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Micromachines, Volume 11, Issue 5

2020 May - 88 articles

Cover Story: Gathering precise information on the mass density, size, and weight of cells or cell aggregates is crucial for applications in many biomedical fields. The research interest is especially increasing for 3D models such as spheroids. Consequently, we developed the first flow-apparatus, associated physical method, and operative protocol for the accurate and simultaneous measurements of mass density, size, and weight of sphere-like samples. The technique is based on detection of the terminal velocity of a free-falling sample into a specifically conceived analysis flow-channel. After validation with standardized polystyrene beads, we measured such parameters on a notable number of live SW620 tumor spheroids. This approach can represent a step towards a deeper understanding of 3D models. View this paper
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Articles (88)

  • Article
  • Open Access
13 Citations
5,297 Views
18 Pages

As the range of applications of organs-on-chips is broadening, the evaluation of aerosol-based therapies using a lung-on-a-chip model has become an attractive approach. Inhalation therapies are not only minimally invasive but also provide optimal pha...

(This article belongs to the Section E: Engineering and Technology)
  • Article
  • Open Access
21 Citations
3,412 Views
13 Pages

In this paper, a discrete second order linear equation with the Krasnosel’skii-Pokrovskii (KP) operator is used to describe the piezoelectric actuated stage. The weights of the KP operators are identified by the gradient descent algorithm. To s...

(This article belongs to the Section E: Engineering and Technology)
  • Feature Paper
  • Article
  • Open Access
12 Citations
7,126 Views
16 Pages

Hemispherical Microelectrode Array for Ex Vivo Retinal Neural Recording

  • Yoonhee Ha,
  • Hyun-Ji Yoo,
  • Soowon Shin and
  • Sang Beom Jun

To investigate the neuronal visual encoding process in the retina, researchers have performed in vitro and ex vivo electrophysiological experiments using animal retinal tissues. The microelectrode array (MEA) has become a key component in retinal exp...

(This article belongs to the Special Issue Micro/Nanofabrication for Retinal Implants)
  • Article
  • Open Access
22 Citations
5,026 Views
16 Pages

To assemble microobjects including biological cells quickly and precisely, a fully automated pick-and-place operation is applied. In micromanipulation in liquid, the challenges include strong adhesion forces and high dynamic viscosity. To solve these...

(This article belongs to the Special Issue Microrobotics for Biological, Biomedical, and Surgical Applications)
  • Feature Paper
  • Review
  • Open Access
30 Citations
11,971 Views
26 Pages

Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients

  • Shinyong Shim,
  • Kyungsik Eom,
  • Joonsoo Jeong and
  • Sung June Kim

Retinal prostheses are implantable devices that aim to restore the vision of blind patients suffering from retinal degeneration, mainly by artificially stimulating the remaining retinal neurons. Some retinal prostheses have successfully reached the s...

(This article belongs to the Special Issue Micro/Nanofabrication for Retinal Implants)
  • Article
  • Open Access
24 Citations
5,368 Views
13 Pages

Direct Write of 3D Nanoscale Mesh Objects with Platinum Precursor via Focused Helium Ion Beam Induced Deposition

  • Alex Belianinov,
  • Matthew J. Burch,
  • Anton Ievlev,
  • Songkil Kim,
  • Michael G. Stanford,
  • Kyle Mahady,
  • Brett B. Lewis,
  • Jason D. Fowlkes,
  • Philip D. Rack and
  • Olga S. Ovchinnikova

The next generation optical, electronic, biological, and sensing devices as well as platforms will inevitably extend their architecture into the 3rd dimension to enhance functionality. In focused ion beam induced deposition (FIBID), a helium gas fiel...

(This article belongs to the Special Issue Nanofabrication with Focused Electron/Ion Beam Induced Processing)
  • Article
  • Open Access
7 Citations
3,943 Views
13 Pages

The purpose of this study was to investigate the effects of the microstructure and properties of Cu/Ni multilayer films prepared by magnetron sputtering and electroplating on the electrical explosion performance of the films. In this study, Cu/Ni mul...

