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Psoriasis Pathogenesis and Treatment

Department of Dermatology, Heidelberg University, 69120 Heidelberg, Germany
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Int. J. Mol. Sci. 2019, 20(6), 1475; https://doi.org/10.3390/ijms20061475
Received: 25 February 2019 / Accepted: 18 March 2019 / Published: 23 March 2019
(This article belongs to the Special Issue Inflammatory Skin Conditions 2018)
Research on psoriasis pathogenesis has largely increased knowledge on skin biology in general. In the past 15 years, breakthroughs in the understanding of the pathogenesis of psoriasis have been translated into targeted and highly effective therapies providing fundamental insights into the pathogenesis of chronic inflammatory diseases with a dominant IL-23/Th17 axis. This review discusses the mechanisms involved in the initiation and development of the disease, as well as the therapeutic options that have arisen from the dissection of the inflammatory psoriatic pathways. Our discussion begins by addressing the inflammatory pathways and key cell types initiating and perpetuating psoriatic inflammation. Next, we describe the role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis. Finally, we include a comprehensive review of well-established widely available therapies and novel targeted drugs. View Full-Text
Keywords: psoriasis; inflammation; chronic skin disease psoriasis; inflammation; chronic skin disease
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Rendon, A.; Schäkel, K. Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci. 2019, 20, 1475.

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