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Journal of Clinical Medicine, Volume 11, Issue 1

2022 January-1 - 282 articles

Cover Story: A series of global mechanisms contribute to systemic iron deficiency in heart failure and its consequences. The causes can be divided into the reduced intake, decreased absorption, and increased loss of iron. Reduced intake could be due to decreased absolute amounts of iron or low iron bioavailability. Reduced absorption is thought to be due to intestinal oedema, increased intestinal pH, increased hepcidin levels, and intestinal hypoperfusion, among others. Increased losses are mainly due to gastro-intestinal bleeding. Iron deficiency results in reduced organ function of the heart and skeletal muscles, anaemia, impaired immune responses, deranged metabolism, and kidney injury. Iron deficiency is associated with impaired exercise tolerance, increased heart failure hospitalisations, and mortality. View this paper
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Articles (282)

  • Review
  • Open Access
14 Citations
12,451 Views
12 Pages

Deep Infiltrating Endometriosis and Adenomyosis: Implications on Pregnancy and Outcome

  • Teresa Mira Gruber,
  • Laura Ortlieb,
  • Wolfgang Henrich and
  • Sylvia Mechsner

29 December 2021

Endometriosis (EM), especially deep infiltrating endometriosis (DIE) and adenomyosis (AM), are known to cause pain and sterility in young women. More recently, they have also been described as risk factors for obstetric complications. While the patho...

(This article belongs to the Special Issue Endometriosis: Current Perspectives on Diagnosis and Treatment)
  • Article
  • Open Access
9 Citations
3,562 Views
10 Pages

Detection of SARS-CoV-2 RNA in Urine by RT-LAMP: A Very Rare Finding

  • Juan García-Bernalt Diego,
  • Pedro Fernández-Soto,
  • Juan Luis Muñoz-Bellido,
  • Begoña Febrer-Sendra and ,
  • Beatriz Crego-Vicente,
  • Cristina Carbonell,
  • Amparo López-Bernús,
  • Miguel Marcos,
  • Moncef Belhassen-García and
  • Antonio Muro
  • + 5 authors+ 0 author

29 December 2021

Detection of SARS-CoV-2 is routinely performed in naso/oropharyngeal swabs samples from patients via RT-qPCR. The RT-LAMP technology has also been used for viral RNA detection in respiratory specimens with both high sensitivity and specificity. Recen...

(This article belongs to the Special Issue Epidemiology and Impact of SARS-CoV-2 Vaccines)
  • Article
  • Open Access
8 Citations
2,621 Views
7 Pages

Fecal Calprotectin Is Increased in Stroke

  • Shin Young Park,
  • Sang Pyung Lee and
  • Woo Jin Kim

29 December 2021

Background: While there have been major advances in unveiling the mechanisms comprising the ischemic cascade of CNS, stroke continues to be a significant burden. There is a need to extend the focus toward peripheral changes, and the brain–gut a...

(This article belongs to the Special Issue Role of Enzyme-Linked Immunosorbent Assay (ELISA))
  • Review
  • Open Access
33 Citations
4,239 Views
10 Pages

Overview of the Development and Use of Akt Inhibitors in Prostate Cancer

  • Anis Gasmi,
  • Guilhem Roubaud,
  • Charles Dariane,
  • Eric Barret and ,
  • Jean-Baptiste Beauval,
  • Laurent Brureau,
  • Gilles Créhange,
  • Gaëlle Fiard,
  • Gaëlle Fromont and
  • Romain Mathieu
  • + 11 authors+ 6 authors

29 December 2021

Deregulation of the PI3K-Akt-mTOR pathway plays a critical role in the development and progression of many cancers. In prostate cancer, evidence suggests that it is mainly driven by PTEN loss of function. For many years, the development of selective...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
5 Citations
2,981 Views
10 Pages

Evolution in Real-World Therapeutic Strategies for HIV Treatment: A Retrospective Study in Southern Italy, 2014–2020

  • Nunzia Papa,
  • Simona Cammarota,
  • Anna Citarella,
  • Luigi Atripaldi and ,
  • Francesca F. Bernardi,
  • Marianna Fogliasecca,
  • Nello Giugliano,
  • Ugo Trama and
  • Micaela Spatarella
  • + 4 authors+ 0 author

29 December 2021

Changes in HIV treatment guidelines over the last two decades reflect the evolving challenges in this field. Our study examined treatment change patterns throughout a 7-year period in a large Italian cohort of HIV patients as well as the reasons and...