(This article belongs to the Special Issue Miniaturized Pyro Devices)
  • Article
  • Open Access
9 Citations
4,051 Views
13 Pages

While nanoscale electrokinetic studies based on ion concentration polarization has been actively researched recently, random vortices naturally occur, leading to significantly destabilize in laboratory experiments or practical applications. These ran...

(This article belongs to the Special Issue Electrokinetics in Micro-/nanofluidic Devices)
  • Feature Paper
  • Review
  • Open Access
58 Citations
8,148 Views
23 Pages

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis

  • Kaoru Hiramoto,
  • Elena Villani,
  • Tomoki Iwama,
  • Keika Komatsu,
  • Shinsuke Inagi,
  • Kumi Y. Inoue,
  • Yuji Nashimoto,
  • Kosuke Ino and
  • Hitoshi Shiku

Mammalian cell analysis is essential in the context of both fundamental studies and clinical applications. Among the various techniques available for cell analysis, electrochemiluminescence (ECL) has attracted significant attention due to its integra...

(This article belongs to the Special Issue Micro and Nano Devices for Cell Analysis)
  • Feature Paper
  • Review
  • Open Access
33 Citations
5,311 Views
19 Pages

Cancer metastasis is the primary cause of high mortality of cancer patients. Enumeration of circulating tumor cells (CTCs) in the bloodstream is a very important indicator to estimate the therapeutic outcome in various metastatic cancers. The aim of...

(This article belongs to the Special Issue Selected Papers from the 2019 International Conference on Smart Sensors (ICSS))
  • Article
  • Open Access
65 Citations
9,222 Views
17 Pages

Development of a Multi-Material Stereolithography 3D Printing Device

  • Bilal Khatri,
  • Marco Frey,
  • Ahmed Raouf-Fahmy,
  • Marc-Vincent Scharla and
  • Thomas Hanemann

Additive manufacturing, or nowadays more popularly entitled as 3D printing, enables a fast realization of polymer, metal, ceramic or composite devices, which often cannot be fabricated with conventional methods. One critical issue for a continuation...

(This article belongs to the Section E: Engineering and Technology)
  • Article
  • Open Access
50 Citations
5,896 Views
22 Pages

The dielectrophoresis (DEP) data reported in the literature since 1994 for 22 different globular proteins is examined in detail. Apart from three cases, all of the reported protein DEP experiments employed a gradient field factor ∇ E m 2 ...

(This article belongs to the Special Issue Micromachines for Dielectrophoresis)
  • Article
  • Open Access
18 Citations
5,240 Views
13 Pages

Magnetostrictive Performance of Electrodeposited TbxDy(1−x)Fey Thin Film with Microcantilever Structures

  • Hang Shim,
  • Kei Sakamoto,
  • Naoki Inomata,
  • Masaya Toda,
  • Nguyen Van Toan and
  • Takahito Ono

The microfabrication with a magnetostrictive TbxDy(1−x)Fey thin film for magnetic microactuators is developed, and the magnetic and magnetostrictive actuation performances of the deposited thin film are evaluated. The magnetostrictive thin film...

(This article belongs to the Section D: Materials and Processing)
  • Article
  • Open Access
8 Citations
5,616 Views
11 Pages

Threshold voltage adjustment in threshold switching (TS) devices with HfO2/Al2O3 superlattice (by means of changing the cycle ratio of HfO2 to Al2O3 in atomic layer deposition) is investigated to implement a transparent cross-point array. TS devices...

(This article belongs to the Special Issue Deformable Bioelectronics Based on Functional Micro/nanomaterials)
  • Article
  • Open Access
43 Citations
5,659 Views
13 Pages

Development of a Portable SPR Sensor for Nucleic Acid Detection

  • Yafeng Huang,
  • Lulu Zhang,
  • Hao Zhang,
  • Yichen Li,
  • Luyao Liu,
  • Yuanyuan Chen,
  • Xianbo Qiu and
  • Duli Yu

Nucleic acid detection is of great significance in clinical diagnosis, environmental monitoring and food safety. Compared with the traditional nucleic acid amplification detection method, surface plasmon resonance (SPR) sensing technology has the adv...

