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Recent Advances in Gastrointestinal Cancer, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 778

Special Issue Editor


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Guest Editor
Department of Human Nutrition and Dietetics, University of Agriculture in Krakow, A. Mickiewicz Av. 21, 31-120 Krakow, Poland
Interests: health prevention; human nutrition; nutrigenomics; nutrition and immunity; epigenetics; functional foods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gastrointestinal cancer is the most common human malignancy, with colorectal and gastric cancer accounting for the third and fifth highest global incidences, respectively. Despite the use of new and innovative chemotherapeutic agents and combination treatment strategies, including chemotherapy, surgery, radiotherapy, and targeted therapies, modern medicine still lacks a fully effective therapy approach. In addition, survival rates remain notably low for patients with advanced-stage malignancies. A better knowledge of the molecular mechanisms that influence cancer progression and the development of optimal therapeutic strategies for gastrointestinal cancer malignancies are urgently needed.

Alongside the need for utilizing existing knowledge regarding the process of developing and synthesizing new, potential chemotherapeutic agents characterized by appropriate effectiveness against gastrointestinal cancer cells, it is also important to emphasize prevention, which may involve, for example, proper nutrition. Numerous studies show that natural plant-derived compounds may contribute to cancer prevention and may also support the treatment of gastrointestinal cancer and other chronic diseases. The anticancer potential of compounds is often related to changes in the expression of genes that are implicated in cell cycle arrest and apoptotic death.

This Special Issue is supervised by Dr. Aneta Koronowicz and assisted by our Topical Advisory Panel Member Dr. Ewelina Piasna-Słupecka (University of Agriculture in Krakow). In this Special Issue, we will discuss recent advances and future directions of therapies for malignant tumors of the gastrointestinal system, as well as describe innovative chemotherapeutic agents. In addition, we will discuss the biological properties of natural products and new and classical dietary bioactive compounds, which may reduce the risk of gastrointestinal cancer in the future.

We look forward to receiving your contributions.

More published papers can be found in the closed Special Issue.
Recent Advances in Gastrointestinal Cancer
Recent Advances in Gastrointestinal Cancer, 2nd Edition

Dr. Aneta Koronowicz
Guest Editor

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Keywords

  • gastrointestinal cancer
  • chemotherapeutic agents
  • innovative therapies
  • human nutrition
  • nutrigenomics
  • nutrition and immunity epigenetics
  • cytotoxicity
  • apoptosis

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Published Papers (1 paper)

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Review

19 pages, 1445 KB  
Review
The Molecular Landscape of Colorectal Laterally Spreading Tumors: From Endoscopic Subtypes to Molecular Targets
by Mara Martinelli, Nicoletta Cascelli, Ottavia Bartolo, Mario Ciuffi, Carmela Mazzoccoli, Rosalia Dieli, Rosa Lioy, Matteo Landriscina, Carlo Calabrese and Fabiana Crispo
Int. J. Mol. Sci. 2025, 26(17), 8445; https://doi.org/10.3390/ijms26178445 - 30 Aug 2025
Viewed by 673
Abstract
Lateral Spreading Tumors (LSTs) are a type of non-polypoid lesion known for their flat morphology, which often leads to them going undetected. However, especially nongranular (NG) LSTs have the potential for malignant transformation. Recent advances in endoscopic technologies have improved the detection of [...] Read more.
Lateral Spreading Tumors (LSTs) are a type of non-polypoid lesion known for their flat morphology, which often leads to them going undetected. However, especially nongranular (NG) LSTs have the potential for malignant transformation. Recent advances in endoscopic technologies have improved the detection of these lesions. Despite growing research interest in their role in colorectal cancer (CRC) development, a comprehensive molecular characterization of LSTs is still lacking. The aim of this review is to highlight the current knowledge of the molecular characteristics of LSTs, that may help in determining whether LSTs can be prognostic indicators and identifying cases where they may rapidly progress to CRC through characteristic molecular pathways. From a mutational point of view, LSTs seem to be more closely associated with inflammatory bowel diseases (IBDs) than with polypoid lesions. Nonetheless, they have peculiar epigenetic and genetic traits, which set them apart from other adenomas or bowel diseases. Elucidating their role in CRC development would provide benefits for their classification and management, by enhancing clinical surveillance strategies for patients diagnosed with these lesions in order to improve the efficient prevention of colorectal cancer. Full article
(This article belongs to the Special Issue Recent Advances in Gastrointestinal Cancer, 3rd Edition)
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