Dysregulation of Bone Health–a Matter of Several Culprits
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 983
Special Issue Editor
Special Issue Information
Dear Colleagues,
Adequate bone mass is established by the balance between bone formation and degradation. Disruptions in this intricate relationship induce states of low bone mass (osteopenia) that may progress to osteoporosis and an increased risk of low-impact fractures. Up to 30% of postmenopausal females and more than 50% of males have osteoporosis due to secondary causes. Secondary causes of reduced bone mass include lung, endocrine, metabolic, hepatic and gastrointestinal disorders, eating disorders, hematological disfunctions, renal disease, cancer and adverse effects of pharmacological therapy. Despite clinical studies on the association of several pathologies with bone loss, few have established a direct relationship between the primary pathology and the secondary cause of bone loss. Moreover, it remains unclear whether different pathologies, namely rare diseases, share the molecular and cellular mechanisms responsible of bone loss. This knowledge is fundamental to design better therapeutic tools and markers of disease severity and/or diagnosis. Additionally, the role of the currently available markers of bone metabolism/health in the diagnosis, follow-up and prediction of the response to treatment is still ambiguous. The main goal of this Special Issue is to gather original and review articles to provide the most recent evidence on the mechanisms and clinical management of secondary bone loss.
Suggested topics include, but are not limited to, the following:
- The identification of the relationship between a specific pathology and secondary bone loss, using human or animal studies.
- Studies on the role of the immune system on bone loss.
- Metabolic pathways leading to bone loss.
- Studies on the role of rare diseases in the identification of new molecular pathways leading to bone loss.
- Studies addressing the specificity, sensitivity and predictive value of the currently available markers of bone metabolism in bone loss.
- The development of new biomarkers to predict and detect bone loss.
- Clinical trials addressing new therapeutic approaches to secondary bone loss.
Dr. Dina Cosme is the Guest Editor Assistant, who will help manage the special issue.
Dr. Ana Gomes
Guest Editor
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Keywords
- bone metabolism
- osteoporosis
- osteopenia
- low-impact fractures
- osteoimmunology
- leptin
- lung disorders
- cancer
- renal disease
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