Biomarkers in Obesity, Metabolic Syndrome, and Weight Loss: Advances in Diagnosis, Risk Stratification, and Personalized Management

Dear Colleagues,

Obesity and metabolic syndrome are complex and multifactorial conditions that represent major global public health challenges. Early identification of individuals at risk and the development of effective, personalized management strategies remain key priorities in clinical and translational research.

In recent years, biomarkers have emerged as valuable tools for improving the diagnosis and characterization of obesity-related metabolic disturbances. Advances in molecular biology, metabolomics, genomics, and clinical research have enabled the identification of novel biomarkers reflecting adipose tissue dysfunction, systemic inflammation, insulin resistance, oxidative stress, and altered metabolic pathways. These biomarkers may support early detection of metabolic abnormalities, improve risk stratification, and provide important insights into disease progression.

At the same time, growing evidence highlights the central role of nutrition and dietary patterns in the development, prevention, and management of obesity and metabolic syndrome. Healthy dietary approaches have been shown to influence metabolic regulation, inflammatory processes, gut microbiota composition, and energy homeostasis. Nutritional interventions may therefore significantly affect biomarker profiles associated with metabolic health and weight loss outcomes.

Understanding the interaction between dietary factors, metabolic pathways, and biomarker responses may contribute to the development of more effective and personalized nutritional strategies. Biomarkers may help identify individuals who are more likely to benefit from specific dietary interventions, monitor adherence to healthy dietary patterns, and evaluate metabolic responses to weight loss programs.

This Special Issue aims to highlight advances in the application of biomarkers related to obesity, metabolic syndrome, and weight loss, with particular attention to their relationship with nutrition and lifestyle interventions. We welcome original research articles, reviews, and meta-analyses focusing on molecular, biochemical, anthropometric, and clinical biomarkers that contribute to improved diagnosis, risk prediction, and personalized management of obesity and metabolic syndrome. Studies exploring biomarkers associated with dietary patterns, functional foods, and lifestyle modification are also encouraged.

Dr. Martina Gažarová
Dr. Petra Lenártová
Dr. Magdalena Górnicka
Guest Editors

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