Research Progress in Cellular Senescence in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 12
Special Issue Editors
Interests: cellular senescence and aging; cell biology; age-related diseases; mesenchymal stem/stromal cells
Special Issue Information
Dear Colleagues,
Cellular senescence is a stable and essentially irreversible state of cell cycle arrest, characterized by extensive morphological, molecular, and functional alterations. It is mechanistically and functionally distinct from quiescence and terminal differentiation, both of which also involve proliferative arrest but lack the specific molecular markers and phenotypic features of senescence.
Currently, cellular senescence is recognized as a complex stress response elicited by a wide array of intrinsic and extrinsic stimuli that compromise genomic or cellular integrity, such as DNA-damaging agents, oxidative stress, nutrient deprivation, hypoxia, mitochondrial dysfunction, and aberrant oncogenic signaling. In response to such insults, cells activate a robust senescence program that entails stable growth arrest mediated by the p53/p21CIP1 and p16INK4a/Rb pathways, along with the secretion of a pro-inflammatory and tissue-remodeling secretome known as the senescence-associated secretory phenotype (SASP).
While cellular senescence is closely associated with organismal aging and the pathogenesis of various age-related disorders, it is not synonymous with chronological aging. Senescent cells can accumulate in tissues independent of age or telomere attrition, such as in response to acute stress or oncogenic activation. Moreover, senescence plays critical roles in physiological processes, including embryonic development, tissue remodeling, and wound healing. It also serves as a potent tumor-suppressive mechanism by halting the proliferation of damaged or potentially malignant cells.
The aim of the Special Issue 'Research Progress in Cellular Senescence in Health and Disease' is to highlight the latest advances in understanding the dual role of cellular senescence in both physiological and pathological conditions, as well as their implications for human health.
Dr. Gabriella Teti
Prof. Dr. Mirella Falconi
Guest Editors
Manuscript Submission Information
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Keywords
- cellular senescence
- physiological relations
- pathological relations
- cell biology in aging
- age-related diseases
- senescence in mesenchymal stroma cells
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