(This article belongs to the Special Issue Clinical Research on Infectious Diseases: State of the Art)
  • Article
  • Open Access
8 Citations
4,212 Views
13 Pages

Recovery Profiles of Sevoflurane and Desflurane with or without M-Entropy Guidance in Obese Patients: A Randomized Controlled Trial

  • Yu-Ming Wu,
  • Yen-Hao Su,
  • Shih-Yu Huang,
  • Po-Han Lo and ,
  • Jui-Tai Chen,
  • Hung-Chi Chang,
  • Yun-Ling Yang,
  • Yih-Giun Cherng,
  • Hsiang-Ling Wu and
  • Ying-Hsuan Tai
  • + 5 authors+ 0 author

29 December 2021

Obesity increases the risk of prolonged emergence from general anesthesia due to the delayed release of anesthetic agents from body fat. This trial aimed to evaluate the effects of sevoflurane and desflurane along with anesthetic depth monitoring on...

(This article belongs to the Collection Neuroscience in Anesthesiology)
  • Article
  • Open Access
13 Citations
2,888 Views
9 Pages

Crown-Cut Endobronchial Ultrasound Guided Transbronchial Aspiration Needle: First Real-World Experiences

  • Filiz Oezkan,
  • Woo Yul Byun,
  • Clemens Loeffler,
  • Udo Siebolts and ,
  • Linda Diessel,
  • Nina Lambrecht and
  • Stephan Eisenmann
  • + 2 authors+ 0 author

29 December 2021

Advancements in personalized medicine have increased the demand for quantity and preservation of tissue architecture of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) samples. These demands may be addressed by the SonoTi...

(This article belongs to the Special Issue Interventional Pulmonology: A New World)
  • Article
  • Open Access
31 Citations
3,327 Views
10 Pages

Validation of Noninvasive Remote Dielectric Sensing System to Quantify Lung Fluid Levels

  • Teruhiko Imamura,
  • Wataru Gonoi,
  • Masakazu Hori,
  • Yohei Ueno and ,
  • Nikhil Narang,
  • Hiroshi Onoda,
  • Shuhei Tanaka,
  • Makiko Nakamura,
  • Naoya Kataoka and
  • Koichiro Kinugawa
  • + 9 authors+ 4 authors

29 December 2021

Background: The accuracy of the remote dielectric sensing (ReDSTM) system, which is a noninvasive electromagnetic-based technology to quantify lung fluid levels, particularly among those with small body size, remains uncertain. Methods: Hospitalized...

(This article belongs to the Special Issue Advances and Perspectives in Heart Failure)
  • Article
  • Open Access
8 Citations
3,407 Views
10 Pages

Trends in the Prevalence and Progression of Diabetic Retinopathy Associated with Hyperglycemic Disorders during Pregnancy in Japan

  • Masahiko Sugimoto,
  • Kohei Sampa,
  • Hideyuki Tsukitome,
  • Kumiko Kato and ,
  • Hisashi Matsubara,
  • Shin Asami,
  • Kaori Sekimoto,
  • Shigehiko Kitano,
  • Shigeo Yoshida and
  • on behalf of the Writing Committee of Japan-Clinical Retina STudy Group (J-CREST)
  • + 20 authors+ 15 authors

29 December 2021

The aim of this study was to determine the prevalence and progression of diabetic retinopathy (DR) with hyperglycemic disorders during pregnancy (HDPs) in Japan between 2013 and 2018 using two cohorts. The patients with HDPs were classified as those...

(This article belongs to the Section Ophthalmology)
  • Review
  • Open Access
60 Citations
28,454 Views
28 Pages

Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging

  • Jennifer S. Weaver,
  • Ernest R. Vina,
  • Peter L. Munk,
  • Andrea S. Klauser and ,
  • Jamie M. Elifritz and
  • Mihra S. Taljanovic
  • + 1 author+ 0 author

29 December 2021

Gout, a crystalline arthropathy caused by the deposition of monosodium urate crystals in the articular and periarticular soft tissues, is a frequent cause of painful arthropathy. Imaging has an important role in the initial evaluation as well as the...

(This article belongs to the Special Issue Diagnostic Imaging of Arthritis)
  • Article
  • Open Access
6 Citations
3,170 Views
11 Pages

Physical Activity and Diet Quality: Effects on Cardiovascular Morbidity in Women with Turner Syndrome—Results from an Online Patient Survey

  • Leonie Arnold,
  • Martina Bacova,
  • Robert Dalla-Pozza,
  • Nikolaus Alexander Haas and
  • Felix Sebastian Oberhoffer

29 December 2021

Turner syndrome (TS) is a rare chromosomal disease with increased cardiovascular morbidity and mortality. The aim of this study was to investigate the influence of physical activity and diet quality on cardiovascular morbidity in German TS women. An...

(This article belongs to the Special Issue Cardiovascular Risk Factors in Childhood and Adolescence)
  • Article
  • Open Access
6 Citations
2,359 Views
10 Pages

COVID-19 in Elderly Patients Surgically Treated for Lower Limbs Fracture

  • Alessandra Colombini,
  • Michele Davide Maria Lombardo,
  • Laura de Girolamo,
  • Elena De Vecchi and ,
  • Riccardo Giorgino,
  • Giuseppe Maria Peretti,
  • Giuseppe Banfi and
  • Laura Mangiavini
  • + 3 authors+ 0 author

29 December 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic outbreak has posed new problems in the context of patients suffering from other diseases. In particular, musculoskeletal sequelae related to the state of debilitation associated with COVID-...

