TRP Channels: Mechanisms, Functions, and Therapeutic Implications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1228
Special Issue Editor
Special Issue Information
Dear Colleagues,
Receptor activation induces downstream events that elicit a variety of responses in diverse cell types. Transient changes in intracellular calcium levels serve as second messengers in mediating the receptor control of cellular processes that are essential for maintaining cells’ function and longevity. For cells to maintain tissue homeostasis, they must express membrane-delimited ion permeation pathways, pumps, and exchangers, which, in concert, enable calcium to serve as a second messenger as long as its intracellular levels are maintained within a certain physiological range. Transient receptor potential (TRP) channels are a class of non-selective ion channels that play a critical role, acting as sensors that enable Ca2+ to serve their essential function as a second messenger. These channels are found in numerous tissues and cell types and are phylogenetically very old; they sense temperature, pain, touch, vision, taste, and smell, and also regulate different cell processes. The function of most TRP channels, especially in non-excitable cells, requires further study. For this Special Issue of IJMS, we seek research and review articles that focus on the functional and pathophysiological roles of TRP channels in normal tissues and in tumorous pathophysiological conditions.
Dr. Stefan Mergler
Guest Editor
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Keywords
- transient receptor potential (TRP) channels
- calcium signaling
- ion channels
- tissue homeostasis
- receptor activation
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