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Journal of Clinical Medicine, Volume 11, Issue 1

2022 January-1 - 282 articles

Cover Story: A series of global mechanisms contribute to systemic iron deficiency in heart failure and its consequences. The causes can be divided into the reduced intake, decreased absorption, and increased loss of iron. Reduced intake could be due to decreased absolute amounts of iron or low iron bioavailability. Reduced absorption is thought to be due to intestinal oedema, increased intestinal pH, increased hepcidin levels, and intestinal hypoperfusion, among others. Increased losses are mainly due to gastro-intestinal bleeding. Iron deficiency results in reduced organ function of the heart and skeletal muscles, anaemia, impaired immune responses, deranged metabolism, and kidney injury. Iron deficiency is associated with impaired exercise tolerance, increased heart failure hospitalisations, and mortality. View this paper
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Articles (282)

  • Article
  • Open Access
6 Citations
2,880 Views
10 Pages

31 December 2021

This study aimed to evaluate the reliability of a trapezium plate for open reduction and internal fixation (ORIF) of mandibular subcondylar fractures with the simultaneous use of an endoscope. We selected and retrospectively studied 18 patients (12 m...

(This article belongs to the Special Issue New Perspectives in Maxillo-Facial Surgery)
  • Article
  • Open Access
14 Citations
3,858 Views
13 Pages

31 December 2021

The perinatal period is considered a window of vulnerability given the increased risk of psychiatric difficulties during this time, such as mood and anxiety disorders (ADs). Pre-pandemic rates of ADs in perinatal women were one in five but have since...

(This article belongs to the Special Issue COVID-19 in Pregnancy: A Clinical Management Protocol and Considerations for Practice)
  • Review
  • Open Access
26 Citations
5,834 Views
18 Pages

Systematic Review of Incidence Studies of Pneumonia in Persons with Spinal Cord Injury

  • Anja Maria Raab,
  • Gabi Mueller,
  • Simone Elsig,
  • Simon C. Gandevia and ,
  • Marcel Zwahlen,
  • Maria T. E. Hopman and
  • Roger Hilfiker
  • + 2 authors+ 0 author

31 December 2021

Pneumonia continues to complicate the course of spinal cord injury (SCI). Currently, clinicians and policy-makers are faced with only limited numbers of pneumonia incidence in the literature. A systematic review of the literature was undertaken to pr...

(This article belongs to the Special Issue Recent Advances in Pneumonia in Older People)
  • Article
  • Open Access
7 Citations
3,067 Views
13 Pages

Impact of Primary Hemostasis Disorders on Late Major Bleeding Events among Anticoagulated Atrial Fibrillation Patients Treated by TAVR

  • Laurent Dietrich,
  • Marion Kibler,
  • Kensuke Matsushita,
  • Benjamin Marchandot and ,
  • Antonin Trimaille,
  • Antje Reydel,
  • Bamba Diop,
  • Phi Dinh Truong,
  • Anh Mai Trung and
  • Olivier Morel
  • + 10 authors+ 5 authors

31 December 2021

Background: Bleeding events are among the striking complications following transcatheter aortic valve replacement (TAVR), and bleeding prediction models are crucially warranted. Several studies have highlighted that primary hemostasis disorders secon...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
28 Citations
11,938 Views
32 Pages

Surgery and Catheter Ablation for Atrial Fibrillation: History, Current Practice, and Future Directions

  • Patrick M. McCarthy,
  • James L. Cox,
  • Olga N. Kislitsina,
  • Jane Kruse and ,
  • Andrei Churyla,
  • S. Chris Malaisrie and
  • Christopher K. Mehta
  • + 2 authors+ 0 author

31 December 2021

Atrial fibrillation (AF) is the most common of all cardiac arrhythmias, affecting roughly 1% of the general population in the Western world. The incidence of AF is predicted to double by 2050. Most patients with AF are treated with oral medications a...

(This article belongs to the Special Issue Cardiac Ablation - Current Practice and Future Trends)
  • Article
  • Open Access
15 Citations
6,730 Views
12 Pages

Expectant Management of PPROM Improves Neonatal Outcome—A Retrospective Study of 562 Patients

  • Roxana Elena Bohilțea,
  • Ana Maria Cioca,
  • Vlad Dima,
  • Ioniță Ducu and ,
  • Corina Grigoriu,
  • Valentin Varlas and
  • Florentina Furtunescu
  • + 2 authors+ 0 author

31 December 2021

Prelabor preterm rupture of the membranes (PPROM) refers to the rupture of the membranes before 37 weeks, but also before the onset of labor. Approximately 3% of pregnancies are complicated by PPROM, which is an important cause of neonatal morbidity...

