Mechanisms and Prevention in Steatotic Liver Disease
A Special Issue of Metabolites (ISSN 2218-1989) belonging to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 20 February 2027 | Viewed by 872
Editor
Interests: steatotic liver disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Steatotic liver disease (SLD) has rapidly evolved into a critical global health menace. Its impact extends far beyond the liver, representing a systemic condition that significantly increases the risk of progressive hepatic damage and multi-organ comorbidities, most notably cardiovascular disease. Despite its rising prevalence, the precise molecular triggers that govern the transition from simple steatosis to advanced disease remain partially obscured. To establish robust preventive and therapeutic strategies, there is an urgent need to clarify the fundamental pathogenic mechanisms that drive this progression.
This Special Issue focuses on the diverse array of metabolites that serve as central orchestrators of liver inflammation and fibrosis—the two pivotal hallmarks of SLD progression. We seek to explore how dietary nutrients, systemic metabolic dysfunction, and the gut-liver axis converge to produce bioactive molecules that dictate cellular behavior.
We specifically invite research that elucidates the roles of key pathogenic players, including but not limited to: Pro-inflammatory Drivers: Palmitate, succinate, free cholesterol, and gut-derived lipopolysaccharides (LPS). Fibrotic Catalysts: Succinate, lactate, and advanced glycation end-products (AGEs).
While the primary focus is on the metabolites themselves, we also welcome work that explores how these molecules influence downstream cellular responses, including the modulation of signaling cascades and associated changes in gene expression. By centering on these metabolic "messengers," we aim to bridge the gap between systemic metabolic health and localized tissue injury.
We invite the submission of original research articles, systematic reviews, and clinical trials that provide novel insights into these metabolic drivers. Contributions that offer potential therapeutic targets or innovative diagnostic approaches based on the hepatic metabolome are particularly encouraged.
Dr. Nobuyuki Toshikuni
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- steatotic liver disease
- hepatocyte inflammation
- liver fibrogenesis
- gut-liver axis metabolites
- lipotoxicity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