(This article belongs to the Special Issue Clinical Features of COVID-19 in Elderly Patients)
  • Article
  • Open Access
7 Citations
3,558 Views
17 Pages

Infection Probability Index: Implementation of an Automated Chronic Wound Infection Marker

  • Franziska Schollemann,
  • Janosch Kunczik,
  • Henriette Dohmeier,
  • Carina Barbosa Pereira and ,
  • Andreas Follmann and
  • Michael Czaplik
  • + 1 author+ 0 author

29 December 2021

The number of people suffering from chronic wounds is increasing due to demographic changes and the global epidemics of obesity and diabetes. Innovative imaging techniques within the field of chronic wound diagnostics are required to improve wound ca...

(This article belongs to the Special Issue Chronic Wounds or Hard to Heal Ulcers: Updating Epidemiology, Physiopathology, and Therapies)
  • Article
  • Open Access
11 Citations
2,744 Views
9 Pages

Impact of the COVID-19 Pandemic on Urologic Oncology Surgery: Implications for Moving Forward

  • Rossella Guerrieri,
  • Lucrezia Rovati,
  • Paolo Dell’Oglio,
  • Antonio Galfano and ,
  • Luca Ragazzoni and
  • Paolo Aseni
  • + 1 author+ 0 author

29 December 2021

The COVID-19 pandemic has caused the destruction of routine hospital services globally, leading to an increase in the backlog of elective surgery cases. The aim of the study was to retrospectively investigate the pandemic’s impact on the urolog...

(This article belongs to the Special Issue COVID-19: Impact on Surgery)
  • Article
  • Open Access
16 Citations
3,000 Views
11 Pages

The Cognitive Consequences of the COVID-19 Pandemic on Members of the General Population in Italy: A Preliminary Study on Executive Inhibition

  • Francesca Favieri,
  • Giuseppe Forte,
  • Francesca Agostini,
  • Jasmine Giovannoli and ,
  • Enrico Di Pace,
  • Viviana Langher,
  • Renata Tambelli,
  • Mariella Pazzaglia,
  • Anna Maria Giannini and
  • Maria Casagrande
  • + 5 authors+ 0 author

29 December 2021

The pandemic period which has characterized the last two years has been associated with increasingly worsening psychological conditions, and previous studies have reported severe levels of anxiety, mood disorder, and psychopathological alteration in...

(This article belongs to the Section Mental Health)
  • Review
  • Open Access
18 Citations
12,643 Views
9 Pages

29 December 2021

The history of continuous renal replacement therapy (CRRT) is marked by technological advances linked to improvements in the knowledge of the mechanisms and kinetics of extracorporeal removal of solutes, and the pathophysiology of acute kidney injury...

(This article belongs to the Section Nephrology & Urology)
  • Brief Report
  • Open Access
7 Citations
4,660 Views
7 Pages

Male vs. Female Differences in Responding to Oxygen–Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

  • Salvatore Chirumbolo,
  • Luigi Valdenassi,
  • Marianno Franzini,
  • Sergio Pandolfi and ,
  • Giovanni Ricevuti and
  • Umberto Tirelli
  • + 1 author+ 0 author

29 December 2021

(1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a syndrome that has fatigue as its major symptom. Evidence suggests that ozone is able to relieve ME/CFS-related fatigue in affected patients. (2) Objective: To evaluate w...

(This article belongs to the Special Issue Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: Diagnosis and Treatment)
  • Article
  • Open Access
7 Citations
4,095 Views
12 Pages

The ED-PLANN Score: A Simple Risk Stratification Tool for Out-of-Hospital Cardiac Arrests Derived from Emergency Departments in Korea

  • Hyouk Jae Lim,
  • Young Sun Ro,
  • Ki Hong Kim,
  • Jeong Ho Park and ,
  • Ki Jeong Hong,
  • Kyoung Jun Song and
  • Sang Do Shin
  • + 2 authors+ 0 author

29 December 2021

Early risk stratification of out-of-hospital cardiac arrest (OHCA) patients with insufficient information in emergency departments (ED) is difficult but critical in improving intensive care resource allocation. This study aimed to develop a simple ri...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
14 Citations
3,331 Views
12 Pages

Heart Team for Left Atrial Appendage Occlusion: A Patient-Tailored Approach

  • Stefano Branzoli,
  • Fabrizio Guarracini,
  • Massimiliano Marini,
  • Giovanni D’Onghia and ,
  • Daniele Penzo,
  • Silvio Piffer,
  • Dimitri Peterlana,
  • Angelo Graffigna,
  • Michele Massimo Gulizia and
  • Mark La Meir
  • + 6 authors+ 1 author

29 December 2021

Background and Purpose: Left atrial appendage occlusion (LAAO) is an accepted therapeutic option for stroke prevention; however, the ideal technique and device have not yet been identified. In this study we evaluate the potential role of a heart team...

