The Effectiveness of Influenza Vaccine

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Influenza Virus Vaccines".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 1843

Special Issue Editors

Special Issue Information

Dear Colleagues,

Influenza vaccines reduce the disease burden by lowering the risk of infection, severe illness, and complications. Their effectiveness can vary each year due to several factors, including changes in the virus, the selection of vaccine strains, age groups, and individual immune responses. Ongoing research aims to improve vaccine formulations and develop influenza vaccines that offer more robust and longer-lasting protection. Research is also critical for evidence-based decision-making in public health and is fundamental to maintaining progress and trust in immunization programs. This Special Issue will address all aspects of influenza vaccine effectiveness.

Dr. Filippo Ansaldi
Dr. Amicizia Daniela
Guest Editors

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Keywords

  • effectiveness
  • influenza vaccines
  • infection control
  • influenza vaccination
  • seasonal influenza vaccines

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Published Papers (1 paper)

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Research

14 pages, 1731 KiB  
Article
COVID-19 Vaccination Enhances the Immunogenicity of Seasonal Influenza Vaccination in the Elderly
by Engin Berber, Fani Pantouli, Hannah B. Hanley and Ted M. Ross
Vaccines 2025, 13(5), 531; https://doi.org/10.3390/vaccines13050531 - 16 May 2025
Viewed by 1549
Abstract
Background/Objectives: The co-circulation of both influenza viruses and SARS-CoV-2 poses a significant health risk, especially for the elderly. While vaccination against both diseases remains an effective strategy to reduce the burden of symptomatic infections, the effect of administering COVID-19 mRNA and seasonal influenza [...] Read more.
Background/Objectives: The co-circulation of both influenza viruses and SARS-CoV-2 poses a significant health risk, especially for the elderly. While vaccination against both diseases remains an effective strategy to reduce the burden of symptomatic infections, the effect of administering COVID-19 mRNA and seasonal influenza vaccines (COV-Flu) on elicited antibody responses has not been explored. Methods: Participants between 18 and 90 years old were vaccinated with COVID-19 mRNA vaccines (n = 67), seasonal influenza vaccines (n = 130), or both (n = 201) within a three-month period between 2021 and 2024. Serum hemagglutination-inhibition (HAI) titers against influenza A (H1N1, H3N2) and B (Yamagata, Victoria) strains were measured from the COV-Flu participants or the participants vaccinated with influenza vaccines only (mono-Flu). SARS-CoV-2 neutralization assays were performed on sera collected from the COV-Flu participants and the participants receiving the mRNA vaccine only (mono-COVID-19). Results: The administration of influenza virus vaccines and COVID-19 mRNA vaccines within a three-month period significantly enhanced the post-vaccination HAI titers against both influenza A and B vaccine components, particularly in the elderly (65–90) participants. There were no significant differences in SARS-CoV-2 neutralization titers in COV-Flu participants compared to mono-COVID-19 participants. Conclusions: Vaccination with both the COVID-19 mRNA and influenza vaccines enhances influenza-specific HAI titers without compromising the neutralization titers elicited by COVID-19 mRNA vaccination against SARS-CoV-2, especially in the elderly. These findings indicate the potential benefits of this approach, particularly for older adults, by boosting influenza virus vaccine-induced serum HAI activity while maintaining COVID-19 protective immunity. Full article
(This article belongs to the Special Issue The Effectiveness of Influenza Vaccine)
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