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Research on Intracellular Signal Transduction Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1083

Special Issue Editor


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Guest Editor
Laboratory of Cell Biology, Department of Biological Chemistry, Graduate School of Science, Osaka Metropolitan University, Sakai 599-8531, Osaka, Japan
Interests: intracellular signal transduction; small GTPases; diabetes
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Special Issue Information

Dear Colleagues,

A variety of extracellular stimuli induce specific cell responses, such as proliferation, differentiation, survival, and death, in virtually all types of cells. Receptors, when occupied by their extracellular ligands, transduce signals into the cell by diverse mechanisms, including the production of second messengers, protein–protein interactions, and post-translational modifications of signaling proteins, leading to gene expression, cytoskeletal rearrangements, and so on. Some of the signaling pathways and their components are common in many types of cells, while others are unique to specific cell types. In addition, aberrations in the intracellular signaling systems of human cells are intimately associated with the development and progression of diseases such as cancer, cardiovascular disease, neurodegenerative disease, and diabetes.

This Special Issue, “Research on Intracellular Signal Transduction Systems”, aims to provide new insights into the physiological functions and regulatory mechanisms of any type of intracellular signal transduction system, ranging from microorganisms to higher organisms. Authors are invited to submit original research and review articles related to these subjects.

Prof. Dr. Takaya Satoh
Guest Editor

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Keywords

  • signal transduction
  • receptor
  • G protein
  • kinase
  • second messenger
  • gene expression
  • cytoskeleton
  • human disease

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Published Papers (1 paper)

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Research

18 pages, 9787 KiB  
Article
Cytochalasin B Mitigates the Inflammatory Response in Lipopolysaccharide-Induced Mastitis by Suppressing Both the ARPC3/ARPC4-Dependent Cytoskeletal Changes and the Association Between HSP70 and the NLRP3 Inflammasome
by An Wang, Yan Chen, Bo Fang, Jiang Zhang, Wenkai Bai, Tingji Yang, Quanwei Zhang, Peiwen Liu, Zhiwei Duan, Ting Lu, Yuxuan He, Yong Zhang, Xingxu Zhao and Weitao Dong
Int. J. Mol. Sci. 2025, 26(7), 3029; https://doi.org/10.3390/ijms26073029 - 26 Mar 2025
Cited by 2 | Viewed by 447
Abstract
Cow mastitis is a major challenge in dairy farming, significantly affecting both milk quality and cow health. Cytochalasin B (CB) is a fungal toxin and an actin cytoskeleton depolymerizing agent that exhibits anti-inflammatory and antitumor properties; however, its mechanism in cow mastitis remains [...] Read more.
Cow mastitis is a major challenge in dairy farming, significantly affecting both milk quality and cow health. Cytochalasin B (CB) is a fungal toxin and an actin cytoskeleton depolymerizing agent that exhibits anti-inflammatory and antitumor properties; however, its mechanism in cow mastitis remains unclear. In this study, we systematically evaluated the effects of CB on mastitis using an LPS-induced inflammation model in bovine mammary epithelial cells (MAC-T) and a mouse mastitis model. The techniques employed included Real-time quantitative PCR detecting system (qPCR), Western blot, HE staining, immunofluorescence (IF), and immunohistochemistry (IHC). The results demonstrated that CB significantly alleviated LPS-induced mastitis by downregulating the expression of pro-inflammatory factors IL-1β, TNF-α, and the NLRP3 inflammasome while also reducing cell apoptosis. Further mechanistic investigations revealed that CB mitigates the inflammatory response by inhibiting the expression of ARPC3, ARPC4, and HSP70, thereby disrupting cytoskeletal rearrangement and the activation of the NLRP3 inflammasome. Overall, this study reveals the potential therapeutic role of CB in cow mastitis and provides a theoretical foundation for developing novel intervention strategies. Full article
(This article belongs to the Special Issue Research on Intracellular Signal Transduction Systems)
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