(This article belongs to the Special Issue State of the Art in Management of Atrial Fibrillation)
  • Article
  • Open Access
5 Citations
4,066 Views
10 Pages

29 December 2021

Recent advances in ocular aberrometry have revealed that ocular surgery increases ocular and corneal higher-order aberrations. This retrospective single-center study aimed to examine the effects of the overhanging bleb on corneal higher-order aberrat...

(This article belongs to the Special Issue Going for Gaps in Glaucoma)
  • Article
  • Open Access
3 Citations
3,237 Views
17 Pages

Short-Time Changes of Intraocular Pressure and Biomechanics of the Anterior Segment of the Eye during Water Drinking Test in Patients with XEN GelStent

  • Joanna Przeździecka-Dołyk,
  • Ewa Wałek,
  • Agnieszka Jóźwik,
  • Iwona Helemejko and ,
  • Magdalena Asejczyk-Widlicka and
  • Marta Misiuk-Hojło
  • + 1 author+ 0 author

29 December 2021

Purpose: Little is known about short-term changes in intraocular pressure (IOP) following minimally invasive glaucoma surgeries, such as post-XEN GelStent implantation. Although the importance of corneal biomechanics in glaucoma diagnostics has been...

(This article belongs to the Special Issue Novel Medical Approach to Diagnostic and Therapeutic Algorithms in Ophthalmology)
  • Article
  • Open Access
5 Citations
2,584 Views
13 Pages

Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease

  • Sang Heon Suh,
  • Tae Ryom Oh,
  • Hong Sang Choi,
  • Chang Seong Kim and ,
  • Kook-Hwan Oh,
  • Joongyub Lee,
  • Yun Kyu Oh,
  • Ji Yong Jung,
  • Kyu Hun Choi and
  • on behalf of the Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease (KNOW-CKD) Investigators
  • + 8 authors+ 3 authors

29 December 2021

Circulating osteoprotegerin (OPG) is a biomarker for cardiovascular complications that are closely related to chronic kidney disease (CKD). To investigate the association between circulating OPG level with long-term visit-to-visit blood pressure vari...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
12 Citations
4,295 Views
10 Pages

Single-Breath Counting Test Predicts Non-Invasive Respiratory Support Requirements in Patients with COVID-19 Pneumonia

  • Yaroslava Longhitano,
  • Christian Zanza,
  • Tatsiana Romenskaya,
  • Angela Saviano and ,
  • Tonia Persiano,
  • Mirco Leo,
  • Andrea Piccioni,
  • Marta Betti,
  • Antonio Maconi and
  • Fabrizio Racca
  • + 9 authors+ 4 authors

29 December 2021

The use of non-invasive respiratory strategies (NIRS) is crucial to improve oxygenation in COVID-19 patients with hypoxemia refractory to conventional oxygen therapy. However, the absence of respiratory symptoms may delay the start of NIRS. The aim o...

(This article belongs to the Special Issue Mechanical Cardiopulmonary Assistance in the ICU)
  • Article
  • Open Access
12 Citations
2,691 Views
11 Pages

Use of Ultrasonography to Discriminate Psoriatic Arthritis from Fibromyalgia: A Post-Hoc Analysis of the ULISSE Study

  • Antonio Marchesoni,
  • Pierluigi Macchioni,
  • Stefania Gasparini,
  • Carlo Perricone and ,
  • Fabio Massimo Perrotta,
  • Rosa Daniela Grembiale,
  • Ettore Silvagni,
  • Roberta Ramonda,
  • Luisa Costa and
  • Carlo Salvarani
  • + 9 authors+ 4 authors

29 December 2021

In psoriatic arthritis (PsA) patients with concomitant chronic widespread pain, the differential diagnosis with fibromyalgia syndrome (FMS) can be challenging. We evaluated whether ultrasound (US) examination of entheseal sites can distinguish pain f...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
19 Citations
2,906 Views
9 Pages

Laser Fiber Displacement Velocity during Tm-Fiber and Ho:YAG Laser Lithotripsy: Introducing the Concept of Optimal Displacement Velocity

  • Frederic Panthier,
  • Thibault Germain,
  • Cyril Gorny,
  • Laurent Berthe and ,
  • Steeve Doizi and
  • Olivier Traxer
  • + 1 author+ 0 author

29 December 2021

Background: Endocorporeal laser lithotripsy (EL) during flexible ureteroscopy (URS-f) often uses “dusting” settings with “painting” technique. The displacement velocity of the laser fiber (LF) at the stone surface remains unkn...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
5 Citations
2,040 Views
9 Pages

Weakening or Structural Strengthening? An Evaluation of Bone Density after MRgFUS Ablation for Treatment of Benign Bone Lesions

  • Camilla de Cataldo,
  • Federico Bruno,
  • Stefano Necozione,
  • Mariangela Novello and ,
  • Pierpaolo Palumbo,
  • Luigi Zugaro,
  • Antonio Barile,
  • Carlo Masciocchi and
  • Francesco Arrigoni
  • + 4 authors+ 0 author

29 December 2021

Previous studies suggest that interventional ablative procedures on bone lesions may weaken the bone, especially when performed through the needle approach. Our purpose was to evaluate, through Computed Tomography (CT), the effects of Magnetic Resona...

