2026 October - 81 articles
Background/Objectives: Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to the global swine industry, while the emergence of variant pseudorabies virus (PRV) strains has further complicated disease control in China....
Background: Human papillomavirus (HPV) is a major preventable cause of cervical and other HPV-related cancers. Despite the proven effectiveness of HPV vaccination, knowledge gaps and misconceptions continue to limit vaccine uptake among young adults....
As the sole viral protein expressed on the surface of viral particles and infected cells, the HIV-1 envelope glycoprotein is the most important target for vaccine development. Structurally defined sites of vulnerability recognized by broadly neutrali...
Background/Objectives: Patients with spondyloarthritis (SpA) frequently receive immunomodulatory therapies that may influence vaccine-induced immune responses. However, evidence comparing the immunogenicity, safety, and clinical outcomes following ho...
The rapid evolution of pathogens, particularly viruses, poses a continuous threat to global public health, necessitating the development of highly scalable and cost-effective vaccine platforms. Plant-based virus-like particles (VLPs) have emerged as...
Background: Varicella-containing vaccines have substantially reduced the burden of varicella worldwide; however, comprehensive evidence on adverse events following vaccination in children remains important for vaccine safety monitoring, vaccine confi...
Background/Objectives: Gaps in routine childhood immunisation coverage persist in the Solomon Islands, with completion of the vaccination schedule varying considerably between remote and geographically isolated communities. While structural and logis...
Background: Costa Rica introduced universal one-dose varicella vaccination in 2007 using a one-dose schedule administered at 15 months of age through the Costa Rican Social Security Fund (CCSS). A previous national study described epidemiological cha...
Background/Objectives: Human organoids have emerged as physiologically relevant models bridging conventional two-dimensional cultures and animal models. This review summarizes advances in their application to infectious disease modeling and vaccine r...
Background: Although HPV vaccination is an effective cancer-prevention strategy, vaccination uptake among young adults remains suboptimal in many countries despite generally positive attitudes towards vaccination. The aim of this study was to assess...
Background/Objectives: Parental attitudes toward vaccination influence the timely and complete immunization of children, including uptake of recommended vaccines. This study assessed self-reported compliance with mandatory vaccination, use of recomme...
Background: Pneumococcal disease imposes a substantial public health burden in India, particularly among older adults and individuals with chronic or immunocompromising conditions. Although the 13-valent pneumococcal conjugate vaccine (PCV13) and the...
African swine fever (ASF) is a highly lethal disease affecting domestic pigs and wild boar, with no safe vaccines available. Macrophages are the primary target cells of African swine fever virus (ASFV), and infection impairs their antiviral functions...
Vaccination represents one of the most effective public health interventions for preventing infectious diseases, reducing morbidity and mortality, and protecting vulnerable populations [...]
Dengue is one of the most rapidly spreading arboviral diseases worldwide, and the development of effective vaccines has long been constrained by antibody-dependent enhancement (ADE) and the difficulty of inducing protective immunity against multiple...
Background/Objectives: Cardiovascular diseases (CVDs) remain a major contributor to morbidity, mortality, and healthcare costs worldwide. Acute respiratory infections such as influenza and pneumococcal disease can precipitate severe cardiovascular ev...
Background/Objectives: Local manufacturing of Measles-Rubella (MR) vaccines is part of a multifaceted approach to improve vaccine accessibility in Africa, yet process development and technology transfer challenges remain for large-scale production of...
Background: Nowadays, poliomyelitis caused by wild polioviruses (PVs) has been virtually eradicated. However, since the removal of the type 2 component from the oral polio vaccine (OPV), immunity to PV2 has declined despite expansion of the use of th...
Background/Objectives: Hantaviruses infections are responsible for a hemorrhagic fever with renal and cardiopulmonary syndrome with case-fatality rates up to 50%. While inactivated vaccines are already available in China and South Korea, several addi...
Background: There is evidence for the protective effects of antibodies targeting non-structural protein 1 (NS1) of Zika virus (ZIKV); however, effective vaccines against ZIKV remain lacking. Methods: In this study, lipid nanoparticle (LNP)-encapsulat...
Tuberculosis (TB) remains one of the leading causes of infectious disease mortality worldwide despite widespread Bacille Calmette-Guérin (BCG) vaccination and decades of control efforts. The limited and variable efficacy of current vaccination...
Background/Objectives: Although the COVID-19 pandemic has ended, emerging SARS-CoV-2 variants remain a future threat. This study evaluated the safety and efficacy of an intranasal live attenuated vaccine (LAV) prototype based on a temperature-sensiti...
Background: Dengue vaccination is a promising preventive strategy. Peru introduced the TAK-003 vaccine in November 2024 for children aged 10–16 years and expanded it in January 2026 to individuals aged 10–20 years and selected priority ad...
Background/Objectives: Pre-existing anti-Ad5 immunity (PEI) impairs the immunogenicity of intramuscular (IM) Ad5-vectored vaccines. Whether respiratory immunization can better preserve vaccine-induced immunity remains unclear. Methods: We established...
Background: Human papillomavirus includes more than 200 types, classified by cancer risk. Since 2006, the vaccine has effectively prevented human papillomavirus infection and associated cancers; however, coverage among adults remains low. Furthermore...
