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  • Review
  • Open Access
495 Citations
90,237 Views
38 Pages

As healthcare systems around the world face challenges such as escalating costs, limited access, and growing demand for personalized care, artificial intelligence (AI) is emerging as a key force for transformation. This review is motivated by the urg...

  • Review
  • Open Access
5 Citations
46,116 Views
26 Pages

Applications of Intravital Imaging in Cancer Immunotherapy

  • Deqiang Deng,
  • Tianli Hao,
  • Lisen Lu,
  • Muyang Yang,
  • Zhen Zeng,
  • Jonathan F. Lovell,
  • Yushuai Liu and
  • Honglin Jin

Currently, immunotherapy is one of the most effective treatment strategies for cancer. However, the efficacy of any specific anti-tumor immunotherapy can vary based on the dynamic characteristics of immune cells, such as their rate of migration and c...

  • Review
  • Open Access
383 Citations
41,188 Views
21 Pages

The integration of artificial intelligence (AI) into medical imaging has guided in an era of transformation in healthcare. This literature review explores the latest innovations and applications of AI in the field, highlighting its profound impact on...

  • Review
  • Open Access
146 Citations
31,418 Views
42 Pages

Medical image segmentation plays a critical role in accurate diagnosis and treatment planning, enabling precise analysis across a wide range of clinical tasks. This review begins by offering a comprehensive overview of traditional segmentation techni...

  • Review
  • Open Access
40 Citations
28,696 Views
22 Pages

Common Methods for Phylogenetic Tree Construction and Their Implementation in R

  • Yue Zou,
  • Zixuan Zhang,
  • Yujie Zeng,
  • Hanyue Hu,
  • Youjin Hao,
  • Sheng Huang and
  • Bo Li

A phylogenetic tree can reflect the evolutionary relationships between species or gene families, and they play a critical role in modern biological research. In this review, we summarize common methods for constructing phylogenetic trees, including d...

  • Review
  • Open Access
84 Citations
27,366 Views
34 Pages

Chlorella sp. and Spirulina (Arthrospira) sp. account for over 90% of the global microalgal biomass production and represent one of the most promising aquiculture bioeconomy systems. These microorganisms have been widely recognized for their nutritio...

  • Systematic Review
  • Open Access
68 Citations
24,906 Views
15 Pages

Analysis of Dental Enamel Remineralization: A Systematic Review of Technique Comparisons

  • Giuseppina Malcangi,
  • Assunta Patano,
  • Roberta Morolla,
  • Matteo De Santis,
  • Fabio Piras,
  • Vito Settanni,
  • Antonio Mancini,
  • Daniela Di Venere,
  • Francesco Inchingolo and
  • Angelo Michele Inchingolo
  • + 2 authors

The demineralization process conditions the structure of the enamel and begins with a superficial decalcification procedure that makes the enamel surface porous and gives it a chalky appearance. White spot lesions (WSLs) are the first clinical sign t...

  • Review
  • Open Access
126 Citations
23,502 Views
48 Pages

Connectivity Analysis in EEG Data: A Tutorial Review of the State of the Art and Emerging Trends

  • Giovanni Chiarion,
  • Laura Sparacino,
  • Yuri Antonacci,
  • Luca Faes and
  • Luca Mesin

Understanding how different areas of the human brain communicate with each other is a crucial issue in neuroscience. The concepts of structural, functional and effective connectivity have been widely exploited to describe the human connectome, consis...

  • Review
  • Open Access
48 Citations
23,275 Views
11 Pages

Current Knowledge on the Healing of the Extraction Socket: A Narrative Review

  • Samuel E. Udeabor,
  • Anja Heselich,
  • Sarah Al-Maawi,
  • Ali F. Alqahtani,
  • Robert Sader and
  • Shahram Ghanaati

The concept of extraction socket healing has been severally researched and reported over the years, since tooth extraction remains one of the most common procedures performed in the dental clinic. Understanding this healing process is of utmost impor...

