Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 447
Special Issue Editor
Interests: antimicrobials; pharmacodynamics; molecular mechanisms; medical informatics; pharmacology; bacterial infections; pulmonary fibrosis
Special Issue Information
Dear Colleagues,
Bacterial resistance is a global health emergency, with resistance detected to almost all antibiotics currently in clinical use. Correspondingly, the pursuit of new antibiotic therapy by humans to curb infections caused by antibiotic-resistant bacteria has also never stopped. Understanding the molecular mechanisms by which bacteria resist the action of antibiotics is crucial for recognizing global resistance patterns, improving the use of existing drugs, and developing new strategies to combat resistance. Similarly, revealing the targets or molecular mechanisms of antimicrobials, especially those of new antibacterial molecules different from traditional antibiotics, against bacterial pathogens is necessary for developing new therapeutics, finding new antibacterial action models, and designing or screening new drugs that are less likely to develop resistance.
Areas of interest include, but are not limited to:
- New horizons in the resistance mechanisms of WHO priority pathogens, ESCAPE pathogens, and other “superbugs”;
- New clues related to antibiotic resistance, such as enzymatic modification, quorum sensing systems, efflux pumps, changed membrane permeability, regulatory genes or factors, etc., mined from DNA sequencing of clinical strains or laboratory induced-bacteria;
- New advances in the molecular targets or mechanisms of traditional bacterostatic, or bactericidal agents, such as small molecule compounds, antimicrobial peptides, antimicrobial combinations, hybrid antibiotics, and repurposing drugs, etc.
- New discoveries and perspectives on non-traditional antibacterial mechanisms of potential medicinal molecules, such as anti-virulence agents, immune modulators, and toxin neutralizers.
Prof. Dr. Xinyi Yang
Guest Editor
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Keywords
- bacterial resistance
- antibiotics
- antimicrobials
- “superbugs”
- clinical strains
- laboratory induced-bacteria
- antimicrobial peptides
- antimicrobial combinations
- hybrid antibiotics
- repurposing drugs
- anti-virulence agents
- immune modulators
- toxin neutralizers
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