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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Aspects of Breast Cancer Metastasis

edited by

Hideki Furuya

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1931 | Submission Open

Keywords: precision medicine; omics-based discovery research (genomics; proteomics; transcriptomics; and radiomics); non-invasive test; liquid biopsy; first-in-class medications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Molecular Advances in Autophagy

edited by

Gloria Riitano

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1904 | Submission Open

Keywords: autophagy; lipid rafts; Beclin 1; autoimmune diseases; cancer; clock genes; CLOCK

(This special issue belongs to the Section Molecular Biology)

Two- and Three-Dimensional Nanostructured Materials for Biosensing Applications

edited by

Ádám Juhász

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1867 | Submission Open

Keywords: biosensors; biomimetics; nanoparticles; nanoclusters; quantum dots; nanostructured carbon; self-assembled structures

(This special issue belongs to the Section Materials Science)

Cutting-Edge Molecular Research in Autoimmunity

edited by

Davide Raineri

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1863 | Submission Open

Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules

(This special issue belongs to the Section Molecular Immunology)

Towards Complex Molecular Cancer Therapies

edited by

Luba Hunáková

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1854 | Submission Open

Keywords: precision medicine; immune system harnessing; targeted therapies TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Oncology)

Biological Role of Oxidative Stress in Inflammatory Diseases: 2nd Edition

edited by

Sara Franceschelli

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1800 | Submission Open

Keywords: oxidative stress; inflammation; endogenous antioxidant enzymes

(This special issue belongs to the Section Molecular Immunology)

Roles of Lipid Rafts in Metabolism

edited by

Kohji Kasahara

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1750 | Submission Open

Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease

(This special issue belongs to the Section Biochemistry)

The Role of Long Non-Coding RNAs in Stress and Diseases

edited by

Antonis Giannakakis

and

Vladimir A. Kuznetsov

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1738 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); human health; core stress response; genotoxic stress; exosomes; biomarkers; stress-related diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Innovations in Synthetic Organic Chemistry

edited by Anand H. Shinde

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1615 | Submission Open

Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry

(This special issue belongs to the Section Biochemistry)

Translational Oncology: From Molecular Basis to Therapy

edited by

Mario Cioce

and Gatti Veronica

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1591 | Submission Open

Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanism and Therapeutic Approach of Metal Toxicity

edited by Grażyna Gromadzka

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1548 | Submission Open

Keywords: metal toxicity; neurodegenerative disease; cancer; stroke; myocardial infarct; atherosclerosis; cardiovascular disease; metal chelators; therapeutic approach of metal toxicity; cobalt toxicity; copper toxicity; iron toxicity; aluminum toxicity; manganese toxicity; molybdenum toxicity; nickel toxicity; zinc toxicity; lead toxicity

(This special issue belongs to the Section Molecular Toxicology)

Exploring Phage–Host Interactions: Novel Findings and Perspectives

edited by

Luís Melo

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1537 | Submission Open

Keywords: bacteriophages; phage therapy; phage/bacteria interactions; genomics; transcriptomics; proteomics; metabolomics; biofilms

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Research on the Glioma and Tumor Microenvironment

edited by

Maria Beatrice Morelli

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1523 | Submission Open

Keywords: tumour microenvironment; immune cells; cell siganling; tumor niche; tumor heterogeneity; TMZ resistance; new therapeutic strategies; endothelial cells; fibroblasts; extracellular matrix

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advance in Plant Abiotic Stress: 3rd Edition

edited by

De-Guo Han

and

Xingguo Li

submission deadline 20 Aug 2025 | 4 articles | Viewed by 1516 | Submission Open

Keywords: abiotic stress; cold; drought; salt; heat; nutrient deficiency; secondary metabolism; stress resistance; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications

edited by Giovanni Gallo and

Martina Aulitto

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1499 | Submission Open

Keywords: microorganism resistance systems; extreme environments; molecular adaptation; genetic pathways; biotechnological applications; industrial biotechnology; environmental remediation; extremophiles; stress tolerance; evolutionary adaptations

(This special issue belongs to the Section Molecular Microbiology)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1475 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Advances in Genetics and Breeding Research in Horticultural Crops

edited by

Hui Zhang

submission deadline 20 Aug 2025 | 3 articles | Viewed by 1467 | Submission Open

Keywords: horticultural crops; genomic sequencing; multi-omics technologies; molecular biology; gene editing; plant breeding; function of genes; molecular marker

