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Metabolites
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Dysbiosis and Metabolic Disorders of the Microbiota
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Dysbiosis and Metabolic Disorders of the Microbiota

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: 1 November 2025 | Viewed by 934

Special Issue Editor

Dr. Guozhu Ye

E-Mail Website
Guest Editor
Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
Interests: metabolomics; functional metabolomics; LC-MS; GC-MS; intestinal micro-biota; metabolism; molecular pathophysiology; molecular toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microbiota has co-evolved with hosts for a long time, and has in vita physiological and pathological roles, such as mediating host metabolism, gut barrier function, immune balance, biological rhythm, and neurobehavior. As signaling molecules and/or biocatalytic substrates, microbiota metabolites can be absorbed to affect physiological and/or pathological processes in vivo. Microbiota is closely related to health in plants, animals, humans, and the environment, which has attracted increasing attention and formed academic hotspots.

Contributions on the following subject areas are welcome, but are not limited to:

  1. Methods developed for wider and/or deeper coverage of metabolome, metaproteome, or metagenome to decipher dysbiosis and metabolic disorders of the microbiota colonizing the gut, plant rhizosphere, soil, water, etc.
  2. Applications of omics and/or other approaches to decipher dysbiosis and metabolic disorders of gut microbiota under specific conditions, such as pathophysiology, exercise training, environmental stimuli, etc.
  3. Applications of omics and/or other approaches to decipher dysbiosis and metabolic disorders of environmental microbiota under specific conditions, such as changes in the climate, cultivation conditions, treatment conditions, exposure to environmental pollutants, etc.

Dr. Guozhu Ye
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • metagenomics
  • metaproteomics
  • metatranscriptomics
  • Liquid Chromatograph-Mass Spectrometer
  • Gas Chromatography-Mass Spectrometer
  • gut microbiota
  • environmental microbiota
  • metabolism
  • metabolic disorders

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Published Papers (2 papers)

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18 pages, 2633 KiB  
Article
Effects of Exercise on Gut Microbiome and Serum Metabolomics in Post-Traumatic Osteoarthritis Rats
by Xiaoxia Hao, Xingru Shang, Yiwen Zhang, Wenjie Hou, Ruimin Chi, Chunran Pan, Jiawei Liu, Xiaofeng Deng, Jiaming Zhang and Tao Xu
Metabolites 2025, 15(5), 341; https://doi.org/10.3390/metabo15050341 - 20 May 2025
Abstract
Objective: The aim of this work is to investigate the impact of exercise on gut microbiome composition, serum metabolites, and their correlation with osteoarthritis (OA) severity. Methods: Thirty-six Sprague-Dawley (SD) rats were randomly divided into four groups: Sham rats without treadmill walking (Sham/Sed [...] Read more.
Objective: The aim of this work is to investigate the impact of exercise on gut microbiome composition, serum metabolites, and their correlation with osteoarthritis (OA) severity. Methods: Thirty-six Sprague-Dawley (SD) rats were randomly divided into four groups: Sham rats without treadmill walking (Sham/Sed group, n = 9), Sham rats with treadmill walking 2 months (Sham/TW2M group, n = 9), PTOA rats without treadmill walking (PTOA/Sed group, n = 9), and PTOA rats with treadmill walking 2 months (PTOA/TW2M group, n = 9). The PTOA model was induced by transection of the anterior cruciate ligament (ACLT) and destabilization of the medial meniscus (DMM). Histological evaluation and micro-CT analysis were performed to observe the pathological changes in cartilage and subchondral bone, respectively. Additionally, we conducted 16S rDNA sequencing of fecal samples and untargeted metabolomic analysis using liquid chromatography–mass spectrometry (LC–MS) of serum samples to detect the alteration of gut microbiota composition and metabolites. Results: Exercise effectively mitigated OA-related pathological changes, including articular cartilage degeneration and subchondral bone loss. Moreover, 16S rDNA sequencing analysis of gut microbiome revealed a decreased abundance of Bacteroidetes (p < 0.01), Bacteroidia (p < 0.01), Rikenellaceae (p < 0.01), [Paraprevotellaceae] (p < 0.01), and Paraprevotella (p < 0.01) but an increase in Firmicutes (p < 0.01) in PTOA/TW2M group rats compared with PTOA/Sed group as a response to exercise. In addition, the results of metabolomics analysis showed that exercise treatment contributed to the upregulation of Daidzein and Anthranilic acid and downregulation of 1-Palmitoyllysophosphatidylcholine. Moreover, the correlation analysis showed that Rikenellaceae significantly positively correlated with both OARSI (r = 0.81, p < 0.01) and Mankin score (r = 0.83, p < 0.01) and negatively correlated with the serum level of Anthranilic acid (r = −0.56, p < 0.01) and Daidzein (r = −0.46, p < 0.01). Conclusions: Exercise can effectively mitigate OA through slowing down articular cartilage degeneration and subchondral bone loss, modulating gut microbiota composition, and increasing beneficial metabolites. Full article
(This article belongs to the Special Issue Dysbiosis and Metabolic Disorders of the Microbiota)
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14 pages, 2979 KiB  
Article
Probiotic Supplementation Improves Hematological Indices and Morphology of Red Blood Cells and Platelets in Obese Women: A Double-Blind, Controlled Pilot Study
by Nina Okuka, Nevena Dj. Ivanovic, Neda Milinkovic, Snezana Polovina, Mirjana Sumarac-Dumanovic, Rajna Minic, Brizita Djordjevic and Ksenija Velickovic
Metabolites 2025, 15(5), 310; https://doi.org/10.3390/metabo15050310 - 6 May 2025
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Abstract
Background/Objectives: The prevalence of obesity worldwide has rapidly increased. Numerous studies showed a beneficial effect of probiotics in obese individuals, and changes in hematological parameters are observed in obesity. Therefore, the aim of this study was to investigate the effect of a novel [...] Read more.
Background/Objectives: The prevalence of obesity worldwide has rapidly increased. Numerous studies showed a beneficial effect of probiotics in obese individuals, and changes in hematological parameters are observed in obesity. Therefore, the aim of this study was to investigate the effect of a novel probiotic approach on the red blood cells (RBCs) and platelets. Methods: Twenty-five obese women participated in a randomized, placebo-controlled study and were divided into the experimental group (one capsule daily containing Lactiplantibacillus plantarum 299v (DSM9843), Saccharomyces cerevisiae var. boulardii, and 40 mg octacosanol; n = 13) and the placebo group (n = 12). Blood samples were collected for light microscopic examination, morphometric analysis, and an automated hematology analyzer. A possible relationship between hematological parameters and body mass index (BMI), a common indicator of obesity, was investigated using Spearman correlation. The plasma concentration of soluble P-selectin and fibrinogen were determined using an ELISA assay. All measurements were performed before (T0) and after 12 weeks of supplementation (T1). Results: The three-month supplementation of probiotics improved hemoglobin levels, chromic status, and red blood cell morphology. The mean platelet volume (MPV), a measure of platelet size, was restored to normal levels, platelet morphology was improved, and the number of activated platelets was significantly reduced (p < 0.05). A strong negative correlation (r = −0.5904, p < 0.05) was found between BMI and platelet distribution width (PDW), a measure of variation in platelet size and shape. Conclusions: The results show that the probiotic approach improves morphology and normalizes the values of disturbed hematological parameters of RBCs and platelets in obese women. Full article
(This article belongs to the Special Issue Dysbiosis and Metabolic Disorders of the Microbiota)
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