Effects of Exercise and Lifestyle on Cardiometabolic Health
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".
Deadline for manuscript submissions: 25 February 2027 | Viewed by 336
Editors
Interests: cardiovascular-kidney-metabolic (CKM) syndrome; precision lifestyle medicine; stage-specific exercise prescription; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic and multi-omic responses to exercise (HIIT, MICT, RT); digital health and AI in cardiometabolic health; health disparities in CKM; exercise hemodynamics; network physiology; network system dynamics; lifestyle medicine; adherence science; digital health and AI-assisted lifestyle medicine; renal lipid metabolism and fatty-acid oxidation; exerkines and inter-organ crosstalk; high-intensity interval training; moderate-intensity continuous training; resistance training; endothelial function and arterial stiffness
Special Issues, Collections and Topics in MDPI journals
Interests: exercise physiology; obesity; aging; rehabilitation; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular–Kidney–Metabolic (CKM) syndrome is a progressive multisystem disorder rooted in chronic metabolic dysregulation. Staging from 0 to 4 offers a clinical rubric, yet pathogenesis is driven by insulin resistance, adipose dysfunction, low-grade inflammation, and impaired endothelial signaling. The liver occupies a central position, with metabolic dysfunction-associated steatotic liver disease (MASLD) acting as a driver and amplifier across the cardiorenal–liver–metabolic axis.
Despite the metabolic etiology, care remains fragmented and medication-centric. Exercise and Lifestyle Medicine provide pleiotropic, disease-modifying effects that target root perturbations, but clinical deployment lacks phenotype-specific precision. The field needs mechanistic studies that connect modality, dose, and timing to metabolite profiles, pathway activity, and inter-organ crosstalk across CKM stages.
This Special Issue seeks original investigations, reviews, and methods papers that examine the effects of exercise and lifestyle on cardiometabolic health through a metabolic lens. Priority topics include:
- Modality-specific effects of moderate-intensity continuous training, high-intensity interval training, resistance training, or combined programs on metabolic pathways and biomarkers, including exerkines, hepatic lipids, inflammatory mediators, mitochondrial function, and endothelial function in CKM and MASLD.
- Targeted, untargeted, and multi-omic approaches that stratify responders and personalize exercise and lifestyle prescriptions for CKM prevention or management.
- Exercise-mediated modulation of MASLD and its links to the cardiorenal-liver-metabolic axis.
- Randomized and pragmatic trials comparing exercise modalities and doses on glycemic control, insulin resistance, atherogenic dyslipidemia, and vascular health in CKM populations.
- Synergistic effects of exercise combined with contemporary pharmacotherapies, including SGLT2 inhibitors and GLP-1 receptor agonists.
- Methodological advances for acquiring, processing, and harmonizing metabolite end points, including quality control, batch correction, and reporting standards.
The aim is to build a robust evidence base that positions exercise and lifestyle as cornerstone therapy for the metabolic drivers of CKM syndrome.
Dr. Zacharias Papadakis
Prof. Dr. Alice S. Ryan
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiovascular–kidney–metabolic (CKM) syndrome
- lifestyle medicine
- exercise prescription
- metabolic perturbations
- metabolites
- metabolomics
- high-intensity interval training (HIIT)
- moderate-intensity continuous training (MICT)
- resistance training (RT)
- metabolic dysfunction-associated steatotic liver disease (MASLD)
- insulin resistance
- exerkines
- mitochondrial function
- cardiometabolic health
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