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Cancers, Volume 16, Issue 6

March-2 2024 - 165 articles

Cover Story: The BCL2 inhibitor venetoclax combined with the hypomethylating agent azacitidine is the new therapeutic standard for elderly or unfit acute myeloid leukemia patients. Despite a 65% composite response rate, overall survival is about 14 months, underlying the need for new therapeutics with improved efficacy and low toxicity. Gene mutations associated with resistance or relapse are TP53, signaling mutations, and the newly described BAX mutations. Venetoclax-based triplet therapies, including IDH and FLT3 inhibitors or menin inhibitors, are under investigation to improve patient outcomes. A better comprehension of genomic and non-genomic evolution upon treatment and the interplay between genomic alterations and apoptosis will allow us to tackle resistance mechanisms in the future. View this paper
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Articles (165)

  • Article
  • Open Access
4 Citations
2,421 Views
14 Pages

Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma

  • Atsushi Kasamatsu,
  • Ryunosuke Nozaki,
  • Kohei Kawasaki,
  • Tomoaki Saito,
  • Chikashi Minemura,
  • Naohiko Seki,
  • Joel Moss and
  • Katsuhiro Uzawa

21 March 2024

microRNAs (miRs) function in cancer progression as post-transcriptional regulators. We previously reported that endogenous circular RNAs (circRNAs) function as efficient miR sponges and could act as novel gene regulators in oral squamous cell carcino...

  • Article
  • Open Access
4 Citations
3,581 Views
11 Pages

Incidence of Catheter-Associated Bloodstream Infections in Stem Cell Recipients—Should We Be “PICCy”?

  • Sławomir Milczarek,
  • Piotr Kulig,
  • Oliwia Piotrowska,
  • Alina Zuchmańska,
  • Ewa Wilk-Milczarek and
  • Bogusław Machaliński

21 March 2024

The management of patients undergoing HSCT requires a multipurpose central venous catheter. Peripheral catheters (PCs), such as peripherally inserted central catheters (PICCs) and MidLine catheters (MLCs), appear to be adequate vascular catheters to...

  • Article
  • Open Access
6 Citations
3,066 Views
16 Pages

Long-Term Follow-Up Outcomes in Women with In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix Undergoing Conservative Treatment—Cervical Adenocarcinoma Study Group Italian Society of Colposcopy and Cervico-Vaginal Pathology

  • Luca Giannella,
  • Giovanni Delli Carpini,
  • Jacopo Di Giuseppe,
  • Camilla Grelloni,
  • Giorgio Bogani,
  • Marco Dri,
  • Francesco Sopracordevole,
  • Nicolò Clemente,
  • Giorgio Giorda and
  • Rosa De Vincenzo
  • + 19 authors

21 March 2024

Objective: The present study aimed to assess long-term follow-up outcomes in women with in situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional study including women with earl...

  • Review
  • Open Access
6 Citations
15,052 Views
23 Pages

Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy

  • Marianna Ciwun,
  • Anna Tankiewicz-Kwedlo and
  • Dariusz Pawlak

21 March 2024

Naltrexone (NTX) is a non-selective antagonist of opioid receptors, primarily used in the therapy of opioid and alcohol dependence. Low-dose naltrexone (LDN) exhibits antagonistic action against the opioid growth factor receptor (OGFr), whose signali...

  • Review
  • Open Access
20 Citations
5,686 Views
30 Pages

Regulation of PD-L1 Expression by YY1 in Cancer: Therapeutic Efficacy of Targeting YY1

  • Ana Dillen,
  • Indy Bui,
  • Megan Jung,
  • Stephanie Agioti,
  • Apostolos Zaravinos and
  • Benjamin Bonavida

21 March 2024

During the last decade, we have witnessed several milestones in the treatment of various resistant cancers including immunotherapeutic strategies that have proven to be superior to conventional treatment options, such as chemotherapy and radiation. T...

  • Review
  • Open Access
10 Citations
2,794 Views
12 Pages

21 March 2024

Pancreatic cancer is on track to become the second leading cause of cancer-related deaths by 2030, yet there is a lack of accurate diagnostic tests for early detection. Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic can...

  • Systematic Review
  • Open Access
2 Citations
5,501 Views
17 Pages

Lung Cancer Proteogenomics: Shaping the Future of Clinical Investigation

  • Theofanis Vavilis,
  • Maria Louiza Petre,
  • Giannis Vatsellas,
  • Alexandra Ainatzoglou,
  • Eleni Stamoula,
  • Athanasios Sachinidis,
  • Malamatenia Lamprinou,
  • Ioannis Dardalas,
  • Ioannis N. Vamvakaris and
  • Ioannis Gkiozos
  • + 2 authors

21 March 2024

Background: Lung cancer is associated with a high incidence of mortality worldwide. Molecular mechanisms governing the disease have been explored by genomic studies; however, several aspects remain elusive. The integration of genomic profiling with i...

  • Article
  • Open Access
1 Citations
3,344 Views
13 Pages

Clinical Outcomes in Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinus: A Comparative Analysis of Treatment Modalities

  • Tae Hoon Lee,
  • Kangpyo Kim,
  • Dongryul Oh,
  • Kyungmi Yang,
  • Han-Sin Jeong,
  • Man Ki Chung and
  • Yong Chan Ahn

21 March 2024

This study aimed to present the treatment patterns and outcomes for adenoid cystic carcinoma (ACC) arising in the nasal cavity and paranasal sinus. Sixty-one sinonasal ACC patients were retrospectively reviewed: 31 (50.8%) underwent surgery followed...

  • Correction
  • Open Access
1,605 Views
5 Pages
  • Article
  • Open Access
2 Citations
2,351 Views
14 Pages

Enhancing Whole-Brain Magnetic Field Homogeneity for 3D-Magnetic Resonance Spectroscopic Imaging with a Novel Unified Coil: A Preliminary Study

  • Archana Vadiraj Malagi,
  • Xinqi Li,
  • Na Zhang,
  • Yucen Liu,
  • Yuheng Huang,
  • Fardad Michael Serry,
  • Ziyang Long,
  • Chia-Chi Yang,
  • Yujie Shan and
  • Yubin Cai
  • + 5 authors

21 March 2024

The spectral quality of magnetic resonance spectroscopic imaging (MRSI) can be affected by strong magnetic field inhomogeneities, posing a challenge for 3D-MRSI’s widespread clinical use with standard scanner-equipped 2nd-order shim coils. To o...

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Cancers - ISSN 2072-6694