Surface-Enhanced Raman Scattering in Biosensing Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2922

Special Issue Editors


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Guest Editor
Laboratory for Molecular Physics and Synthesis of New Materials, Division of Materials Physics, Ruđer Bošković Institute, Bijenička Cesta 54, 10 000 Zagreb, Croatia
Interests: SERS solid substrates fabrication; SERS applications; low-pressure chemical vapor deposition; nanomaterials; Si nanotrees

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Guest Editor
School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Interests: chromatographic analysis; surface-enhanced Raman spectroscopy; development of functional separation media, food and drug analysis
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Special Issue Information

Dear Colleagues,

The main features of surface-enhanced Raman spectroscopy (SERS) are ultra-high sensitivity, molecular specificity, short measuring time, low cost and wide range applications. In the last few decades, the development of high-quality and affordable SERS substrates has been accompanied by an increase in the number of applications and a similar growth trend is expected until 2030 and beyond. SERS currently finds the largest number of applications in medical research and pharmacy. However, areas of application for which accelerated development is expected are food safety and environmental protection.

This Special Issue aims to provide an overview of research that includes SERS analysis of biomolecules examined in the aforementioned research areas and wider. Biomolecules can be investigated on standard or innovative SERS substrates following direct or indirect approach methods. Papers including a portable Raman spectrometer system for accurate on-site diagnostics of bio-analytes are encouraged.

The topics of the Special Issue "Surface-Enhanced Raman Scattering in Biosensing Applications" include, but are not limited to:

  1. Novel SERS substrates for biosensing applications;
  2. SERS analysis of environmental hazards;
  3. Food safety: SERS characterization of food and drink pathogens;
  4. SERS novelties in bio-medical applications;
  5. Advanced portable biosensors.

Dr. Hrvoje Gebavi
Prof. Dr. Yuling Hu
Guest Editors

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Keywords

  • SERS substrate development
  • SERS for biosensing applications
  • food contaminant detection
  • environmental pollution control
  • machine learning (SERS)
  • SERS sensors
  • quantitative SERS methods
  • biohazardous molecules
  • forensic substances

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Published Papers (1 paper)

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Research

19 pages, 10129 KiB  
Article
Binding of Glutamic Acid to Silver and Gold Nanoparticles Investigated by Surface-Enhanced Raman Spectroscopy
by Vlasta Mohaček-Grošev, Marko Škrabić, Hrvoje Gebavi, Vesna Blažek Bregović, Ivan Marić, Vincenzo Amendola and Jože Grdadolnik
Biosensors 2024, 14(11), 522; https://doi.org/10.3390/bios14110522 - 25 Oct 2024
Viewed by 2527
Abstract
Glutamate is the most important excitatory neurotransmitter, which is relevant for the study of several diseases such as amyotrophic lateral sclerosis and Alzheimer. It is the form L-glutamic acid (Glu) takes at physiologically relevant pHs. The surface-enhanced Raman spectra of Glu obtained at [...] Read more.
Glutamate is the most important excitatory neurotransmitter, which is relevant for the study of several diseases such as amyotrophic lateral sclerosis and Alzheimer. It is the form L-glutamic acid (Glu) takes at physiologically relevant pHs. The surface-enhanced Raman spectra of Glu obtained at pH values ranging from 3.3 to 12 are collected in the presence of silver and gold colloids and on solid substrates. The observed bands are compared with the positions of calculated normal modes for free neutral glutamic acid, glutamic acid monohydrate, glutamic acid bound to gold and silver atoms, and sodium glutamate. Although gold atoms prefer to bind to the NH2 group as compared to carbonyl groups, silver atoms prefer binding to hydroxyl groups more than binding to the amino group. SERS spectra of glutamic acid solutions with a pH value of 12, in which both carboxylic groups are deprotonated, indicate a complexation of the glutamic acid dianion with the sodium cation, which was introduced into the solution to adjust the pH value. Further research towards an optimal substrate is needed. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering in Biosensing Applications)
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