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Bioengineering, Volume 10, Issue 9

2023 September - 117 articles

Cover Story: Muscle tissue engineering aims to repair or regenerate defective muscle tissue lost by trauma or disease. Despite its great potential, the number of clinical trials in this field is very limited. In this context, several parameters need to be addressed towards the development of advanced regenerative therapies employing myogenic cells. Bioprocess considerations covering the cell isolation step starting from different tissue sources (i.e., stem/progenitor cells vs. more committed precursors), as well as the need for robust and cost-effective protocols featuring easy scalability envisioning clinical applications, which are approached herein. Overall, the ultimate goal would be to obtain clinically relevant cell numbers, while maintaining cell/tissue identity and functionality. View this paper
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Articles (117)

  • Article
  • Open Access
8 Citations
3,880 Views
13 Pages

Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation

  • Andrea Cafarchio,
  • Marcello Iasiello,
  • Maria Chiara Brunese,
  • Giampiero Francica,
  • Aldo Rocca and
  • Assunta Andreozzi

To investigate the in vivo ablation characteristics of a microwave ablation antenna in the livers of humans with tumors, a retrospective analysis of the ablation zones was conducted after applying Emprint microwave ablation systems for treatment. Per...

  • Article
  • Open Access
8 Citations
5,061 Views
30 Pages

The current manuscript addresses the problem of parameter estimation for kinetic models of chemical reaction networks from observed time series partial experimental data of species concentrations. It is demonstrated how the Kron reduction method of k...

  • Article
  • Open Access
4 Citations
3,354 Views
11 Pages

This study aimed to investigate the dynamic behavior of different torque archwires for fixed orthodontic treatment using an automated, force-controlled biomechanical simulation system. A novel biomechanical simulation system (HOSEA) was used to simul...

  • Article
  • Open Access
4 Citations
2,657 Views
13 Pages

Characterizing the brain’s dynamic pattern of response to an input in electroencephalography (EEG) is not a trivial task due to the entanglement of the complex spontaneous brain activity. In this context, the brain’s response can be defin...

  • Article
  • Open Access
3,282 Views
14 Pages

A Fast Calibration Method for Pneumotachograph with a 3L Syringe

  • Yueqi Li,
  • Xin Qiu,
  • Hao Zhang,
  • Lirui Xu,
  • Saihu Lu,
  • Lidong Du,
  • Xianxiang Chen and
  • Zhen Fang

The pneumotachograph (PNT), a commonly used flowmeter in pulmonary function diagnostic equipment, is the required frequency calibration to maintain high accuracy. Aiming to simplify calibration steps, we developed a fast calibration system with a com...

  • Review
  • Open Access
44 Citations
12,685 Views
13 Pages

Three-dimensional bioprinting is a rapidly evolving technology that holds the promise of addressing the increasing demand for organs, tissues, and personalized medicine. By employing computer-aided design and manufacturing processes, 3D bioprinting a...

  • Article
  • Open Access
25 Citations
20,378 Views
14 Pages

Biomechanical Effects of Different Sitting Postures and Physiologic Movements on the Lumbar Spine: A Finite Element Study

  • Mingoo Cho,
  • Jun-Sang Han,
  • Sungwook Kang,
  • Chang-Hwan Ahn,
  • Dong-Hee Kim,
  • Chul-Hyun Kim,
  • Kyoung-Tae Kim,
  • Ae-Ryoung Kim and
  • Jong-Moon Hwang

This study used the finite element method(FEM) to investigate how pressure on the lumbar spine changes during dynamic movements in different postures: standing, erect sitting on a chair, slumped sitting on a chair, and sitting on the floor. Three loa...

  • Article
  • Open Access
1 Citations
1,893 Views
9 Pages

Determining the Relationship between Mechanical Properties and Quantitative Magnetic Resonance Imaging of Joint Soft Tissues Using Patient-Specific Templates

  • Takehito Hananouchi,
  • Shinji Satake,
  • Kei Sakao,
  • Hiroshi Katsuda,
  • Nagakazu Shimada,
  • Erik W. Dorthe and
  • Darryl D. D’Lima

To determine whether the mechanical properties of joint soft tissues such as cartilage can be calculated from quantitative magnetic resonance imaging (MRI) data, we investigated whether the mechanical properties of articular cartilage and meniscus sc...

