TRP Channels: Mechanisms, Functions, and Therapeutic Implications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 23
Special Issue Editor
Special Issue Information
Dear Colleagues,
Receptor activation induces downstream events that elicit a variety of responses in diverse cell types. Transient changes in intracellular calcium levels serve as second messengers in mediating the receptor control of cellular processes that are essential for maintaining cells’ function and longevity. For cells to maintain tissue homeostasis, they must express membrane-delimited ion permeation pathways, pumps, and exchangers, which, in concert, enable calcium to serve as a second messenger as long as its intracellular levels are maintained within a certain physiological range. Transient receptor potential (TRP) channels are a class of non-selective ion channels that play a critical role, acting as sensors that enable Ca2+ to serve their essential function as a second messenger. These channels are found in numerous tissues and cell types and are phylogenetically very old; they sense temperature, pain, touch, vision, taste, and smell, and also regulate different cell processes. The function of most TRP channels, especially in non-excitable cells, requires further study. For this Special Issue of IJMS, we seek research and review articles that focus on the functional and pathophysiological roles of TRP channels in normal tissues and in tumorous pathophysiological conditions.
Dr. Stefan Mergler
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- transient receptor potential (TRP) channels
- calcium signaling
- ion channels
- tissue homeostasis
- receptor activation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
