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Biosensors
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Biosensors Based on Self-Assembly and Boronate Affinity Interaction
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Biosensors Based on Self-Assembly and Boronate Affinity Interaction

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 12452

Special Issue Editor

Dr. Lin Liu

E-Mail Website
Guest Editor
Henan Province of Key Laboratory of New Optoelectronic Functional Materials, Anyang Normal University, Anyang, China
Interests: biosensors; electrocatalysts; self-assembly; metal–peptide complexes; nanomaterials; signal amplification
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors show promising prospects in the assays of various targets due to their advantages of high sensitivity, good selectivity and rapid response. Self-assembled nanomaterials have witnessed tremendous progress in a variety of biosensing and biomedical applications due to their intriguing characteristics, such as facile processability, structure tailoring and excellent biocompatibility. Molecular recognition is a key event of biosensors. Boronic acid-based materials have been widely used as synthetic receptors for the specific recognition and detection of cis-diol-containing species. Contributions to this Special Issue should cover the advances in biosensors based on self-assembly and/or boronate affinity interaction. The analytes include small molecules, nucleic acids, proteins, enzymes, exosomes, virus and cells.

Dr. Lin Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • self-assembly
  • molecular recognition
  • boronate affinity
  • metal–organic frameworks
  • covalent organic frameworks
  • hydrogen-bonded organic frameworks
  • organic nanocrystals
  • aggregation-induced emission

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Published Papers (5 papers)

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Review

20 pages, 5748 KiB  
Review
Nanolabels Prepared by the Entrapment or Self-Assembly of Signaling Molecules for Colorimetric and Fluorescent Immunoassays
by Ning Xia, Yadi Li, Cancan He and Dehua Deng
Biosensors 2024, 14(12), 597; https://doi.org/10.3390/bios14120597 - 6 Dec 2024
Cited by 1 | Viewed by 930
Abstract
Nanomaterials have attracted significant attention as signal reporters for immunoassays. They can directly generate detectable signals or release a large number of signaling elements for readout. Among various nanolabels, nanomaterials composed of multiple signaling molecules have shown great potential in immunoassays. Generally, signaling [...] Read more.
Nanomaterials have attracted significant attention as signal reporters for immunoassays. They can directly generate detectable signals or release a large number of signaling elements for readout. Among various nanolabels, nanomaterials composed of multiple signaling molecules have shown great potential in immunoassays. Generally, signaling molecules can be entrapped in nanocontainers or self-assemble into nanostructures for signal amplification. In this review, we summarize the advances of signaling molecules-entrapped or assembled nanomaterials for colorimetric and fluorescence immunoassays. The nanocontainers cover liposomes, polymers, mesoporous silica, metal–organic frameworks (MOFs), various nanosheets, nanoflowers or nanocages, etc. Signaling molecules mainly refer to visible and/or fluorescent organic dyes. The design and application of immunoassays are emphasized from the perspective of nanocontainers, analytes, and analytical performances. In addition, the future challenges and research trends for the preparation of signaling molecules-entrapped or assembled nanolabels are briefly discussed. Full article
(This article belongs to the Special Issue Biosensors Based on Self-Assembly and Boronate Affinity Interaction)
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Graphical abstract

23 pages, 9012 KiB  
Review
Overview of Gas-Generating-Reaction-Based Immunoassays
by Zhao-Jiang Yu, De-Hua Deng, Si-Rui Liang, Ya-Liang Huang and Xin-Yao Yi
Biosensors 2024, 14(12), 580; https://doi.org/10.3390/bios14120580 - 28 Nov 2024
Viewed by 835
Abstract
Point-of-care (POC) immunoassays have become convincing alternatives to traditional immunosensing methods for the sensitive and real-time detection of targets. Immunoassays based on gas-generating reactions were recently developed and have been used in various fields due to their advantages, such as rapid measurement, direct [...] Read more.
Point-of-care (POC) immunoassays have become convincing alternatives to traditional immunosensing methods for the sensitive and real-time detection of targets. Immunoassays based on gas-generating reactions were recently developed and have been used in various fields due to their advantages, such as rapid measurement, direct reading, simple operation, and low cost. Enzymes or nanoparticles modified with antibodies can effectively catalyze gas-generating reactions and convert immunorecognition events into gas pressure signals, which can be easily recorded by multifunctional portable devices. This article summarizes the advances in gas-generating-reaction-based immunoassays, according to different types of signal output systems, including distance-based readout, pressure differential, visualized detection, and thermal measurement. The review mainly focuses on the role of photothermal materials and the working principle of immunoassays. In addition, the challenges and prospects for the future development of gas-generating-reaction-based immunoassays are briefly discussed. Full article
(This article belongs to the Special Issue Biosensors Based on Self-Assembly and Boronate Affinity Interaction)
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Graphical abstract