  • Article
  • Open Access
6 Citations
3,063 Views
14 Pages

Retention of Human iPSC-Derived or Primary Cells Following Xenotransplantation into Rat Immune-Privileged Sites

  • Thomas Später,
  • Giselle Kaneda,
  • Melissa Chavez,
  • Julia Sheyn,
  • Jacob Wechsler,
  • Victoria Yu,
  • Patricia Del Rio,
  • Dave Huang,
  • Melodie Metzger and
  • Dmitriy Sheyn
  • + 1 author

In regenerative medicine, experimental animal models are commonly used to study potential effects of human cells as therapeutic candidates. Although some studies describe certain cells, such as mesenchymal stromal cells (MSC) or human primary cells,...

  • Article
  • Open Access
4 Citations
2,685 Views
17 Pages

Discriminative-Region Multi-Label Classification of Ultra-Widefield Fundus Images

  • Van-Nguyen Pham,
  • Duc-Tai Le,
  • Junghyun Bum,
  • Seong Ho Kim,
  • Su Jeong Song and
  • Hyunseung Choo

Ultra-widefield fundus image (UFI) has become a crucial tool for ophthalmologists in diagnosing ocular diseases because of its ability to capture a wide field of the retina. Nevertheless, detecting and classifying multiple diseases within this imagin...

  • Article
  • Open Access
1 Citations
2,518 Views
14 Pages

The primary aim of this systematic analysis is to highlight opportunities to improve the environmental impact of advanced therapy medicinal products (ATMP) manufacturing. We have compared the Greenhouse Gas (GHG) emissions expressed in CO2eq of a cla...

  • Article
  • Open Access
12 Citations
5,244 Views
13 Pages

Survival prediction models play a key role in patient prognosis and personalized treatment. However, their accuracy can be improved by incorporating patient similarity networks, which uncover complex data patterns. Our study uses Graph Neural Network...

  • Article
  • Open Access
10 Citations
4,240 Views
12 Pages

Tunable Double-Network GelMA/Alginate Hydrogels for Platelet Lysate-Derived Protein Delivery

  • Andrea Marfoglia,
  • Fahd Tibourtine,
  • Ludovic Pilloux and
  • Sophie Cazalbou

Hydrogels (gels) are attractive tools for tissue engineering and regenerative medicine due to their potential for drug delivery and ECM-like composition. In this study, we use rheology to characterize GelMA/alginate gels loaded with human platelet ly...

  • Article
  • Open Access
23 Citations
4,827 Views
14 Pages

MRI-Based Deep Learning Method for Classification of IDH Mutation Status

  • Chandan Ganesh Bangalore Yogananda,
  • Benjamin C. Wagner,
  • Nghi C. D. Truong,
  • James M. Holcomb,
  • Divya D. Reddy,
  • Niloufar Saadat,
  • Kimmo J. Hatanpaa,
  • Toral R. Patel,
  • Baowei Fei and
  • Joseph A. Maldjian
  • + 5 authors

Isocitrate dehydrogenase (IDH) mutation status has emerged as an important prognostic marker in gliomas. This study sought to develop deep learning networks for non-invasive IDH classification using T2w MR images while comparing their performance to...

  • Article
  • Open Access
7 Citations
6,206 Views
23 Pages

Transcranial photobiomodulation (tPBM) has been suggested as a non-invasive neuromodulation tool. The repetitive administration of light-emitting diode (LED)-based tPBM for several weeks significantly improves human cognition. To understand the elect...

  • Article
  • Open Access
4 Citations
2,221 Views
13 Pages

Spinal fusion surgery leads to the restriction of mobility in the vertebral segments postoperatively, thereby causing stress to rise at the adjacent levels, resulting in early degeneration and a high risk of adjacent vertebral fractures. Thus, to add...

