3rd Edition: Safety and Autoimmune Response to SARS-CoV-2 Vaccination

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "COVID-19 Vaccines and Vaccination".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1900

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Guest Editor
Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Interests: PET/CT; COVID-19; Vaccine; Vaccination
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Special Issue Information

Dear Colleagues,

COVID-19 remains a public health concern. Vaccination is important to prevent disease. SARS-CoV-2 vaccines are considered highly effective and safe despite several indications of adverse events following immunization. These transient symptoms have been reported to include cerebral venous sinus thrombosis, demyelinating episodes, lymphadenopathy, cognitive decline, and myalgia/arthralgia.
We invite you to contribute your work to this Special Issue titled “Safety and Autoimmune Response to SARS-CoV-2 Vaccination”. This Special Issue aims to publish high-quality reviews, regular research papers, and communications on the safety of the SARS-CoV-2 vaccine in the general population and special groups, proposals of different schedules and their effects on vaccine safety, security of neurological adverse events following immunization, and other aspects that may be proposed.

We look forward to receiving your contributions.

Dr. Minghui Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19 vaccine
  • vaccine efficacy
  • vaccine safety
  • adverse events following immunization

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Published Papers (1 paper)

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12 pages, 1521 KB  
Case Report
Thyroid Eye Disease Following SARS-CoV-2 Vaccination: Experience of a Case Series
by Alin Abreu Lomba, María Elena Tello-Cajiao, Mónica Morales, Alexander Martínez, Mauricio Andrés Salazar Moreno, David Alexander Vernaza Trujillo, Alice Gaibor-Pazmiño and Juan S. Izquierdo-Condoy
Vaccines 2026, 14(1), 37; https://doi.org/10.3390/vaccines14010037 - 28 Dec 2025
Cited by 1 | Viewed by 1271
Abstract
Background: Thyroid eye disease (TED), or Graves’ orbitopathy, is the most common extra-thyroidal manifestation of Graves’ disease, but it has only rarely been reported after SARS-CoV-2 vaccination. Autoimmune thyroid disease, including subacute thyroiditis and Graves’ disease, has been described following COVID-19 vaccination; we [...] Read more.
Background: Thyroid eye disease (TED), or Graves’ orbitopathy, is the most common extra-thyroidal manifestation of Graves’ disease, but it has only rarely been reported after SARS-CoV-2 vaccination. Autoimmune thyroid disease, including subacute thyroiditis and Graves’ disease, has been described following COVID-19 vaccination; we present a case series of TED occurring shortly after different COVID-19 vaccines to provide clinical data on this potential safety signal. Case presentation: We describe five women (mean age 47 years; range 27–69) who developed TED 3–20 days after COVID-19 vaccination with mRNA or adenoviral vector vaccines, three of whom had pre-existing thyroid disease. Presentations included ocular and retro-orbital pain, exophthalmos, headache, goiter, tremor, depressive symptoms, and, in one case, anterior neck pain and fever. TED severity (ETA/EUGOGO) ranged from mild to severe, with frequent findings of suppressed TSH, elevated thyroid autoantibodies, and inflammatory markers, as well as imaging evidence of exophthalmos, extraocular muscle enlargement, and diffuse or multinodular goiter. Management with intravenous corticosteroids, selenium, levothyroxine adjustment, and/or intramuscular corticosteroids led to improvement in thyroid function and inflammation by 3 months, although mild TED often persisted. Conclusions: This case series supports a temporal association between COVID-19 vaccination and new-onset or exacerbated TED in individuals with autoimmune thyroid disease. Although vaccination benefits outweigh potential risks, clinicians should remain alert to ocular and thyroid symptoms after immunization to ensure timely diagnosis and management. Full article
(This article belongs to the Special Issue 3rd Edition: Safety and Autoimmune Response to SARS-CoV-2 Vaccination)
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