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Bioengineering, Volume 9, Issue 10

October 2022 - 118 articles

Cover Story: Shiga toxin is a common food contaminant responsible for bloody diarrhea and occasionally severe kidney damage leading to hemolytic uremic syndrome (HUS). We report the engineering of a designed ankyrin repeat protein (DARPin), SD5, for neutralizing Shiga toxin 2, the major culprit for HUS. The constituent monomeric DARPins of SD5 separately inhibit the toxin’s catalytic activity and toxin attachment to host cells. SD5 efficiently protects mice from toxin challenge, pointing to a high potential of this DARPin as a therapeutic for treating infection by Shiga-toxin-producing E. coli. View this paper
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Articles (118)

  • Review
  • Open Access
8 Citations
6,273 Views
14 Pages

Surgical Treatment of Pediatric Scoliosis: Historical Origins and Review of Current Techniques

  • Andrew M. Block,
  • Lisa M. Tamburini,
  • Francine Zeng,
  • Michael R. Mancini,
  • Casey A. Jackson,
  • Christopher L. Antonacci,
  • Owen P. Karsmarski,
  • John W. Stelzer,
  • Ian J. Wellington and
  • Mark C. Lee

The treatment of scoliosis has been explored and debated in medicine since the first recorded texts. Scoliosis treatment has shifted over time from external modalities, such as traction and bracing, to internal stabilization techniques that leverage...

  • Review
  • Open Access
16 Citations
4,563 Views
24 Pages

Latest Findings of the Regenerative Materials Application in Periodontal and Peri-Implant Surgery: A Scoping Review

  • Simone Gallo,
  • Maurizio Pascadopoli,
  • Matteo Pellegrini,
  • Federica Pulicari,
  • Mattia Manfredini,
  • Paolo Zampetti,
  • Francesco Spadari,
  • Carlo Maiorana and
  • Andrea Scribante

Regenerative dentistry represents a therapeutic modern approach involving biomaterials and biologics such as mesenchymal stem cells. The role of regenerative dentistry is promising in all branches of dentistry, especially in periodontology and implan...

  • Article
  • Open Access
4 Citations
2,827 Views
17 Pages

Hydrogen Dynamics in Hydrated Chitosan by Quasi-Elastic Neutron Scattering

  • Yuki Hirota,
  • Taiki Tominaga,
  • Takashi Kawabata,
  • Yukinobu Kawakita and
  • Yasumitsu Matsuo

Chitosan, an environmentally friendly and highly bio-producible material, is a potential proton-conducting electrolyte for use in fuel cells. Thus, to microscopically elucidate proton transport in hydrated chitosan, we employed the quasi-elastic neut...

  • Article
  • Open Access
11 Citations
3,922 Views
14 Pages

Relationships between the Clinical Test Results and Neurophysiological Findings in Patients with Thoracic Outlet Syndrome

  • Agata Maria Kaczmarek,
  • Juliusz Huber,
  • Katarzyna Leszczyńska,
  • Paulina Wietrzak and
  • Katarzyna Kaczmarek

A thoracic outlet syndrome (TOS) is the type of brachial plexus disorder most difficult to objectively assess using a clinical examination and differential diagnosis. Its symptoms can be frequently misdiagnosed, especially among others with cervical...

  • Systematic Review
  • Open Access
7 Citations
2,733 Views
14 Pages

Background: The objective of this systematic review is to assess the effect of the adjuvant use of platelet-rich plasma (PRP) and its type on new bone formation by anorganic bovine bone during maxillary sinus floor augmentation procedure. Methods: Pu...

  • Article
  • Open Access
5 Citations
2,972 Views
17 Pages

Neuroprotective Effect of Abelmoschus manihot Flower Extracts against the H2O2-Induced Cytotoxicity, Oxidative Stress and Inflammation in PC12 Cells

  • Shih-Wei Wang,
  • Chi-Chang Chang,
  • Chin-Feng Hsuan,
  • Tzu-Hsien Chang,
  • Ya-Ling Chen,
  • Yun-Ya Wang,
  • Teng-Hung Yu,
  • Cheng-Ching Wu and
  • Jer-Yiing Houng

The progression of neurodegenerative diseases is associated with oxidative stress and inflammatory responses. Abelmoschus manihot L. flower (AMf) has been shown to possess excellent antioxidant and anti-inflammatory activities. This study investigate...

  • Brief Report
  • Open Access
6 Citations
3,090 Views
18 Pages

A Novel Method to Achieve Precision and Reproducibility in Exposure Parameters for Low-Frequency Pulsed Magnetic Fields in Human Cell Cultures

  • Michael Ronniger,
  • Blanche Aguida,
  • Christina Stacke,
  • Yangmengfan Chen,
  • Sabrina Ehnert,
  • Niklas Erdmann,
  • Georg Eschenburg,
  • Karsten Falldorf,
  • Marootpong Pooam and
  • Anthony Wing
  • + 1 author

The effects of extremely low-frequency electromagnetic field (ELF-MF) exposure on living systems have been widely studied at the fundamental level and also claimed as beneficial for the treatment of diseases for over 50 years. However, the underlying...

  • Article
  • Open Access
3 Citations
3,555 Views
13 Pages

A Portable Servoregulation Controller to Automate CO2 Removal in Artificial Lungs

  • Navid Shaikh,
  • Andrew Zhang,
  • Jesse Jenter,
  • Brandon Nikpreljevic,
  • John Toomasian,
  • William Lynch,
  • Alvaro Rojas-Peña,
  • Robert H. Bartlett and
  • Joseph A. Potkay

Artificial lung (AL) systems provide respiratory support to patients with severe lung disease, but none can adapt to the changing respiratory needs of the patients. Precisely, none can automatically adjust carbon dioxide (CO2) removal from the blood...

  • Article
  • Open Access
2 Citations
2,616 Views
12 Pages

Impact of Age and Sex on Electrical Impedance Values in Healthy Oral Mucosa

  • Kristina Horvat,
  • Ivica Richter,
  • Vesna Vucelić,
  • Krešimir Gršić,
  • Dinko Leović,
  • Ivana Škrinjar,
  • Ana Andabak Rogulj,
  • Marko Velimir Grgić and
  • Vlaho Brailo

Background: Electrical impedance (EI) is a property of all living tissues and represents the resistance to the electric current flow through a living tissue. EI depends on the structure and chemical composition of the tissue. The aim of this study wa...

  • Article
  • Open Access
5 Citations
3,531 Views
15 Pages

Modified MRI Anonymization (De-Facing) for Improved MEG Coregistration

  • Ricardo Bruña,
  • Delshad Vaghari,
  • Andrea Greve,
  • Elisa Cooper,
  • Marius O. Mada and
  • Richard N. Henson

Localising the sources of MEG/EEG signals often requires a structural MRI to create a head model, while ensuring reproducible scientific results requires sharing data and code. However, sharing structural MRI data often requires the face go be hidden...

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Bioengineering - ISSN 2306-5354