2026 March - 117 articles
Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external...
Myogenic mechanobiology governs how mechanical cues regulate myocyte organization, alignment, and functional maturation; however, in vitro platforms that enable quantitative control and real-time readout of myogenic mechanical microenvironments remai...
To address the limited accuracy of speech-based Alzheimer’s Disease (AD) screening and the shortage of paired multimodal data, this paper proposes a detection framework based on feature alignment and Rectified Flow-driven latent representation...
Background/Objectives: Despite advances in preventive dental care, tooth enamel erosion remains a relevant concern, and very few comparisons of surface topography have been carried out under controlled conditions in the laboratory. This study primari...
Custom-made subperiosteal implants are increasingly used in clinical cases where significant bone loss due to trauma or disease renders conventional endosseous implant placement unfeasible. This study investigated how different internal structural de...
Background: While hydroxyapatite (HA) is considered stable and non-resorbable, other calcium phosphate phases such as Tricalcium Phosphate (TCP), Brushite, and Monetite are characterized by higher solubility and biodegradation rates. This review aims...
The relationship between lifestyle, ocular biomechanical behavior, and myopia is not well established in the literature. The present study aims to describe changes in ocular biomechanics during adolescence and to explore their relationship with lifes...
Background: Large Language Models (LLMs) are reshaping medical research workflows. Objective: This narrative review synthesizes evidence on LLM applications across systematic reviews, scientific writing, and clinical research. Methods: We reviewed li...
Electromagnetic field-based stimulation has emerged as a promising noninvasive approach for enhancing bone fracture healing. Beyond conventional pulsed electromagnetic field (PEMF) therapies employing spatially uniform fields, dielectrophoretic-force...
Lab-on-a-Chip (LoC) and microfluidic technologies are rapidly reshaping the development pipeline for nano drug delivery systems (DDSs) by enabling precise control of physicochemical properties, high-throughput screening, and integrated biological eva...
(1) Purpose: To compare the fabrication accuracy, internal fit, and marginal adaptation of three-unit definitive resin fixed dental prostheses (FDPs) produced by subtractive milling and additive manufacturing. (2) Materials and Methods: A typodont ma...
Carbon-Fiber-Reinforced Polyetheretherketone (CFR-PEEK) instrumentation is increasingly preferred in spinal oncology for its physical properties, minimizing imaging artifacts and facilitating precise postoperative radiotherapy planning and tumor surv...
Parkinson’s disease (PD) is associated with progressive gait deterioration; however, widely used clinical scales such as the Hoehn & Yahr (H&Y) stage are limited in capturing continuous severity changes due to subjectivity and discrete...
Landfill leachate is considered one of the most recalcitrant wastewaters due to its high organic strength, elevated ammonia concentrations, and complex chemical composition. This study evaluates integrated technologies for treating highly loaded land...
Electroencephalography (EEG) has become an increasingly important tool in depression research due to its ability to capture objective neurophysiological abnormalities associated with depressive disorders, offering high temporal resolution, non-invasi...
Cartilage is an important yet vulnerable tissue with limited self-healing capacity, where damage often progresses to joint degeneration, which eventually leads to severe osteoarthritis (OA). Current tissue engineering strategies focus on biocompatibl...
Early detection is critical for improving outcomes in gastric cancer, yet lesion recognition in capsule endoscopy is challenged by interference from different gastric anatomical sites, patient posture changes, and gastric peristalsis. This study aims...
Tendon-derived stem cells (TDSCs) are a unique cell population found in tendons, exhibiting both mesenchymal stem cell (MSC)-like phenotypes and tendon-specific markers. They have emerged as a promising research tool in tendon-related tissue engineer...
Purpose: To investigate whether an AI-based approach combining deep learning myocardial segmentation with attenuation-normalized myocardial mapping (colormaps) improves detection of myocardial ischemia and infarction on emergency ECG-gated CT angiogr...
Effective management of acute, complex, and chronic wounds requires constructs that simultaneously support tissue repair and provide sustained infection control. Biologic-derived materials, despite their regenerative potential, are limited by insuffi...
Ultrasound computed tomography (USCT) has emerged as a promising tool for quantitative assessment of musculoskeletal (MSK) diseases. However, the accuracy of echo intensity—a key imaging biomarker—is often compromised by non-optimal imagi...
Background: Qualitative motion analysis revealed that the cervical spine moves according to a consistent pattern. Current data analysis methods are limited by the extensive time required to process the retrieved data. A previous study demonstrated th...
Rehabilitation is a critical component in the recovery of patients with either complete or partial loss of motor movements. Repeated and slow limb movements are usually advised by practitioners. Advanced robotic systems can help to configure monotono...
Physiologically relevant in vitro intestinal models are essential for studying key physiological processes, including barrier function, drug screening and gut-microbiota interactions. However, conventional 2D culture systems often fail to recapitulat...
This study investigates whether multi-component T2 mapping, using bi-exponential (BE) and stretched-exponential (SE) models, enhances the early detection of knee osteoarthritis (OA) compared with the conventional mono-exponential (ME) approach. T2 re...
High-quality Fourier Transform Infrared (FTIR) imaging usually needs extensive signal averaging to reduce noise and drift, which severely limits clinical speed. Deep learning can accelerate imaging by reconstructing spectra from rapid, single-scan in...