(This article belongs to the Special Issue Recent Research in Diagnosis and Treatment of Benign Osteocytic Tumours (Osteoma, Osteoid Osteoma, Osteoblastoma))
  • Review
  • Open Access
48 Citations
5,267 Views
12 Pages

Conservative Surgery in Endometrial Cancer

  • Alessandra Gallo,
  • Ursula Catena,
  • Gabriele Saccone and
  • Attilio Di Spiezio Sardo

29 December 2021

Endometrial cancer (EC) is the sixth most common female cancer worldwide. The median age of diagnosis is 65 years. However, 4% of women diagnosed with EC are younger than 40 years old, and 70% of these women are nulliparous. These data highlight the...

(This article belongs to the Special Issue Fertility Preservation and Conservative Therapy in Malignant and Benign Gynecological Diseases)
  • Article
  • Open Access
9 Citations
5,117 Views
10 Pages

Pleomorphic Adenoma of the Parotid Gland and the Parapharyngeal Space: Two Diametrically Opposing Surgical Philosophies for the Same Histopathologic Entity?

  • Benita Hornung,
  • Jannis Constantinidis,
  • Vivian Thimsen,
  • Abbas Agaimy and ,
  • Michael Koch,
  • Antoniu-Oreste Gostian,
  • Matti Sievert,
  • Sarina Katrin Müller,
  • Heinrich Iro and
  • Konstantinos Mantsopoulos
  • + 5 authors+ 0 author

28 December 2021

Background: The aim of this study was to investigate the histopathologic findings in parotid and parapharyngeal pleomorphic adenomas and draw conclusions concerning the surgical strategy. Methods: Retrospective study of medical charts of patients wit...

(This article belongs to the Section Otolaryngology)
  • Article
  • Open Access
31 Citations
6,086 Views
16 Pages

Cerebellar Transcranial Direct Current Stimulation in Children with Autism Spectrum Disorder: A Pilot Study on Efficacy, Feasibility, Safety, and Unexpected Outcomes in Tic Disorder and Epilepsy

  • Giordano D’Urso,
  • Elena Toscano,
  • Veronica Sanges,
  • Anne Sauvaget and ,
  • Christine E. Sheffer,
  • Maria Pia Riccio,
  • Roberta Ferrucci,
  • Felice Iasevoli,
  • Alberto Priori and
  • Andrea de Bartolomeis
  • + 6 authors+ 1 author

28 December 2021

Patients with autism spectrum disorder (ASD) display distinctive neurophysiological characteristics associated with significant cognitive, emotional, and behavioral symptoms. Transcranial direct current stimulation (tDCS) applied to the frontal or te...

(This article belongs to the Collection Advances in Neurostimulation: Understanding of the Mechanisms and Clinical Applications)
  • Article
  • Open Access
10 Citations
2,316 Views
8 Pages

Perioperative Predictive Factors for Positive Outcomes in Spine Fusion for Adult Deformity Correction

  • Alice Baroncini,
  • Filippo Migliorini,
  • Francesco Langella,
  • Paolo Barletta and ,
  • Per Trobisch,
  • Riccardo Cecchinato,
  • Marco Damilano,
  • Emanuele Quarto,
  • Claudio Lamartina and
  • Pedro Berjano
  • + 5 authors+ 0 author

28 December 2021

Purpose: Identifying perioperative factors that may influence the outcomes of long spine fusion for the treatment of adult deformity is key for tailored surgical planning and targeted informed consent. The aim of this study was to analyze the associa...

(This article belongs to the Special Issue Current Advances in Spinal Diseases of Elderly Patients)
  • Article
  • Open Access
6 Citations
3,088 Views
13 Pages

Operator Performance of the Digital Setup Fabrication for Orthodontic–Orthognathic Treatment: An Explorative Study

  • Olivier de Waard,
  • Robin Bruggink,
  • Frank Baan,
  • Hendrikus A. J. Reukers and ,
  • Ewald M. Bronkhorst,
  • Anne Marie Kuijpers-Jagtman and
  • Edwin M. Ongkosuwito
  • + 2 authors+ 0 author

28 December 2021

The purpose of this study was to explore the operator performance of the fabrication of digital orthodontic setups integrated into cone beam computed tomography (CBCT) scans. Fifteen patients who underwent a combined orthodontic–orthognathic su...