  • Article
  • Open Access
8 Citations
2,726 Views
20 Pages

To understand human emotional states, local activities in various regions of the cerebral cortex and the interactions among different brain regions must be considered. This paper proposes a hierarchical emotional context feature learning model that i...

  • Systematic Review
  • Open Access
20 Citations
6,557 Views
11 Pages

Artificial Intelligence Advances in Transplant Pathology

  • Md Arafatur Rahman,
  • Ibrahim Yilmaz,
  • Sam T. Albadri,
  • Fadi E. Salem,
  • Bryan J. Dangott,
  • C. Burcin Taner,
  • Aziza Nassar and
  • Zeynettin Akkus

Transplant pathology plays a critical role in ensuring that transplanted organs function properly and the immune systems of the recipients do not reject them. To improve outcomes for transplant recipients, accurate diagnosis and timely treatment are...

  • Review
  • Open Access
30 Citations
9,153 Views
24 Pages

Exoskeletons: Contribution to Occupational Health and Safety

  • Omar Flor-Unda,
  • Bregith Casa,
  • Mauricio Fuentes,
  • Santiago Solorzano,
  • Fabián Narvaez-Espinoza and
  • Patricia Acosta-Vargas

This review aims to characterize the current landscape of exoskeletons designed to promote medical care and occupational safety in industrial settings. Extensive exploration of scientific databases spanning industries, health, and medicine informs th...

  • Article
  • Open Access
11 Citations
2,694 Views
19 Pages

Background: More than ~70% of the aqueous humor exits the eye through the conventional aqueous outflow pathway that is comprised of the trabecular meshwork (TM), juxtacanalicular tissue (JCT), the inner wall endothelium of Schlemm’s canal (SC)....

  • Article
  • Open Access
3 Citations
2,670 Views
16 Pages

Current auricular cartilage replacements for pediatric microtia fail to address the need for long-term integration and neocartilage formation. While collagen hydrogels have been successful in fostering neocartilage formation, the toughness and extens...

  • Article
  • Open Access
21 Citations
3,850 Views
22 Pages

Carotid artery diseases, such as atherosclerosis, are a major cause of death in the United States. Wall shear stresses are known to prompt plaque formation, but there is limited understanding of the complex flow structures underlying these stresses a...

  • Article
  • Open Access
5 Citations
2,295 Views
19 Pages

Evaluation of a Granular Bone Substitute for Bone Regeneration Using an Optimized In Vivo Alveolar Cleft Model

  • Alban Destrez,
  • Emilien Colin,
  • Sylvie Testelin,
  • Bernard Devauchelle,
  • Stéphanie Dakpé and
  • Marie Naudot

Alveolar cleft is a common congenital deformity that requires surgical intervention, notably using autologous bone grafts in young children. Bone substitutes, in combination with mesenchymal stem cells (MSCs), have shown promise in the repair of thes...

  • Article
  • Open Access
3 Citations
2,343 Views
12 Pages

Magnetotactic bacteria have great potential for use in biomedical and environmental applications due to the ability to direct their navigation with a magnetic field. Applying and accurately controlling a magnetic field within a microscopic region dur...

  • Article
  • Open Access
6 Citations
4,106 Views
17 Pages

Astaxanthin is a powerful antioxidant and is used extensively as an animal feed additive and nutraceutical product. Here, we report the use of the β-carotene hydroxylase (CBFD1) and the β-carotene ketolase (HBFD1) from Adonis aestivalis, a...

  • Brief Report
  • Open Access
2,716 Views
7 Pages

FD-2, an Anticervical Stenosis Device for Patients Undergoing Radical Trachelectomy or Cervical Conization

  • Seiji Mabuchi,
  • Shoji Kamiura,
  • Takuya Saito,
  • Hayato Furukawa,
  • Azusa Abe and
  • Takashi Sasagawa

This study aimed to introduce FD-2, a newly developed anticervical stenosis device for patients with cervical cancer undergoing radical trachelectomy. Using ethylene-vinyl acetate copolymers, we developed FD-2 to prevent uterine cervical stenosis aft...

