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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research on Inflammasome Signaling

edited by

Soren Hayrabedyan

submission deadline 30 Jun 2026 | Viewed by 214 | Submission Open

Keywords: PANoptosis; NLRP6; NLRP12; CARD8; non-immune cells; viral proteins; gasdermin family; inflammasome-independent signaling; inflammaging; MxA inflammasome

(This special issue belongs to the Section Biochemistry)

Bioactive Peptides: From Discovery and Characterization to Production, Therapeutic Applications, and Mechanistic Elucidation

edited by

José Thalles Lacerda

Taliana Bezerra

and

Luiz Juliano

submission deadline 30 Jun 2026 | Viewed by 211 | Submission Open

Keywords: bioactive peptides; mass spectrometry; machine learning; molecular dynamics simulation; synthetic biology; enzymology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Single Cell Transcriptomics in Human Disease

edited by

Md. Mahmudul Hasan

submission deadline 30 Jun 2026 | Viewed by 205 | Submission Open

Keywords: single-cell RNA sequencing; brain aging; neurodegeneration; cellular heterogeneity; transcriptomics; neuronal aging; glial cells; senescence; cognitive decline; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

New Molecular Perspectives on Diabetic Retinopathy

edited by Martina Tomić and

Tomislav Bulum

submission deadline 30 Jun 2026 | Viewed by 204 | Submission Open

Keywords: diabetic retinopathy; diabetes; complications; vascular endothelial growth factor; retina; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Omics Approaches in Toxicology and Precision Pharmacology

edited by

Mirjana M. Djukić

submission deadline 30 Jun 2026 | Viewed by 203 | Submission Open

Keywords: toxicology; precision pharmacology; omics technologies; proteomics; mode of action (MoA); mechanism of activity; biomarkers; prediction and modeling

(This special issue belongs to the Section Molecular Toxicology)

Liposome-Related Nanotechnology and Lipid-Based Nanocarriers

edited by

Carla Matos

submission deadline 30 Jun 2026 | Viewed by 195 | Submission Open

Keywords: liposomes; lipid nanoparticles; solid lipid nanoparticles; nanostructured lipid carriers; nanocarriers; drug delivery; controlled release

(This special issue belongs to the Section Molecular Nanoscience)

Emerging Insights into Endothelial Biology and Metabolism

edited by

Hemant Giri

submission deadline 30 Jun 2026 | Viewed by 193 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; vascular biology; endothelial migration; angiogenesis; vascular permeability; shear stress; microvascular and macrovascular remodeling; leukocyte trafficking; mitochondrial function

(This special issue belongs to the Section Molecular Biology)

Molecular Mediators at the Crossroads of Microbes, the Microbiome, and Cancer

edited by

Syed Azmal Ali

submission deadline 30 Jun 2026 | Viewed by 190 | Submission Open

Keywords: molecular mediators; microbiome-cancer interface; proteomics; multi-omics; functional characterization

(This special issue belongs to the Section Molecular Microbiology)

New Perspectives and Challenges in the Mechanisms, Diagnosis and Management of Skin Diseases

edited by

Emanuela Bastonini

, Daniela Kovacs and

Giorgia Cardinali

submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open

Keywords: skin diseases; precision medicine; molecular pathogenesis; regenerative medicine; lipidomics; targeted biologics; inflammatory skin diseases; skin cancers; skin aging; gut– skin axis; skin regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy in Physiology and Pathophysiology: Recent Advances

edited by

María Isabel Colombo

and Claudio Marcelo Fader

submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open

Keywords: macroautophagy; microautophagy; chaperone-mediated autophagy (CMA); autophagy-related genes (ATG); xenophagy; mitophagy; pexophagy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

KCTD Proteins in Cellular Processes Regulation: Advances and Challenges

edited by

Giovanni Pecoraro

submission deadline 30 Jun 2026 | Viewed by 189 | Submission Open

Keywords: KCTD proteins; cancer biology; cell signaling pathway; ubiquitination; genetic disorder; protein– protein interaction; developmental biology; protein stability; gene expression; new therapeutic target

(This special issue belongs to the Section Molecular Biology)

Host–Microbiome Crosstalk: Mitochondria, Extracellular Vesicles, and Redox Regulation in Aging

edited by

Efthalia Moustakli

submission deadline 30 Jun 2026 | Viewed by 188 | Submission Open

Keywords: gut microbiome; redox homeostasis; mitochondria

(This special issue belongs to the Section Molecular Microbiology)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 30 Jun 2026 | Viewed by 182 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Recent Trends in Metal–Organic and Covalent Organic Frameworks

edited by

Muhammad Asad

submission deadline 30 Jun 2026 | Viewed by 176 | Submission Open

Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors

(This special issue belongs to the Section Materials Science)

