

(This special issue belongs to the Section Materials Science)

Current Advances in Stem Cell Research for Regenerative Medicine

edited by Luca Giacomello

submission deadline 30 Jun 2026 | Viewed by 174 | Submission Open

Keywords: regenerative medicine; stem cells; disease modeling; drug testing; iPSCs; tissue engineering; biomaterials; organoids; organ-on-chip; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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