(This article belongs to the Section B: Biology and Biomedicine)
  • Article
  • Open Access
31 Citations
7,240 Views
13 Pages

PIN-PMN-PT Single Crystal 1-3 Composite-based 20 MHz Ultrasound Phased Array

  • Wei Zhou,
  • Tao Zhang,
  • Jun Ou-Yang,
  • Xiaofei Yang,
  • Dawei Wu and
  • Benpeng Zhu

Based on a modified dice-and-fill technique, a PIN-PMN-PT single crystal 1-3 composite with the kerf of 12 μm and pitch of 50 μm was prepared. The as-made piezoelectric composite material behaved with high piezoelectric constant (d33 = 1500 pC/...

(This article belongs to the Special Issue Piezoelectric Transducers: Materials, Devices and Applications)
  • Article
  • Open Access
8 Citations
4,418 Views
10 Pages

A Facile Preparation and Energetic Characteristics of the Core/Shell CoFe2O4/Al Nanowires Thermite Film

  • Chunpei Yu,
  • Wei Ren,
  • Ganggang Wu,
  • Wenchao Zhang,
  • Bin Hu,
  • Debin Ni,
  • Zilong Zheng,
  • Kefeng Ma,
  • Jiahai Ye and
  • Chenguang Zhu

In this study, CoFe2O4 is selected for the first time to synthesize CoFe2O4/Al nanothermite films via an integration of nano-Al with CoFe2O4 nanowires (NWs), which can be prepared through a facile hydrothermal-annealing route. The resulting nanotherm...

(This article belongs to the Special Issue Miniaturized Pyro Devices)
  • Article
  • Open Access
10 Citations
4,499 Views
16 Pages

Bidirectional Linear Motion by Travelling Waves on Legged Piezoelectric Microfabricated Plates

  • Víctor Ruiz-Díez,
  • Jorge Hernando-García,
  • Javier Toledo,
  • Abdallah Ababneh,
  • Helmut Seidel and
  • José Luis Sánchez-Rojas

This paper reports the design, fabrication and performance of MEMS-based piezoelectric bidirectional conveyors featuring 3D printed legs, driven by linear travelling waves (TW). The structures consisted of an aluminium–nitride (AlN) piezoelectr...

(This article belongs to the Section A: Physics)
  • Article
  • Open Access
27 Citations
6,529 Views
13 Pages

3D printing has lately received considerable critical attention for the fast fabrication of 3D structures to be utilized in various industrial applications. This study aimed to fabricate a micro beam with digital light processing (DLP) based 3D print...

(This article belongs to the Special Issue 3D Printing of MEMS Technology)
  • Review
  • Open Access
30 Citations
7,848 Views
21 Pages

Vertical GaN-on-GaN Schottky Diodes as α-Particle Radiation Sensors

  • Abhinay Sandupatla,
  • Subramaniam Arulkumaran,
  • Ng Geok Ing,
  • Shugo Nitta,
  • John Kennedy and
  • Hiroshi Amano

Among the different semiconductors, GaN provides advantages over Si, SiC and GaAs in radiation hardness, resulting in researchers exploring the development of GaN-based radiation sensors to be used in particle physics, astronomic and nuclear science...

(This article belongs to the Special Issue Wide Bandgap Based Devices: Design, Fabrication and Applications)
  • Article
  • Open Access
22 Citations
4,637 Views
18 Pages

Performance and Accuracy of the Shifted Laser Surface Texturing Method

  • Jiří Martan,
  • Denys Moskal,
  • Ladislav Smeták and
  • Milan Honner

A shifted laser surface texturing method (sLST) was developed for the improvement of the production speed of functional surface textures to enable their industrial applicability. This paper compares the shifted method to classic methods using a pract...

(This article belongs to the Special Issue Advanced Techniques for Ultrafast Laser Nano/Micro Patterning)
  • Article
  • Open Access
60 Citations
5,632 Views
15 Pages

Route to Intelligent Imaging Reconstruction via Terahertz Nonlinear Ghost Imaging

  • Juan S. Totero Gongora,
  • Luana Olivieri,
  • Luke Peters,
  • Jacob Tunesi,
  • Vittorio Cecconi,
  • Antonio Cutrona,
  • Robyn Tucker,
  • Vivek Kumar,
  • Alessia Pasquazi and
  • Marco Peccianti

Terahertz (THz) imaging is a rapidly emerging field, thanks to many potential applications in diagnostics, manufacturing, medicine and material characterisation. However, the relatively coarse resolution stemming from the large wavelength limits the...