  • Article
  • Open Access
13 Citations
3,538 Views
14 Pages

New Approach for Generating Synthetic Medical Data to Predict Type 2 Diabetes

  • Zarnigor Tagmatova,
  • Akmalbek Abdusalomov,
  • Rashid Nasimov,
  • Nigorakhon Nasimova,
  • Ali Hikmet Dogru and
  • Young-Im Cho

The lack of medical databases is currently the main barrier to the development of artificial intelligence-based algorithms in medicine. This issue can be partially resolved by developing a reliable high-quality synthetic database. In this study, an e...

  • Article
  • Open Access
7 Citations
3,309 Views
10 Pages

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication, and repetitive or stereotyped behaviors. Previous studies have reported altered brain connectivity in ASD children comp...

  • Review
  • Open Access
6 Citations
3,607 Views
10 Pages

Effects of tDCS on Foot Biomechanics: A Narrative Review and Clinical Applications

  • Songlin Xiao,
  • Bin Shen,
  • Chuyi Zhang,
  • Zhen Xu,
  • Jingjing Li,
  • Weijie Fu and
  • Jing Jin

In recent years, neuro-biomechanical enhancement techniques, such as transcranial direct current stimulation (tDCS), have been widely used to improve human physical performance, including foot biomechanical characteristics. This review aims to summar...

  • Article
  • Open Access
1 Citations
2,310 Views
17 Pages

Estimation of continuous motion of human joints using surface electromyography (sEMG) signals has a critical part to play in intelligent rehabilitation. Traditional methods always use sEMG signals as inputs to build regression or biomechanical models...

  • Article
  • Open Access
5 Citations
2,010 Views
14 Pages

A person’s present mental state is closely associated with the frequency and temporal domain features of spontaneous electroencephalogram (EEG) impulses, which directly reflect neurophysiological signals of brain activity. EEG signals are emplo...

  • Article
  • Open Access
7 Citations
2,813 Views
13 Pages

Timely detection and response to Intraoperative Hypotension (IOH) during surgery is crucial to avoid severe postoperative complications. Although several methods have been proposed to predict IOH using machine learning, their performance still has sp...

  • Article
  • Open Access
16 Citations
4,691 Views
16 Pages

Development of a New Wearable Device for the Characterization of Hand Tremor

  • Basilio Vescio,
  • Marida De Maria,
  • Marianna Crasà,
  • Rita Nisticò,
  • Camilla Calomino,
  • Federica Aracri,
  • Aldo Quattrone and
  • Andrea Quattrone

Rest tremor (RT) is observed in subjects with Parkinson’s disease (PD) and Essential Tremor (ET). Electromyography (EMG) studies have shown that PD subjects exhibit alternating contractions of antagonistic muscles involved in tremors, while the...

  • Article
  • Open Access
16 Citations
4,960 Views
13 Pages

Predicting Respiratory Rate from Electrocardiogram and Photoplethysmogram Using a Transformer-Based Model

  • Qi Zhao,
  • Fang Liu,
  • Yide Song,
  • Xiaoya Fan,
  • Yu Wang,
  • Yudong Yao,
  • Qian Mao and
  • Zheng Zhao

The respiratory rate (RR) serves as a critical physiological parameter in the context of both diagnostic and prognostic evaluations. Due to the challenges of direct measurement, RR is still predominantly measured through the traditional manual counti...

  • Article
  • Open Access
3 Citations
3,889 Views
12 Pages

The Use of a CAD/CAM Thermoformed Splints System in Closed Reduction of Condylar Fractures

  • Cristina Grippaudo,
  • Antonino Lo Giudice,
  • Gianmarco Saponaro,
  • Mattia Todaro,
  • Alessandro Moro and
  • Antonio D’Addona

(1) Background: Mandibular fractures are very common. Common indications of closed treatment for mandibular fractures are non-displaced or minimally displaced simple fractures in adult compliant patients with good dentition, the absence of occlusal d...