  • Review
  • Open Access
132 Citations
22,662 Views
51 Pages

A Comprehensive Review on Synergy of Multi-Modal Data and AI Technologies in Medical Diagnosis

  • Xi Xu,
  • Jianqiang Li,
  • Zhichao Zhu,
  • Linna Zhao,
  • Huina Wang,
  • Changwei Song,
  • Yining Chen,
  • Qing Zhao,
  • Jijiang Yang and
  • Yan Pei

Disease diagnosis represents a critical and arduous endeavor within the medical field. Artificial intelligence (AI) techniques, spanning from machine learning and deep learning to large model paradigms, stand poised to significantly augment physician...

  • Systematic Review
  • Open Access
6 Citations
22,372 Views
19 Pages

Evaluation of the Effectiveness of Different Types of Professional Tooth Whitening: A Systematic Review

  • Andrea Butera,
  • Carolina Maiorani,
  • Gitana Rederiene,
  • Stefano Checchi and
  • Gianna Maria Nardi

Background/Objectives: Tooth whitening is a cosmetic dental treatment that improves the color of natural teeth, making them whiter and brighter; this review aimed to evaluate the greater effectiveness of in-office, at-home, and combined bleaching wit...

  • Article
  • Open Access
1 Citations
22,228 Views
28 Pages

Intervertebral disc degeneration (IVDD) is a significant cause of chronic pain and disability, necessitating innovative therapeutic strategies. This study investigates the combined effect of a novel siCOL1A2-encapsulated hydrogel and acupuncture on I...

  • Review
  • Open Access
39 Citations
21,193 Views
31 Pages

In recent years, the proliferation of wearable healthcare devices has marked a revolutionary shift in the personal health monitoring and management paradigm. These devices, ranging from fitness trackers to advanced biosensors, have not only made heal...

  • Review
  • Open Access
7 Citations
20,699 Views
23 Pages

Tissue Engineering for Penile Reconstruction

  • Elissa Elia,
  • Christophe Caneparo,
  • Catherine McMartin,
  • Stéphane Chabaud and
  • Stéphane Bolduc

The penis is a complex organ with a development cycle from the fetal stage to puberty. In addition, it may suffer from either congenital or acquired anomalies. Penile surgical reconstruction has been the center of interest for many researchers but is...

  • Review
  • Open Access
19 Citations
20,350 Views
20 Pages

The Use of Artificial Intelligence in Caries Detection: A Review

  • Khalifa S. Al-Khalifa,
  • Walaa Magdy Ahmed,
  • Amr Ahmed Azhari,
  • Masoumah Qaw,
  • Rasha Alsheikh,
  • Fatema Alqudaihi and
  • Amal Alfaraj

Advancements in artificial intelligence (AI) have significantly impacted the field of dentistry, particularly in diagnostic imaging for caries detection. This review critically examines the current state of AI applications in caries detection, focusi...

  • Review
  • Open Access
101 Citations
19,724 Views
30 Pages

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

  • Harshita Tiwari,
  • Nilesh Rai,
  • Swati Singh,
  • Priyamvada Gupta,
  • Ashish Verma,
  • Akhilesh Kumar Singh,
  • Kajal,
  • Prafull Salvi,
  • Santosh Kumar Singh and
  • Vibhav Gautam

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis and treatment. Nanomaterials are extensively employed in the field of oncology because of their minute size and ultra-specificit...

  • Review
  • Open Access
33 Citations
18,120 Views
41 Pages

Three-Dimensional Bioprinting: A Comprehensive Review for Applications in Tissue Engineering and Regenerative Medicine

  • Nicholas A. Mirsky,
  • Quinn T. Ehlen,
  • Jason A. Greenfield,
  • Michael Antonietti,
  • Blaire V. Slavin,
  • Vasudev Vivekanand Nayak,
  • Daniel Pelaez,
  • David T. Tse,
  • Lukasz Witek and
  • Paulo G. Coelho
  • + 1 author

Since three-dimensional (3D) bioprinting has emerged, it has continuously to evolved as a revolutionary technology in surgery, offering new paradigms for reconstructive and regenerative medical applications. This review highlights the integration of...

