Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.8
5.6
Journals
Biosensors
Special Issues
Nanotechnology Biosensing in Bioanalysis and Beyond
share announcement

Nanotechnology Biosensing in Bioanalysis and Beyond

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 1 December 2026 | Viewed by 4896

Special Issue Editors

Dr. Yao Ni

E-Mail Website
Guest Editor
School of Integrated Circuits, Guangdong University of Technology, Guangzhou 510006, China
Interests: artificial neural device; artificial neural network architecture; bionic human-machine interface
Special Issues, Collections and Topics in MDPI journals
Dr. Silu Feng

E-Mail Website
Guest Editor
School of Integrated Circuits, Guangdong University of Technology, Panyu District, Guangzhou 510006, China
Interests: micro- and nanofabrication methods and applications; MEMS optical biosensors
Dr. Lu Liu

E-Mail
Guest Editor
School of Material Science and Engineering, University of Jinan, Jinan 250022, China
Interests: neuromorphic electronic devices; functional nanomaterials; artificial nerve

Special Issue Information

Dear Colleagues,

Nanotechnology has significantly advanced the field of biosensing, enabling the detection and analysis of biological and chemical analytes with unprecedented sensitivity, specificity, and speed. The integration of nanoscale materials—such as nanoparticles, nanotubes, nanowires, and nanopores—into biosensing platforms has opened new avenues in bioanalysis, clinical diagnostics, environmental monitoring, food safety, and beyond. This Special Issue seeks to explore recent developments in and innovative applications of nanotechnology-based biosensors, highlighting their transformative potential across diverse analytical fields.

We invite submissions addressing novel nanomaterials and fabrication strategies, improvements in sensor performance (e.g., sensitivity, selectivity, stability, reproducibility), innovative bio-recognition elements (e.g., aptamers, antibodies, enzymes), and emerging signal transduction mechanisms (electrochemical, optical, mechanical, magnetic, and others). Additionally, manuscripts exploring the translation of nanobiosensors from the laboratory to real-world applications, including point-of-care diagnostics, wearable biosensors, environmental sensing, and food quality assessment, are particularly encouraged.

By showcasing interdisciplinary research at the intersection of nanotechnology and biosensing, this Special Issue aims to provide an authoritative platform for researchers and practitioners, fostering collaborations and inspiring future innovations. Submissions should emphasize clear demonstrations of nanotechnological advantages and address current limitations, providing insights into future opportunities in biosensing technologies.

Dr. Yao Ni
Dr. Silu Feng
Dr. Lu Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotechnology
  • biosensors
  • bioanalysis
  • nanomaterials
  • nanofabrication
  • sensitivity and selectivity
  • point-of-care diagnostics
  • wearable sensors
  • environmental monitoring
  • signal transduction mechanisms

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 2247 KB  
Article
Label-Free Impedimetric Biosensor Based on Molecularly Imprinted PPy/MWCNTs Nanocomposites for Sensitive and Selective Detection of Escherichia coli
by Wenbin Zhang, Ningran Wang, Tong Qi, Hebin Sun, Lijuan Liang and Jianlong Zhao
Biosensors 2026, 16(4), 210; https://doi.org/10.3390/bios16040210 - 9 Apr 2026
Viewed by 386
Abstract
Escherichia coli (E. coli) is a microorganism commonly found in water and food matrices, and its rapid and accurate detection is crucial for maintaining public health and ensuring food safety. However, traditional molecularly imprinted polymer (MIP) sensors often face challenges such [...] Read more.
Escherichia coli (E. coli) is a microorganism commonly found in water and food matrices, and its rapid and accurate detection is crucial for maintaining public health and ensuring food safety. However, traditional molecularly imprinted polymer (MIP) sensors often face challenges such as tedious template removal and prolonged sensing times. This study develops a label-free bacterial molecularly imprinted sensor that utilizes the synergistic effect of polypyrrole (PPy) and multi-walled carbon nanotubes (MWCNTs) to achieve highly sensitive detection of E. coli. Based on the large specific surface area and superior conductivity of MWCNTs, as well as the favorable electrochemical polymerization properties of PPy, a PPy/MWCNTs composite film was fabricated via a one-step electropolymerization process. The prepared sensor exhibited excellent kinetic characteristics, with a template removal time of only 15 min, and could be regenerated and used for subsequent detection within 30 min. Under optimized conditions, the biosensor showed a satisfactory linear response over the concentration range of 102–108 CFU/mL, with a low detection limit of 65 CFU/mL (3σ/S). Furthermore, recovery experiments conducted in tap water and lemon juice samples yielded satisfactory recoveries ranging from 87.1% to 114.8%, demonstrating the reliability and practical applicability of the proposed sensor for bacterial detection in real samples. This sensor offers advantages such as simple preparation, low material cost, and high sensitivity, providing a reliable and practical analytical platform for the rapid and reliable detection of bacteria. Full article
(This article belongs to the Special Issue Nanotechnology Biosensing in Bioanalysis and Beyond)
►▼ Show Figures