Background/Objectives: Brucellosis is a widespread intracellular zoonosis that continues to impose substantial public-health and economic burdens in endemic regions. No human brucellosis vaccine has yet been approved, and most existing multi-epitope...
Plant-derived compounds, particularly saponins and polysaccharides, have attracted interest as vaccine adjuvants because of their diverse immunomodulatory activities. Increasing evidence suggests that the immunological activities of these compounds a...
Background/Objectives: Recent outbreaks of the mpox virus (MPVX) have highlighted the threat posed by the Orthopoxvirus (OPXV) genus, which includes variola, the causative agent of smallpox. Since routine Vaccinia virus (VACV) vaccination campaigns t...
Background/Objectives: SARS-CoV-2-specific antibody levels vary among patients with systemic autoimmune rheumatic diseases (SARDs). In rheumatoid arthritis (RA), the most prevalent SARD, this is further shaped by rheumatoid factors (RFs). Attenuated...
Background/Objectives: Fractional intradermal administration may offer a dose-sparing approach to dengue vaccination. This randomized pilot study explored the administration of a fractional intradermal second dose of TAK-003 and described immune resp...
Background: Cellular responses to live attenuated herpes zoster vaccination and their variation with age remain incompletely characterized. We aimed to define their temporal and cellular organization and identify immune features that differed between...
Background/Objectives: Mobile phone-based vaccination interventions, including SMS reminders, voice calls and tracking applications, have repeatedly shown effectiveness in controlled settings across sub-Saharan Africa. Many nevertheless stop operatin...
Background/Objectives: This study aims to determine university students’ knowledge and attitudes in Cyprus regarding human papillomavirus (HPV) and the HPV vaccine. Methods: We conducted a cross-sectional study of 601 university students in Cyp...
Background/Objectives: Seasonal influenza vaccines have been developed to reduce the risk of severe complications in older adults, who are at increased risk of influenza-related morbidity and mortality. This study aimed to synthesize the available ev...
Objective: RSV is a significant contributor to severe acute respiratory infection (SARI) admissions. Despite national recommendations for RSV vaccination in Ireland, they have not been implemented due to cost concerns and evidence gaps. We assessed R...
Hepatitis B remains an important occupational risk for undergraduate nursing students, particularly due to potential exposure, making vaccination and infection knowledge essential for protection throughout their professional careers. Objective: This...
Background: Group A Streptococcus (GAS) remains a leading cause of preventable mortality and disability among older adults, yet its long-term epidemiological trajectory in Asia’s rapidly ageing populations remains poorly characterised. Methods:...
Background/Objectives: The recombinant zoster vaccine (RZV), Shingrix®, has shown great efficacy in protecting against herpes zoster. However, emerging evidence suggests that this RZV might provide benefits that extend beyond preventing varicella...
Background: Bacillus Calmette–Guérin (BCG) vaccination is essential for preventing severe tuberculosis in early childhood. The BCG vaccine is administered at birth and carries a risk of disseminated disease, especially in immunocompromis...
Objectives: To evaluate the real-world effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in reducing all-cause, pneumonia-related, and chronic obstructive pulmonary disease (COPD)-related mortality in adults aged ≥60 year...
Background/Objectives: Vaccination is the most important way to prevent infection-related morbidity and mortality, but delays in the acceptance or refusal of vaccines despite the availability of vaccination services can adversely affect health outcom...
Background: Evidence on the real-world use of the MAV/06-strain live attenuated varicella vaccine (BARYCELA inj.) in adolescents and adults is limited. We described postvaccination ELISA seropositivity and recorded medically attended events in recipi...
Seasonal influenza and the ongoing emergence of zoonotic influenza viruses, including highly pathogenic avian influenza A (H5N1), remain substantial global public health threats, underscoring the need for rapidly adaptable vaccine platforms. This sta...
Background/Objectives: School-based vaccination is a major strategy for improving human papillomavirus (HPV) vaccination coverage, but implementation varies across countries. This study aimed to identify common organisational components of internatio...
Vaccination is one of the most cost-effective public health interventions, yet parental knowledge gaps remain a barrier to timely childhood immunization. Digital health platforms offer new opportunities for scalable education. Objective: To evaluate...
Background/Objective: Since 2004, seasonal influenza vaccination has been technically recommended for poultry workers as a public health measure to reduce the risk of co-infection with human and avian influenza viruses and the potential emergence of...
Background/Objectives: Despite the availability of safe and highly effective human papillomavirus (HPV) vaccines, vaccination coverage remains below global targets in many low- and middle-income countries. School-based HPV prevention campaigns repres...
Typhoid fever, caused by Salmonella enterica serovars Typhi and Paratyphi, remains a major public health threat across Africa and Asia and causes substantial annual morbidity. Transmission persists in low- and middle-income countries (LMICs), where a...
Background/Objectives: The clinical implications of HBsAg seroreversion following HBV functional cure therapies remain unclear. In two randomized phase 2 trials, therapeutic vaccine BRII-179 or siRNA elebsiran in combination with PEG-IFNα was e...
Objectives: Mycobacterium bovis (M. bovis) infection in children is uncommon but may remain unrecognized because routine laboratory methods often fail to distinguish it from Mycobacterium tuberculosis. In addition, Bacillus Calmette–Guér...
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