  • Article
  • Open Access
9 Citations
3,280 Views
16 Pages

Technical Evaluation of a New Medical Device Based on Rigenase in the Treatment of Chronic Skin Lesions

  • Eugenia Romano,
  • Claudio Campagnuolo,
  • Roberta Palladino,
  • Giulia Schiavo,
  • Barbara Maglione,
  • Cristina Luceri and
  • Natascia Mennini

Chronic wound is characterized by slow healing time, persistence, and abnormal healing progress. Therefore, serious complications can lead at worst to the tissue removal. In this scenario, there is an urgent need for an ideal dressing capable of high...

  • Article
  • Open Access
26 Citations
3,727 Views
16 Pages

Intelligent Grapevine Disease Detection Using IoT Sensor Network

  • Mihaela Hnatiuc,
  • Simona Ghita,
  • Domnica Alpetri,
  • Aurora Ranca,
  • Victoria Artem,
  • Ionica Dina,
  • Mădălina Cosma and
  • Mazin Abed Mohammed

The Internet of Things (IoT) has gained significance in agriculture, using remote sensing and machine learning to help farmers make high-precision management decisions. This technology can be applied in viticulture, making it possible to monitor dise...

  • Article
  • Open Access
2 Citations
2,238 Views
12 Pages

Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis

  • Suryyani Deb,
  • Mohammad Azharuddin,
  • Sofia Ramström,
  • Kanjaksha Ghosh,
  • Santiswarup Singha,
  • Thobias Romu and
  • Hirak Kumar Patra

Arterial thrombosis (AT) originates through platelet-mediated thrombus formation in the blood vessel and can lead to heart attack, stroke, and peripheral vascular diseases. Restricting the thrombus growth and its simultaneous monitoring by visualisat...

  • Article
  • Open Access
13 Citations
3,717 Views
17 Pages

Functionalized 3D-Printed PLA Biomimetic Scaffold for Repairing Critical-Size Bone Defects

  • Xiao Liu,
  • Jianpeng Gao,
  • Xiang Cui,
  • Shaobo Nie,
  • Xiaoyong Wu,
  • Licheng Zhang,
  • Peifu Tang,
  • Jianheng Liu and
  • Ming Li

The treatment of critical-size bone defects remains a complicated clinical challenge. Recently, bone tissue engineering has emerged as a potential therapeutic approach for defect repair. This study examined the biocompatibility and repair efficacy of...

  • Article
  • Open Access
9 Citations
2,596 Views
15 Pages

Comparison of Mid-Infrared Handheld and Benchtop Spectrometers to Detect Staphylococcus epidermidis in Bone Grafts

  • Richard Lindtner,
  • Alexander Wurm,
  • Katrin Kugel,
  • Julia Kühn,
  • David Putzer,
  • Rohit Arora,
  • Débora Cristina Coraça-Huber,
  • Philipp Zelger,
  • Michael Schirmer and
  • Johannes Dominikus Pallua
  • + 3 authors

Bone analyses using mid-infrared spectroscopy are gaining popularity, especially with handheld spectrometers that enable on-site testing as long as the data quality meets standards. In order to diagnose Staphylococcus epidermidis in human bone grafts...

  • Article
  • Open Access
7 Citations
3,438 Views
16 Pages

High-strength wastewaters from a variety of sources, including the food industry, domestic septage, and landfill leachate, are often hauled to municipal wastewater treatment plants (WWTPs) for co-treatment. Due to their high organic loadings, these w...

  • Article
  • Open Access
3 Citations
2,203 Views
12 Pages

The Development of a Permanent Implantable Spacer with the Function of Size Adjustability for Customized Treatment of Regurgitant Heart Valve Disease

  • Min-Ku Chon,
  • Su-Jin Jung,
  • Jae-Young Seo,
  • Dong-Hoon Shin,
  • Jun-Hui Park,
  • Hyun-Sook Kim,
  • Joo-Yong Hahn,
  • Eun-Kyoung Kim,
  • Seung-Whan Lee and
  • June-Hong Kim
  • + 2 authors

The Pivot Mandu is an innovative device featuring a leak-tight adjustable 3D balloon spacer, incorporating inner mesh support, an outer e-PTFE layer, and a compliant balloon in the middle layer with a specialized detachable system. To assess its feas...