(This article belongs to the Special Issue Nonlinear Photonics Devices)
  • Article
  • Open Access
10 Citations
5,565 Views
13 Pages

Mechanically Enabled Two-Axis Ultrasonic-Assisted System for Ultra-Precision Machining

  • Nan Yu,
  • Jinghang Liu,
  • Hélène Mainaud Durand and
  • Fengzhou Fang

With the use of ultrasonic-assisted diamond cutting, an optical surface finish can be achieved on hardened steel or even brittle materials such as glass and infrared materials. The proposed ultrasonic vibration cutting system includes an ultrasonic g...

(This article belongs to the Special Issue Ultra Precision Technologies for Micromachining)
  • Article
  • Open Access
5 Citations
4,706 Views
13 Pages

Experiments on Liquid Flow through Non-Circular Micro-Orifices

  • Stefano Cassineri,
  • Andrea Cioncolini,
  • Liam Smith,
  • Michele Curioni and
  • Fabio Scenini

Microfluidics is an active research area in modern fluid mechanics, with several applications in science and engineering. Despite their importance in microfluidic systems, micro-orifices with non-circular cross-sections have not been extensively inve...

(This article belongs to the Section A: Physics)
  • Article
  • Open Access
9 Citations
4,533 Views
12 Pages

Micromachining of High Quality PMN–31%PT Single Crystals for High-Frequency (>20 MHz) Ultrasonic Array Transducer Applications

  • Zhihong Lei,
  • Yan Chen,
  • Guisheng Xu,
  • Jinfeng Liu,
  • Maodan Yuan,
  • Lvming Zeng,
  • Xuanrong Ji and
  • Dawei Wu

A decrease of piezoelectric properties in the fabrication of ultra-small Pb(Mg1/3Nb2/3)–x%PbTiO3 (PMN–x%PT) for high-frequency (>20 MHz) ultrasonic array transducers remains an urgent problem. Here, PMN–31%PT with micron-sized ke...

(This article belongs to the Section D: Materials and Processing)
  • Article
  • Open Access
17 Citations
4,444 Views
16 Pages

AC/DC Fields Demodulation Methods of Resonant Electric Field Microsensor

  • Pengfei Yang,
  • Xiaolong Wen,
  • Zhaozhi Chu,
  • Xiaoming Ni and
  • Chunrong Peng

Electric field microsensors have the advantages of a small size, a low power consumption, of avoiding wear, and of measuring both direct-current (DC) and alternating-current (AC) fields, which are especially suited to applications in power systems. H...

(This article belongs to the Special Issue Power Electronics and Sensors)
  • Review
  • Open Access
35 Citations
7,141 Views
24 Pages

Cell dielectric properties, a type of intrinsic property of cells, can be used as electrophysiological biomarkers that offer a label-free way to characterize cell phenotypes and states, purify clinical samples, and identify target cancer cells. Here,...

(This article belongs to the Special Issue Electrokinetics in Micro-/nanofluidic Devices)
  • Article
  • Open Access
14 Citations
5,254 Views
14 Pages

Label-Free, High-Throughput Assay of Human Dendritic Cells from Whole-Blood Samples with Microfluidic Inertial Separation Suitable for Resource-Limited Manufacturing

  • Mohamed Yousuff Caffiyar,
  • Kue Peng Lim,
  • Ismail Hussain Kamal Basha,
  • Nor Hisham Hamid,
  • Sok Ching Cheong and
  • Eric Tatt Wei Ho

Microfluidics technology has not impacted the delivery and accessibility of point-of-care health services, like diagnosing infectious disease, monitoring health or delivering interventions. Most microfluidics prototypes in academic research are not e...