34 pages, 10921 KiB  
Review
Progress in Electrochemical Immunosensors with Alkaline Phosphatase as the Signal Label
by Changdong Chen, Ming La, Xinyao Yi, Mengjie Huang, Ning Xia and Yanbiao Zhou
Biosensors 2023, 13(9), 855; https://doi.org/10.3390/bios13090855 - 29 Aug 2023
Cited by 6 | Viewed by 2486
Abstract
Electrochemical immunosensors have shown great potential in clinical diagnosis, food safety, environmental protection, and other fields. The feasible and innovative combination of enzyme catalysis and other signal-amplified elements has yielded exciting progress in the development of electrochemical immunosensors. Alkaline phosphatase (ALP) is one [...] Read more.
Electrochemical immunosensors have shown great potential in clinical diagnosis, food safety, environmental protection, and other fields. The feasible and innovative combination of enzyme catalysis and other signal-amplified elements has yielded exciting progress in the development of electrochemical immunosensors. Alkaline phosphatase (ALP) is one of the most popularly used enzyme reporters in bioassays. It has been widely utilized to design electrochemical immunosensors owing to its significant advantages (e.g., high catalytic activity, high turnover number, and excellent substrate specificity). In this work, we summarized the achievements of electrochemical immunosensors with ALP as the signal reporter. We mainly focused on detection principles and signal amplification strategies and briefly discussed the challenges regarding how to further improve the performance of ALP-based immunoassays. Full article
(This article belongs to the Special Issue Biosensors Based on Self-Assembly and Boronate Affinity Interaction)
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Figure 1

35 pages, 8869 KiB  
Review
Biosensors with Boronic Acid-Based Materials as the Recognition Elements and Signal Labels
by Lin Liu, Xiaohua Ma, Yong Chang, Hang Guo and Wenqing Wang
Biosensors 2023, 13(8), 785; https://doi.org/10.3390/bios13080785 - 3 Aug 2023
Cited by 20 | Viewed by 4590
Abstract
It is of great importance to have sensitive and accurate detection of cis-diol-containing biologically related substances because of their important functions in the research fields of metabolomics, glycomics, and proteomics. Boronic acids can specifically and reversibly interact with 1,2- or 1,3-diols to [...] Read more.
It is of great importance to have sensitive and accurate detection of cis-diol-containing biologically related substances because of their important functions in the research fields of metabolomics, glycomics, and proteomics. Boronic acids can specifically and reversibly interact with 1,2- or 1,3-diols to form five or six cyclic esters. Based on this unique property, boronic acid-based materials have been used as synthetic receptors for the specific recognition and detection of cis-diol-containing species. This review critically summarizes the recent advances with boronic acid-based materials as recognition elements and signal labels for the detection of cis-diol-containing biological species, including ribonucleic acids, glycans, glycoproteins, bacteria, exosomes, and tumor cells. We also address the challenges and future perspectives for developing versatile boronic acid-based materials with various promising applications. Full article
(This article belongs to the Special Issue Biosensors Based on Self-Assembly and Boronate Affinity Interaction)
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Figure 1

30 pages, 7668 KiB  
Review
Advancements in Biosensors Based on the Assembles of Small Organic Molecules and Peptides
by Dehua Deng, Yong Chang, Wenjing Liu, Mingwei Ren, Ning Xia and Yuanqiang Hao
Biosensors 2023, 13(8), 773; https://doi.org/10.3390/bios13080773 - 29 Jul 2023
Cited by 11 | Viewed by 3163
Abstract
Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures of small organic molecules and peptides with intriguing characteristics (e.g., structure tailoring, facile processability, and excellent biocompatibility) have shown outstanding [...] Read more.
Over the past few decades, molecular self-assembly has witnessed tremendous progress in a variety of biosensing and biomedical applications. In particular, self-assembled nanostructures of small organic molecules and peptides with intriguing characteristics (e.g., structure tailoring, facile processability, and excellent biocompatibility) have shown outstanding potential in the development of various biosensors. In this review, we introduced the unique properties of self-assembled nanostructures with small organic molecules and peptides for biosensing applications. We first discussed the applications of such nanostructures in electrochemical biosensors as electrode supports for enzymes and cells and as signal labels with a large number of electroactive units for signal amplification. Secondly, the utilization of fluorescent nanomaterials by self-assembled dyes or peptides was introduced. Thereinto, typical examples based on target-responsive aggregation-induced emission and decomposition-induced fluorescent enhancement were discussed. Finally, the applications of self-assembled nanomaterials in the colorimetric assays were summarized. We also briefly addressed the challenges and future prospects of biosensors based on self-assembled nanostructures. Full article
(This article belongs to the Special Issue Biosensors Based on Self-Assembly and Boronate Affinity Interaction)
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