Vaccines and Immunization: Measles, Mumps, and Rubella

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Epidemiology and Vaccination".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 577

Special Issue Editor


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Guest Editor
Kawasaki City Institute for Public Health, Kawasaki City 210-0821, Kanagawa, Japan
Interests: infectious diseases; pediatric infectious diseases; virology; immunization

Special Issue Information

Dear Colleagues,

Measles, mumps, and rubella are viral diseases with many complications. Measles can become severe and often lead to death, mumps are associated with hearing loss, and rubella infection in pregnant women can cause fetal infection and CRS at high rates. Fortunately, the number of cases has dropped dramatically in countries and regions where vaccines are widely used. However, the COVID-19 pandemic, poverty, and conflicts have significantly impacted vaccination efforts. In areas where immunization rates have declined, a resurgence of these diseases is also affecting neighboring countries. Moreover, while measles, mumps, and rubella have typically been viewed as childhood diseases, recent epidemiological trends show that their impact extends to adults and the elderly. This Special Issue aims to explore the future of these diseases, focusing on advancements in understanding their pathology and virology, changes in the epidemiological landscape, and progress in developing future vaccines.

We look forward to your contributions and insights on this important topic.

Dr. Nobuhiko Okabe
Guest Editor

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Keywords

  • measles
  • mumps
  • rubella
  • SSPE
  • hearing loss
  • CRS
  • immune mechanism
  • epidemiology
  • resurgence
  • life-course immunization

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Published Papers (1 paper)

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Research

18 pages, 849 KiB  
Article
Seroprevalence of Measles-, Mumps-, and Rubella-Specific Antibodies in Future Healthcare Workers in Serbia: A Cross-Sectional Study
by Ana Banko, Andja Cirkovic, Vladimir Petrovic, Mioljub Ristic, Vladimir Vukovic, Dobrila Stankovic-Djordjevic and Danijela Miljanovic
Vaccines 2025, 13(7), 700; https://doi.org/10.3390/vaccines13070700 - 27 Jun 2025
Viewed by 304
Abstract
Background/Objectives: Measles, mumps, and rubella (MMR) continue to pose a significant public health challenge due to insufficient immunization coverage. This study aimed to provide the first seroprevalence data against MMR and to explore self-reported immunity among future healthcare workers (HCWs) in Serbia, including [...] Read more.
Background/Objectives: Measles, mumps, and rubella (MMR) continue to pose a significant public health challenge due to insufficient immunization coverage. This study aimed to provide the first seroprevalence data against MMR and to explore self-reported immunity among future healthcare workers (HCWs) in Serbia, including women of childbearing age. Methods: We included 1296 future health care workers (HCWs) aged 19 to 29, born in Serbia. All HCWs supplied a blood sample for serology and filled in a questionnaire. Antibodies were measured using an enzyme immunoassay against measles, mumps, and rubella (MMR). Results: Anti-measles, -mumps, and -rubella seronegativity rates were 25.6%, 26.5%, and 4.4%, respectively, among future HCWs in Serbia. The mumps seronegativity rate was significantly higher in the oldest (27–29-year) age group, accompanied by significantly lower anti-mumps IgG GMCs in the same age group compared to younger participants (p = 0.035 and p < 0.001, respectively). Anti-mumps seronegativity also increased significantly across birth cohorts, from the youngest to the oldest (p = 0.004). Furthermore, anti-mumps IgG antibody GMCs were significantly higher among females, those who attended nursery/kindergarten, and unvaccinated individuals (p = 0.050, p = 0.020, and p = 0.005, respectively). Finally, older age and unvaccinated status were identified as independent factors associated with anti-measles and anti-mumps seronegativity among future HCWs in Serbia. Conclusions: The cross-sectional seroprevalence data revealed insufficient seroprotection in this population of particular importance, i.e., future HCWs, and women of childbearing age. These results strongly support the national recommendations for the mandatory vaccination of these populations. Identified immunity gaps should be closed promptly by strategic, targeted serologic screening, followed by vaccination of those lacking MMR antibodies. Full article
(This article belongs to the Special Issue Vaccines and Immunization: Measles, Mumps, and Rubella)
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