Metabolomics: Evaluating the Metabolic Profile of Biological Samples

Dear Colleagues,

Metabolic profiling of biological samples has become a central approach in contemporary biomedical and environmental research. By capturing coordinated changes in low-molecular-weight metabolites, metabolomics enables the evaluation of biochemical phenotypes in cells, tissues, and biofluids, providing biologically relevant information that bridges molecular perturbations and functional outcomes related to physiological regulation, environmental exposure, and disease-associated processes.

This article collection is dedicated to original research and critical reviews that apply metabolomics to the evaluation and interpretation of metabolic profiles of biological samples analyzed within experimental and clinical contexts. Emphasis is placed on studies that move beyond descriptive profiling to provide biological insight, comparative analysis across conditions, and mechanistic understanding.

Contributions addressing exposure- and disease-related metabolic signatures, mechanisms of toxicity, nutrition–health interactions, and human biomonitoring are particularly encouraged. The integration of metabolic profiling with advanced biological models, complementary omics approaches, and translational strategies is also within the scope of this collection.

By reinforcing the central role of biological samples in metabolomics research, this collection aims to support a more integrative and human-based use of metabolomics, strengthening its relevance for health-related research, risk assessment, and decision-making in complex biological systems.

Dr. Ana Margarida Araújo
Dr. Marcel Kwiatkowski
Topic Editors