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Macrophages in Tumors

edited by

Julia Kzhyshkowska

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1455 | Submission Open

Keywords: tumor-associated macrophages; transcriptome; metabolome; epigenetics; angiogenesis; metastasis; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges

edited by

Elena Grossini

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1437 | Submission Open

Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Embryonic Development

edited by

Jacek Z. Kubiak

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1415 | Submission Open

Keywords: embryonic development; molecular mechanisms; cellular mechanisms; model embryos; genetic

(This special issue belongs to the Section Molecular Biology)

Molecular Toxicity Research of Biological Venoms

edited by

Karla De Castro Figueiredo Bordon

and Suely Vilela Sampaio

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1393 | Submission Open

Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application

(This special issue belongs to the Section Molecular Toxicology)

Cardioprotection in Drug-Induced Cardiotoxicity

edited by Roisin Kelly-Laubscher

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1390 | Submission Open

Keywords: cardioprotection; cardiotoxicity; anthracycline; cardiac dysfunction; heart failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Novel Therapies for Lymphoma

edited by Fulvio Massaro

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1357 | Submission Open

Keywords: Hodgkin lymphoma; non-Hodgkin lymphoma; hematopathology; biomarker; new therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Cell Organelle Stress Responses and Implications in Human Diseases

edited by

Jaeseok Han

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1335 | Submission Open

Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Bioactive Compounds in Human Diseases

edited by

Raju Dash

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1314 | Submission Open

Keywords: plant extracts; plant-derived compounds; secondary metabolites; mechanism of action; bioavailability; human health and disease; computer-aided drug design; machine learning and artificial Intelligence

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Spectroscopy Research: New Findings and Perspectives

edited by

Marta Arczewska

submission deadline 20 Aug 2025 | Viewed by 1309 | Submission Open

Keywords: molecular spectroscopy; atomic spectroscopy; chemical analysis; molecular interaction; IR/FT-IR/ATR; Raman and SERS spectroscopy and imaging; UV-Vis; XRD; computational methods

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Interplay Between Cellular Stress and Human Diseases

edited by

Daniele Vergara

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1283 | Submission Open

Keywords: cellular stress; DNA damage response; unfolded protein response; autophagy; senescence; apoptosis; repair pathways; mitochondrial stress; nutrient deprivation; oxidative stress

(This special issue belongs to the Section Biochemistry)

Microsatellite Instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice

edited by Federica Zito Marino

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1183 | Submission Open

Keywords: microsatellite instability (MSI); mismatch repair deficient (dMMR); immunotherapy; next-generation sequencing (NGS); immunohistochemistry (IHC); polymerase chain reaction (PCR); MSI-positive tumors

(This special issue belongs to the Section Molecular Biology)

Research on Luminescent Materials and Their Luminescence Mechanism

edited by

María Teresa Colomer

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1120 | Submission Open

Keywords: luminescence; molecular/ionic level; mechanism

(This special issue belongs to the Section Materials Science)

Amyloid Hetero-Aggregation: 2nd Edition

edited by

Ludmilla A. Morozova-Roche

submission deadline 20 Aug 2025 | Viewed by 1091 | Submission Open

Keywords: amyloid; co-aggregation; hetero-aggregation; human proteins; bacterial amyloids; viral proteins; cytotoxicity; structure; function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Phytochemicals in Antioxidation, Antimicrobial, and Cytoprotective Properties

edited by

Mihaela Niculae

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1055 | Submission Open

Keywords: phytochemicals; antioxidant; antimicrobial; cytoprotective; in vitro screening; in vivo evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Autophagy and Retinal Degeneration

edited by

Francesco Fornai

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1028 | Submission Open

Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease

edited by David Rohde

submission deadline 20 Aug 2025 | 1 articles | Viewed by 977 | Submission Open

Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Hepatic Disease and Hepatocellular Carcinoma

edited by

Soon Kyu Lee

and Jong-Young Choi

submission deadline 20 Aug 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: hepatology; viral hepatitis; liver cirrhosis; hepatocellular carcinoma; liver transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Modulation of the Immune System and Oxidative Stress in Liver Illnesses

edited by

Vlad Pădureanu

and Dan Ionuț Gheonea

submission deadline 20 Aug 2025 | 1 articles | Viewed by 908 | Submission Open

Keywords: oxidative stress; liver illnesses; immune system; inflammatory

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media

edited by

Ana M. Mainar

and

José S. Urieta

submission deadline 20 Aug 2025 | 1 articles | Viewed by 864 | Submission Open

Keywords: water solubility ; water-solute interactions ; solvation; hydrophobic and hydrophilic effects ; improving water solubility and prediction ; solution of chemicals in biological media ; diffusivity ; drug transport and bioavailability; chemicals diffusivity across biological barriers

