2025 July - 74 articles
Immunoassays relying on highly specific antigen–antibody recognition are important tools for effectively measuring the levels of various targets. Efforts have been made in the development of various methods to improve the detection sensitivity...
Food safety plays an important and fundamental role, primarily for human health and certainly for the food industry. In this context, developing efficient, highly sensitive, safe, inexpensive, and fast analytical methods for determining chemical and...
Efficient and rapid detection of bacterial pathogens is crucial for food safety and effective disease control. While conventional methods such as PCR and ELISA are accurate, they are time-consuming, costly, and often require specialized infrastructur...
Liquid metals (LMs), with their unique combination of high electrical conductivity and mechanical deformability, have emerged as promising materials for stretchable electronics and biointerfaces. However, the practical application of bulk LMs in wear...
Early diagnosis of Alzheimer’s disease (AD) is essential for effective treatment; however current diagnostic methods are often complex, costly, and unsuitable for point-of-care testing. Graphene-based biosensors offer an alternative due to thei...
Salmonella is a rapidly spreading and widespread zoonotic infectious disease that poses a serious threat to the safety of both poultry and human lives. Therefore, the timely detection of Salmonella in foods and animals has become an urgent need for f...
In recent decades, flexible electronics have witnessed remarkable advancements in multiple fields, encompassing wearable electronics, human–machine interfaces (HMI), clinical diagnosis, and treatment, etc. Nevertheless, conventional rigid elect...
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Biosensors play a central role in the early detection of abnormal glucose levels in individuals with diabetes; therefore, the development of less invasive systems is essential. Herein, a 3D-printed colorimetric biosensor combining microneedles and ch...
The rapid and accurate detection of pathogenic bacteria and viruses is critical for infectious disease control and public health protection. While conventional methods (e.g., culture, microscopy, serology, and PCR) are widely used, they are often lim...
We present a miniaturized, inexpensive, and user-friendly microfluidic platform to support biological applications. The system integrates a mini-incubator providing controlled environmental conditions and housing a microfluidic device for long-term c...
Highly infectious and pathogenic viruses seriously threaten global public health, underscoring the need for rapid and accurate diagnostic methods to effectively manage and control outbreaks. In this study, we developed a comprehensive Surface-Enhance...
The organic volatile compound gases (VOCs) emitted by the rubber running tracks in the park pose a threat to human health. Currently, the challenge lies in how to detect the VOC gas concentration to ensure it is below the level that is harmful to hum...
Artificial insemination (AI) is a key breeding technique in the swine industry; however, the lack of reliable biomarkers for semen quality limits its effectiveness. Seminal plasma (SP) contains extracellular vesicles (EVs) that present a promising, n...
Nanomotion sensors have emerged as a pivotal technology in microbiology and biology, leveraging advances in nanotechnology, microelectronics, and optics to provide a highly sensitive, label-free detection of biological activity and interactions. Thes...
A novel nanomaterial photoelectrochemical aptamer sensor based on CdS@NiMoS heterojunction nanocomposites was constructed for highly sensitive detection of chloramphenicol (CAP) in antibiotic residues. Through optimization of the material synthesis p...
Dengue virus (DENV) poses a major global health concern, with over 6.5 million cases and 7300 deaths reported in 2023. Accurate serological assays are essential for tracking infection history, evaluating disease severity, and guiding vaccination stra...
Förster resonance energy transfer (FRET)-based biosensors are versatile tools for obtaining insights into various biological processes. Their working principles are based on nonradiative energy transfer from donor to acceptor fluorophores. This...
The increasing prevalence of diabetes mellitus necessitates the development of advanced glucose-monitoring systems that are non-invasive, reliable, and capable of real-time analysis. Wearable electrochemical biosensors have emerged as promising tools...
In ecotoxicological risk assessment, current methods for measuring the transfer and bioavailability of organic pollutants like polycyclic aromatic hydrocarbons (PAHs) in bioindicators are often destructive and environmentally unfriendly. These limita...
In this paper, we present the development of a new semi-distributed interferometer (SDI) biosensor with a Zn, Cu, and Co metal oxide nanopowder coating for the detection of a kidney disease biomarker as a model system. The combination of nanopowder c...
Shaking off the forgetfulness towards the methodological power of inosine-mediated error-prone PCR (epPCR), this study reintroduces an often-underappreciated method as a considerably powerful approach for generating aptamer libraries from a single de...
In clinical applications of surface-enhanced Raman spectroscopy (SERS) immunosensors, accurately determining analyte biomarker concentrations is essential. This study presents a non-invasive approach for quantifying various breast cancer biomarkers&m...
A fluorescent sandwich assay was devised to quantify CK-MB. In a typical immunoassay, antibodies bind to the target, and the detected signal is quantified according to the target’s concentration. We innovated a unique fluorescence assay known a...
Chronic kidney disease (CKD) is associated with heart failure and neurological disorders. Therefore, point-of-care (POC) detection of CKD is essential, allowing disease monitoring from home and alleviating healthcare professionals’ workload. La...