(This article belongs to the Special Issue Microfluidics Technologies for Cell-based Assays)
  • Article
  • Open Access
9 Citations
7,508 Views
11 Pages

A Simple and Rapid Fungal DNA Isolation Assay Based on ZnO Nanoparticles for the Diagnosis of Invasive Aspergillosis

  • Zhen Qiao,
  • Huifang Liu,
  • Geun Su Noh,
  • Bonhan Koo,
  • Qingshuang Zou,
  • Kyusik Yun,
  • Yoon Ok Jang,
  • Sung-Han Kim and
  • Yong Shin

Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised people. Imaging and specimen tests used in the clinical diagnosis of aspergillosis with weak and indistinct defects leads to delay in the treatment o...

(This article belongs to the Section B: Biology and Biomedicine)
  • Article
  • Open Access
16 Citations
5,293 Views
11 Pages

Effects of Intense Pulsed Light (IPL) Rapid Annealing and Back-Channel Passivation on Solution-Processed In-Ga-Zn-O Thin Film Transistors Array

  • Hyun Jae Kim,
  • Chul Jong Han,
  • Byungwook Yoo,
  • Jeongno Lee,
  • Kimoon Lee,
  • Kyu Hyoung Lee and
  • Min Suk Oh

We report on the effects of the intense pulsed light (IPL) rapid annealing process and back-channel passivation on the solution-processed In-Ga-Zn-O (IGZO) thin film transistors (TFTs) array. To improve the electrical properties, stability and unifor...

(This article belongs to the Section A: Physics)
  • Article
  • Open Access
16 Citations
5,088 Views
13 Pages

Hybrid Process Chain for the Integration of Direct Ink Writing and Polymer Injection Molding

  • Dario Loaldi,
  • Leonardo Piccolo,
  • Eric Brown,
  • Guido Tosello,
  • Corey Shemelya and
  • Davide Masato

The integration of additive manufacturing direct-writing technologies with injection molding provides a novel method to combine functional features into plastic products, and could enable mass-manufacturing of custom-molded plastic parts. In this wor...

(This article belongs to the Special Issue Latest Advancements in Micro Nano Molding Technologies – Process Developments and Optimization, Materials, Applications, Key Enabling Technologies)
  • Article
  • Open Access
5 Citations
4,768 Views
11 Pages

Microelectrode Array based Functional Testing of Pancreatic Islet Cells

  • Ahmad Alassaf,
  • Matthew Ishahak,
  • Annie Bowles and
  • Ashutosh Agarwal

Electrophysiological techniques to characterize the functionality of islets of Langerhans have been limited to short-term, one-time recordings such as a patch clamp recording. We describe the use of microelectrode arrays (MEAs) to better understand t...

(This article belongs to the Special Issue Microelectrode Arrays and Application to Medical Devices)
  • Article
  • Open Access
15 Citations
3,238 Views
14 Pages

Increasing the power density and bandwidth are two major challenges associated with microelectromechanical systems (MEMS)-based vibration energy harvesting devices. Devices implementing magnetic forces have been used to create nonlinear vibration str...

  • Article
  • Open Access
30 Citations
5,167 Views
17 Pages

Dielectrophoretic Immobilization of Yeast Cells Using CMOS Integrated Microfluidics

  • Honeyeh Matbaechi Ettehad,
  • Pouya Soltani Zarrin,
  • Ralph Hölzel and
  • Christian Wenger

This paper presents a dielectrophoretic system for the immobilization and separation of live and dead cells. Dielectrophoresis (DEP) is a promising and efficient investigation technique for the development of novel lab-on-a-chip devices, which charac...

(This article belongs to the Special Issue Micromachines for Dielectrophoresis)
  • Article
  • Open Access
9 Citations
3,819 Views
28 Pages

STT-DPSA: Digital PUF-Based Secure Authentication Using STT-MRAM for the Internet of Things

  • Wei-Chen Chien,
  • Yu-Chian Chang,
  • Yao-Tung Tsou,
  • Sy-Yen Kuo and
  • Ching-Ray Chang

Physical unclonable function (PUF), a hardware-efficient approach, has drawn a lot of attention in the security research community for exploiting the inevitable manufacturing variability of integrated circuits (IC) as the unique fingerprint of each I...

