Biological Hallmarks and Therapeutic Strategies in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 2142
Special Issue Editor
Interests: cell signaling; carcinogenesis; drug resistance; synthetic lethality; therapeutic targets; small molecule drug discovery
Special Issue Information
Dear Colleagues,
The hallmarks of cancer represent a set of functional capabilities acquired by normal cells towards the initiation of abnormal proliferative capabilities, induction of carcinogenesis, and the rise in malignant tumors. Originally, Hanahan and Weinberg proposed six acquired capabilities in 2000 and conducted research that resulted in two emerging hallmarks increasing to eight in 2011. These conceptualizations have enabled scientists to understand the distinctive stages of tumorigenesis and the characteristics needed to navigate through deep therapeutic exploration.
Cancer is a complex disease that is tightly regulated by cross-talk between various cell signaling. Cancer cells often switch to intrinsic and acquired resistance to escape from chemotherapeutic agents. The development of drug resistance is one of the key challenges to improving progression-free survival and overall survival among cancer patients. In this issue, we propose to present new information on a broad range of therapeutic targets and approaches to address this problem. In addition to target-specific inhibitors and degraders, we aim to present new information on the convergence of key oncogenic signaling, synthetic lethality, and combination therapy approaches to spread among the scientific community. Collectively, we invite manuscripts from researchers working in academic and industry research settings. I am looking forward to working with you.
Dr. Ramesh Kumar
Guest Editor
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Keywords
- hallmarks of cancer
- cancer progression
- chemotherapy
- tumorigenesis
- oncogenic signaling
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