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Cellular and Molecular Mechanisms of Cardiovascular Repair

edited by

Isotta Chimenti

submission deadline 20 Aug 2025 | 1 articles | Viewed by 838 | Submission Open

Keywords: fibroblasts; injury repair; cardiac scar; extracellular matrix; fibrosis; angiogenesis; inflammation; cardioprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Progression of Developing Novel Chiral Separation Materials, Chiral Selectors and Chiral Products

edited by István Ilisz

submission deadline 20 Aug 2025 | 1 articles | Viewed by 831 | Submission Open

Keywords: chirality; enantioselective separations; chiral selector molecules; chiral stationary phases; chiral sensors; enantiorecognition; chiral separation mechanisms

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Nanomaterials in Immunology

edited by

Alexandru Mihai Grumezescu

submission deadline 20 Aug 2025 | 1 articles | Viewed by 804 | Submission Open

Keywords: nanomaterials; immunology; nanoparticles; drug delivery; cancer immunotherapy; immune modulation; vaccine adjuvants; immunotoxicity; autoimmune diseases; biocompatibility; nanotechnology in immune diseases; nanostructures in tissue engineering; nanomedicine; diagnostic nanomaterials; immune cell interaction

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms of Neurodegeneration and Neuroprotection for Retinal and Optic Nerve Diseases

edited by

Toshiyuki Oshitari

submission deadline 20 Aug 2025 | 1 articles | Viewed by 797 | Submission Open

Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Organic Compounds in Photodynamic Therapy: Synthesis, Mechanism of Action and Biological Potential

edited by

Maria G. P. M. S. Neves

Nuno M. M. Moura

and

Catarina I. V. Ramos

submission deadline 20 Aug 2025 | 1 articles | Viewed by 788 | Submission Open

Keywords: organic photosensitizers; photodynamic therapy; synthetic strategies; mechanism of action; cancer cells; microorganisms

(This special issue belongs to the Section Biochemistry)

Gynecological Oncology: From Molecular Basis to Therapy

edited by

Martin Götte

and Lars Hanker

submission deadline 20 Aug 2025 | 1 articles | Viewed by 751 | Submission Open

Keywords: gynecological oncology; molecular basis; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Research of Kidney Diseases

edited by Andrea Angioi

submission deadline 20 Aug 2025 | Viewed by 744 | Submission Open

Keywords: molecular genetics; kidney disease; biomarkers; cellular signaling; target therapeutics; innovative treatments

(This special issue belongs to the Section Molecular Biology)

DNA-Based Vaccines Against Infectious Diseases and Cancer

edited by

Srinivasa Reddy Bonam

submission deadline 20 Aug 2025 | Viewed by 731 | Submission Open

Keywords: DNA vaccine; immune responses; infectious disease; plasmids; vaccine

(This special issue belongs to the Section Molecular Immunology)

Aging: From Molecular Mechanisms and Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Darío Acuña-Castroviejo

submission deadline 20 Aug 2025 | 1 articles | Viewed by 658 | Submission Open

Keywords: human aging; molecular clock; aging genes; epigenetics; nutrigenomics; inflammaging; stem cells; telomeres; mitochondria; brain-gut axis; brain-muscle axis; gut microbiota; chronodisruption

(This special issue belongs to the Section Molecular Biology)

Precision Cancer Medicine: Molecular Insights, Biological Events and Clinical Perspectives

edited by

Dimitrios H. Roukos

submission deadline 20 Aug 2025 | Viewed by 638 | Submission Open

Keywords: multi-omics at bulk level; single-cell multi-omics; precision oncology; precision immune-oncology; tumor molecular profiling

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Micropollutants in Various Enviroments

edited by

Anna Lenart-Boroń

submission deadline 20 Aug 2025 | 1 articles | Viewed by 595 | Submission Open

Keywords: airborne microorganisms; antibiotics; antibiotic resistance; circular economy of water; environmental bacteria and fungi; wastewater treatment; waterborne microorganisms; water quality

(This special issue belongs to the Section Molecular Toxicology)

Lung Diseases and Lung Transplantations: Molecular Pathogenesis and Advanced Therapies

edited by Christopher Lambers

submission deadline 20 Aug 2025 | Viewed by 590 | Submission Open

Keywords: lung disease; lung transplantation; ECMO; EVLP; LAS; antibody-mediated rejection (AMR); CLAD; RAS/BOS; immunosuppression; pathogenesis; cell-free DNA; IPF therapies; gene therapies; stem cell therapies; immunotherapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Design Strategies for Carbonaceous Nanomaterials

edited by