(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
  • Review
  • Open Access
51 Citations
7,558 Views
15 Pages

Radiation-Induced Heart Disease

  • Juan A. Quintero-Martinez,
  • Sandra N. Cordova-Madera and
  • Hector R. Villarraga

28 December 2021

Cancer incidence and survivorship have had a rising tendency over the last two decades due to better treatment modalities. One of these is radiation therapy (RT), which is used in 20–55% of cancer patients, and its basic principle consists of i...

(This article belongs to the Special Issue Imaging Research in Cardiovascular Diseases)
  • Article
  • Open Access
22 Citations
3,154 Views
10 Pages

Antibody Response to mRNA Vaccines against SARS-CoV-2 with Chronic Kidney Disease, Hemodialysis, and after Kidney Transplantation

  • Lukas Buchwinkler,
  • Claire Anne Solagna,
  • Janosch Messner,
  • Markus Pirklbauer and ,
  • Michael Rudnicki,
  • Gert Mayer and
  • Julia Kerschbaum
  • + 2 authors+ 0 author

28 December 2021

Most trials on mRNA vaccines against SARS-CoV-2 did not include patients with chronic kidney disease (CKD), hemodialysis (HD) patients, or kidney transplant recipients (KTR). However, those patients have a higher risk for a severe course of COVID-19...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
15 Citations
4,647 Views
16 Pages

28 December 2021

Stroke remains one of the leading causes of disability in adults, and lower limb spasticity, affected stance, and balance impact everyday life and activities of such patients. Robotic therapy and assessment are becoming important tools to clinical ev...

(This article belongs to the Special Issue Neurorehabilitation: Progress and Challenges)
  • Article
  • Open Access
6 Citations
6,328 Views
13 Pages

Intraoperative 3D Comparison of Round and Anatomical Breast Implants: Dispelling a Myth

  • Luisa Lotter,
  • Isabel Zucal,
  • Vanessa Brébant,
  • Norbert Heine and ,
  • Robin Hartmann,
  • Karolina Mueller,
  • Lukas Prantl and
  • Daniel Schiltz
  • + 3 authors+ 0 author

28 December 2021

Background: Thanks to 3D imaging, it is possible to measure the influence of different parameters on breast augmentation. In this study, we compare the effect of different shapes and sizes of breast implants on the topography of the resulting breast....

(This article belongs to the Special Issue Updates in Aesthetic and Reconstructive Surgery)
  • Article
  • Open Access
8 Citations
3,898 Views
18 Pages

Validation and Cross-Cultural Adaptation of the Spanish Version of the Pain Sensitivity Questionnaire (PSQ-S)

  • María del Rocío Ibancos-Losada,
  • María Catalina Osuna-Pérez,
  • Irene Cortés-Pérez,
  • Desirée Montoro-Cárdenas and
  • Ángeles Díaz-Fernández

28 December 2021

Experimental pain testing requires specific equipment and may be uncomfortable for patients. The Pain Sensitivity Questionnaire (PSQ) was developed to assess pain sensitivity, based on the pain intensity ratings (range: 0–10) of painful situati...

(This article belongs to the Special Issue Recent Advances in Musculoskeletal Pain and Its Management)
  • Article
  • Open Access
6 Citations
4,522 Views
8 Pages

Physical Tests Are Poorly Related to Patient-Reported Outcome Measures during Severe Acute Exacerbations of COPD

  • Kirsten Quadflieg,
  • Ana Machado,
  • Sarah Haesevoets,
  • Marc Daenen and ,
  • Michiel Thomeer,
  • David Ruttens,
  • Martijn A. Spruit and
  • Chris Burtin
  • + 3 authors+ 0 author

28 December 2021

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a negative impact on patients’ health status, including physical function and patient-reported outcomes. We aimed to explore the associations between physical tests and...

(This article belongs to the Special Issue Recent Research in Pulmonary Rehabilitation)
  • Article
  • Open Access
10 Citations
3,569 Views
12 Pages

Assessment of Asymptomatic Severe Aortic Regurgitation by Doppler-Derived Echo Indices: Comparison with Magnetic Resonance Quantification

  • Zuzana Hlubocká,
  • Radka Kočková,
  • Hana Línková,
  • Alena Pravečková and ,
  • Jaroslav Hlubocký,
  • Gabriela Dostálová,
  • Martin Bláha,
  • Martin Pěnička and
  • Aleš Linhart
  • + 4 authors+ 0 author

28 December 2021

Reliable quantification of aortic regurgitation (AR) severity is essential for clinical management. We aimed to compare quantitative and indirect echo-Doppler indices to quantitative cardiac magnetic resonance (CMR) parameters in asymptomatic chronic...