Emerging Molecular Research on Photocatalytic Functional Materials

edited by Yifan Chen

submission deadline 30 Jun 2026 | Viewed by 171 | Submission Open

Keywords: photocatalytic materials; molecular level; functional optimization; mechanism; synergistic effects

(This special issue belongs to the Section Materials Science)

Exploring Molecular Mechanisms Involved in Head and Neck Cancer

edited by Jae Won Chang

submission deadline 30 Jun 2026 | Viewed by 168 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Perspectives on Natural Antioxidants in Health and Disease

edited by

Jinbong Park

submission deadline 30 Jun 2026 | Viewed by 168 | Submission Open

Keywords: natural antioxidants; oxidative stress; molecular mechanisms; polyphenols; NRF2 signaling pathway; mitochondrial homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Trends and Prospects in Biomaterials

edited by Gabriela Graziani and

Daniele Ghezzi

submission deadline 30 Jun 2026 | Viewed by 166 | Submission Open

Keywords: biomaterials; orthopaedics; wound healing; additive manufacturing; infection; tissue modelling; tissue regeneration; orthopaedics; wound healing; antibacterial materials; regenerative medicine; reparative medicine

(This special issue belongs to the Section Materials Science)

Current Advances in Stem Cell Research for Regenerative Medicine

edited by Luca Giacomello

submission deadline 30 Jun 2026 | Viewed by 161 | Submission Open

Keywords: regenerative medicine; stem cells; disease modeling; drug testing; iPSCs; tissue engineering; biomaterials; organoids; organ-on-chip; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Alcohol Metabolism: Molecular, Physiological, and Behavioral Consequences from Basic Research to Translational Applications

edited by Analia G. Karadayian

submission deadline 30 Jun 2026 | Viewed by 159 | Submission Open

Keywords: alcohol metabolism; acetaldehyde; mitochondrial dysfunction; oxidative stress; behavioral outcomes; animal models; translational research

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Impact of Microbiome on Gastrointestinal Disorders

edited by

Hirokazu Fukui

submission deadline 30 Jun 2026 | Viewed by 158 | Submission Open

Keywords: gut microbiome; inflammation; functional gastrointestinal disorders; gut hormone; pathology; carcinogenesis; inflammatory bowel disease; mucosal barrier; immunity; gut– bain axis; stress; innate immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research on Cotton Breeding and Genetics

edited by

Yanpeng Zhao

submission deadline 30 Jun 2026 | Viewed by 155 | Submission Open

Keywords: cotton genomics; molecular breeding; gene regulation; abiotic stress tolerance; fiber quality improvement; disease resistance; genetic engineering; marker-assisted selection; transcriptomics; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Hematopoietic Stem Cell Differentiation and Regeneration

edited by

Baobing Zhao

submission deadline 30 Jun 2026 | Viewed by 148 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; anemia; myelodysplastic syndromes; myeloproliferative neoplasm; myelofibrosis; erythropoiesis; hematopoietic stem cell

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Stroke: Biomarkers and Mechanisms

edited by Jae Sang Oh

submission deadline 30 Jun 2026 | Viewed by 144 | Submission Open

Keywords: stroke; glymphatic system; biomarkers; human-derived specimens; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Advances in Fluorescent Biosensors

edited by

Xiaolong Liu

submission deadline 30 Jun 2026 | Viewed by 143 | Submission Open

Keywords: single molecule imaging; fluorescent probes; super-resolution imaging

(This special issue belongs to the Section Molecular Biophysics)

Molecular Advances in Quantum Neuroactivity

edited by

Mihai V. V. Putz

submission deadline 30 Jun 2026 | Viewed by 140 | Submission Open

Keywords: neurosciences; neurochemistry; neurobiology; quantum theory and computation; neuromorphisms; QSAR (quantitative structure-activity relationships); bio- and nano-materials; (artificial) neural networks.

(This special issue belongs to the Section Molecular Neurobiology)

New Developments in Fluorescent Biosensors

edited by

Chin-Feng Wan

submission deadline 30 Jun 2026 | Viewed by 133 | Submission Open

Keywords: carbon-based luminescent materials; green fluorescent sensors; C-dots; environmental sensing; biomedical applications; green synthesis strategies; fluorescence quenching; heavy metal detection

(This special issue belongs to the Section Molecular Biophysics)

Plant Molecular Ecology and Genomic Perspectives

edited by

Peng Zhao

submission deadline 1 Jul 2026 | Viewed by 467 | Submission Open

Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Breast Cancer: From Molecular Mechanism to Therapeutic Strategy

edited by

Anna Makuch-Kocka

submission deadline 10 Jul 2026 | 2 articles | Viewed by 1917 | Submission Open

Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Structure and Characterization of Optical Materials

edited by

Andrzej Kruk

submission deadline 10 Jul 2026 | 1 articles | Viewed by 763 | Submission Open

Keywords: luminescence; structure modification; spectroscopy; measurement techniques; Kerr effect; Faraday effects; doping; molecular structure

