The Role of Lipid Metabolism in Health and Disease
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 54
Special Issue Editor
Interests: lipidomics; metabolomics; bile acids; mass spectrometry; liquid chromatography; gas chromatography; pediatric metabolic disorders; statistics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipids are vital to human health, functioning as structural components of cellular membranes, reservoirs of metabolic energy, and modulators of signaling pathways that govern key physiological processes. Their roles in apoptosis, inflammation, immune regulation, and cellular stress responses highlight their importance in maintaining systemic homeostasis. Disruptions in lipid metabolism—whether due to genetic mutations, environmental exposures, or lifestyle factors—are increasingly recognized as contributors to a wide range of diseases, including metabolic, cardiovascular, hepatic, neurological, and immune-related conditions.
The global rise in metabolic disorders such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease underscores the need for a deeper understanding of lipid biology in both health and disease. At the same time, rare and complex lipid-related disorders are gaining visibility thanks to advances in lipidomic technologies. High-resolution mass spectrometry and integrative omics approaches are enabling the precise characterization of lipid species and their dynamic roles in pathophysiology, offering new opportunities for biomarker discovery and therapeutic innovation.
This Special Issue, “The Role of Lipid Metabolism in Health and Disease,” invites original research articles, reviews, and perspectives that explore the multifaceted roles of lipids in human biology and pathology. We welcome contributions from basic, translational, and clinical research domains with a focus on how lipid metabolism influences disease mechanisms, diagnostics, and treatment strategies. Topics of interest include, but are not limited to, the following:
- Lipidomic profiling in health and disease;
- Mechanistic insights into lipid metabolism and its dysregulation;
- Lipid-based biomarkers for disease risk, progression, and therapeutic response;
- The role of lipids in inflammation, immunity, and cellular stress;
- Lipid metabolism in rare and complex disorders;
- Integrative approaches combining lipidomics with genomics, proteomics, and metabolomics;
- Translational applications of lipid research in clinical practice and public health.
Through this Special Issue, we aim to highlight the central role of lipid metabolism in human health and disease, and to foster interdisciplinary collaboration that drives innovation in diagnostics, therapeutics, and preventive medicine.
Dr. Mónica Narváez-Rivas
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipid metabolism
- lipidomics
- dyslipidemia
- mass spectrometry
- lipid biomarkers
- lipid signaling
- therapeutic targets
- bioinformatics
- clinical lipidomics
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