(This article belongs to the Special Issue Valvular Heart Disease: A World in Constant Motion)
  • Article
  • Open Access
20 Citations
3,567 Views
15 Pages

Liver Injury and Elevated FIB-4 Define a High-Risk Group in Patients with COVID-19

  • Dana Crisan,
  • Lucretia Avram,
  • Cristiana Grapa,
  • Alexandra Dragan and ,
  • Dan Radulescu,
  • Sorin Crisan,
  • Alin Grosu,
  • Valentin Militaru,
  • Elena Buzdugan and
  • Rares Craciun
  • + 16 authors+ 11 authors

28 December 2021

Liver involvement in Coronavirus Disease 2019 (COVID-19) has been widely documented. However, data regarding liver-related prognosis are scarce and heterogeneous. The current study aims to evaluate the role of abnormal liver tests and incidental elev...

(This article belongs to the Special Issue Clinical Impact of COVID-19 on Liver Diseases)
  • Article
  • Open Access
33 Citations
11,885 Views
13 Pages

The Spatial Extent of Pain Is Associated with Pain Intensity, Catastrophizing and Some Measures of Central Sensitization in People with Frozen Shoulder

  • Mercè Balasch-Bernat,
  • Lirios Dueñas,
  • Marta Aguilar-Rodríguez,
  • Deborah Falla and ,
  • Alessandro Schneebeli,
  • Marta Navarro-Bosch,
  • Enrique Lluch and
  • Marco Barbero
  • + 3 authors+ 0 author

28 December 2021

The aim of this cross-sectional study was to explore the spatial extent of pain and its association with clinical symptoms, psychological features, and pain sensitization in people with frozen shoulder (FS). Forty-eight individuals with FS completed...

(This article belongs to the Special Issue Recent Advances in Musculoskeletal Pain and Its Management)
  • Article
  • Open Access
8 Citations
4,695 Views
11 Pages

28 December 2021

Background: Since the association between disparity in physician distribution and specific healthcare outcomes is poorly documented, we aimed to clarify the association between physician maldistribution and cerebrovascular disease (CeVD), a high-prio...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
34 Citations
5,343 Views
9 Pages

TXI (Texture and Color Enhancement Imaging) for Serrated Colorectal Lesions

  • Toshihiro Nishizawa,
  • Osamu Toyoshima,
  • Shuntaro Yoshida,
  • Chie Uekura and ,
  • Ken Kurokawa,
  • Munkhbayar Munkhjargal,
  • Miho Obata,
  • Tomoharu Yamada,
  • Mitsuhiro Fujishiro and
  • Hidekazu Suzuki
  • + 6 authors+ 1 author

27 December 2021

Background and aim: Olympus Corporation released the texture and color enhancement imaging (TXI) technology as a novel image-enhancing endoscopic technique. We investigated the effectiveness of TXI in the imaging of serrated colorectal polyps, includ...

(This article belongs to the Special Issue 10th Anniversary of JCM—Recent Diagnostic and Therapeutic Advance in Gastroenterology and Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
20 Citations
4,891 Views
12 Pages

Canonical (CD74/CD44) and Non-Canonical (CXCR2, 4 and 7) MIF Receptors Are Differentially Expressed in Rheumatoid Arthritis Patients Evaluated by DAS28-ESR

  • Gabriela Athziri Sánchez-Zuno,
  • Richard Bucala,
  • Jorge Hernández-Bello,
  • Ilce Valeria Román-Fernández and ,
  • Mariel García-Chagollán,
  • Ferdinando Nicoletti,
  • Mónica Guadalupe Matuz-Flores,
  • Samuel García-Arellano,
  • Judith Alejandra Esparza-Michel and
  • José Francisco Muñoz-Valle
  • + 7 authors+ 2 authors

27 December 2021

Macrophage migration inhibitory factor (MIF) significantly contributes to rheumatoid arthritis (RA) pathogenesis. We aimed to evaluate the canonical (CD74/CD44) and non-canonical MIF receptors (CXCR2,4 and 7) expression and sCD74 to establish their a...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
6 Citations
3,787 Views
12 Pages

Usefulness of the MAGGIC Score in Predicting the Competing Risk of Non-Sudden Death in Heart Failure Patients Receiving an Implantable Cardioverter-Defibrillator: A Sub-Analysis of the OBSERVO-ICD Registry

  • Marco Canepa,
  • Pietro Palmisano,
  • Gabriele Dell’Era,
  • Matteo Ziacchi and ,
  • Ernesto Ammendola,
  • Michele Accogli,
  • Eraldo Occhetta,
  • Mauro Biffi,
  • Gerardo Nigro and
  • Federico Guerra
  • + 9 authors+ 4 authors

27 December 2021

The role of prognostic risk scores in predicting the competing risk of non-sudden death in heart failure patients with reduced ejection fraction (HFrEF) receiving an implantable cardioverter-defibrillator (ICD) is unclear. To this goal, we evaluated...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
25 Citations
8,979 Views
14 Pages

Long-Term Outcomes of Staged Revision Surgery for Chronic Periprosthetic Joint Infection of Total Hip Arthroplasty

  • Christopher W. Day,
  • Kerry Costi,
  • Susan Pannach,
  • Gerald J. Atkins and ,
  • Jochen G. Hofstaetter,
  • Stuart A. Callary,
  • Renjy Nelson,
  • Donald W. Howie and
  • Lucian B. Solomon
  • + 4 authors+ 0 author

27 December 2021

Periprosthetic joint infection (PJI) is a serious complication of total hip arthroplasty. Staged revision surgery is considered effective in eradicating PJI. We aimed to determine the rate of infection resolution after each stage of staged revision s...