(This article belongs to the Special Issue Preterm Newborn at the Border between Obstetrics and Neonatology: Advances in the Interdisciplinary Management)
  • Article
  • Open Access
14 Citations
3,241 Views
13 Pages

Fluorescence-Aided Identification Technique (FIT) Improves Tooth Surface Clean-Up after Debonding of Buccal and Lingual Orthodontic Appliances

  • Olivia Engeler,
  • Oliver Stadler,
  • Simone Horn,
  • Christian Dettwiler and ,
  • Thomas Connert,
  • Carlalberta Verna and
  • Georgios Kanavakis
  • + 2 authors+ 0 author

31 December 2021

The aim of this study was to evaluate the use of fluorescence inducing light to aid the clean-up of tooth surfaces after bracket removal when using buccal or lingual orthodontic appliances. Two full sets of dental arches using extracted human teeth w...

(This article belongs to the Topic Diagnosis of Craniofacial Changes: Conventional Approaches and Novel Methodologies)
  • Review
  • Open Access
17 Citations
3,980 Views
15 Pages

An Update on Usage of High-Risk Donors in Liver Transplantation

  • Haris Muhammad,
  • Duha Zaffar,
  • Aniqa Tehreem,
  • Peng-Sheng Ting and ,
  • Cem Simsek,
  • Ilker Turan,
  • Saleh Alqahtani,
  • Behnam Saberi and
  • Ahmet Gurakar
  • + 4 authors+ 0 author

31 December 2021

The ideal management for end stage liver disease, acute liver failure, and hepatocellular carcinoma (HCC), within specific criteria, is liver transplantation (LT). Over the years, there has been a steady increase in the candidates listed for LT, with...

(This article belongs to the Special Issue Challenges in Liver Transplantation: Extended Criteria Donors)
  • Article
  • Open Access
20 Citations
5,279 Views
11 Pages

Diagnostic Accuracy and Detection Rate of Glaucoma Screening with Optic Disk Photos, Optical Coherence Tomography Images, and Telemedicine

  • Alfonso Anton,
  • Karen Nolivos,
  • Marta Pazos,
  • Gianluca Fatti and ,
  • Miriam Eleonora Ayala,
  • Elena Martínez-Prats,
  • Oscar Peral,
  • Vladimir Poposki,
  • Evangelos Tsiroukis and
  • Xavier Castells
  • + 7 authors+ 2 authors

31 December 2021

Purpose: The aim of this study was to evaluate the diagnostic accuracy of optical coherence tomography (OCT) and retinography in the detection of glaucoma through a telemedicine program. Methods: A population-based sample of 4113 persons was randomly...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
9 Citations
5,544 Views
13 Pages

Effect of Early Supraglottic Airway Device Insertion on Chest Compression Fraction during Simulated Out-of-Hospital Cardiac Arrest: Randomised Controlled Trial

  • Loric Stuby,
  • Laurent Jampen,
  • Julien Sierro,
  • Maxime Bergeron and ,
  • Erik Paus,
  • Thierry Spichiger,
  • Laurent Suppan and
  • David Thurre
  • + 3 authors+ 0 author

31 December 2021

Early insertion of a supraglottic airway (SGA) device could improve chest compression fraction by allowing providers to perform continuous chest compressions or by shortening the interruptions needed to deliver ventilations. SGA devices do not requir...

(This article belongs to the Collection “Italian Resuscitation Council” on Resuscitation Science and Emergencies—Part I)
  • Article
  • Open Access
8 Citations
3,383 Views
13 Pages

Machine Learning to Calculate Heparin Dose in COVID-19 Patients with Active Cancer

  • Egidio Imbalzano,
  • Luana Orlando,
  • Angela Sciacqua,
  • Giuseppe Nato and ,
  • Francesco Dentali,
  • Veronica Nassisi,
  • Vincenzo Russo,
  • Giuseppe Camporese,
  • Gianluca Bagnato and
  • Pierpaolo Di Micco
  • + 10 authors+ 5 authors

31 December 2021

To realize a machine learning (ML) model to estimate the dose of low molecular weight heparin to be administered, preventing thromboembolism events in COVID-19 patients with active cancer. Methods: We used a dataset comprising 131 patients with activ...