Graphical abstract

22 pages, 4296 KB  
Article
Development of Advanced Nanobiosensors and a Portable Monitoring System for Pesticide Detection at the Point of Need
by Evangelos Skotadis, Menelaos Tsigkourakos, Emmanouil Anthoulakis, Myrto-Kyriaki Filippidou, Sotirios Ntouskas, Maria Kainourgiaki, Charalampos Tsioustas, Chrysi Panagopoulou, Stergios Dimou-Sakellariou, Nikos Kalatzis, Eleftherios A. Petrakis, Nikolaos Alexis, George Tsekenis, Angeliki Tserepi, Stavros Chatzandroulis and Dimitris Tsoukalas
Biosensors 2026, 16(2), 109; https://doi.org/10.3390/bios16020109 - 7 Feb 2026
Viewed by 732
Abstract
This work presents the development of an automated and portable monitoring system for the point-of-need detection of tebuconazole and lambda-cyhalothrin. The system features nanoparticle/aptamer-modified electrochemical sensors that are integrated into a microfluidic chip based on polydimethylsiloxane (PDMS). More specifically, rapid and selective detection [...] Read more.
This work presents the development of an automated and portable monitoring system for the point-of-need detection of tebuconazole and lambda-cyhalothrin. The system features nanoparticle/aptamer-modified electrochemical sensors that are integrated into a microfluidic chip based on polydimethylsiloxane (PDMS). More specifically, rapid and selective detection of both pesticides is achieved using target-specific aptamers immobilized on two-dimensional platinum nanoparticle films that serve as expanded nano-gapped electrodes to enhance sensor sensitivity. The effect of the device substrate (i.e., silicon versus flexible substrates) and measurement setup on biosensing performance has also been investigated. The final monitoring system is characterized by high sensitivity and selectivity in the cases of both target analytes and substrates. Τhe system features a limit of detection of 9.85 pM for tebuconazole, which is one of the lowest reported values in the literature; for lambda-cyhalothrin, it is worth noting that the results reported herein represent one of the few studies on an electrochemical aptamer-based sensor for this analyte, featuring a limit of detection of 48.5 pM. The system is also capable of selectively detecting both targets for complex cross-reactive sample matrices consisting of commercially available pesticides. Moreover, its use could be expanded to detect additional pollutants by functionalizing the biosensor surface with appropriate aptamers. Full article
(This article belongs to the Special Issue Nanotechnology Biosensing in Bioanalysis and Beyond)
►▼ Show Figures

Figure 1

23 pages, 4378 KB  
Article
Novel Nanocomposites of Carbon Nanomaterials and Poly(Neutral Red) Electropolymerized from Reline for DNA Damage Detection and Beverage Antioxidant Influence Assessment
by Anastasia Malanina, Rufiia Derbisheva, Tatiana Krasnova, Rezeda Shamagsumova, Vladimir Evtugyn, Alexey Ivanov and Anna Porfireva
Biosensors 2025, 15(11), 735; https://doi.org/10.3390/bios15110735 - 3 Nov 2025
Cited by 1 | Viewed by 778
Abstract
Novel nanocomposites based on carbon black or multi-walled carbon nanotubes functionalized with carboxylic groups and Neutral red electropolymerized from reline were obtained in a one-step protocol and used for DNA biosensor development. The synthesis was carried out in potentiodynamic mode in a deep [...] Read more.
Novel nanocomposites based on carbon black or multi-walled carbon nanotubes functionalized with carboxylic groups and Neutral red electropolymerized from reline were obtained in a one-step protocol and used for DNA biosensor development. The synthesis was carried out in potentiodynamic mode in a deep eutectic solvent reline consisting of a mixture of choline chloride and urea. The nanocomposite based on carbon black and poly(Neutral red) was applied for a voltammetric DNA biosensor developed to discriminate DNA damage. The sensor developed allowed the native, thermally denatured, and chemically oxidized DNA discrimination with either current changes or peak potential shifts. The nature of the DNA used had affected the sensor’s analytical response value. The DNA biosensor suggested was tested for the assessment of antioxidant capacity in such beverages as tea, coffee, white wine, and fruit-based drink purchased from local market. Simple, fast, and inexpensive approach of sensor modifying layer assembly would be demanded in control of food products and beverages quality, as well as for medical purposes. Full article
(This article belongs to the Special Issue Nanotechnology Biosensing in Bioanalysis and Beyond)
►▼ Show Figures

