Micromachines, Volume 11, Issue 5 (May 2020) – 88 articles
Cover Story (view full-size image): Gathering precise information on the mass density, size, and weight of cells or cell aggregates is crucial for applications in many biomedical fields. The research interest is especially increasing for 3D models such as spheroids. Consequently, we developed the first flow-apparatus, associated physical method, and operative protocol for the accurate and simultaneous measurements of mass density, size, and weight of sphere-like samples. The technique is based on detection of the terminal velocity of a free-falling sample into a specifically conceived analysis flow-channel. After validation with standardized polystyrene beads, we measured such parameters on a notable number of live SW620 tumor spheroids. This approach can represent a step towards a deeper understanding of 3D models. View this paper
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