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Bone Metabolism and Bone Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1217

Special Issue Editor

Special Issue Information

Dear Colleagues,

Bone is a dynamic tissue that undergoes continuous remodelling thanks to the activity of bone resorbing cells, the osteoclasts, and bone forming cells, the osteoblasts. Bone remodelling is orchestrated by the osteocytes, a process that can be regulated by different local and systemic factors, including hormones, physical activity, genetics, and nutrition. Special attention will be given to the role of these factors on bone metabolism in health and diseases. Mechanisms underlying bone metabolism are essential to guarantee its health.

Thus, manuscripts covering the following topics will be accepted:

  • Pathways active in bone health and diseases;
  • Role of different bone cells;
  • Nutrients and bone metabolism;
  • In vivo models;
  • New therapeutic approaches for bone diseases.

Research papers, reviews, and methodology papers are welcome.

Dr. Giacomina Brunetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone metabolism
  • bone diseases
  • osteoclast
  • osteoblasts and osteocytes
  • bone remodelling

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Published Papers (2 papers)

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Research

14 pages, 942 KB  
Article
Effects of L-Arginine on Bone Metabolism: Evidence from In Vitro and In Vivo Models
by Clara Pertusa, Álvaro Carrasco-García, Rosa Aliaga, Loreto Suay, Eulalia Alonso-Iglesias, Antonio Cano, Juan J. Tarín and Miguel Ángel García-Pérez
Int. J. Mol. Sci. 2025, 26(17), 8484; https://doi.org/10.3390/ijms26178484 - 1 Sep 2025
Viewed by 439
Abstract
Despite the rising incidence of osteoporosis (the most common bone disorder) as life expectancy increases worldwide, the genetic and metabolic factors contributing to this multifactorial disease are still poorly understood. This study investigated the role of arginine metabolism in bone formation and its [...] Read more.
Despite the rising incidence of osteoporosis (the most common bone disorder) as life expectancy increases worldwide, the genetic and metabolic factors contributing to this multifactorial disease are still poorly understood. This study investigated the role of arginine metabolism in bone formation and its potential for preventing bone loss in postmenopausal osteoporosis. The osteogenic effects of arginine were evaluated in vitro by determining calcium mineral deposition and the expression of marker genes in the human osteoblastic cell line Saos-2. In vivo analyses were conducted in ovariectomized mice treated with arginine, focusing on femoral bone microarchitecture, marker gene expression and serum metabolite profiles. Arginine treatment enhanced calcium deposition and osteoblastic differentiation in vitro. In contrast, however, this treatment had a deleterious effect in vivo, exacerbating trabecular bone loss. These results are particularly relevant given the wide availability of arginine as a dietary supplement, and our findings underscore the necessity of verifying the safety of nutritional supplements in different populations and in the presence of disease. Full article
(This article belongs to the Special Issue Bone Metabolism and Bone Diseases)
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13 pages, 2092 KB  
Article
Serum Osteocalcin in Pediatric Osteogenesis Imperfecta: Impact of Disease Type and Bisphosphonate Therapy
by Jakub Krzysztof Nowicki and Elżbieta Jakubowska-Pietkiewicz
Int. J. Mol. Sci. 2025, 26(16), 7953; https://doi.org/10.3390/ijms26167953 - 18 Aug 2025
Viewed by 555
Abstract
The aim of this study was to analyze the factors that may influence serum osteocalcin levels in children with osteogenesis imperfecta treated with intravenous sodium pamidronate and to define the role of osteocalcin assessment. The study included 61 patients diagnosed with osteogenesis imperfecta [...] Read more.
The aim of this study was to analyze the factors that may influence serum osteocalcin levels in children with osteogenesis imperfecta treated with intravenous sodium pamidronate and to define the role of osteocalcin assessment. The study included 61 patients diagnosed with osteogenesis imperfecta type 1 or 3, aged 2 to 18, hospitalized for intravenous sodium pamidronate administration. A retrospective analysis of medical records was conducted, collecting information on age, sex, body weight, height, the number of long bone fractures throughout life, serum levels of osteocalcin, creatinine, alkaline phosphatase, 25(OH)D3, and DXA BMD z-scores for the L1–L4 spine segment. The concentration of osteocalcin is higher in patients with osteogenesis imperfecta than the reference ranges for sex and age. Patients diagnosed with type 3 have significantly lower osteocalcin levels compared to patients with type 1. Also, increasing the age-standardized pamidronate cycle rate significantly reduced osteocalcin concentration. The strongest predictor of osteocalcin concentration among the factors studied is the type of osteogenesis imperfecta. L1–L4 BMD value and fracture frequency were unrelated to osteocalcin concentration. Osteocalcin is an important marker of bone formation that should be measured at the beginning of treatment, as its concentration decreases after successive doses of bisphosphonates. Full article
(This article belongs to the Special Issue Bone Metabolism and Bone Diseases)
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