2026 May - 108 articles
Dermatophytosis is commonly assessed using potassium hydroxide (KOH) microscopy, yet accurate recognition of fungal hyphae is hindered by preparation-related artifacts, heterogeneous keratin clearance, and notable inter-observer variability. This stu...
Dental implant therapy demonstrates high long-term survival; however, biological, behavioral, and technical complications remain prevalent. The objective of this project report was to introduce GF-Predictability for Dental Implants (GF-PreDImp), a no...
Three-dimensional (3D) bioreactor systems are essential for vascular tissue engineering as they provide controlled environments that better mimic physiological conditions compared to static culture systems. In this study, an IoT-enabled modular rotat...
In this work, we propose ARTEMIS, a novel and highly interpretable deep learning pipeline for the automatic classification of Chest X-ray (CXR) and Computed Tomography (CT) images into different categories related to important clinical outcomes: COVI...
Silver nanoparticles (AgNPs) have attracted substantial scientific interest in biomedical research owing to their unique physicochemical characteristics, broad-spectrum antimicrobial activity, plasmonic properties, and therapeutic versatility. Althou...
Attention Deficit Hyperactivity Disorder (ADHD) is a heterogeneous neurodevelopmental disorder whose diagnosis is mainly based on behavioral assessment and is often delayed due to clinical complexity and limited availability of specialists. Resting-s...
Osteochondral defects of the knee represent a significant clinical challenge due to the limited regenerative capacity of the osteochondral unit. The aim of this study was to evaluate the therapeutic potential of calcium phosphate-based biomaterials c...
Neck pain is increasingly associated with exposure-dependent dysfunction linked to digitally mediated behaviors, prolonged near-work, sustained postures, and reduced movement variability, whereas cervical assessment remains dominated by static imagin...
This study explores the formation of inclusion complexes between a newly synthesized N-(2-(butylamino)-2-oxoethyl)-2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxamide with β-cyclodextrin using density functional theory with dispersion c...
Purpose: To compare hypopyon detection using anterior segment optical coherence tomography (ASOCT) versus slit lamp examination (SLE) in microbial keratitis, and to evaluate intra- and inter-grader agreement for ASOCT hypopyon measurement. Methods: T...
The purpose of this study was to use the finite element analysis method to determine the influence of framework material on stresses in different parts of a model of an All-on-4 prosthesis supported by bendable monoblock implants. A three-dimensional...
Purpose: The aim of this study is to describe a slit-modified 23-gauge infusion trocar designed to enable early postoperative hypotony-free sclerotomy closure by allowing scleral suturing prior to complete trocar removal, and to report initial clinic...
Scaling biotechnology processes such as gas fermentation remains resource- and time-intensive, both experimentally and in modeling. To improve the efficiency of reactor geometry optimization, we evaluated the transferability of findings from pilot-sc...
Electroencephalogram (EEG) signals hold significant research value in brain function decoding, disease diagnosis, and brain–computer interfaces (BCIs). Few-channel EEG recording devices feature superior portability, simple operation, and facili...
Osteoarthritis (OA) is a multifactorial degenerative joint disease characterized by chronic inflammation, progressive cartilage extracellular matrix (ECM) degradation, and impaired joint lubrication, creating a complex pathological microenvironment t...
Foundation models are reshaping computational pathology by enabling scalable task-agnostic representations of histopathological whole-slide images (WSIs). Unlike earlier task-specific deep learning systems, pathology foundation models (PFMs) leverage...
In sports science, there is a growing demand to apply the principles of classical and modern physics to understand human movement, prevent injuries, and enhance performance [...]
We investigated whether bone morphology alone can inform implant selection in shoulder arthroplasty using a hypothesis-driven deep learning framework applied to preoperative computed tomography (CT) scans. The proposed approach extends a previously v...
Extracellular vesicles (EVs) hold significant potential in cardiovascular diagnosis and treatment. However, their clinical applications are limited by challenges such as isolation efficiency, subpopulation heterogeneity, analytical standardization, a...
Radiotherapy simulation is essential for accurately targeting tumors while preserving healthy tissue, ensuring treatment precision and safety. This study aimed to develop an integrated radiotherapy simulation system capable of automated segmentation,...
Background: The current study integrates AlphaFold2-based structural modeling of DNA-PKcs with an experimentally resolved DNA-PKcs structure, large-scale molecular docking of over 1500 known DNA-PK inhibitors, aiming to identify clinically relevant c...
Worldwide, breast cancer is the leading cause of death in women. This emphasizes the significance of an accurate breast cancer detection system. This study presents a unified framework for segmentation of breast cancer using multimodal imaging, such...
3D bioprinting technology has made great strides in the field of bone tissue engineering. It has been able to create personalized biological structures on a macroscopic scale. In terms of microstructure bionics, 3D printing technology has also made s...
As global population aging intensifies, fall-related injuries among the elderly have become a critical public health concern. Existing fall detection methods based on wearable IMUs all extract features in the sensor’s body frame, failing to exploit t...
Cranial vault reconstruction is a critical component of care following trauma, decompressive craniectomy, infection, or oncologic resection. Large and complex cranial defects present unique reconstructive challenges, as autologous reconstruction may...
Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, a global public health burden for which current pharmacological and surgical treatments provide symptomatic relief but fail to reverse the underlying degenerative process....
Ultra-wide field (UWF) fundus image classification is an important part of the entire process of medical screening and decision support. However, the discrimination of various retinal disease classes is difficult due to the similarity between classes...
The diagnosis of skin cancer remains a growing challenge because of its high variability as a result of the varying imaging conditions in clinical settings. This paper proposes a multimodal deep learning framework to address these challenges by combi...
Background: Knee osteoarthritis (OA) is one of the leading causes of disability in older adults. As definitive treatment often involves knee replacement surgery, effective non-invasive approaches capable of alleviating symptoms and preserving mobilit...
The advancement of modern regenerative medicine is closely associated with additive technologies that enable the creation of tissue-engineered constructs and personalized bioprostheses. Three-dimensional bioprinting allows precise modeling of tissue...
Real-time detection of motor intent using electroencephalography (EEG) with high accuracy remains a technical challenge for neurorehabilitation. Brain–computer interface-based neurofeedback training (BCI-NFT) paradigms need to detect pre-moveme...
Magnetizing living cells with superparamagnetic iron oxide nanoparticles (SPIONs) enables their remote manipulation using external magnetic field. This lays the foundation for magnetically assembling tissue precursors within cell-friendly, proliferat...
Wearable devices increasingly capture biosignals such as electrocardiograms, photoplethysmograms, inertial signals, and electrodermal activity during daily life, enabling earlier detection and continuous monitoring outside the clinic. Real-time edge...
Sustainable production in dental and orthodontic 3D printing has gained increasing attention due to environmental concerns and the need for cost-effective and resource-saving solutions. This study presents a proof of concept for using recycled polyme...
Cryopreservation integrates technologies that enable the long-term preservation of biological materials at extremely low temperatures. Since the serendipitous discovery by Audrey Smith and Christopher Polge that glycerol enhances the survival of froz...
Peripheral nerve blocks can effectively reduce the use of general anesthesia and opioids in situations where robust pain management is critical, such as severe extremity trauma and hip, femur, and knee surgeries. Despite these benefits, nerve blocks...
Recent advances in medical image segmentation have introduced a wide spectrum of deep learning paradigms, including 2D/3D convolutional neural networks (CNNs), transformer-based architectures, vision-language models (VLMs), prompt-driven foundation m...
Heart rate variability (HRV) refers to variations in the time intervals between consecutive heart beats. Changes in HRV reflect changes in either sympathetic or decreased parasympathetic tone that can originate in the brain. This brain–heart co...
Thoracic diseases represent a significant threat to human health. Chest X-ray imaging, owing to its cost-effectiveness and rapid imaging capabilities, has been widely adopted as a primary diagnostic tool in clinical practice. However, existing models...
Lung cancer rates are the highest among cancers, making it the leading cause of death worldwide. With advances in new technologies and diverse diagnostic methods, Computer-Aided Diagnosis Systems (CADx) have improved pulmonary nodule classification w...
Following traumatic injury, nerve repair is essential to the restoration of muscle function and sensation. The current gold standard of nerve repair is microsuture repair, which requires trained microsurgeons to perform time-intensive and technically...
The Focused Assessment with Sonography in Trauma (FAST) enables rapid point-of-care screening for internal hemorrhage by detecting free fluid, but its accuracy is highly operator-dependent and prone to missed diagnoses in emergency settings. While de...
Hyperspectral (HS) imaging has proven to be a promising intraoperative tool for tissue discrimination. However, obtaining representative datasets for intraoperative imaging remains challenging due to the complexity of surgical workflows and the sensi...
Corneal diseases affect a significant proportion of the global population, with younger age groups being particularly vulnerable. In severe cases involving vision loss, standard techniques such as keratoplasty often fail. These cases require more inv...
Objective: Effectively eliminating xenoimmunogenicity and achieving recellularization in cardiac xenografts remains a critical challenge in developing an ideal implantable xenograft. We have previously demonstrated that the removal of major antigens,...
Unsupervised anomaly detection in medical imaging aims to automatically identify potential lesions that deviate from normal patterns in multimodal medical images without requiring annotations of abnormal samples, and is of great clinical value for ea...
For testing ocular irritation, 3D corneal models mimicking the corneal epithelium are considered reliable eye irritation tests and are detailed in regulatory guideline OECD Test Guideline (TG) 492. The aim of the present study was to develop and vali...
Degenerative disc disease is a leading cause of chronic low back pain and disability worldwide, and current treatments primarily address symptoms rather than the underlying biological degeneration of the intervertebral disc. Mesenchymal stem cells (M...
Biogas produced from the anaerobic digestion of organic matter holds much promise as a renewable energy source for decentralized systems. However, raw biogas contains substantial volumes of carbon dioxide, hydrogen sulfide, water vapor, and other tra...
(1) Background: The development of advanced dental biomaterials has significantly improved restorative dentistry, shifting the focus from purely mechanical restoration toward materials capable of interacting biologically with oral tissues. Modern res...
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