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Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 5

Special Issue Editor


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Guest Editor
Second Department of Cardiology, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece
Interests: rheumatoid arthritis; cardiovascular disease; cohort study; antiphospholipid syndrome; phospholipid antibody; prothrombin; maturity onset diabetes of the young; sodium glucose cotransporter 2; cardiovascular system
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Special Issue Information

Dear Colleagues,

Cardiovascular diseases remain a leading cause of death globally, yet the molecular pathways underlying their development are not fully understood. Recent advances highlight the critical role of epigenetic regulation—including DNA methylation, histone modifications, and non-coding RNAs—in modulating gene expression and driving cardiovascular pathology. This Special Issue of the International Journal of Molecular Sciences will focus on the latest molecular research exploring how epigenetic mechanisms influence key processes such as vascular inflammation, myocardial remodeling, atherosclerosis, and heart failure. We invite original research articles and reviews that present molecular data and mechanistic insights into the role of epigenetic regulation in cardiovascular diseases. Submissions employing state-of-the-art molecular techniques and addressing potential therapeutic implications are highly encouraged. We hope that this collection will provide a comprehensive view of the epigenetic landscape in cardiovascular diseases and foster the development of novel diagnostic and therapeutic strategies.

Dr. Paschalis Karakasis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetic regulation
  • cardiovascular disease
  • DNA methylation
  • histone modifications
  • non-coding RNAs
  • vascular inflammation
  • myocardial remodeling
  • molecular mechanisms
  • thera-peutic targets

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Published Papers

This special issue is now open for submission.
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