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Stroke: Novel Molecular Mechanisms and Therapeutic Approaches
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Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 837

Special Issue Editor

Dr. Kang-Ho Choi

E-Mail Website
Guest Editor
Department of Neurology, Chonnam National University School of Medicine and Hospital, Gwangju 61469, Republic of Korea
Interests: stroke; neurodegenerative disease; headache; sleep disorder

Special Issue Information

Dear Colleagues,

The special issue "Stroke: Novel Molecular Mechanisms and Therapeutic Approaches" is a collection dedicated to exploring recent advances in the emerging molecular basis and treatment of stroke and neurotrauma.

Our focus concerns the latest updates on the pathophysiology, diagnosis, monitoring, and treatments for cerebrovascular disease. Researchers and clinicians will share their experiences and results in the latest research advances and novel therapeutic approaches. This Special Issue aims to provide the scientific community with an in-depth understanding of the pathogenesis and molecular pathways of cerebrovascular diseases to provide the basis for developing new treatments. The Special Issue will include treatment innovations in cerebrovascular disease and neurotrauma, including drug therapy, nano therapy, gene therapy, stem cell therapy, and the latest technology.

This Special Issue will comprehensively select recent research topics and review articles. We invite submissions on various issues related to novel and emerging molecular mechanisms and therapeutic approaches in stroke. These include exploratory or fundamental scientific studies, preclinical, cross-sectional, and clinical studies, and systematic and narrative/comprehensive reviews. We hope this collection will be a valuable guide for researchers and clinicians.

Dr. Kang-Ho Choi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • cerebrovascular disease
  • mechanisms
  • treatment
  • diagnosis

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Published Papers (1 paper)

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Research

17 pages, 5312 KiB  
Article
Positive Behavioral, Morphophysiological, and Gene Expression Effects of the Administration of Virgin Coconut Oil in an Ischemic Stroke Surgical Rat Model
by Rodel Jonathan S. Vitor II, Ryota Tochinai, Shin-Ichi Sekizawa and Masayoshi Kuwahara
Int. J. Mol. Sci. 2025, 26(13), 6215; https://doi.org/10.3390/ijms26136215 - 27 Jun 2025
Viewed by 98
Abstract
Stroke is still considered a predominant cause of morbidity and mortality, for which research on prevention and cure has been sought to prevent neuronal damage after a stroke incident. In this research, we evaluated the protective effects of virgin coconut oil (VCO) using [...] Read more.
Stroke is still considered a predominant cause of morbidity and mortality, for which research on prevention and cure has been sought to prevent neuronal damage after a stroke incident. In this research, we evaluated the protective effects of virgin coconut oil (VCO) using behavioral, morphophysiological, and gene expression parameters using an ischemic stroke surgical rat model using Sprague Dawley (SD) rats. Eight-week-old SD rats were subjected to repeated oral administration (5 mL/kg/day) of either 1% Tween 80 or VCO. For behavioral and morphophysiological parameters, surgery was performed for each group, after which neurological scoring was performed at 4 h, 24 h, 48 h, 5 d, and 10 d. Further, hematological and brain morphology assessment was performed after euthanasia and necropsy of the animals. For gene expression studies, surgery was performed with animals sacrificed at different time points (baseline, before surgery, 4 h, 24 h, and 48 h after surgery) to collect the brain. Results of the study showed that there are differences in the neurological scores between the two treatments 24 h, 48 h, and 5 d after surgery. Brain morphology assessment also showed favorable results for VCO for infarct size, edema, and hypoxic neurons. Gene expression studies also showed positive results with an increase in the relative expression of angiogenin (Ang), angiopoietin (Angpt 1), Parkin, dynamin-related protein 1 (Drp 1), mitofusin 2 (Mfn 2), and mitochondrial rho (Miro) and decreased relative expression of caspase 3, receptor for advanced glycation end-product (Rage), and glyceraldehyde-3-phosphate dehydrogenase (Gapdh). In summary, the current study shows that VCO may have protective effects on the brain after stroke, which may be explained by the results of the gene expression studies. Full article
(This article belongs to the Special Issue Stroke: Novel Molecular Mechanisms and Therapeutic Approaches)
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