(This article belongs to the Special Issue Progress of Emerging Hardware Development for Post-Moore’s Computing)
  • Article
  • Open Access
35 Citations
5,572 Views
15 Pages

Integrated Immunomagnetic Bead-Based Microfluidic Chip for Exosomes Isolation

  • Fuzhou Niu,
  • Xifu Chen,
  • Xuemei Niu,
  • Yifan Cai,
  • Qingkui Zhang,
  • Tao Chen and
  • Hao Yang

Exosomes are essential early biomarkers for health monitoring and cancer diagnosis. A prerequisite for further investigation of exosomes is the isolation, which is technically challenging due to the complexity of body fluids. This paper presents the...

(This article belongs to the Section B: Biology and Biomedicine)
  • Article
  • Open Access
13 Citations
11,422 Views
12 Pages

150–200 V Split-Gate Trench Power MOSFETs with Multiple Epitaxial Layers

  • Feng-Tso Chien,
  • Zhi-Zhe Wang,
  • Cheng-Li Lin,
  • Tsung-Kuei Kang,
  • Chii-Wen Chen and
  • Hsien-Chin Chiu

A rating voltage of 150 and 200 V split-gate trench (SGT) power metal-oxide- semiconductor field-effect transistor (Power MOSFET) with different epitaxial layers was proposed and studied. In order to reduce the specific on-resistance (Ron,sp) of a 15...

(This article belongs to the Special Issue Miniaturized Transistors, Volume II)
  • Article
  • Open Access
9 Citations
4,842 Views
14 Pages

Patterning of Particles and Live Cells at Single Cell Resolution

  • Adar Hacohen,
  • Hadass R. Jessel,
  • Alon Richter-Levin and
  • Orit Shefi

The ability to manipulate and selectively position cells into patterns or distinct microenvironments is an important component of many single cell experimental methods and biological engineering applications. Although a variety of particles and cell...

  • Article
  • Open Access
39 Citations
8,726 Views
15 Pages

Driving Waveform Design of Electrophoretic Display Based on Optimized Particle Activation for a Rapid Response Speed

  • Wenyao He,
  • Zichuan Yi,
  • Shitao Shen,
  • Zhenyu Huang,
  • Linwei Liu,
  • Taiyuan Zhang,
  • Wei Li,
  • Li Wang,
  • Lingling Shui and
  • Guofu Zhou
  • + 1 author

Electrophoretic displays (EPDs) have excellent paper-like display features, but their response speed is as long as hundreds of milliseconds. This is particularly important when optimizing the driving waveform for improving the response speed. Hence,...

(This article belongs to the Special Issue Micromachines for Dielectrophoresis)
  • Article
  • Open Access
15 Citations
5,587 Views
11 Pages

Transparent Microelectrode Arrays Fabricated by Ion Beam Assisted Deposition for Neuronal Cell In Vitro Recordings

  • Tomi Ryynänen,
  • Ropafadzo Mzezewa,
  • Ella Meriläinen,
  • Tanja Hyvärinen,
  • Jukka Lekkala,
  • Susanna Narkilahti and
  • Pasi Kallio

Microelectrode array (MEA) is a tool used for recording bioelectric signals from electrically active cells in vitro. In this paper, ion beam assisted electron beam deposition (IBAD) has been used for depositing indium tin oxide (ITO) and titanium nit...

(This article belongs to the Special Issue Microelectrode Arrays and Application to Medical Devices)
  • Article
  • Open Access
8 Citations
4,395 Views
11 Pages

Thin-Film MEMS Resistors with Enhanced Lifetime for Thermal Inkjet

  • Elkana Bar-Levav,
  • Moshe Witman and
  • Moshe Einat

In this paper, the failure mechanisms of the thermal inkjet thin-film resistors are recognized. Additionally, designs of resistors to overcome these mechanisms are suggested and tested by simulation and experiment. The resulting resistors are shown t...

(This article belongs to the Special Issue 3D Printing of MEMS Technology)
  • Article
  • Open Access
22 Citations
5,650 Views
13 Pages

The flow of data between processing and memory units in contemporary computing systems is their main performance and energy-efficiency bottleneck, often referred to as the ‘von Neumann bottleneck’ or ‘memory wall’. Emerging re...