(This article belongs to the Special Issue Unusual Clinical Presentation of COVID-19)
  • Article
  • Open Access
15 Citations
3,503 Views
11 Pages

Comparison of Robotic and Conventional Unicompartmental Knee Arthroplasty Outcomes in Patients with Osteoarthritis: A Retrospective Cohort Study

  • Christopher Wu,
  • Nobuei Fukui,
  • Yen-Kuang Lin,
  • Ching-Yu Lee and ,
  • Shih-Hsiang Chou,
  • Tsung-Jen Huang,
  • Jen-Yuh Chen and
  • Meng-Huang Wu
  • + 3 authors+ 0 author

31 December 2021

Robotic-arm-assisted unicompartmental knee arthroplasty (RUKA) was developed to increase the accuracy of bone alignment and implant positioning. This retrospective study explored whether RUKA has more favorable overall outcomes than conventional unic...

(This article belongs to the Topic Orthopaedic Diseases and Innovative Intervention Strategies)
  • Article
  • Open Access
21 Citations
4,696 Views
7 Pages

31 December 2021

Background: Sclerobanding is a novel technique combining rubber band ligation with 3% polidocanol foam sclerotherapy for the treatment of hemorrhoidal disease (HD). The aim of this study is to evaluate the feasibility, safety and short-term outcomes...

(This article belongs to the Special Issue Colorectal Surgery: Latest Advances and Prospects)
  • Article
  • Open Access
7 Citations
2,867 Views
7 Pages

Placental Leucine Aminopeptidase as a Potential Specific Urine Biomarker for Invasive Ovarian Cancer

  • Tetsuya Matsukawa,
  • Shigehiko Mizutani,
  • Kunio Matsumoto,
  • Yukio Kato and ,
  • Masato Yoshihara,
  • Hiroaki Kajiyama and
  • Kiyosumi Shibata
  • + 2 authors+ 0 author

31 December 2021

Background: A non-invasive and sensitive biomarker for the detection of ovarian cancer (OvCa) is lacking. We aim to investigate if urinary placental leucine aminopeptidase (P-LAP) can serve as a reliable biomarker for OvCa. Methods: P-LAP activity wa...

(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Gynecological Malignancies)
  • Review
  • Open Access
138 Citations
11,806 Views
19 Pages

31 December 2021

Background: Exoscopes are a safe and effective alternative or adjunct to the existing binocular surgical microscope for brain tumor, skull base surgery, aneurysm clipping and both cervical and lumbar complex spine surgery that probably will open a ne...

(This article belongs to the Special Issue New Technologies for Personalized Medicine in Head and Neck Oncologic and Reconstructive Surgery)
  • Systematic Review
  • Open Access
44 Citations
7,509 Views
22 Pages

A Systematic Review of the Safety of Blocking the IL-1 System in Human Pregnancy

  • Marie-Eve Brien,
  • Virginie Gaudreault,
  • Katia Hughes,
  • Dexter J. L. Hayes and ,
  • Alexander E. P. Heazell and
  • Sylvie Girard
  • + 1 author+ 0 author

31 December 2021

Blockade of the interleukin-1 (IL-1) pathway has been used therapeutically in several inflammatory diseases including arthritis and cryopyrin-associated periodic syndrome (CAPS). These conditions frequently affect women of childbearing age and contin...

(This article belongs to the Special Issue Diagnostic or Therapeutic Strategies for Pregnancy Complications)
  • Article
  • Open Access
16 Citations
6,744 Views
13 Pages

Urinary Tract Infections in Kidney Transplant Recipients—Is There a Need for Antibiotic Stewardship?

  • Jens Strohaeker,
  • Victoria Aschke,
  • Alfred Koenigsrainer,
  • Silvio Nadalin and
  • Robert Bachmann

31 December 2021

(1) Background: Urinary tract infections (UTI) are the most common infections after kidney transplantation. Given the risk of urosepsis and the potential threat to the graft, the threshold for treating UTI and asymptomatic bacteriuria with broad spec...

(This article belongs to the Special Issue Infections, Complications and Management of Kidney Transplantation)
  • Article
  • Open Access
18 Citations
5,171 Views
15 Pages

ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome

  • Ignacio Martin-Loeches,
  • Anna Motos,
  • Rosario Menéndez,
  • Albert Gabarrús and ,
  • Jessica González,
  • Laia Fernández-Barat,
  • Adrián Ceccato,
  • Raquel Pérez-Arnal,
  • Dario García-Gasulla and
  • Antoni Torres
  • + 48 authors+ 43 authors

31 December 2021

Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, les...

