Molecular Mechanisms of Ozone Therapy

Dear Colleagues,

This Special Issue on Molecular Mechanisms of Ozone Therapy focuses on advancing the understanding of how medical ozone exerts its therapeutic effects beyond the well-established activation of the Nrf2 pathway. Ozone therapy has demonstrated benefits in modulating cellular redox balance, regulating mitochondrial function, and enhancing cellular signaling processes such as autophagy and apoptosis.

This Special Issue aims to describe lesser-known molecular mechanisms, including the role of ozone in modulating immune response, improving endothelial function, and influencing key transcription factors and signaling cascades like NF-κB, HIF-1α, and MAPKs. By highlighting these underexplored pathways, this Special Issue seeks to provide a comprehensive view of the cellular and molecular basis of ozone therapy, with its potential applications in managing conditions such as pain, chronic inflammation, ischemic syndromes, ischemia–reperfusion injury, and neurodegenerative disorders. We are open to expanding the areas of interest of this Special Issue to include potential in vivo and ex vivo mechanisms of action of ozone that are relevant to the management of infectious diseases, their complications, and/or pathogen control, with a particular focus on addressing antimicrobial resistance and emerging infectious diseases.

Dr. Francisco Rodríguez-Esparragón
Dr. Bernadino Clavo
Dr. Jacob Lorenzo-Morales
Guest Editors

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