Microfluidic Devices for Biological Sample Analysis
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 91
Special Issue Editor
Interests: microfluidics; micro- and nanofabrication technologies applied in the biomedical field
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, part of the scientific community has been moving towards the development of innovative devices for biological sample analysis, reaching unprecedented resolution and simplifying screening protocols. The detection of traces of biological species from biological samples is of extreme importance for the possible impact on human health. However, a great number of issues come into play before a biological sample may be used in routine screening procedures. The handling and analysis of complex biological samples, in which individuating a single component among a cluster of molecules is involved, is challenging and conventionally requires complicated protocols to pretreat complex samples. The analysis of biological samples is often translated into the detection of a few molecules in diluted solutions, which are invisible to the current sensors due to a limit in the resolution of analysis. Moreover, for some screening procedures, it is important to not affect the phenotype of the biological sample, especially for analysis over a long period of a specific sample (e.g., specific cell populations). Thus, it becomes important to introduce new methodologies, which are not invasive with respect to the analytes. Finally, the heterogeneity of the behavior of the human body and its response to medical treatments requires the development of tools which are compatible with personalized medicine, and this is translated to the development of devices that are portable and fast, providing, in parallel, high-throughput and high content analysis with reduced costs. It then becomes important for scientific research and clinical diagnostic applications to obtain a sequential handling and manipulation of biological samples.
Microfluidics is an interdisciplinary field that focuses on the transport, manipulation, and analysis of small amounts of liquids, cells, and particles. These devices guarantee high portability, accurate control for handling samples, simplified sample pretreatment protocols, a low consumption of samples and reagents, a high resolution of analysis, and the integration of sensors allowing for the monitoring of cells over a long period in a label-free manner, so as to not affect cell phenotype and metabolism. This might help to overcome the aforementioned issues.
The scope of the Special Issue is to gather the recent contributions from all over the world regarding research performed in the field of microfluidic devices for biological sample analysis to understand and evaluate the levels of the development, integration, and automation of these devices. The intention is to resolve certain challenges, such as the existing gap between developer technological challenges and user difficulties to integrate these devices into standard conventional biological, biotechnological, and medical procedures.
Dr. Gerardo Perozziello
Guest Editor
Manuscript Submission Information
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Keywords
- microfluidics
- optical sensors
- cell screening
- microbioreactors
- lab on a chip
- optofluidics
- plasmonics
- nanodevices
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