(This article belongs to the Section Respiratory Medicine)
  • Review
  • Open Access
36 Citations
4,680 Views
16 Pages

Invasive Assessment of Coronary Microvascular Function

  • Fabio Mangiacapra,
  • Michele Mattia Viscusi,
  • Giuseppe Verolino,
  • Luca Paolucci and ,
  • Annunziata Nusca,
  • Rosetta Melfi,
  • Gian Paolo Ussia and
  • Francesco Grigioni
  • + 3 authors+ 0 author

31 December 2021

The critical role of the coronary microvascular compartment and its invasive functional assessment has become apparent in light of the significant proportion of patients presenting signs and symptoms of myocardial ischemia, despite the absence of epi...

(This article belongs to the Special Issue Recent Advances in Coronary Artery Disease)
  • Article
  • Open Access
13 Citations
5,293 Views
9 Pages

Spontaneous Bacterial Peritonitis among Cirrhotic Patients: Prevalence, Clinical Characteristics, and Outcomes

  • Naim Abu-Freha,
  • Tal Michael,
  • Liat Poupko,
  • Asia Estis-Deaton and ,
  • Muhammad Aasla,
  • Omar Abu-Freha,
  • Ohad Etzion and
  • Lior Nesher
  • + 3 authors+ 0 author

31 December 2021

(1) Background: Spontaneous bacterial peritonitis (SBP) is a feared complication of liver cirrhosis. We investigated the prevalence of SBP, positive ascitic fluid cultures, and risk factors for mortality. (2) Methods: A retrospective analysis of all...

(This article belongs to the Collection Clinical Research in Hepatology)
  • Article
  • Open Access
23 Citations
2,764 Views
12 Pages

An Application of Machine Learning That Uses the Magnetic Resonance Imaging Metric, Mean Apparent Diffusion Coefficient, to Differentiate between the Histological Types of Ovarian Cancer

  • Heekyoung Song,
  • Seongeun Bak,
  • Imhyeon Kim,
  • Jae Yeon Woo and ,
  • Eui Jin Cho,
  • Youn Jin Choi,
  • Sung Eun Rha,
  • Shin Ah Oh,
  • Seo Yeon Youn and
  • Sung Jong Lee
  • + 5 authors+ 0 author

31 December 2021

This retrospective single-center study included patients diagnosed with epithelial ovarian cancer (EOC) using preoperative pelvic magnetic resonance imaging (MRI). The apparent diffusion coefficient (ADC) of the axial MRI maps that included the large...

(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Gynecological Malignancies)
  • Review
  • Open Access
62 Citations
16,547 Views
14 Pages

Treatment of Sialolithiasis: What Has Changed? An Update of the Treatment Algorithms and a Review of the Literature

  • Michael Koch,
  • Konstantinos Mantsopoulos,
  • Sarina Müller,
  • Matti Sievert and
  • Heinrich Iro

31 December 2021

Treatment for sialolithiasis has undergone significant changes since the 1990s. Following the development of new minimally invasive and gland-preserving treatment modalities, a 40–50% rate of gland resection was reduced to less than 5%. Extraco...

(This article belongs to the Special Issue Treatment of Salivary Gland Diseases: Established Knowledge, Current Challenges and New Insights)
  • Article
  • Open Access
19 Citations
3,661 Views
18 Pages

Effect of Antipsychotic Treatment on Neutrophil-to-Lymphocyte Ratio during Hospitalization for Acute Psychosis in the Course of Schizophrenia—A Cross-Sectional Retrospective Study

  • Bartosz Dawidowski,
  • Grzegorz Grelecki,
  • Adam Biłgorajski,
  • Piotr Podwalski and ,
  • Błażej Misiak and
  • Jerzy Samochowiec
  • + 1 author+ 0 author

31 December 2021

Background: Studies have shown that there are deviations in the results of peripheral blood counts, which lead to increased values of the neutrophils-to-lymphocytes ratio (NLR) in schizophrenia. Antipsychotic drugs have proven to lower the levels of...

(This article belongs to the Special Issue Schizophrenia Research and Care—Advancements and Challenges)
  • Article
  • Open Access
18 Citations
4,500 Views
10 Pages

Association of Regular Endoscopic Screening with Interval Gastric Cancer Incidence in the National Cancer Screening Program

  • Choong-Kyun Noh,
  • Eunyoung Lee,
  • Gil Ho Lee,
  • Sun Gyo Lim and ,
  • Bumhee Park,
  • Sung Jae Shin,
  • Jae Youn Cheong and
  • Kee Myung Lee
  • + 3 authors+ 0 author

31 December 2021

Although regular endoscopic screening may help in early detection of gastric cancer, interval cancer remains a problem in the screening program. This study evaluated the association between regular endoscopic screening and interval cancer detection i...

