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Molecular Pathology and Treatment of Heart Failure

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 779

Special Issue Editor


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Guest Editor
Geriatric Division, University Hospital "Renato Dulbecco", 88100 Catanzaro, Italy
Interests: geriatric; heart failure; arterial hypertension; atrial fibrillation

Special Issue Information

Dear Colleagues,

This Special Issue represents an important opportunity for a better understanding of the molecular pathophysiological mechanisms involved in the onset and maintenance of heart failure, such as oxidative stress, platelet activation, systemic inflammation, etc. In this context, it appears interesting to search for possible molecules with a potential prognostic role, not only on the risk of cardiovascular death but also on the risk of hospitalization. Given the new pharmacological classes, it also appears interesting to assess the possible effect of these therapies on the aforementioned pathophysiological mechanisms. Furthermore, the integrated management of cardiovascular and non-cardiovascular comorbidities appears to be of increasing interest and prognostic significance, including considering what the potential clinical benefit of such an approach might be.

Dr. Giuseppe Armentaro
Guest Editor

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Keywords

  • heart failure
  • oxidative stress
  • platelet activation
  • inflammation
  • biomarkers
  • pathophysiology
  • comorbidities

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Published Papers (1 paper)

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Research

11 pages, 490 KB  
Article
Early Effect of Supplementation with Essential Amino Acids on Cardiac Performance in Elderly Patients with Heart Failure and Sarcopenia
by Giuseppe Armentaro, Velia Cassano, Pasquale Loiacono, Carlo Fuoco, Giandomenico Severini, Carlo Alberto Pastura, Alberto Panza, Marilisa Panza, Elisa Mazza, Sofia Miceli, Arturo Pujia, Tiziana Montalcini and Angela Sciacqua
Int. J. Mol. Sci. 2025, 26(15), 7533; https://doi.org/10.3390/ijms26157533 - 4 Aug 2025
Viewed by 454
Abstract
The aim of the present observational study was to evaluate the early effect of free-form essential amino acid (EAA) supplementation on cardiac and muscular performance in elderly patients with chronic heart failure (HF) with reduced ejection fraction (HFrEF) and sarcopenia, as add-on to [...] Read more.
The aim of the present observational study was to evaluate the early effect of free-form essential amino acid (EAA) supplementation on cardiac and muscular performance in elderly patients with chronic heart failure (HF) with reduced ejection fraction (HFrEF) and sarcopenia, as add-on to the optimized medical therapy (OMT) for HF. The present study included 60 elderly Caucasian patients suffering from HFrEF and sarcopenia. At the baseline and at follow-up, all patients underwent complete physical examination with the determination of the main anthropometric and hemodynamic parameters. After 6 months of supplementation with EAAs, we observed significant improvements in the parameters of sarcopenia. In addition, there was a significant improvement in glycol-metabolic parameters, and in inflammatory index as high sensitivity C-reactive protein (hs-CRP). In accordance with these results, significant decreases were observed in circulating levels of oxidative stress biomarkers Nox-2 (p < 0.001) and 8-Isoprostane (p < 0.001), and platelet aggregation biomarkers such as sP-Selectin (p < 0.001) and Gp-VI (p < 0.001). Of particular interest, after 6 months’ follow-up, there was a significant improvement in LVEF and global longitudinal strain (GLS). In conclusion, this study demonstrates that targeted nutritional intervention with EEAAs represents a viable therapeutic strategy for addressing the complex interplay between cardiac dysfunction and skeletal muscle wasting in elderly HF patients. Full article
(This article belongs to the Special Issue Molecular Pathology and Treatment of Heart Failure)
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