The Critical Role of Adjuvants in Modern Vaccinology

Dear Colleagues,

There is a lack of safe and effective adjuvants to support the development of new and improved vaccines. Often, different types of adjuvants are necessary to induce optimal immune responses for specific diseases, and adjuvants may need to be tailored to specific age groups. Historically, the development of adjuvants has relied mainly on empirical experience, with only a handful of adjuvants approved for human use since the first, Alum, was discovered over 90 years ago. However, substantial advances have been made over the last three decades in our understanding of how adjuvants function.

This Special Issue will include commentaries, original research articles, and reviews related to the discovery and development of adjuvants for various types of vaccines, such as subunit and mRNA-based vaccines to combat infectious diseases, cancer, and immune-mediated diseases. Additionally, we welcome studies on the mechanisms of adjuvants and investigations into the development of combinatorial adjuvants for vaccine applications.

Dr. Xinyuan Chen
Guest Editor

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