  • Review
  • Open Access
43 Citations
17,950 Views
33 Pages

Placental-Derived Biomaterials and Their Application to Wound Healing: A Review

  • Nicole M. Protzman,
  • Yong Mao,
  • Desiree Long,
  • Raja Sivalenka,
  • Anna Gosiewska,
  • Robert J. Hariri and
  • Stephen A. Brigido

Chronic wounds are associated with considerable patient morbidity and present a significant economic burden to the healthcare system. Often, chronic wounds are in a state of persistent inflammation and unable to progress to the next phase of wound he...

  • Article
  • Open Access
5 Citations
17,902 Views
26 Pages

Sleeping for One Week on a Temperature-Controlled Mattress Cover Improves Sleep and Cardiovascular Recovery

  • Nicole E. Moyen,
  • Tatiana R. Ediger,
  • Kathryn M. Taylor,
  • Erin G. Hancock,
  • Lucas D. Holden,
  • Emma E. Tracy,
  • Philip H. Kay,
  • Charles R. Irick,
  • Kevin J. Kotzen and
  • David D. He

Body temperature should be tightly regulated for optimal sleep. However, various extrinsic and intrinsic factors can alter body temperature during sleep. In a free-living study, we examined how sleep and cardiovascular health metrics were affected by...

  • Review
  • Open Access
29 Citations
17,367 Views
14 Pages

Response to Mechanical Properties and Physiological Challenges of Fascia: Diagnosis and Rehabilitative Therapeutic Intervention for Myofascial System Disorders

  • Yuya Kodama,
  • Shin Masuda,
  • Toshinori Ohmori,
  • Akihiro Kanamaru,
  • Masato Tanaka,
  • Tomoyoshi Sakaguchi and
  • Masami Nakagawa

Damage to the fascia can cause significant performance deficits in high-performance sports and recreational exercise and may contribute to the development of musculoskeletal disorders and persistent potential pain. The fascia is widely distributed fr...

  • Article
  • Open Access
18 Citations
16,797 Views
14 Pages

Biomechanical Effects of Different Sitting Postures and Physiologic Movements on the Lumbar Spine: A Finite Element Study

  • Mingoo Cho,
  • Jun-Sang Han,
  • Sungwook Kang,
  • Chang-Hwan Ahn,
  • Dong-Hee Kim,
  • Chul-Hyun Kim,
  • Kyoung-Tae Kim,
  • Ae-Ryoung Kim and
  • Jong-Moon Hwang

This study used the finite element method(FEM) to investigate how pressure on the lumbar spine changes during dynamic movements in different postures: standing, erect sitting on a chair, slumped sitting on a chair, and sitting on the floor. Three loa...

  • Review
  • Open Access
84 Citations
16,740 Views
33 Pages

Nano-Biofertilizer Formulations for Agriculture: A Systematic Review on Recent Advances and Prospective Applications

  • Diksha Garg,
  • Kandi Sridhar,
  • Baskaran Stephen Inbaraj,
  • Prince Chawla,
  • Manikant Tripathi and
  • Minaxi Sharma

In the twenty-first century, nanotechnology has emerged as a potentially game-changing innovation. Essential minerals are mostly unavailable in modern cropping systems without the application of synthetic fertilizers, which have a serious negative im...

  • Article
  • Open Access
24 Citations
16,503 Views
18 Pages

Are Activity Wrist-Worn Devices Accurate for Determining Heart Rate during Intense Exercise?

  • Pilar Martín-Escudero,
  • Ana María Cabanas,
  • María Luisa Dotor-Castilla,
  • Mercedes Galindo-Canales,
  • Francisco Miguel-Tobal,
  • Cristina Fernández-Pérez,
  • Manuel Fuentes-Ferrer and
  • Romano Giannetti

The market for wrist-worn devices is growing at previously unheard-of speeds. A consequence of their fast commercialization is a lack of adequate studies testing their accuracy on varied populations and pursuits. To provide an understanding of wearab...