(This article belongs to the Special Issue Gastrointestinal Malignancies: Screening, Diagnosis, and Treatment)
  • Article
  • Open Access
32 Citations
4,653 Views
11 Pages

Transurethral Resection of Non-Muscle Invasive Bladder Tumors Combined with Fluorescence Diagnosis and Photodynamic Therapy with Chlorin e6-Type Photosensitizers

  • Andrey V. Kustov,
  • Nataliya L. Smirnova,
  • Oleg A. Privalov,
  • Tatyana M. Moryganova and ,
  • Alexander I. Strelnikov,
  • Philipp K. Morshnev,
  • Oscar I. Koifman,
  • Alex V. Lyubimtsev,
  • Tatyana V. Kustova and
  • Dmitry B. Berezin
  • + 5 authors+ 0 author

31 December 2021

Bladder cancer is a common disease with a high recurrence rate. In order to improve the treatment of superficial bladder tumors, we evaluated the efficacy and safety of transurethral resection (TURB) followed by fluorescence diagnosis (FD) and photod...

(This article belongs to the Special Issue Clinical Practice of Photodynamic Therapy for Cancers: Latest Advances and Prospects)
  • Opinion
  • Open Access
9 Citations
2,958 Views
9 Pages

30 December 2021

The current management of patients with schizophrenia is marked by a lack of personalization. After the diagnosis is made, a second-generation antipsychotic is usually prescribed based on the current clinician’s preferences, sometimes accompani...

(This article belongs to the Special Issue Schizophrenia Research and Care—Advancements and Challenges)
  • Article
  • Open Access
31 Citations
4,446 Views
12 Pages

Factors Associated with the Development of Coagulopathy after Open Traumatic Brain Injury

  • Yuhui Chen,
  • Jun Tian,
  • Bin Chi,
  • Shangming Zhang and ,
  • Liangfeng Wei and
  • Shousen Wang
  • + 1 author+ 0 author

30 December 2021

Background: The incidence of coagulopathy after open traumatic brain injury (TBI) is high. Coagulopathy can aggravate intracranial hemorrhage and further increase morbidity and mortality. The purpose of this study was to determine the clinical charac...

(This article belongs to the Special Issue Advances in Neurotrauma)
  • Review
  • Open Access
20 Citations
5,317 Views
17 Pages

30 December 2021

Eating behavior is controlled by hypothalamic circuits in which agouti-related peptide-expressing neurons when activated in the arcuate nucleus, promote food intake while pro-opiomelanocortin-producing neurons promote satiety. The respective neurotra...

(This article belongs to the Special Issue Advances in the Aetiology and Treatment of Anorexia Nervosa)
  • Editorial
  • Open Access
3 Citations
2,398 Views
3 Pages

Myeloid-Derived Suppressor Cells (MDSCs) in Haematology

  • Nikoleta Bizymi and
  • Helen A. Papadaki

30 December 2021

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunomodulating properties, mainly acting by suppressing T-cell responses [...]

(This article belongs to the Special Issue Myeloid-Derived Suppressor Cells (MDSCs) in Haematology)
  • Article
  • Open Access
69 Citations
13,547 Views
14 Pages

From Emotional (Dys)Regulation to Internet Addiction: A Mediation Model of Problematic Social Media Use among Italian Young Adults

  • Alessandro Quaglieri,
  • Silvia Biondi,
  • Paolo Roma,
  • Manuel Varchetta and ,
  • Angelo Fraschetti,
  • Jessica Burrai,
  • Giulia Lausi,
  • Manuel Martí-Vilar,
  • Francisco González-Sala and
  • Emanuela Mari
  • + 7 authors+ 2 authors

30 December 2021

Internet addiction (IA) has mostly been investigated with the fear of missing out and difficulties in emotional regulation. The present study examined the link between IA and variables related to problematic social media use (i.e., fear of missing ou...

(This article belongs to the Special Issue Gambling, Gaming and Other Behavioural Addictions)
  • Article
  • Open Access
9 Citations
6,306 Views
14 Pages

Multispectral Imaging Algorithm Predicts Breslow Thickness of Melanoma

  • Szabolcs Bozsányi,
  • Noémi Nóra Varga,
  • Klára Farkas,
  • András Bánvölgyi and ,
  • Kende Lőrincz,
  • Ilze Lihacova,
  • Alexey Lihachev,
  • Emilija Vija Plorina,
  • Áron Bartha and
  • Norbert M. Wikonkál
  • + 11 authors+ 6 authors

30 December 2021

Breslow thickness is a major prognostic factor for melanoma. It is based on histopathological evaluation, and thus it is not available to aid clinical decision making at the time of the initial melanoma diagnosis. In this work, we assessed the effica...

