Novel Designs and Applications for Electrochemical Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 549

Special Issue Editors


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Guest Editor
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China
Interests: biosensors; nanotechnology and materials; drug delivery systems

Special Issue Information

Dear Colleagues,

Electrochemical biosensors have emerged as pivotal tools in the realm of analytical chemistry and biotechnology, converting biochemical interactions into measurable electrical signals, thus enabling the detection of a wide range of biological analytes, including enzymes, antibodies, nucleic acids, and small molecules. Recent advancements in materials science and engineering have spurred the development of novel designs for electrochemical biosensors, enhancing their performance and expanding their application scope. Innovations such as nanomaterials, conductive polymers, and biomimetic surfaces have improved the sensitivity and selectivity of these sensors, allowing for the detection of analytes at extremely low concentrations.

Consequently, the applications of electrochemical biosensors are both diverse and impactful. Certain nanomaterials (e.g., MOFs, COFs, LDHs, MXenes, graphene, precious metals, etc.) can change the electrochemical signal by changing electron conduction rates, thereby improving sensor sensitivity and reducing the detection limit. Upon binding with the target analyte, the electrical signal is either quenched or amplified, enabling real-time and accurate detection of the target in various environments. In clinical settings, these biosensors facilitate the rapid detection of disease biomarkers for diagnosis and monitoring (e.g., chlorpromazine hydrochloride, alkaline phosphatase, microRNA, CA-125, cTnI, etc.). In environmental contexts, they are employed to monitor pollutant levels and assess ecological health (e.g., bisphenol A, Hg²⁺, pyrethroid pesticides, organophosphates, halogenated aromatic hydrocarbons, etc.). Furthermore, electrochemical biosensors are being advanced in the field of food safety (e.g., aflatoxins, zearalenone, nitrites, etc.).

In this Special Issue 'Novel Designs and Applications for Electrochemical Biosensors', we anticipate receiving articles or reviews of manuscripts that illuminate the latest technological advancements, the underlying principles guiding their functionality, and the transformative potential that they hold across various sectors.

Dr. Defang Liu
Dr. Kevin C. Honeychurch
Guest Editors

Manuscript Submission Information

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Keywords

  • electrochemical
  • biosensors
  • electrochemical analysis
  • nanomaterial
  • electrochemiluminescence
  • immunosensor

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Published Papers (1 paper)

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Review

30 pages, 5618 KiB  
Review
High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations
by Keying Yu, Sirui Yang, Hongxu Song, Zhou Sun, Kaichao Wang, Yuqi Zhu, Chengkai Yang, Rongzhang Hao and Yuanyuan Cao
Biosensors 2025, 15(4), 242; https://doi.org/10.3390/bios15040242 - 11 Apr 2025
Viewed by 388
Abstract
Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, and increasing evidence suggests that environmental pollutants can significantly accelerate this process by interfering with oxidative stress, neuroinflammation, and mitochondrial function-related signaling pathways. Traditional studies have focused on the direct [...] Read more.
Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, and increasing evidence suggests that environmental pollutants can significantly accelerate this process by interfering with oxidative stress, neuroinflammation, and mitochondrial function-related signaling pathways. Traditional studies have focused on the direct damage of pollutants on macromolecules (e.g., proteins, DNA), while the central role of senescence-associated small molecules (e.g., ROS, PGE2, lactate) in early regulatory mechanisms has been long neglected. In this study, we innovatively proposed a cascade framework of “small molecule metabolic imbalance-signaling pathway dysregulation-macromolecule collapse”, which reveals that pollutants exacerbate the dynamics of brain aging through activation of NLRP3 inflammatory vesicles and inhibition of HIF-1α. Meanwhile, to address the technical bottleneck of small molecule spatiotemporal dynamics monitoring, this paper systematically reviews the cutting-edge detection tools such as electrochemical sensors, genetically encoded fluorescent probes and antioxidant quantum dots (AQDs). Among them, AQDs show unique advantages in real-time monitoring of ROS fluctuations and intervention of oxidative damage by virtue of their ultra-high specific surface area, controllable surface modification, and free radical scavenging ability. By integrating multimodal detection techniques and mechanism studies, this work provides a new perspective for analyzing pollutant-induced brain aging and lays a methodological foundation for early intervention strategies based on small molecule metabolic networks. Full article
(This article belongs to the Special Issue Novel Designs and Applications for Electrochemical Biosensors)
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