  • Review
  • Open Access
19 Citations
15,930 Views
37 Pages

Toward Digital Periodontal Health: Recent Advances and Future Perspectives

  • Fatemeh Soheili,
  • Niloufar Delfan,
  • Negin Masoudifar,
  • Shahin Ebrahimni,
  • Behzad Moshiri,
  • Michael Glogauer and
  • Ebrahim Ghafar-Zadeh

Periodontal diseases, ranging from gingivitis to periodontitis, are prevalent oral diseases affecting over 50% of the global population. These diseases arise from infections and inflammation of the gums and supporting bones, significantly impacting o...

  • Article
  • Open Access
6 Citations
15,817 Views
12 Pages

Multicomponent Velocity Measurement for Linear Sprinting: Usain Bolt’s 100 m World-Record Analysis

  • Stanislav Štuhec,
  • Peter Planjšek,
  • Milan Čoh and
  • Krzysztof Mackala

The purpose of this report is to provide additional analysis and commentary on the men’s 100 m world record of 9.58 s, set by Usain Bolt in the 2009 Berlin World Championships in Athletics. In addition, the entire race underwent a unique kinema...

  • Review
  • Open Access
54 Citations
15,765 Views
18 Pages

The utilization of lasers has been regarded as a novel technique for the purposes of clinical use in the dental field. Recently, numerous studies have been conducted on the potential applications of laser therapy in endodontics. Moreover, due to thei...

  • Article
  • Open Access
67 Citations
15,200 Views
16 Pages

Early diagnosis and classification of arrhythmia from an electrocardiogram (ECG) plays a significant role in smart healthcare systems for the health monitoring of individuals with cardiovascular diseases. Unfortunately, the nonlinearity and low ampli...

  • Article
  • Open Access
2 Citations
15,116 Views
13 Pages

Artificial Intelligence for Predicting the Aesthetic Component of the Index of Orthodontic Treatment Need

  • Leah Stetzel,
  • Florence Foucher,
  • Seung Jin Jang,
  • Tai-Hsien Wu,
  • Henry Fields,
  • Fernanda Schumacher,
  • Stephen Richmond and
  • Ching-Chang Ko

The aesthetic component (AC) of the Index of Orthodontic Treatment Need (IOTN) is internationally recognized as a reliable and valid method for assessing aesthetic treatment need. The objective of this study is to use artificial intelligence (AI) to...

  • Review
  • Open Access
57 Citations
14,953 Views
32 Pages

Silk Fibroin Materials: Biomedical Applications and Perspectives

  • Giuseppe De Giorgio,
  • Biagio Matera,
  • Davide Vurro,
  • Edoardo Manfredi,
  • Vardan Galstyan,
  • Giuseppe Tarabella,
  • Benedetta Ghezzi and
  • Pasquale D’Angelo

The golden rule in tissue engineering is the creation of a synthetic device that simulates the native tissue, thus leading to the proper restoration of its anatomical and functional integrity, avoiding the limitations related to approaches based on a...

  • Review
  • Open Access
30 Citations
14,823 Views
28 Pages

The measurement and analysis of fetal heart rate (FHR) and uterine contraction (UC) patterns, known as cardiotocography (CTG), is a key technology for detecting fetal compromise during labour. This technology is commonly used by clinicians to make de...

  • Systematic Review
  • Open Access
31 Citations
14,714 Views
12 Pages

The Role and Applications of Artificial Intelligence in Dental Implant Planning: A Systematic Review

  • Monica Macrì,
  • Vincenzo D’Albis,
  • Giuseppe D’Albis,
  • Marta Forte,
  • Saverio Capodiferro,
  • Gianfranco Favia,
  • Abdulrahman Omar Alrashadah,
  • Victor Diaz-Flores García and
  • Felice Festa

Artificial intelligence (AI) is revolutionizing dentistry, offering new opportunities to improve the precision and efficiency of implantology. This literature review aims to evaluate the current evidence on the use of AI in implant planning assessmen...

  • Review
  • Open Access
30 Citations
14,659 Views
19 Pages

Surgical ligatures are a critical component of any surgical procedure since they are the device that provides immediate post-surgical tissue apposition. There have been several studies to improve the design and use of these wound closure devices for...

  • Communication
  • Open Access
25 Citations
14,486 Views
10 Pages

Remote photoplethysmography (rPPG) is a promising contactless technology that uses videos of faces to extract health parameters, such as heart rate. Several methods for transforming red, green, and blue (RGB) video signals into rPPG signals have been...

  • Review
  • Open Access
18 Citations
14,361 Views
18 Pages

Recent Advances in Apical Periodontitis Treatment: A Narrative Review

  • Zulema Arias,
  • Mohammed Zahedul Islam Nizami,
  • Xiaoting Chen,
  • Xinyi Chai,
  • Bin Xu,
  • Canyan Kuang,
  • Kazuhiro Omori and
  • Shogo Takashiba

Apical periodontitis is an inflammatory response caused by pulp infection. It induces bone resorption in the apical and periapical regions of the tooth. The most conservative approach to treat this condition is nonsurgical endodontic treatment. Howev...

  • Article
  • Open Access
6 Citations
14,292 Views
10 Pages

Clinical and Technological Evaluation of the Remineralising Effect of Biomimetic Hydroxyapatite in a Population Aged 6 to 18 Years: A Randomized Clinical Trial

  • Andrea Scribante,
  • Saverio Cosola,
  • Maurizio Pascadopoli,
  • Annamaria Genovesi,
  • Rebecca Andrea Battisti and
  • Andrea Butera

The aim of this randomized clinical trial was to evaluate the efficacy of two different remineralising toothpastes in preventing dental caries and promoting oral health. Patients aged 6–18 years old with healthy and fully erupted first permanen...

  • Article
  • Open Access
12 Citations
14,211 Views
35 Pages

Improvement of HEK293 Cell Growth by Adapting Hydrodynamic Stress and Predicting Cell Aggregate Size Distribution

  • Stefan Seidel,
  • Rüdiger W. Maschke,
  • Fruhar Mozaffari,
  • Regine Eibl-Schindler and
  • Dieter Eibl

HEK293 is a widely used cell line in the fields of research and industry. It is assumed that these cells are sensitive to hydrodynamic stress. The aim of this research was to use particle image velocimetry validated computational fluid dynamics (CFD)...

  • Review
  • Open Access
36 Citations
13,710 Views
19 Pages

Surgical management of fractures has advanced with the incorporation of advanced technology, surgical techniques, and regenerative therapies, but delayed bone healing remains a clinical challenge and the prevalence of long bone nonunion ranges from 1...

  • Review
  • Open Access
38 Citations
13,668 Views
25 Pages

This paper provides a systematic and in-depth examination of large language models (LLMs) in the healthcare domain, addressing their significant potential to transform medical practice through advanced natural language processing capabilities. Curren...

  • Review
  • Open Access
47 Citations
13,592 Views
27 Pages

fNIRS-EEG BCIs for Motor Rehabilitation: A Review

  • Jianan Chen,
  • Yunjia Xia,
  • Xinkai Zhou,
  • Ernesto Vidal Rosas,
  • Alexander Thomas,
  • Rui Loureiro,
  • Robert J. Cooper,
  • Tom Carlson and
  • Hubin Zhao

Motor impairment has a profound impact on a significant number of individuals, leading to a substantial demand for rehabilitation services. Through brain–computer interfaces (BCIs), people with severe motor disabilities could have improved comm...

  • Review
  • Open Access
53 Citations
13,540 Views
20 Pages

Cardiovascular diseases are the leading cause of morbidity and mortality in the United States. Cardiac tissue engineering is a direction in regenerative medicine that aims to repair various heart defects with the long-term goal of artificially rebuil...

  • Review
  • Open Access
21 Citations
13,356 Views
57 Pages

Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization

  • Vicente Javier Clemente-Suárez,
  • Alexandra Martín-Rodríguez,
  • Agustín Curiel-Regueros,
  • Alejandro Rubio-Zarapuz and
  • José Francisco Tornero-Aguilera

The interplay between nutrition, physical activity, and mental health has emerged as a frontier in bioengineering research, offering innovative pathways for enhancing cognitive function and psychological resilience. This review explores the neurobiol...