(This article belongs to the Special Issue Progress of Emerging Hardware Development for Post-Moore’s Computing)
  • Article
  • Open Access
18 Citations
3,802 Views
13 Pages

Micro-end-milling is a cutting technology that removes redundant material from machined workpieces by small-diameter end mills, and is widely used to manufacture miniature complex parts. During micro-end-milling, the cutting vibration caused by weak...

(This article belongs to the Section D: Materials and Processing)
  • Article
  • Open Access
14 Citations
6,255 Views
13 Pages

Photocatalytic Nanofabrication and Intracellular Raman Imaging of Living Cells with Functionalized AFM Probes

  • Takayuki Shibata,
  • Hiromi Furukawa,
  • Yasuharu Ito,
  • Masahiro Nagahama,
  • Terutake Hayashi,
  • Miho Ishii-Teshima and
  • Moeto Nagai

Atomic force microscopy (AFM) is an effective platform for in vitro manipulation and analysis of living cells in medical and biological sciences. To introduce additional new features and functionalities into a conventional AFM system, we investigated...

(This article belongs to the Special Issue Selected Papers from the 10th Symposium on Micro-Nano Science and Technology on Micromachines)
  • Article
  • Open Access
22 Citations
4,937 Views
16 Pages

Novel Hybrid Manufacturing Process of CM247LC and Multi-Material Blisks

  • Xiqian Wang,
  • Luke N. Carter,
  • Nicholas J. E. Adkins,
  • Khamis Essa and
  • Moataz M. Attallah

The study on CM247LC used the traditional approach for Near-Netshape Hot Isostatic Pressing (NNSHIP) with sacrificial low carbon steel tooling, which was built using Selective Laser Melting (SLM), to produce a shaped CM247LC blisk. The assessment of...

(This article belongs to the Section E: Engineering and Technology)
  • Article
  • Open Access
12 Citations
4,274 Views
13 Pages

With the continuous development of cancer therapy, conventional animal models have exposed a series of shortcomings such as ethical issues, being time consuming and having an expensive cost. As an alternative method, microfluidic devices have shown a...

(This article belongs to the Section B: Biology and Biomedicine)
  • Review
  • Open Access
26 Citations
6,800 Views
19 Pages

Advances in the Development of Innovative Sensor Platforms for Field Analysis

  • Silvia Rizzato,
  • Angelo Leo,
  • Anna Grazia Monteduro,
  • Maria Serena Chiriacò,
  • Elisabetta Primiceri,
  • Fausto Sirsi,
  • Angelo Milone and
  • Giuseppe Maruccio

Sustainable growth, environmental preservation, and improvement of life quality are strategic fields of worldwide interest and cornerstones of international policies. Humanity health and prosperity are closely related to our present choices on sustai...

(This article belongs to the Section B: Biology and Biomedicine)
  • Article
  • Open Access
13 Citations
5,016 Views
14 Pages

Large-Field-of-View Visualization with Small Blind Spots Utilizing Tilted Micro-Camera Array for Laparoscopic Surgery

  • Alex J. Watras,
  • Jae-Jun Kim,
  • Jianwei Ke,
  • Hewei Liu,
  • Jacob A. Greenberg,
  • Charles P. Heise,
  • Yu Hen Hu and
  • Hongrui Jiang

Existing laparoscopic surgery systems use a single laparoscope to visualize the surgical area with a limited field of view (FoV), necessitating maneuvering the laparoscope to search a target region. In some cases, the laparoscope needs to be moved fr...

(This article belongs to the Section E: Engineering and Technology)
  • Article
  • Open Access
2 Citations
3,781 Views
11 Pages

All-Optical Formation and Manipulation of Microbubbles on a Porous Gold Nanofilm

  • Qin Cao,
  • Tianli Wu,
  • Xixi Chen,
  • Zhiyong Gong and
  • Ahao Wen

Microbubble generation and manipulation in aqueous environments are techniques that have attracted considerable attention for their microfluidic and biological applications. Ultrasonic and hydrodynamic methods are commonly used to form and manipulate...

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Micromachines - ISSN 2072-666X