(This article belongs to the Special Issue Advance in Melanoma)
  • Article
  • Open Access
12 Citations
3,189 Views
13 Pages

Effect of Prehospital Epinephrine Use on Survival from Out-of-Hospital Cardiac Arrest and on Emergency Medical Services

  • Song Yi Park,
  • Daesung Lim,
  • Seong Chun Kim,
  • Ji Ho Ryu and ,
  • Yong Hwan Kim,
  • Byungho Choi and
  • Sun Hyu Kim
  • + 2 authors+ 0 author

30 December 2021

This study was to identify the effect of epinephrine on the survival of out-of-hospital cardiac arrest (OHCA) patients and changes in prehospital emergency medical services (EMSs) after the introduction of prehospital epinephrine use by EMS providers...

(This article belongs to the Section Emergency Medicine)
  • Review
  • Open Access
4 Citations
4,583 Views
13 Pages

30 December 2021

Our health requires continual protein synthesis for maintaining and repairing tissues. For protein synthesis to function, all the essential (indispensable) amino acids (IAAs) must be available in the diet, along with those AAs that the cells can synt...

(This article belongs to the Special Issue Molecular Mechanisms of Appetite Regulation)
  • Article
  • Open Access
17 Citations
3,810 Views
7 Pages

Surgical Applications of Lymphatic Vessel Visualization Using Photoacoustic Imaging and Augmented Reality

  • Yushi Suzuki,
  • Hiroki Kajita,
  • Shiho Watanabe,
  • Marika Otaki and ,
  • Keisuke Okabe,
  • Hisashi Sakuma,
  • Yoshifumi Takatsume,
  • Nobuaki Imanishi,
  • Sadakazu Aiso and
  • Kazuo Kishi
  • + 5 authors+ 0 author

30 December 2021

Lymphaticovenular anastomosis (LVA) is a widely performed surgical procedure for the treatment of lymphedema. For good LVA outcomes, identifying lymphatic vessels and venules is crucial. Photoacoustic lymphangiography (PAL) is a new technology for vi...

(This article belongs to the Special Issue Surgical Management of Lymphedema: Past, Present, and Future)
  • Article
  • Open Access
31 Citations
5,938 Views
19 Pages

30 December 2021

Background: Heart rate variability (HRV) and electrocardiogram (ECG)-derived respiration (EDR) have been used to detect sleep apnea (SA) for decades. The present study proposes an SA-detection algorithm using a machine-learning framework and bag-of-f...

(This article belongs to the Special Issue Current Perspectives on the Treatment of Obstructive Sleep Apnea - Part I)
  • Review
  • Open Access
19 Citations
4,723 Views
17 Pages

Contemporary Fertility-Sparing Management Options of Early Stage Endometrioid Endometrial Cancer in Young Nulliparous Patients

  • Gulzhanat Aimagambetova,
  • Sanja Terzic,
  • Antonio Simone Laganà,
  • Gauri Bapayeva and ,
  • Philip la Fleur and
  • Milan Terzic
  • + 1 author+ 0 author

30 December 2021

Incidence of endometrial cancer (EC) has been increasing in recent years, especially in high-income countries. The disease commonly affects peri- and postmenopausal women; however, about 5% of women are diagnosed with EC in their reproductive age. Du...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
3 Citations
2,426 Views
8 Pages

Aspirin Use Is Not Associated with the Risk of Metachronous Gastric Cancer in Patients without Helicobacter pylori Infection

  • Ji Eun Kim,
  • Tae Jun Kim,
  • Hyuk Lee,
  • Yeong Chan Lee and ,
  • Hwe Hoon Chung,
  • Yang Won Min,
  • Byung-Hoon Min,
  • Jun Haeng Lee and
  • Jae J. Kim
  • + 4 authors+ 0 author

30 December 2021

Introduction: Helicobacter pylori (H. pylori) eradication can prevent metachronous gastric cancer (MGC) after the performance of an endoscopic resection for early gastric cancer (EGC). However, 50% of infections persist after eradication, and the ide...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Review
  • Open Access
41 Citations
8,735 Views
20 Pages

Lifestyle and Pain following Cancer: State-of-the-Art and Future Directions

  • Astrid Lahousse,
  • Eva Roose,
  • Laurence Leysen,
  • Sevilay Tümkaya Yilmaz and ,
  • Kenza Mostaqim,
  • Felipe Reis,
  • Emma Rheel,
  • David Beckwée and
  • Jo Nijs
  • + 4 authors+ 0 author

30 December 2021

This review discusses chronic pain, multiple modifiable lifestyle factors, such as stress, insomnia, diet, obesity, smoking, alcohol consumption and physical activity, and the relationship between these lifestyle factors and pain after cancer. Chroni...