  • Review
  • Open Access
41 Citations
13,287 Views
36 Pages

Notably, 3D-printed flexible and wearable biosensors have immense potential to interact with the human body noninvasively for the real-time and continuous health monitoring of physiological parameters. This paper comprehensively reviews the progress...

  • Review
  • Open Access
25 Citations
13,112 Views
24 Pages

Artificial Intelligence in Dentistry: A Descriptive Review

  • Sreekanth Kumar Mallineni,
  • Mallika Sethi,
  • Dedeepya Punugoti,
  • Sunil Babu Kotha,
  • Zikra Alkhayal,
  • Sarah Mubaraki,
  • Fatmah Nasser Almotawah,
  • Sree Lalita Kotha,
  • Rishitha Sajja and
  • Srinivasulu Sakhamuri
  • + 2 authors

Artificial intelligence (AI) is an area of computer science that focuses on designing machines or systems that can perform operations that would typically need human intelligence. AI is a rapidly developing technology that has grabbed the interest of...

  • Review
  • Open Access
27 Citations
12,988 Views
17 Pages

Dental Fiber-Post Systems: An In-Depth Review of Their Evolution, Current Practice and Future Directions

  • Abdulrahman Alshabib,
  • Khaled Abid Althaqafi,
  • Hani S. AlMoharib,
  • Mahir Mirah,
  • Yasser F. AlFawaz and
  • Hamad Algamaiah

The field of dental medicine is constantly evolving and advancing toward minimally invasive techniques. Several studies have demonstrated that bonding to the tooth structure, particularly enamel, yields the most predictable results. In some instances...

  • Article
  • Open Access
46 Citations
12,922 Views
13 Pages

Machine Learning-Based Prediction of Mental Well-Being Using Health Behavior Data from University Students

  • Hanif Abdul Rahman,
  • Madeline Kwicklis,
  • Mohammad Ottom,
  • Areekul Amornsriwatanakul,
  • Khadizah H. Abdul-Mumin,
  • Michael Rosenberg and
  • Ivo D. Dinov

Background: Since the onset of the COVID-19 pandemic in early 2020, the importance of timely and effective assessment of mental well-being has increased dramatically. Machine learning (ML) algorithms and artificial intelligence (AI) techniques can be...

  • Review
  • Open Access
17 Citations
12,913 Views
40 Pages

Alzheimer’s Disease: Models and Molecular Mechanisms Informing Disease and Treatments

  • Kaden L. Nystuen,
  • Shannon M. McNamee,
  • Monica Akula,
  • Kristina M. Holton,
  • Margaret M. DeAngelis and
  • Neena B. Haider

Alzheimer’s Disease (AD) is a complex neurodegenerative disease resulting in progressive loss of memory, language and motor abilities caused by cortical and hippocampal degeneration. This review captures the landscape of understanding of AD pat...

  • Review
  • Open Access
79 Citations
12,836 Views
15 Pages

Advancements in biological wastewater treatment with sustainable and circularity approaches have a wide scope of application. Biological wastewater treatment is widely used to remove/recover organic pollutants and nutrients from a diverse wastewater...

  • Review
  • Open Access
60 Citations
12,779 Views
16 Pages

Global pollution from fossil plastics is one of the top environmental threats of our time. At their end-of-life phase, fossil plastics, through recycling, incineration, and disposal result in microplastic formation, elevated atmospheric CO2 levels, a...

  • Review
  • Open Access
49 Citations
12,601 Views
27 Pages

Deep Learning-Based Reconstruction for Cardiac MRI: A Review

  • Julio A. Oscanoa,
  • Matthew J. Middione,
  • Cagan Alkan,
  • Mahmut Yurt,
  • Michael Loecher,
  • Shreyas S. Vasanawala and
  • Daniel B. Ennis

Cardiac magnetic resonance (CMR) is an essential clinical tool for the assessment of cardiovascular disease. Deep learning (DL) has recently revolutionized the field through image reconstruction techniques that allow unprecedented data undersampling...

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Bioengineering - ISSN 2306-5354