Indoleamine 2,3-dioxygenase 1 (IDO-1) and interferon-gamma (IFN-γ) are proteins that play a significant role in inflammatory conditions and tumor development. The detection of IDO1 and IFN-γ is crucial for understanding their interplay in...
The escalating threat of infectious diseases necessitates the development of diagnostic technologies that are not only rapid and sensitive but also deployable at the point of care. Electrochemical impedance spectroscopy (EIS) has emerged as a leading...
Background: Early identification of left ventricular ejection fraction (LVEF) levels during the progression of hypertension is essential to prevent cardiac deterioration. However, achieving a non-invasive, cost-effective, and definitive assessment is...
The non-monotonic behavior of amperometric enzyme-based biosensors under uncompetitive and noncompetitive (mixed) substrate inhibition is investigated computationally using a two-compartment model consisting of an enzyme layer and an outer diffusion...
Electroanalysis of monoamine neurotransmitters is a useful tool for monitoring relevant neurodegenerative disorders and diseases. Electroanalysis of neurotransmitters using analytical devices consisting of electrodes modified with tailored and nanost...
Endothelial dysfunction appears early in type 1 diabetes (T1D). The detection of the first vascular disturbances in T1D patients is crucial, and the introduction of novel techniques, such as flow-mediated skin fluorescence (FMSF) and adaptive optics...
Heavy metal ions pose a significant threat to the environment and human health due to their high toxicity and bioaccumulation. Traditional instrumentations, although sensitive, are often complex, costly, and unsuitable for on-site rapid detection of...
Metal–organic framework (MOF)-based nanozymes represent a groundbreaking frontier in advanced microbial biosensing, offering unparalleled catalytic precision and structural tunability to mimic natural enzymes with superior stability and specifi...
The COVID-19 pandemic and recent viral outbreaks have highlighted the need for viral diagnostics that balance accuracy with accessibility. While traditional laboratory methods remain essential, point-of-care solutions are critical for decentralized t...
Nanozymes constitute a rapidly advancing frontier in scientific research, attracting widespread international interest, particularly for their role in facilitating cascade reactions. Despite their initial discovery a few years ago, significant hurdle...
Accurate and sensitive detection of protein biomarkers is critical for advancing in vitro diagnostics (IVD), yet conventional enzyme-linked immunosorbent assays (ELISA) often fall short in terms of sensitivity compared to nucleic acid-based tests. Br...
Diuron (DU) is a widely used phenylurea herbicide designed to inhibit weed growth, but its high toxicity and prolonged half-life contribute significantly to environmental contamination. The majority of electrochemical (EC) sensors typically rely on a...
Canine distemper, a fatal and highly transmissible disease caused by the canine distemper virus (CDV), poses a major threat to the companion animal industry. An urgent need exists for a rapid, specific, and simple method for the detection of this dis...
Celiac disease (CD), a human leukocyte antigen-associated disorder, is caused by gluten sensitivity and is characterized by mucosal alterations in the small intestine. Currently, its diagnosis involves the determination of serological markers. The tr...
The engineering of proteins, nucleic acids, and nanomaterials has significantly advanced the development of biosensors for the monitoring of rare diseases. These innovative biosensing technologies facilitate the early detection and management of cond...
Ketones, which are key biomarkers of fat oxidation, are relevant for metabolic health maintenance and disease development, making continuous monitoring essential. In this study, we introduce a novel colorimetric sensor designed for potential continuo...
An electrochemical immunosensor for the quantification of prostate-specific antigens (PSAs) using silver nanocrystals (AgNCs) is reported. The silver nanocrystals were synthesized using a conventional citrate reduction protocol. The silver nanocrysta...
The possibility of tightly controlling the cellular microenvironment within microfluidic devices represents an important step toward precision analysis of cellular phenotypes in vitro. Microfluidic platforms that allow both long-term mammalian cell c...
MXenes are a class of two-dimensional materials exhibiting excellent surface-enhanced Raman scattering (SERS) performance. Currently, the SERS studies of MXenes have been primarily focused on those with M2X and M3X2 structural motifs. In order to exp...
In the pharmaceutical field, lipid-based nanoparticles are extensively used for drug or vaccine delivery, particularly for treating respiratory disorders. However, their physico-chemical instability, particularly associated with lipid degradation thr...
The rapid advancement of flexible sensor technology has profoundly transformed neural interface research, enabling multimodal information acquisition, real-time neurochemical and electrophysiological signal monitoring, and adaptive closed-loop regula...
Photoplethysmography (PPG) is a widely adopted optical technique for cardiovascular monitoring, but its accuracy is often compromised by skin pigmentation, which attenuates the signal in individuals with darker skin tones. This research addresses the...
Point-of-care testing (POCT) offers a transformative approach to diagnostics by enabling rapid and accurate results at or near the site of patient care. This is especially valuable in critical care, emergency settings, and resource-limited areas. How...
Salivary
Salivary cortisol is widely used to assess stress and circadian rhythms, yet its control variables in neonates, particularly regarding postnatal age, remain poorly understood. To elucidate age-specific effects of clinical variables on cortisol levels...
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