(This article belongs to the Special Issue Advances in Understanding the Pathogenesis and Pathophysiology of Orthopaedic-Related Infections)
  • Article
  • Open Access
11 Citations
3,923 Views
11 Pages

The Role of Factor Xa-Independent Pathway and Anticoagulant Therapies in Cancer-Related Stroke

  • Hyung Jun Kim,
  • Jong-Won Chung,
  • Oh Young Bang,
  • Yeon Hee Cho and ,
  • Yun Jeong Lim,
  • Jaechun Hwang,
  • Woo-Keun Seo,
  • Gyeong-Moon Kim,
  • Hee-Jin Kim and
  • Myung-Ju Ahn
  • + 5 authors+ 0 author

27 December 2021

Background: The optimal strategy for stroke prevention in cancer patients is unknown. We compared the underlying mechanisms of coagulopathy and the effects of anticoagulants in patients with active cancer and atrial fibrillation (AF). Methods: We ret...

(This article belongs to the Special Issue New Frontiers in the Clinical Management of Stroke)
  • Article
  • Open Access
22 Citations
6,507 Views
15 Pages

Positive ROS (Reactive Oxygen Species) Modulator Engineered Device Support Skin Treatment in Locally Advanced Breast Cancer (LABC) Enhancing Patient Quality of Life

  • Donato Casella,
  • Paolo Palumbo,
  • Sara Sandroni,
  • Claudio Caponi and ,
  • Francesca Littori,
  • Francesca Capuano,
  • Luca Grimaldi,
  • Marco Marcasciano and
  • Roberto Cuomo
  • + 4 authors+ 0 author

27 December 2021

The development of research in genetic and biochemical fields has made it possible to investigate certain metabolic aspects of the microenvironment of chronic skin lesions, including altered cell signalling, highlighting its importance in determining...

(This article belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
  • Article
  • Open Access
5 Citations
4,368 Views
12 Pages

How to Predict Outcomes from a Biofeedback and Pelvic Floor Muscle Electric Stimulation Program in Patients with Urinary Incontinence after Radical Prostatectomy

  • Stefano Salciccia,
  • Alessandro Sciarra,
  • Martina Moriconi,
  • Martina Maggi and ,
  • Pietro Viscuso,
  • Davide Rosati,
  • Marco Frisenda,
  • Giovanni Battista Di Pierro,
  • Vittorio Canale and
  • Gianna Mariotti
  • + 10 authors+ 5 authors

27 December 2021

Objectives: The objective of this study was to analyze the pre-operative and intra-operative variables that can condition urinary incontinence (UI) after radical prostatectomy (RP), as well as continence rate recovery during a pelvic floor rehabilita...

(This article belongs to the Section Nephrology & Urology)
  • Review
  • Open Access
14 Citations
3,798 Views
8 Pages

Needleless Ablation of Osteoid Osteoma and Osteoblastoma: The Emergent Role of MRgFUS

  • Flavia Cobianchi Bellisari,
  • Pierpaolo Palumbo,
  • Carlo Masciocchi,
  • Carmine Zoccali and ,
  • Antonio Barile and
  • Francesco Arrigoni
  • + 1 author+ 0 author

27 December 2021

Osteoblastoma (OB) and osteoid osteoma (OO) are benign bone-forming tumors, with nearly identical basic microscopic features. The main difference is dimension (OO has usually a nidus measuring <2 cm in diameter). In addition, OB is biologically mo...

(This article belongs to the Special Issue Recent Research in Diagnosis and Treatment of Benign Osteocytic Tumours (Osteoma, Osteoid Osteoma, Osteoblastoma))
  • Review
  • Open Access
17 Citations
8,943 Views
16 Pages

Targeting Aggressive Pituitary Adenomas at the Molecular Level—A Review

  • Benjamin Voellger,
  • Zhuo Zhang,
  • Julia Benzel,
  • Junwen Wang and ,
  • Ting Lei,
  • Christopher Nimsky and
  • Jörg-Walter Bartsch
  • + 2 authors+ 0 author

27 December 2021

Pituitary adenomas (PAs) are mostly benign endocrine tumors that can be treated by resection or medication. However, up to 10% of PAs show an aggressive behavior with invasion of adjacent tissue, rapid proliferation, or recurrence. Here, we provide a...

(This article belongs to the Special Issue Management of Pituitary Tumors: Current and Future Treatment Options)

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J. Clin. Med. - ISSN 2077-0383