The Development of mRNA Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "DNA and mRNA Vaccines".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 468

Special Issue Editors


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Guest Editor
Advanced Research Institute of Multidisciplinary Sciences, Beijing Institute of Technology, Beijing, China
Interests: infectious disease; mRNA vaccine; coronavirus; immunology; adjuvant
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Guest Editor
School of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Interests: vaccine; virus–host interactions; antiviral immunity; coronavirus; enterovirus

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Guest Editor
School of Life Science, Beijing Institute of Technology, Beijing, China
Interests: nucleic acid therapeutics; lipid nanoparticle; targeting delivery; cancer; immunoregulation; vaccines

Special Issue Information

Dear Colleagues,

mRNA vaccines have emerged as a transformative platform in modern medicine, demonstrating remarkable success in combating infectious diseases, such as COVID-19 and RSV. This Special Issue aims to explore the latest advancements in mRNA vaccine research, encompassing a wide range of applications, from infectious disease prevention to tumor immunity. Topics of interest include innovative mRNA delivery systems that enhance stability and efficiency, novel vaccine designs targeting emerging pathogens and cancer antigens, and the development of next-generation adjuvants to optimize immune responses. Additionally, we welcome studies addressing manufacturing scalability, regulatory challenges, and strategies to broaden mRNA vaccine accessibility. By showcasing cutting-edge research, this Special Issue seeks to advance the field and inspire new approaches to address global health challenges.

Dr. Minghui Yang
Dr. Yuming Li
Dr. Bo Hu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • nanoparticle delivery system
  • mRNA vaccines
  • infectious disease
  • tumor immunity
  • adjuvant

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Published Papers (1 paper)

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Research

23 pages, 4903 KiB  
Article
Highly Effective mRNA-LNP Vaccine Against Respiratory Syncytial Virus (RSV) in Multiple Models
by Huarong Bai, Xueliang Yu, Yue Gao, Qin Li, Baigang Wen and Rongkuan Hu
Vaccines 2025, 13(6), 625; https://doi.org/10.3390/vaccines13060625 - 10 Jun 2025
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Abstract
Background: The transmembrane fusion (F) protein of RSV plays important roles in RSV pathogenesis as it mediates the fusion between the virus and the target cell membrane. During the fusion process, the F protein transits from a metastable state (prefusion, preF) to a [...] Read more.
Background: The transmembrane fusion (F) protein of RSV plays important roles in RSV pathogenesis as it mediates the fusion between the virus and the target cell membrane. During the fusion process, the F protein transits from a metastable state (prefusion, preF) to a stable state (postfusion, postF) after the merging of the virus and cell membranes. The majority of highly neutralizing antibodies induced by natural infection or immunization target the preF form, which makes it the preferred antigen for vaccine development. Methods: Here, we designed an effective RSV mRNA vaccine, STR-V003, consisting of mRNA encoding preF protein in lipid nanoparticles (LNPs). The immunogenicity, protection efficacy and toxicity were measured in multiple animal models. Results: STR-V003 demonstrated robust immunogenicity in both mice and cotton rats, inducing high levels of neutralizing antibodies and RSV preF-specific IgG antibodies and significantly reducing the RSV viral loads in the lung and nose tissue of challenged animals. In addition, STR-V003 did not show significant enhancement of lung pathology without causing vaccine-enhanced disease (VED). The repeated dose general toxicology studies and local tolerance studies of STR-V003 were evaluated in rats and non-human primate (NHP). Conclusions: STR-V003 demonstrates a favorable safety profile and induces robust protective immunity against RSV. Full article
(This article belongs to the Special Issue The Development of mRNA Vaccines)
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