Figure 1

11 pages, 1778 KB  
Communication
Ultra-Sensitive Detection of Chloramphenicol by CdS@NiMoS Nanorods-Based Photoelectrochemical Aptasensor
by Hebin Sun, Yimeng Sun, Tong Qi, Zhenyu Wang, Jianlong Zhao and Lijuan Liang
Biosensors 2025, 15(7), 454; https://doi.org/10.3390/bios15070454 - 14 Jul 2025
Cited by 2 | Viewed by 1365
Abstract
A novel nanomaterial photoelectrochemical aptamer sensor based on CdS@NiMoS heterojunction nanocomposites was constructed for highly sensitive detection of chloramphenicol (CAP) in antibiotic residues. Through optimization of the material synthesis process, the optimal doping ratio of MoS2 to Ni3+ (70% MoS2 [...] Read more.
A novel nanomaterial photoelectrochemical aptamer sensor based on CdS@NiMoS heterojunction nanocomposites was constructed for highly sensitive detection of chloramphenicol (CAP) in antibiotic residues. Through optimization of the material synthesis process, the optimal doping ratio of MoS2 to Ni3+ (70% MoS2 and 10% Ni3+) was identified, which significantly enhanced the photogenerated carrier separation efficiency. In thin-film preparation, comparative analysis of four film-forming methods led to the determination of an optimal process with stability. To achieve highly specific CAP detection, the nanocomposite chip was integrated with nucleic acid aptamer biorecognition elements within a standard three-electrode detection system. Experimental results demonstrated a linear response (R2 = 0.998) in the 0.1–2 μM concentration range, with a detection limit of 3.69 nM (3σ/S). Full article
(This article belongs to the Special Issue Nanotechnology Biosensing in Bioanalysis and Beyond)
►▼ Show Figures

Figure 1

Review

Jump to: Research

89 pages, 6795 KB  
Review
Fungal Frontiers in (Bio)sensing
by Gerardo Grasso
Biosensors 2026, 16(2), 131; https://doi.org/10.3390/bios16020131 - 22 Feb 2026
Cited by 1 | Viewed by 987
Abstract
Filamentous fungi are increasingly recognized as versatile biological platforms for the development of advanced (bio)sensing technologies, owing to their extensive secretory capacity, material-forming ability, and intrinsic bioelectrical activity. This review critically surveys recent progress in fungal-based sensing within a multiscale framework spanning molecular, [...] Read more.
Filamentous fungi are increasingly recognized as versatile biological platforms for the development of advanced (bio)sensing technologies, owing to their extensive secretory capacity, material-forming ability, and intrinsic bioelectrical activity. This review critically surveys recent progress in fungal-based sensing within a multiscale framework spanning molecular, material, computational, and ecological domains, with particular emphasis on developments reported over the past five years. Key advances involving secretome-derived biomolecules, mycogenic nanomaterials, mycelium-based living materials, and fungal electrophysiology are discussed alongside emerging approaches for environmental monitoring that integrate sensor networks, imaging platforms, and data-driven analytics. Collectively, these works demonstrate that fungal systems can enhance biosensor sensitivity, selectivity, and sustainability, while enabling unconventional paradigms of signal transduction, material-integrated sensing, and biologically mediated computation. At larger spatial and temporal scales, mycelial growth dynamics and electrical activity provide measurable responses to mechanical, chemical, and environmental perturbations, supporting early applications in wearable devices, structural materials, and ecosystem monitoring. Despite significant progress, challenges remain in reproducibility, long-term stability, mechanistic understanding, and scalable device integration. Overall, the evidence reviewed highlights filamentous fungi as biologically adaptive and ecologically embedded systems with substantial potential to support next-generation (bio)sensing technologies, while underscoring the need for integrative approaches that combine biological insight with materials science, electronics, and artificial intelligence. Full article
(This article belongs to the Special Issue Nanotechnology Biosensing in Bioanalysis and Beyond)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop