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Antibodies in Autoimmune, Chronic, and Infectious Diseases: Pathogenic Mechanisms, Biomarkers,...
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Antibodies in Autoimmune, Chronic, and Infectious Diseases: Pathogenic Mechanisms, Biomarkers, and Vaccine Development

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines, Clinical Advancement, and Associated Immunology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 3122

Special Issue Editors

Dr. Jorge Hernández-Bello

E-Mail Website
Guest Editor
Instituto de Investigación en Ciencias Biomédicas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico
Interests: autoimmune diseases; antibody biomarkers; immunogenetics; inflammation; cytokines; B cell immunity; vaccines; chronic inflammatory diseases
Dr. Mariel García Chagollán

E-Mail Website
Guest Editor
Instituto de Investigación en Ciencias Biomédicas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico
Interests: cancer immunology; tumor microenvironment; antibody-based therapies; cytokines and inflammation; cellular immunotherapy; immunopathology; monoclonal and bispecific antibodies
Dr. Francisco Javier Turrubiates Hernández

E-Mail Website
Guest Editor
Instituto de Investigación en Ciencias Biomédicas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Mexico
Interests: autoimmune diseases; immunogenetics; inflammatory markers; antibody responses; cytokine networks; chronic inflammatory conditions; clinical immunology; diagnostic biomarkers; nutrition

Special Issue Information

Dear Colleagues,

Antibodies are central players in the immune system, acting as both sentinels and effectors in a wide range of physiological and pathological processes. In autoimmune diseases, antibodies often lose their specificity for foreign antigens and instead target self-components, contributing to chronic inflammation and tissue damage. In chronic conditions, antibodies may serve as biomarkers or modulators of disease progression, while in infectious diseases they are key components of both natural and vaccine-induced immunity.

The growing understanding of antibody diversity, functionality, and regulation has opened new avenues for diagnostic, prognostic, and therapeutic innovations. Moreover, the development of monoclonal antibodies, bispecific constructs, and antibody-based vaccines offers promising strategies for managing diseases that were previously difficult to treat.

This Special Issue aims to gather original research articles and comprehensive reviews that explore the roles of antibodies in autoimmune, chronic, and infectious diseases. We especially welcome contributions focused on antibody mechanisms, engineering, clinical applications, immune evasion strategies by pathogens, and novel approaches to antibody-based vaccine development.

We look forward to your valuable contributions.

Dr. Jorge Hernández-Bello
Dr. Mariel García Chagollán
Dr. Francisco Javier Turrubiates Hernández
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoantibodies
  • monoclonal antibodies
  • chronic diseases
  • infectious diseases
  • autoimmune diseases
  • antibody-based vaccines
  • immunotherapy
  • antibody biomarkers
  • b cell response
  • translational immunology

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Published Papers (1 paper)

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Research

14 pages, 1317 KB  
Article
Decreasing Antibody Titers and the Slow Decay of Measles Immunity in Mexico’s Current Epidemiological Landscape
by José Francisco Muñoz-Valle, Gabriela Macedo-Ojeda, Francisco Javier Turrubiates-Hernández, Jorge Hernández-Bello, Samuel García-Arellano, Cristian Oswaldo Hernández-Ramírez, Christian Johana Baños-Hernández, Pablo Moisés Coronado-Carrillo, Juan Carlos Lona-Reyes and Oliver Viera-Segura
Vaccines 2026, 14(3), 234; https://doi.org/10.3390/vaccines14030234 - 4 Mar 2026
Viewed by 1723
Abstract
Background: Measles remains a global public health threat despite the availability of an effective vaccine and substantial progress toward elimination in many countries. Outbreaks in highly vaccinated settings suggest that waning vaccine-induced immunity, particularly among adults, may create silent susceptibility gaps capable of [...] Read more.
Background: Measles remains a global public health threat despite the availability of an effective vaccine and substantial progress toward elimination in many countries. Outbreaks in highly vaccinated settings suggest that waning vaccine-induced immunity, particularly among adults, may create silent susceptibility gaps capable of sustaining viral transmission. Aim: To evaluate age- and cohort-specific patterns of measles-specific antibody levels in Mexican adults and to examine evidence suggesting lower vaccine-induced antibody levels in younger vaccinated cohorts. Methods: A cross-sectional seroepidemiological study was conducted among 302 voluntary blood donors aged 18–70 years. Demographic, clinical, and vaccination data were collected through structured interviews. Serum anti-measles-virus (MV) IgG levels were quantified using a commercial ELISA. Antibody concentrations were analyzed according to age, sex, vaccination history, self-reported measles infection, and historical vaccination strategies. Multivariate linear models were applied to identify factors associated with IgG levels. Results: Anti-MV IgG seropositivity (>200 mIU/mL) was 67.2%, with a geometric mean concentration (GMC) of 270.43 mIU/mL. A positive correlation was observed between age and antibody levels (rs = 0.161, p = 0.005). Individuals born before the introduction of the measles vaccine (pre-1970) had significantly higher GMCs (1096.63 mIU/mL) than younger cohorts. A history of natural infection tended to be associated with higher antibody levels (GMC: 428.38 vs. 257.24 mIU/mL; p = 0.051). In multivariate analysis, historical vaccination strategy emerged as the primary factor associated with antibody levels, whereas age alone was not significant. Conclusions: Cohort-specific differences in measles IgG levels suggest generational patterns of immunity and are consistent with diminished vaccine-induced antibody levels in younger adults in the absence of natural boosting. These findings highlight the importance of ongoing serological surveillance in post-elimination settings and underscore the need for targeted public health interventions. Full article
(This article belongs to the Special Issue Antibodies in Autoimmune, Chronic, and Infectious Diseases: Pathogenic Mechanisms, Biomarkers, and Vaccine Development)
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