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Cancer Immunotherapy on Checkpoint Inhibitors: Future Directions

edited by

Hui Yen Chuang

submission deadline 10 Jul 2026 | 1 articles | Viewed by 380 | Submission Open

Keywords: immune checkpoint inhibitors (ICIs); PD-1/PD-L1 blockade; combination immunotherapy; immunotherapy resistance; tumor microenvironment (TME); predictive biomarkers; immune-related adverse events (irAEs); novel immune targets (LAG-3/TIM-3); personalized medicine; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Molecular Physiopathological Role of Hypoxia

edited by

Michele Aventaggiato

submission deadline 10 Jul 2026 | Viewed by 231 | Submission Open

Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developing the Coupling or De-Coupling of Osteoclastogenesis vs. Osteogenesis at the Osteoimmune Interface

edited by Andy Yen-Tung Teng

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1017 | Submission Open

Keywords: bone and immune cells; osteoclasts vs. osteoblasts; interactions between osteoclasts and osteoblasts; osteoimmune interactions in health and/or disease; developmental lineages or pathways of osteoclastogenesis; coupling and/or de-coupling (or crosstalk) for osteoclastogenesis and/or osteogenesis; biomaterials and/or bio-mimics for bone genesis and/or loss

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism of Circadian Rhythm

edited by Rosângela Vieira de Andrade

submission deadline 20 Jul 2026 | 3 articles | Viewed by 45570 | Submission Open

Keywords: circadian cycle; exercise; aging; clock genes; health

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism

edited by

José L. Quiles

submission deadline 20 Jul 2026 | 19 articles | Viewed by 40750 | Submission Open

Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Interplay Between the Human Microbiome and Diseases

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 20 Jul 2026 | 11 articles | Viewed by 29962 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Jul 2026 | 7 articles | Viewed by 29073 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies in Skeletal Muscle Diseases

edited by Valeria Guglielmi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 24847 | Submission Open

Keywords: skeletal muscle; skeletal muscle diseases; pathogenesis; molecular mechanism; muscle degeneration; muscle regeneration; myokines; cell therapy; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Epigenetic Influences on Personality Traits and Athletic Performance

edited by

Kinga Huminska-Lisowska

submission deadline 20 Jul 2026 | 4 articles | Viewed by 24680 | Submission Open

Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights into Immunity and Inflammation in Cardiovascular Diseases

edited by

David J. Vigerust

submission deadline 20 Jul 2026 | 7 articles | Viewed by 23942 | Submission Open

Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Research in Prebiotics, Probiotics and Postbiotics: 2nd Edition

edited by

Julio Villena

and Haruki Kitazawa

submission deadline 20 Jul 2026 | 7 articles | Viewed by 23660 | Submission Open

Keywords: probiotics; prebiotics; postbiotics; symbiotics; immunobiotics; functional foods; health improvement; mucosal immunology; microbiota

(This special issue belongs to the Section Molecular Microbiology)

Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools

edited by

Federica Iavarone

submission deadline 20 Jul 2026 | 4 articles | Viewed by 22657 | Submission Open

Keywords: mass spectrometry; quantitative analysis; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics

edited by

Francesco Sessa

Lasse Lindahl

and

Apostolos Zaravinos

submission deadline 20 Jul 2026 | 18 articles | Viewed by 20443 | Submission Open

Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 20 Jul 2026 | 4 articles | Viewed by 18323 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Genome Editing

edited by Lei Gao

submission deadline 20 Jul 2026 | 5 articles | Viewed by 16885 | Submission Open

Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database

(This special issue belongs to the Section Molecular Plant Sciences)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 20 Jul 2026 | 2 articles | Viewed by 16850 | Submission Open

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 20 Jul 2026 | 7 articles | Viewed by 16574 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 14181 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 20 Jul 2026 | 6 articles | Viewed by 13668 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adaptations of Plant Metabolism and Their Consequences on Nutritive Potential and Bioactivity, 2nd Edition

edited by

Ivana Sola

submission deadline 20 Jul 2026 | 2 articles | Viewed by 13225 | Submission Open

Keywords: plant primary metabolism; plant specialized metabolism; phytochemistry; plant bioactive components; plant metabolic plasticity; plant nutritional value; bioactivity of plant extracts; plant– stress response; abiotic stress; climate change; global warming; environmental pressure; biotic stress; anthropogenic influence on plant metabolites; predictive models

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 551-600 on page 12 of 64.

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