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Effects of Bioactive Compounds in Oxidative Stress and Inflammation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1660

Special Issue Editors

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Guest Editor
Department of Biomedical Sciences, Faculty of Medicine and Biological Sciences, “Ștefan cel Mare” University of Suceava, 720229 Suceava, Romania
Interests: oxidative stress; inflammation; bioactive compounds; cardiovascular diseases

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Guest Editor
Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca, Victor Babes, 8, 400000 Cluj-Napoca, Romania
Interests: spectroscopy; chromatography; mass spectrometry; plant bioactive compounds; antioxidant activity; oxidative stress and inflammation; cardiovascular diseases
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Special Issue Information

Dear Colleagues,

Oxidative stress and inflammation play important roles in the pathogenesis of different diseases. However, the difficulty in controlling these pathophysiological processes has encouraged researchers to investigate potential bioactive compounds with anti-inflammatory and antioxidant effects.

Bioactive compounds have emerged as key food components related to healthy status and disease prevention, as they are a promising alternative for disease prevention and treatment, in some cases. Although a great number of bioactive compounds have already been isolated and investigated, nature is still an endless source of medical drugs with anti-inflammatory and/or antioxidant properties that are waiting to be discovered.

This Special Issue may publish original research papers and reviews on aspects related to the anti-inflammatory and/or antioxidant properties of different bioactive compounds, focusing on their molecular mechanisms.

Dr. Paul-Mihai Boarescu
Dr. Raluca Maria Pop
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural products
  • antioxidant effects
  • anti-inflammatory effects
  • molecular targets
  • health beneficial effect
  • bioactive compounds

Published Papers (1 paper)

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15 pages, 602 KiB  
Phytochemical Analysis and Antioxidant Effects of Prunella vulgaris in Experimental Acute Inflammation
by Camelia-Manuela Mîrza, Tudor-Valentin Mîrza, Antonia Cristina Maria Odagiu, Ana Uifălean, Anca Elena But, Alina Elena Pârvu and Adriana-Elena Bulboacă
Int. J. Mol. Sci. 2024, 25(9), 4843; https://doi.org/10.3390/ijms25094843 - 29 Apr 2024
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Prunella vulgaris (PV) is one of the most commonly used nutraceuticals as it has been proven to have anti-inflammatory and antioxidant properties. The aim of this study was to evaluate the phytochemical composition of PV and its in vivo antioxidant properties. A phytochemical [...] Read more.
Prunella vulgaris (PV) is one of the most commonly used nutraceuticals as it has been proven to have anti-inflammatory and antioxidant properties. The aim of this study was to evaluate the phytochemical composition of PV and its in vivo antioxidant properties. A phytochemical analysis measuring the total phenolic content (TPC), the identification of phenolic compounds by HPLC-DAD-ESI, and the evaluation of the in vitro antioxidant activity by the DPPH assay of the extract were performed. The antioxidant effects on inflammation induced by turpentine oil were experimentally tested in rats. Seven groups with six animals each were used: a control group, the experimental inflammation treatment group, the experimental inflammation and diclofenac sodium (DS) treatment group, and four groups with their inflammation treated using different dilutions of the extract. Serum redox balance was assessed based on total oxidative status (TOS), nitric oxide (NO), malondialdehyde (MDA), total antioxidant capacity (TAC), total thiols, and an oxidative stress index (OSI) contents. The TPC was 0.28 mg gallic acid equivalents (GAE)/mL extract, while specific representatives were represented by caffeic acid, p-coumaric acid, dihydroxybenzoic acid, gentisic acid, protocatechuic acid, rosmarinic acid, vanillic acid, apigenin–glucuronide, hesperidin, kaempferol–glucuronide. The highest amount (370.45 μg/mL) was reported for hesperidin, which is a phenolic compound belonging to the flavanone subclass. The antioxidant activity of the extracts, determined using the DPPH assay, was 27.52 mmol Trolox/mL extract. The PV treatment reduced the oxidative stress by lowering the TOS, OSI, NO, and MDA and by increasing the TAC and thiols. In acute inflammation, treatment with the PV extract reduced oxidative stress, with lower concentrations being more efficient and having a better effect than DS. Full article
(This article belongs to the Special Issue Effects of Bioactive Compounds in Oxidative Stress and Inflammation)
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