Smart knee replacement technology seeks to provide an in vivo method of tracking long-term postoperative joint loads with the goal of identifying clinically relevant phenomena linked to postoperative dissatisfaction in real time. This study evaluated...
Ultrasound patches represent a transformative advancement beyond conventional ultrasonography, evolving into intelligent theranostic systems for personalized healthcare. This evolution is propelled by synergistic innovations in flexible piezoelectric...
Peripheral nerve injuries pose a significant clinical challenge due to the limited self-repair capacity and the complexity of neural tissue architecture. Tissue engineering strategies applied to the peripheral nerve system aim to restore functional n...
Medial meniscus posterior root tears (MMPRTs) with focal cartilage defects present a therapeutic challenge, even in neutral-to-mild varus knees. Although transtibial pullout repair is standard for MMPRTs without advanced osteoarthritis, coexisting ca...
Feeding intolerance (FI) is common in preterm infants and disrupts enteral nutrition. Because clinical signs of FI are nonspecific, objective biomarkers are needed. In this exploratory study, we evaluated whether electrogastrography (EGG) can disting...
This study investigates two graphene oxide (GO)-based coating architectures on urinary catheter substrates—layered (PEI+GO) and embedded (PEI/GO)—loaded with antimicrobial peptides (E14LKK and fLFB), with the aim of elucidating how coatin...
Conventional drug delivery systems often suffer from problems such as limited targeting specificity, short half-lives, poor biocompatibility, and systemic toxicity, which significantly limit their therapeutic efficacy against major diseases like canc...
Physiological dysregulation arising from chronic stress is a key mechanism linking psychosocial factors to long-term health outcomes, yet early identification typically relies on invasive or resource-intensive measurements. This study evaluates wheth...
Objective: The biocompatibility of adhesive systems is essential for the long-term success of restorative dental procedures due to their close proximity to dentin and pulpal tissues. This study aimed to evaluate the cytotoxic effects of adhesive syst...
Background: Individuals with attention deficit hyperactivity disorder (ADHD) can exhibit neurocognitive deficits, psychosocial alterations, and changes in sleep regulation. In this sense, non-invasive techniques such as transcranial magnetic stimulat...
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related death, yet adequate in vitro models mimicking the tumor immune microenvironment (TIME) are rare. Specifically, the role of the transcription factor nuclear factor erythroid 2-re...
The liver possesses a remarkable regenerative capacity following injury, a process fundamentally orchestrated by the dynamic extracellular matrix (ECM). Far beyond a passive scaffold, the liver matrisome functions as an integrative mechano-biochemica...
Colorectal cancer (CRC) remains a leading cause of cancer mortality globally, yet current histopathological diagnostics capture only limited features. This study aimed to discover subtle, prognostically significant histomorphological patterns in CRC...
Electrochemiluminescence immunoassay (ECLIA) is widely used in clinical diagnostics owing to its high sensitivity, broad dynamic range, and excellent analytical stability. However, the influence of magnetic bead deposition behavior on electrochemilum...
The primary objective of this study is to develop a specialized deep learning framework specifically adapted for the unique physical characteristics of neurovascular Optical Coherence Tomography (OCT) imaging. Although Polyp-PVT, originally designed...
Transmembrane pressure (TMP) is a central state variable in haemodialysis (HD) and haemodiafiltration (HDF), governing ultrafiltration dynamics, convective transport, and membrane performance. Although dialysis devices specify high maximum allowable...
Accurate measurement of spinal metrics is critical for diagnosing and treating spinal disorders. However, discrepancies between X-ray and ultrasound imaging data pose a challenge in standardizing clinical assessments. This study introduces a novel me...
Chronic obstructive pulmonary disease, interstitial lung disease, and post-lung trans-plantation are often accompanied by skeletal muscle dysfunction that worsens the quality of life. Such physiological changes are driven by physical inactivity, syst...
The goal of this paper was to determine the efficacy of the surgical treatment of two-wall peri-implant defects filled with L-PRF/xenograft block in the reduction of peri-implant marginal bone levels after 12 months. Ten patients with two-wall peri-i...
Background: Revision anterior cruciate ligament reconstruction (ACLR) presents an increasing clinical challenge with higher failure rates than primary reconstruction. However, the evolving research landscape and clinical evidence regarding key biomec...
Three-dimensional (3D) bioprinting provides new options for airway reconstruction by enabling the fabrication of customizable, biodegradable scaffolds designed to support in situ tissue regeneration. Building on our established large-animal platform,...
Slaughterhouse by-products are promising feedstocks for anaerobic digestion due to their high lipid and protein content. However, their complex structures often limit hydrolysis, and excessive pretreatment can induce inhibitory conditions. This study...
Background: Lumbosacral plexopathy (LSP) is characterized by severe neuropathic pain, motor weakness, and sensory deficits in the lumbosacral plexus region, often leading to significant functional impairment and reduced quality of life. Post-traumati...
This study investigates the ongoing electrical activity of local neural networks—referred to as neurodynamics—across 37 anatomically defined brain regions. We analyzed stereotactic intracranial EEG (sEEG) recordings from 106 subjects duri...
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