Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
4.9
Journals
IJMS
Special Issues
Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 219

Special Issue Editors

Prof. Dr. Nuno Taveira

E-Mail Website
Guest Editor
Research Institute for Medicines-FFUL (iMed.ULisboa), Universidade de Lisboa (University of Lisbon), Lisbon, Portugal
Interests: HIV; antivirals and vaccines; drug resistance; pathogenesis; antibody neutralization; virus evolution
Special Issues, Collections and Topics in MDPI journals
Dr. Inês Bártolo

E-Mail Website
Guest Editor
iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, 1649-019 Lisboa, Portugal
Interests: HIV; RNA respiratory viruses; molecular epidemiology; evolution; drug resistance mutations; discovery of new antivirals; spiro-beta-lactam compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite researchers, scientists and clinicians to submit their original research, reviews and perspectives for publication in our forthcoming Special Issue on "Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence". This Special Issue aims to explore the molecular pathways of HIV infection, persistence and disease, and the latest advances in therapeutic strategies. Topics of interest include the following: molecular biology of HIV entry, replication and latency; host–virus interactions and immune evasion mechanisms; HIV reservoir dynamics and eradication strategies; novel therapeutic approaches, including gene editing and immunotherapy; and biomarkers of disease progression and treatment efficacy. We welcome submissions of original research articles, comprehensive reviews and short communications that contribute to a deeper understanding of HIV pathogenesis and treatment.

Prof. Dr. Nuno Taveira
Dr. Inês Bártolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HIV pathogenesis
  • molecular virology
  • antiretroviral therapy
  • virus–host interactions
  • HIV eradication strategies

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

25 pages, 1836 KB  
Review
The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation
by Manlio Tolomeo and Antonio Cascio
Int. J. Mol. Sci. 2025, 26(18), 9123; https://doi.org/10.3390/ijms26189123 - 18 Sep 2025
Abstract
The STAT (Signal Transducer and Activator of Transcription) signaling pathway plays a central role in immune regulation by mediating cytokine responses and orchestrating both innate and adaptive immunity. Although CD4+ T cell depletion is the main driver of HIV-1–induced immunodeficiency, the virus also [...] Read more.
The STAT (Signal Transducer and Activator of Transcription) signaling pathway plays a central role in immune regulation by mediating cytokine responses and orchestrating both innate and adaptive immunity. Although CD4+ T cell depletion is the main driver of HIV-1–induced immunodeficiency, the virus also exerts a significant and often underestimated impact by disrupting the function of STAT family members, thereby exacerbating immune imbalance and accelerating disease progression. Specifically, HIV-1 suppresses STAT1 activation, impairing the induction of antiviral genes; inhibits IL-23–driven STAT3 activation in CD4+ Th17 cells with a reduction in IL-17; alters STAT3-dependent functions in antigen-presenting cells; and imposes profound—and at times opposing—dysregulations of STAT5, including the induction of a truncated isoform that contributes to latency. Notably, pharmacological inhibition of the JAK/STAT axis, particularly with JAK2 inhibitors, has been shown to reduce integrated proviral DNA and viral replication in vitro and in early clinical studies. This review provides an updated overview of the roles of individual STAT proteins in HIV-1 infection and pathogenesis, emphasizing the intricate interplay between viral factors and host signaling, highlighting the potential therapeutic implications, and suggesting that immunological assessment in HIV-1 patients should extend beyond CD4+ T cell counts and the CD4/CD8 ratio to include functional analysis of STAT signaling for deeper insights into immune dysfunction and chronic inflammation. Full article
(This article belongs to the Special Issue Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop