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Micromachines, Volume 11, Issue 5

2020 May - 88 articles

Cover Story: Gathering precise information on the mass density, size, and weight of cells or cell aggregates is crucial for applications in many biomedical fields. The research interest is especially increasing for 3D models such as spheroids. Consequently, we developed the first flow-apparatus, associated physical method, and operative protocol for the accurate and simultaneous measurements of mass density, size, and weight of sphere-like samples. The technique is based on detection of the terminal velocity of a free-falling sample into a specifically conceived analysis flow-channel. After validation with standardized polystyrene beads, we measured such parameters on a notable number of live SW620 tumor spheroids. This approach can represent a step towards a deeper understanding of 3D models. View this paper
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Articles (88)

  • Article
  • Open Access
10 Citations
4,741 Views
18 Pages

As the range of applications of organs-on-chips is broadening, the evaluation of aerosol-based therapies using a lung-on-a-chip model has become an attractive approach. Inhalation therapies are not only minimally invasive but also provide optimal pha...

  • Article
  • Open Access
19 Citations
3,012 Views
13 Pages

In this paper, a discrete second order linear equation with the Krasnosel’skii-Pokrovskii (KP) operator is used to describe the piezoelectric actuated stage. The weights of the KP operators are identified by the gradient descent algorithm. To s...

  • Feature Paper
  • Article
  • Open Access
11 Citations
6,277 Views
16 Pages

Hemispherical Microelectrode Array for Ex Vivo Retinal Neural Recording

  • Yoonhee Ha,
  • Hyun-Ji Yoo,
  • Soowon Shin and
  • Sang Beom Jun

To investigate the neuronal visual encoding process in the retina, researchers have performed in vitro and ex vivo electrophysiological experiments using animal retinal tissues. The microelectrode array (MEA) has become a key component in retinal exp...

  • Article
  • Open Access
19 Citations
4,555 Views
16 Pages

To assemble microobjects including biological cells quickly and precisely, a fully automated pick-and-place operation is applied. In micromanipulation in liquid, the challenges include strong adhesion forces and high dynamic viscosity. To solve these...

  • Feature Paper
  • Review
  • Open Access
28 Citations
10,315 Views
26 Pages

Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients

  • Shinyong Shim,
  • Kyungsik Eom,
  • Joonsoo Jeong and
  • Sung June Kim

Retinal prostheses are implantable devices that aim to restore the vision of blind patients suffering from retinal degeneration, mainly by artificially stimulating the remaining retinal neurons. Some retinal prostheses have successfully reached the s...

  • Article
  • Open Access
22 Citations
4,681 Views
13 Pages

Direct Write of 3D Nanoscale Mesh Objects with Platinum Precursor via Focused Helium Ion Beam Induced Deposition

  • Alex Belianinov,
  • Matthew J. Burch,
  • Anton Ievlev,
  • Songkil Kim,
  • Michael G. Stanford,
  • Kyle Mahady,
  • Brett B. Lewis,
  • Jason D. Fowlkes,
  • Philip D. Rack and
  • Olga S. Ovchinnikova

The next generation optical, electronic, biological, and sensing devices as well as platforms will inevitably extend their architecture into the 3rd dimension to enhance functionality. In focused ion beam induced deposition (FIBID), a helium gas fiel...

  • Article
  • Open Access
6 Citations
3,517 Views
13 Pages

The purpose of this study was to investigate the effects of the microstructure and properties of Cu/Ni multilayer films prepared by magnetron sputtering and electroplating on the electrical explosion performance of the films. In this study, Cu/Ni mul...

  • Article
  • Open Access
9 Citations
3,623 Views
13 Pages

While nanoscale electrokinetic studies based on ion concentration polarization has been actively researched recently, random vortices naturally occur, leading to significantly destabilize in laboratory experiments or practical applications. These ran...

  • Feature Paper
  • Review
  • Open Access
52 Citations
7,209 Views
23 Pages

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis

  • Kaoru Hiramoto,
  • Elena Villani,
  • Tomoki Iwama,
  • Keika Komatsu,
  • Shinsuke Inagi,
  • Kumi Y. Inoue,
  • Yuji Nashimoto,
  • Kosuke Ino and
  • Hitoshi Shiku

Mammalian cell analysis is essential in the context of both fundamental studies and clinical applications. Among the various techniques available for cell analysis, electrochemiluminescence (ECL) has attracted significant attention due to its integra...

  • Feature Paper
  • Review
  • Open Access
30 Citations
4,722 Views
19 Pages

Cancer metastasis is the primary cause of high mortality of cancer patients. Enumeration of circulating tumor cells (CTCs) in the bloodstream is a very important indicator to estimate the therapeutic outcome in various metastatic cancers. The aim of...

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Micromachines - ISSN 2072-666X