(This article belongs to the Special Issue Lifestyle and Chronic Pain)
  • Article
  • Open Access
3,299 Views
15 Pages

Date of Admission during COVID-19 Pandemic Impacted Patient Outcomes in Addition to the Higher Efficacy of Tocilizumab Plus High-Dose Corticosteroid Therapy Compared to Tocilizumab Alone

  • Moncef Belhassen-García,
  • Antonio Sánchez-Puente,
  • Pedro-Ignacio Dorado-Díaz,
  • Amparo López-Bernús and ,
  • Jesús Sampedro-Gómez,
  • Raúl Azibeiro-Melchor,
  • Edgard Marcano-Millán,
  • Beatriz Rodríguez-Alonso,
  • María-Elisa Sánchez-Barrado and
  • José-Ángel Martín-Oterino
  • + 28 authors+ 23 authors

30 December 2021

Background: The evidence for the efficacy of glucocorticoids combined with tocilizumab (TCZ) in COVID-19 comes from observational studies or subgroup analysis. Our aim was to compare outcomes between hospitalized COVID-19 patients who received high-d...

(This article belongs to the Special Issue Epidemiology and Impact of SARS-CoV-2 Vaccines)
  • Article
  • Open Access
6 Citations
3,606 Views
14 Pages

Poor Long-Term Renal Allograft Survival in Patients with Chronic Antibody-Mediated Rejection, Irrespective of Treatment—A Single Center Retrospective Study

  • Kaiyin Wu,
  • Danilo Schmidt,
  • Covadonga López del Moral,
  • Bilgin Osmanodja and ,
  • Nils Lachmann,
  • Qiang Zhang,
  • Fabian Halleck,
  • Mira Choi,
  • Friederike Bachmann and
  • Klemens Budde
  • + 10 authors+ 5 authors

30 December 2021

The Banff 2017 report permits the diagnosis of pure chronic antibody-mediated rejection (cAMR) in absence of microcirculation inflammation. We retrospectively investigated renal allograft function and long-term outcomes of 67 patients with cAMR, and...

(This article belongs to the Collection Novel Insights in Renal Transplantation)
  • Article
  • Open Access
23 Citations
3,398 Views
15 Pages

Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus—Report 2: Diabetic Kidney Disease

  • Aníbal Alé-Chilet,
  • Carolina Bernal-Morales,
  • Marina Barraso,
  • Teresa Hernández and ,
  • Cristian Oliva,
  • Irene Vinagre,
  • Emilio Ortega,
  • Marc Figueras-Roca,
  • Anna Sala-Puigdollers and
  • Javier Zarranz-Ventura
  • + 9 authors+ 4 authors

30 December 2021

The purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete oc...

(This article belongs to the Special Issue State-of-the-Art Research on Diabetic Retinopathy)
  • Review
  • Open Access
33 Citations
7,533 Views
22 Pages

Acute Mesenteric Ischemia in COVID-19 Patients

  • Dragos Serban,
  • Laura Carina Tribus,
  • Geta Vancea,
  • Anca Pantea Stoian and ,
  • Ana Maria Dascalu,
  • Andra Iulia Suceveanu,
  • Ciprian Tanasescu,
  • Andreea Cristina Costea,
  • Mihail Silviu Tudosie and
  • Daniel Ovidiu Costea
  • + 8 authors+ 3 authors

30 December 2021

Acute mesenteric ischemia is a rare but extremely severe complication of SARS-CoV-2 infection. The present review aims to document the clinical, laboratory, and imaging findings, management, and outcomes of acute intestinal ischemia in COVID-19 patie...

(This article belongs to the Special Issue COVID-19 and Gastrointestinal Disease: Current Insights and Future Management)
  • Article
  • Open Access
16 Citations
2,907 Views
10 Pages

Evolution of Salvage Radical Prostatectomy from Open to Robotic and Further to Retzius Sparing Surgery

  • Viktoria Schuetz,
  • Philipp Reimold,
  • Magdalena Goertz,
  • Luisa Hofer and ,
  • Svenja Dieffenbacher,
  • Joanne Nyarangi-Dix,
  • Stefan Duensing,
  • Markus Hohenfellner and
  • Gencay Hatiboglu
  • + 4 authors+ 0 author

30 December 2021

Salvage radical prostatectomy (sRP) has evolved from open to minimally invasive approaches. sRP can be offered to patients with local recurrence to improve biochemical recurrence (BCR)-free and overall survival. We evaluate oncological outcome and co...

