International Journal of Molecular Sciences

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Dear Colleagues,

Oxidative stress and inflammation play important roles in the pathogenesis of different diseases. However, the difficulty in controlling these pathophysiological processes has encouraged researchers to investigate potential bioactive compounds with anti-inflammatory and antioxidant effects.

Bioactive compounds have emerged as key food components related to healthy status and disease prevention, as they are a promising alternative for disease prevention and treatment, in some cases. Although a great number of bioactive compounds have already been isolated and investigated, nature is still an endless source of medical drugs with anti-inflammatory and/or antioxidant properties that are waiting to be discovered.

This Special Issue may publish original research papers and reviews on aspects related to the anti-inflammatory and/or antioxidant properties of different bioactive compounds, focusing on their molecular mechanisms.

Dr. Paul-Mihai Boarescu
Dr. Raluca Maria Pop
Guest Editors

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Keywords

natural products
antioxidant effects
anti-inflammatory effects
molecular targets
health beneficial effect
bioactive compounds

Published Papers (1 paper)

Research

15 pages, 602 KiB

Open AccessArticle

Phytochemical Analysis and Antioxidant Effects of Prunella vulgaris in Experimental Acute Inflammation

by Camelia-Manuela Mîrza, Tudor-Valentin Mîrza, Antonia Cristina Maria Odagiu, Ana Uifălean, Anca Elena But, Alina Elena Pârvu and Adriana-Elena Bulboacă

Int. J. Mol. Sci. 2024, 25(9), 4843; https://doi.org/10.3390/ijms25094843 - 29 Apr 2024

Viewed by 221

Abstract

Prunella vulgaris (PV) is one of the most commonly used nutraceuticals as it has been proven to have anti-inflammatory and antioxidant properties. The aim of this study was to evaluate the phytochemical composition of PV and its in vivo antioxidant properties. A phytochemical analysis measuring the total phenolic content (TPC), the identification of phenolic compounds by HPLC-DAD-ESI, and the evaluation of the in vitro antioxidant activity by the DPPH assay of the extract were performed. The antioxidant effects on inflammation induced by turpentine oil were experimentally tested in rats. Seven groups with six animals each were used: a control group, the experimental inflammation treatment group, the experimental inflammation and diclofenac sodium (DS) treatment group, and four groups with their inflammation treated using different dilutions of the extract. Serum redox balance was assessed based on total oxidative status (TOS), nitric oxide (NO), malondialdehyde (MDA), total antioxidant capacity (TAC), total thiols, and an oxidative stress index (OSI) contents. The TPC was 0.28 mg gallic acid equivalents (GAE)/mL extract, while specific representatives were represented by caffeic acid, p-coumaric acid, dihydroxybenzoic acid, gentisic acid, protocatechuic acid, rosmarinic acid, vanillic acid, apigenin–glucuronide, hesperidin, kaempferol–glucuronide. The highest amount (370.45 μg/mL) was reported for hesperidin, which is a phenolic compound belonging to the flavanone subclass. The antioxidant activity of the extracts, determined using the DPPH assay, was 27.52 mmol Trolox/mL extract. The PV treatment reduced the oxidative stress by lowering the TOS, OSI, NO, and MDA and by increasing the TAC and thiols. In acute inflammation, treatment with the PV extract reduced oxidative stress, with lower concentrations being more efficient and having a better effect than DS. Full article

(This article belongs to the Special Issue Effects of Bioactive Compounds in Oxidative Stress and Inflammation)

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