  • Article
  • Open Access
13 Citations
4,448 Views
21 Pages

Vision transformers represent the cutting-edge topic in computer vision and are usually employed on two-dimensional data following a transfer learning approach. In this work, we propose a trained-from-scratch stacking ensemble of 3D-vision transforme...

  • Article
  • Open Access
10 Citations
3,513 Views
16 Pages

Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel

  • Riley B. Brackin,
  • Gail E. McColgan,
  • Saitheja A. Pucha,
  • Michael A. Kowalski,
  • Hicham Drissi,
  • Thanh N. Doan and
  • Jay M. Patel

Traumatic joint injuries are common, leading to progressive tissue degeneration and the development of osteoarthritis. The post-traumatic joint experiences a pro-inflammatory milieu, initiating a subtle but deteriorative process in cartilage tissue....

  • Article
  • Open Access
4 Citations
2,194 Views
12 Pages

To build a representative 3D finite element model (FEM) for intracorneal ring segment (ICRS) implantation and to investigate localized optical changes induced by different ICRS geometries, a hyperelastic shell FEM was developed to compare the effect...

  • Systematic Review
  • Open Access
46 Citations
12,696 Views
44 Pages

Emerging Trends in Fast MRI Using Deep-Learning Reconstruction on Undersampled k-Space Data: A Systematic Review

  • Dilbag Singh,
  • Anmol Monga,
  • Hector L. de Moura,
  • Xiaoxia Zhang,
  • Marcelo V. W. Zibetti and
  • Ravinder R. Regatte

Magnetic Resonance Imaging (MRI) is an essential medical imaging modality that provides excellent soft-tissue contrast and high-resolution images of the human body, allowing us to understand detailed information on morphology, structural integrity, a...

  • Article
  • Open Access
3 Citations
4,060 Views
13 Pages

Measuring Bone Healing: Parameters and Scores in Comparison

  • Nicolas Söhling,
  • Olivia Von Jan,
  • Maren Janko,
  • Christoph Nau,
  • Ulrike Ritz,
  • Ingo Marzi,
  • Dirk Henrich and
  • René D. Verboket

(1) Background: Bone healing is a complex process that can not be replicated in its entirety in vitro. Research on bone healing still requires the animal model. The critical size femur defect (CSFD) in rats is a well-established model for fractures i...

  • Review
  • Open Access
109 Citations
18,526 Views
33 Pages

Nano-Biofertilizer Formulations for Agriculture: A Systematic Review on Recent Advances and Prospective Applications

  • Diksha Garg,
  • Kandi Sridhar,
  • Baskaran Stephen Inbaraj,
  • Prince Chawla,
  • Manikant Tripathi and
  • Minaxi Sharma

In the twenty-first century, nanotechnology has emerged as a potentially game-changing innovation. Essential minerals are mostly unavailable in modern cropping systems without the application of synthetic fertilizers, which have a serious negative im...

  • Article
  • Open Access
3 Citations
3,813 Views
17 Pages

Unsupervised Multitaper Spectral Method for Identifying REM Sleep in Intracranial EEG Recordings Lacking EOG/EMG Data

  • Kyle Q. Lepage,
  • Sparsh Jain,
  • Andrew Kvavilashvili,
  • Mark Witcher and
  • Sujith Vijayan

A large number of human intracranial EEG (iEEG) recordings have been collected for clinical purposes, in institutions all over the world, but the vast majority of these are unaccompanied by EOG and EMG recordings which are required to separate Wake e...

  • Article
  • Open Access
6 Citations
2,381 Views
17 Pages

Decidual natural killer cells (dNK cells) are an essential component of the immune cells present at the maternal–foetal interface during early pregnancy, and they play a vital role in various physiological processes. Abnormalities in the ratio...

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Bioengineering - ISSN 2306-5354