(This article belongs to the Section Nephrology & Urology)
  • Editorial
  • Open Access
7 Citations
2,234 Views
3 Pages

30 December 2021

Bladder cancer (BC) is a complex disease with the following presentations, which are completely different from one another: non-muscle-infiltrating bladder cancer (NMIBC) and muscle-infiltrating bladder cancer (MIBC) [...]

(This article belongs to the Special Issue Advances in Management of Bladder Cancer)
  • Article
  • Open Access
2 Citations
2,962 Views
10 Pages

Triage Strategies Based on C-Reactive Protein Levels and SARS-CoV-2 Tests among Individuals Referred with Suspected COVID-19: A Prospective Cohort Study

  • Erika Olivia Boyesen,
  • Ida Maria Balsby,
  • Marius Henriksen,
  • Robin Christensen and ,
  • Jens Henning Rasmussen,
  • Finn Erland Nielsen,
  • Hanne Nygaard,
  • Lennart Jan Friis-Hansen,
  • Susanne Dam Nielsen and
  • Henning Bliddal
  • + 8 authors+ 3 authors

30 December 2021

C-reactive protein (CRP) has prognostic value in hospitalized patients with COVID-19; the importance of CRP in pre-hospitalized patients remains to be tested. Methods: Individuals with symptoms of COVID-19 had a SARS-CoV-2 PCR oropharyngeal swab test...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
5 Citations
2,993 Views
13 Pages

Coronary Flow Velocity Reserve Using Dobutamine Test for Noninvasive Functional Assessment of Myocardial Bridging

  • Srdjan B. Aleksandric,
  • Ana D. Djordjevic-Dikic,
  • Vojislav L. Giga,
  • Milorad B. Tesic and ,
  • Ivan A. Soldatovic,
  • Marko D. Banovic,
  • Milan R. Dobric,
  • Vladan Vukcevic,
  • Miloje V. Tomasevic and
  • Branko D. Beleslin
  • + 11 authors+ 6 authors

30 December 2021

Background: It has been shown that coronary flow velocity reserve (CFVR) measurement by transthoracic Doppler echocardiography (TTDE) during dobutamine (DOB) provocation provides a more accurate functional evaluation of myocardial bridging (MB) compa...

(This article belongs to the Special Issue Imaging Research in Cardiovascular Diseases)
  • Article
  • Open Access
6 Citations
3,656 Views
20 Pages

Structural Changes in Trabecular Bone, Cortical Bone and Hyaline Cartilage as Well as Disturbances in Bone Metabolism and Mineralization in an Animal Model of Secondary Osteoporosis in Clostridium perfringens Infection

  • Agnieszka Tomczyk-Warunek,
  • Tomasz Blicharski,
  • Siemowit Muszyński,
  • Ewa Tomaszewska and ,
  • Piotr Dobrowolski,
  • Rudolf Blicharski,
  • Jaromir Jarecki,
  • Anna Arczewska-Włosek,
  • Sylwester Świątkiewicz and
  • Damian Józefiak
  • + 5 authors+ 0 author

30 December 2021

There is no information regarding whether changes in the microbiological balance of the gastrointestinal tract as a result of an infection with Clostridium perfringens influence the development of metabolic bone disorders. The experiment was carried...

(This article belongs to the Special Issue Secondary Osteoporosis and Metabolic Bone Diseases)
  • Article
  • Open Access
23 Citations
3,004 Views
12 Pages

Association between Enzyme-Linked Immunosorbent Assay-Measured Kidney Injury Markers and Urinary Cadmium Levels in Chronic Kidney Disease

  • Kai-Fan Tsai,
  • Pai-Chin Hsu,
  • Chien-Te Lee,
  • Chia-Te Kung and ,
  • Yi-Chin Chang,
  • Lung-Ming Fu,
  • Yu-Che Ou,
  • Kuo-Chung Lan,
  • Tzung-Hai Yen and
  • Wen-Chin Lee
  • + 5 authors+ 0 author

29 December 2021

Cadmium exposure is associated with chronic kidney disease (CKD), but the optimal biomarker for early cadmium-associated nephrotoxicity in low-level exposure has not yet been established. We conducted a cross-sectional investigation involving 167 CKD...

(This article belongs to the Special Issue Role of Enzyme-Linked Immunosorbent Assay (ELISA))

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J. Clin. Med. - ISSN 2077-0383