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Bioactive Compounds in Neurodegenerative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 837

Special Issue Editor


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Guest Editor
Laboratory of Neurochemistry and Cellular Biology, Institute of Health Sciences, Federal University of Bahia, Av. Reitor Miguel Calmon S/N, Salvador 40231-300, BA, Brazil
Interests: bioactive compounds; antioxidant state; vascular damage; neurotoxicity

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are a group of progressive conditions that affect the nervous system, leading to the gradual deterioration and death of neurons. These diseases, which include Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS), among others, are characterized by various pathological hallmarks such as the accumulation of misfolded proteins, neuroinflammation, and oxidative stress.

Bioactive compounds have emerged as potential therapeutic agents in the context of neurodegenerative diseases. These molecules can modulate various cellular pathways and targets associated with disease pathology. They are known to play roles in suppressing inflammation, regulating gene expression, maintaining cellular membrane fluidity, and supporting immune functionality.

This Special Issue aims to uncover the role of bioactive molecules in treatment strategies in neurodegenerative diseases, as well as their potential to mitigate neuroinflammation, oxidative stress, and neuronal loss. Original and review articles, including basic studies, are all welcome to be submitted.

Dr. Silvia Lima Costa
Guest Editor

Manuscript Submission Information

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Keywords

  • bioactive compounds
  • neurodegenerative diseases
  • neuroinflammation
  • oxidative stress

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Published Papers (1 paper)

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Research

19 pages, 2543 KiB  
Article
Synthesis of Naringenin and Senecioic Acid Ester Derivatives and Biological Evaluation of the Astrocyte Antioxidant Mechanism and Reactivity After Inflammatory Stimulus
by Janaína Ribeiro Pereira Soares, Cleonice Creusa dos Santos, Lucas Matheus Gonçalves de Oliveira, Heráclito Rocha Neto, Maurício Moraes Victor, Elivana Lima França, Maria de Fátima Dias Costa, Silvia Lima Costa and Juciele Valeria Ribeiro de Oliveira
Int. J. Mol. Sci. 2025, 26(5), 2215; https://doi.org/10.3390/ijms26052215 - 28 Feb 2025
Cited by 2 | Viewed by 642
Abstract
The imbalance between the overproduction of reactive species and antioxidant mechanisms can result in astrogliosis and oxidative stress associated with neurodegeneration. Based on the described antioxidant activity of naturally occurring flavonoids, this study evaluated the antioxidant mechanisms of the flavonoid naringenin and the [...] Read more.
The imbalance between the overproduction of reactive species and antioxidant mechanisms can result in astrogliosis and oxidative stress associated with neurodegeneration. Based on the described antioxidant activity of naturally occurring flavonoids, this study evaluated the antioxidant mechanisms of the flavonoid naringenin and the senecioic acid ester derivatives in cortical astrocytes. Naringenin and (S)-naringenin were purified from Citrus paradisi, and from them 7,4-O-disenecioic ester naringenin, (S)-7,4-O-disenecioic ester naringenin, and 7-O-senecioic ester naringenin were synthesized and tested for antioxidant activity by the free-radical scavenging reaction with DPPH. The flavonoids’ toxicity and glutathione (GS) depletion were determined in rat astrocyte cultures; the effects on the astrocytes’ reactivity was determined by the expression of the glial fibrillary acidic protein (GFAP) and by measuring nitric oxide (NO) production in astrocytes treated with lipopolysaccharide (LPS, 1 µg/mL/24 h). The compounds (1–10 μM) presented antioxidant effects, and the (S)-7,4′-O-disenecioic ester naringenin was the most effective. The compounds (1–100 μM) were not toxic to the astrocytes, also promoting an antioxidant effect by increasing GSH. Moreover, naringenin, (S)-7,4′-O-disenecioic ester naringenin, and 7-O-senecioc ester naringenin mitigated the astrocyte reactivity induced by LPS, reducing GFAP expression and NO production. These findings indicate that naringenin and senecioic acid ester derivatives present a pharmacological potential as antioxidant and anti-inflammatory compounds for brain diseases via the modulation of astrocyte response. Full article
(This article belongs to the Special Issue Bioactive Compounds in Neurodegenerative Diseases)
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